PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34183021-11 2021 TI activated the Akt/Nrf2 pathway to promote the expression of antioxidant-related proteins such as phosphorylation of Akt, nuclear factor erythroid 2 related factor 2 (Nrf2), quinone oxidoreductase-1 (NQO-1) and heme oxygenase-1 (HO-1) expression in t-BHP-stimulated H9c2 cells. tert-Butylhydroperoxide 251-256 NFE2 like bZIP transcription factor 2 Rattus norvegicus 21-25 34183021-11 2021 TI activated the Akt/Nrf2 pathway to promote the expression of antioxidant-related proteins such as phosphorylation of Akt, nuclear factor erythroid 2 related factor 2 (Nrf2), quinone oxidoreductase-1 (NQO-1) and heme oxygenase-1 (HO-1) expression in t-BHP-stimulated H9c2 cells. tert-Butylhydroperoxide 251-256 NFE2 like bZIP transcription factor 2 Rattus norvegicus 124-167 34183021-11 2021 TI activated the Akt/Nrf2 pathway to promote the expression of antioxidant-related proteins such as phosphorylation of Akt, nuclear factor erythroid 2 related factor 2 (Nrf2), quinone oxidoreductase-1 (NQO-1) and heme oxygenase-1 (HO-1) expression in t-BHP-stimulated H9c2 cells. tert-Butylhydroperoxide 251-256 NFE2 like bZIP transcription factor 2 Rattus norvegicus 169-173 34211633-9 2021 The results demonstrated that activation of the Nrf2/Sirt3 pathway inhibited tert-butyl hydroperoxide- (TBHP-) induced apoptosis and mitochondrial dysfunction in vitro. tert-Butylhydroperoxide 77-101 NFE2 like bZIP transcription factor 2 Rattus norvegicus 48-52 34211633-9 2021 The results demonstrated that activation of the Nrf2/Sirt3 pathway inhibited tert-butyl hydroperoxide- (TBHP-) induced apoptosis and mitochondrial dysfunction in vitro. tert-Butylhydroperoxide 104-108 NFE2 like bZIP transcription factor 2 Rattus norvegicus 48-52 34211633-10 2021 In addition to apoptosis, upregulation of the Nrf2/Sirt3 pathway induced by t-BHQ restored TBHP-induced autophagic flux disturbances. tert-Butylhydroperoxide 91-95 NFE2 like bZIP transcription factor 2 Rattus norvegicus 46-50 35450408-0 2022 Selenium Attenuates TBHP-Induced Apoptosis of Nucleus Pulposus Cells by Suppressing Mitochondrial Fission through Activating Nuclear Factor Erythroid 2-Related Factor 2. tert-Butylhydroperoxide 20-24 NFE2 like bZIP transcription factor 2 Rattus norvegicus 125-168 35450408-12 2022 Taken together, our results demonstrated that Se suppressed TBHP-induced oxidative stress and mitochondrial fission by activating the Nrf2 pathway, thereby inhibiting the apoptosis of NPCs and ameliorating IDD. tert-Butylhydroperoxide 60-64 NFE2 like bZIP transcription factor 2 Rattus norvegicus 134-138 30779107-8 2019 Also, we found GES might rescue TBHP-induced NPCs degeneration by enhancing Nrf2-mediated antioxidant defense system. tert-Butylhydroperoxide 32-36 NFE2 like bZIP transcription factor 2 Rattus norvegicus 76-80 33833406-9 2022 Furthermore, we found that calcitonin gene-related peptide (CGRP), a neural inflammatory mediator, was accumulated around the vessel in synovium and subchondral bone in OA rats and in TBHP-treated primary cortical neurons; MB administration significantly inhibited CGRP expression through upregulation of Nrf2 and PRDX1. tert-Butylhydroperoxide 184-188 NFE2 like bZIP transcription factor 2 Rattus norvegicus 305-309 32652517-5 2020 PHC Nrf2-dependently alleviated tert-butyl hydroperoxide-induced reactive oxygen species production in alveolar macrophages. tert-Butylhydroperoxide 32-56 NFE2 like bZIP transcription factor 2 Rattus norvegicus 4-8 31336342-5 2019 Once the expression of nuclear factor E2-related factor 2 (Nrf2) was silenced in H9C2 cells, aldehydes no longer produced enough antioxidant enzymes to reverse the oxidative damage caused by tert-butyl hydroperoxide (TBHP). tert-Butylhydroperoxide 191-215 NFE2 like bZIP transcription factor 2 Rattus norvegicus 23-57 31336342-5 2019 Once the expression of nuclear factor E2-related factor 2 (Nrf2) was silenced in H9C2 cells, aldehydes no longer produced enough antioxidant enzymes to reverse the oxidative damage caused by tert-butyl hydroperoxide (TBHP). tert-Butylhydroperoxide 191-215 NFE2 like bZIP transcription factor 2 Rattus norvegicus 59-63 31336342-5 2019 Once the expression of nuclear factor E2-related factor 2 (Nrf2) was silenced in H9C2 cells, aldehydes no longer produced enough antioxidant enzymes to reverse the oxidative damage caused by tert-butyl hydroperoxide (TBHP). tert-Butylhydroperoxide 217-221 NFE2 like bZIP transcription factor 2 Rattus norvegicus 23-57 31336342-5 2019 Once the expression of nuclear factor E2-related factor 2 (Nrf2) was silenced in H9C2 cells, aldehydes no longer produced enough antioxidant enzymes to reverse the oxidative damage caused by tert-butyl hydroperoxide (TBHP). tert-Butylhydroperoxide 217-221 NFE2 like bZIP transcription factor 2 Rattus norvegicus 59-63 30779107-9 2019 Silencing Nrf2 partly abolished the protective effects of GES on apoptosis and ECM disruption in TBHP-treated NPCs. tert-Butylhydroperoxide 97-101 NFE2 like bZIP transcription factor 2 Rattus norvegicus 10-14 24675471-7 2014 The involvement of Akt and Fyn kinase in influencing Nrf2 signaling was further confirmed in oxidatively stressed hepatocytes by using tert-butyl hydroperoxide (tBHP). tert-Butylhydroperoxide 135-159 NFE2 like bZIP transcription factor 2 Rattus norvegicus 53-57 24675471-7 2014 The involvement of Akt and Fyn kinase in influencing Nrf2 signaling was further confirmed in oxidatively stressed hepatocytes by using tert-butyl hydroperoxide (tBHP). tert-Butylhydroperoxide 161-165 NFE2 like bZIP transcription factor 2 Rattus norvegicus 53-57 24675471-8 2014 tBHP-induced decrease in Nrf2 levels was associated with enhanced Fyn kinase phosphorylation, Fyn kinase nuclear translocation and decreased levels of phosphorylated GSK3beta(Ser9) in a time-dependent manner. tert-Butylhydroperoxide 0-4 NFE2 like bZIP transcription factor 2 Rattus norvegicus 25-29 22864849-8 2013 Taken together, these results suggest that chrysin, apigenin, and luteolin inhibit tBHP-induced oxidative stress by up-regulating HO-1, GCLC, and GCLM gene transcription via the ERK2/Nrf2/ARE signaling pathways in rat primary hepatocytes. tert-Butylhydroperoxide 83-87 NFE2 like bZIP transcription factor 2 Rattus norvegicus 183-187