PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30349447-9	2018	Afterward, a PI3K inhibitor, LY294002, was applied to confirm the influence of the PI3K/Akt pathway on TBHP-treated cells of 3,5-diCQA.	tert-Butylhydroperoxide	103-107	AKT serine/threonine kinase 1	Rattus norvegicus	88-91	
31120192-7	2019	In short, our results suggested that the cardioprotective role of SDX was related to the suppression of ER stress in mice MI/R models and TBHP-induced H9C2 cell injury which was through the PI3K/Akt signalling pathway.	tert-Butylhydroperoxide	138-142	AKT serine/threonine kinase 1	Rattus norvegicus	195-198	
30349447-12	2018	Moreover, 3,5-diCQA decreased expressions of Bax and caspase-3 but increased the phosphorylation levels of PI3K and Akt in TBHP-treated cells, which are the key molecules mediating cell survival, whereas phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphorylation was unchanged.	tert-Butylhydroperoxide	123-127	AKT serine/threonine kinase 1	Rattus norvegicus	116-119	
24675471-7	2014	The involvement of Akt and Fyn kinase in influencing Nrf2 signaling was further confirmed in oxidatively stressed hepatocytes by using tert-butyl hydroperoxide (tBHP).	tert-Butylhydroperoxide	135-159	AKT serine/threonine kinase 1	Rattus norvegicus	19-22	
24675471-7	2014	The involvement of Akt and Fyn kinase in influencing Nrf2 signaling was further confirmed in oxidatively stressed hepatocytes by using tert-butyl hydroperoxide (tBHP).	tert-Butylhydroperoxide	161-165	AKT serine/threonine kinase 1	Rattus norvegicus	19-22	
24675471-9	2014	Interestingly, tBHP induced site-specific deactivation of Akt as only Akt(Ser473) phosphorylation was observed to be affected.	tert-Butylhydroperoxide	15-19	AKT serine/threonine kinase 1	Rattus norvegicus	58-61	
24675471-10	2014	Further, protein expression as well as nuclear localization of PHLPP2, a phosphatase specific for Akt(Ser473), was found to be significantly enhanced in tBHP-stressed hepatocytes.	tert-Butylhydroperoxide	153-157	AKT serine/threonine kinase 1	Rattus norvegicus	98-101	
34183021-11	2021	TI activated the Akt/Nrf2 pathway to promote the expression of antioxidant-related proteins such as phosphorylation of Akt, nuclear factor erythroid 2 related factor 2 (Nrf2), quinone oxidoreductase-1 (NQO-1) and heme oxygenase-1 (HO-1) expression in t-BHP-stimulated H9c2 cells.	tert-Butylhydroperoxide	251-256	AKT serine/threonine kinase 1	Rattus norvegicus	17-20	
34183021-11	2021	TI activated the Akt/Nrf2 pathway to promote the expression of antioxidant-related proteins such as phosphorylation of Akt, nuclear factor erythroid 2 related factor 2 (Nrf2), quinone oxidoreductase-1 (NQO-1) and heme oxygenase-1 (HO-1) expression in t-BHP-stimulated H9c2 cells.	tert-Butylhydroperoxide	251-256	AKT serine/threonine kinase 1	Rattus norvegicus	119-122