PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26576227-0	2015	Lico A Enhances Nrf2-Mediated Defense Mechanisms against t-BHP-Induced Oxidative Stress and Cell Death via Akt and ERK Activation in RAW 264.7 Cells.	tert-Butylhydroperoxide	57-62	nuclear factor, erythroid derived 2, like 2	Mus musculus	16-20	
33027770-4	2020	SAC increased the nuclear translocation of Nrf2 and activated the Nrf2/HO1 signaling pathway in TBHP-treated chondrocytes.	tert-Butylhydroperoxide	96-100	nuclear factor, erythroid derived 2, like 2	Mus musculus	66-70	
33027770-5	2020	Furthermore, Nrf2 knockdown abrogated the antiapoptotic, antisenescence, and ECM regulatory effects of SAC in TBHP-treated chondrocytes.	tert-Butylhydroperoxide	110-114	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17	
33027770-7	2020	Collectively, these findings show that SAC ameliorates OA pathology in TBHP-treated chondrocytes and DMM model mice by activating the Nrf2/HO1 signaling pathway.	tert-Butylhydroperoxide	71-75	nuclear factor, erythroid derived 2, like 2	Mus musculus	134-138	
27907038-12	2016	Importantly, Nrf2 siRNA interference induced CHOP and attenuated the effect of equol to inhibit t-BHP mediated CHOP induction, furthermore, abrogated cell apoptosis induced by t-BHP, suggesting a role for Nrf2 in the protective effect of equol in HUVECs.	tert-Butylhydroperoxide	96-101	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17	
27907038-12	2016	Importantly, Nrf2 siRNA interference induced CHOP and attenuated the effect of equol to inhibit t-BHP mediated CHOP induction, furthermore, abrogated cell apoptosis induced by t-BHP, suggesting a role for Nrf2 in the protective effect of equol in HUVECs.	tert-Butylhydroperoxide	96-101	nuclear factor, erythroid derived 2, like 2	Mus musculus	205-209	
27907038-12	2016	Importantly, Nrf2 siRNA interference induced CHOP and attenuated the effect of equol to inhibit t-BHP mediated CHOP induction, furthermore, abrogated cell apoptosis induced by t-BHP, suggesting a role for Nrf2 in the protective effect of equol in HUVECs.	tert-Butylhydroperoxide	176-181	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17	
30668448-0	2019	Rutin protects t-butyl hydroperoxide-induced oxidative impairment via modulating the Nrf2 and iNOS activity.	tert-Butylhydroperoxide	15-36	nuclear factor, erythroid derived 2, like 2	Mus musculus	85-89	
28188924-0	2017	Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death.	tert-Butylhydroperoxide	66-90	nuclear factor, erythroid derived 2, like 2	Mus musculus	19-23	
28188924-0	2017	Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death.	tert-Butylhydroperoxide	92-97	nuclear factor, erythroid derived 2, like 2	Mus musculus	19-23	
28188924-7	2017	Furthermore, Daph exposure suppressed t-BHP-induced cytotoxicity and ROS overproduction, which are mostly blocked in Nrf2 knockout RAW 264.7 cells and peritoneal macrophages.	tert-Butylhydroperoxide	38-43	nuclear factor, erythroid derived 2, like 2	Mus musculus	117-121	
28188924-8	2017	Accordingly, Daph exhibited protective roles against t-BHP-triggered oxidative damage and mitochondrial dysfunction by the upregulation of Nrf2 antioxidant signaling pathways, which may be involved in the activation of JNK and ERK.	tert-Butylhydroperoxide	53-58	nuclear factor, erythroid derived 2, like 2	Mus musculus	139-143	
26576227-7	2015	Therefore, Lico A might have a protective role against t-BHP-induced cytotoxicity by modulating HO-1 and by scavenging ROS via the activation of the PI3K/Akt and ERK/Nrf2 signaling pathways.	tert-Butylhydroperoxide	55-60	nuclear factor, erythroid derived 2, like 2	Mus musculus	166-170	
18824057-7	2008	Taken together, these results suggest that the protective effects of AC against t-BHP-induced hepatotoxicity may, at least in part, be due to its ability to scavenge ROS and to regulate the antioxidant enzyme HO-1 via the ERK1/2 and p38/Nrf2 signaling pathways.	tert-Butylhydroperoxide	80-85	nuclear factor, erythroid derived 2, like 2	Mus musculus	237-241	
34511883-9	2021	0.025 and 0.05 microM BM prevented TBHP-induced mitochondrial damage and apoptosis in chondrocytes BM activated heme oxygenase-1 (HO-1)/NADPH quinone oxidoreductase 1 (NOQ1) signaling pathway through targeting nuclear factor erythroid derived-2-related factor 2 (Nrf2).	tert-Butylhydroperoxide	35-39	nuclear factor, erythroid derived 2, like 2	Mus musculus	210-261	
34511883-9	2021	0.025 and 0.05 microM BM prevented TBHP-induced mitochondrial damage and apoptosis in chondrocytes BM activated heme oxygenase-1 (HO-1)/NADPH quinone oxidoreductase 1 (NOQ1) signaling pathway through targeting nuclear factor erythroid derived-2-related factor 2 (Nrf2).	tert-Butylhydroperoxide	35-39	nuclear factor, erythroid derived 2, like 2	Mus musculus	263-267