PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24857917-0	2014	The cytoprotective effect of sulfuretin against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2/ARE and JNK/ERK MAPK-mediated heme oxygenase-1 expression.	tert-Butylhydroperoxide	48-72	mitogen-activated protein kinase 3	Homo sapiens	125-129	
16028365-6	2005	Pretreatment with the p38 MAP kinase inhibitor, SB203580 and the ERK1/2 inhibitor, PD98059, prevented t-BHP-induced increases in p65 translocation, NF-kappaB luciferase activity, and phospho-IKKalpha/beta.	tert-Butylhydroperoxide	102-107	mitogen-activated protein kinase 3	Homo sapiens	65-71	
32331354-7	2020	The protective effect of crocetin is mediated via the preservation of energy production pathways and activation of ERK1/2 in the first minutes of TBHP exposure to potentiate survival pathways.	tert-Butylhydroperoxide	146-150	mitogen-activated protein kinase 3	Homo sapiens	115-121	
18666426-7	2008	It was found that genistein, at 1 microM, diminished t-BHP-induced down-regulation of the IGF-I receptor, Shc, Sos and phosphorylated ERK1/ERK2 expression in fibroblasts.	tert-Butylhydroperoxide	53-58	mitogen-activated protein kinase 3	Homo sapiens	134-138	
24741394-5	2014	Moreover, TBHP-induced oxidative stress resulted in a transient ERK1/2 activation and a sustained increase of JNK1/2 activation.	tert-Butylhydroperoxide	10-14	mitogen-activated protein kinase 3	Homo sapiens	64-70	
18666426-9	2008	These results suggest that the mechanism of the protective effect of genistein on collagen biosynthesis in t-BHP-treated fibroblasts may be due to prevention of disturbances in the IGF-I receptor-mediated, ERK1/ERK2-associated signaling pathway evoked by the oxidant.	tert-Butylhydroperoxide	107-112	mitogen-activated protein kinase 3	Homo sapiens	206-210	
16705147-7	2006	In contrast, activation of ERK1/2 by expression of constitutively active MEK1 suppressed basal, uncoupled, and state 3 respirations in noninjured RPTC to the levels observed in TBHP-injured RPTC.	tert-Butylhydroperoxide	177-181	mitogen-activated protein kinase 3	Homo sapiens	27-33	
16705147-3	2006	Sublethal injury produced by tert-butylhydroperoxide (TBHP) resulted in three- to fivefold increase in phosphorylation of ERK1/2 and p38 but not JNK.	tert-Butylhydroperoxide	29-52	mitogen-activated protein kinase 3	Homo sapiens	122-128	
16705147-3	2006	Sublethal injury produced by tert-butylhydroperoxide (TBHP) resulted in three- to fivefold increase in phosphorylation of ERK1/2 and p38 but not JNK.	tert-Butylhydroperoxide	54-58	mitogen-activated protein kinase 3	Homo sapiens	122-128