PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21839169-6	2011	We detected a significant decrease in the amount of p-radixin that co-immunoprecipitated with Mrp2 after tertiary-butylhydroperoxide (t-BHP) treatment.	tert-Butylhydroperoxide	105-132	ATP binding cassette subfamily C member 2	Rattus norvegicus	94-98	
10937881-0	2000	Retrieval of the mrp2 gene encoded conjugate export pump from the canalicular membrane contributes to cholestasis induced by tert-butyl hydroperoxide and chloro-dinitrobenzene.	tert-Butylhydroperoxide	125-149	ATP binding cassette subfamily C member 2	Rattus norvegicus	17-21	
10937881-2	2000	In this study we have characterized the short-term effects of tert-butyl hydroperoxide (t-BOOH)- and 1-chloro-2,4-dinitrobenzene (CDNB) on the mrp2 gene encoded canalicular export pump (Mrp2).	tert-Butylhydroperoxide	62-86	ATP binding cassette subfamily C member 2	Rattus norvegicus	143-147	
10937881-2	2000	In this study we have characterized the short-term effects of tert-butyl hydroperoxide (t-BOOH)- and 1-chloro-2,4-dinitrobenzene (CDNB) on the mrp2 gene encoded canalicular export pump (Mrp2).	tert-Butylhydroperoxide	62-86	ATP binding cassette subfamily C member 2	Rattus norvegicus	186-190	
30538149-5	2019	During this time period, HO-1 induction fully prevented the pro-oxidant tert-butylhydroperoxide (tBuOOH)-induced drop in bile flow, and in the biliary excretion of bile salts and glutathione, the two main driving forces of bile flow; this was associated with preservation of the membrane localization of their respective canalicular transporters, bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2), which are otherwise endocytosed by OS.	tert-Butylhydroperoxide	72-95	ATP binding cassette subfamily C member 2	Rattus norvegicus	380-421	
30538149-5	2019	During this time period, HO-1 induction fully prevented the pro-oxidant tert-butylhydroperoxide (tBuOOH)-induced drop in bile flow, and in the biliary excretion of bile salts and glutathione, the two main driving forces of bile flow; this was associated with preservation of the membrane localization of their respective canalicular transporters, bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2), which are otherwise endocytosed by OS.	tert-Butylhydroperoxide	72-95	ATP binding cassette subfamily C member 2	Rattus norvegicus	423-427	
30538149-5	2019	During this time period, HO-1 induction fully prevented the pro-oxidant tert-butylhydroperoxide (tBuOOH)-induced drop in bile flow, and in the biliary excretion of bile salts and glutathione, the two main driving forces of bile flow; this was associated with preservation of the membrane localization of their respective canalicular transporters, bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2), which are otherwise endocytosed by OS.	tert-Butylhydroperoxide	97-103	ATP binding cassette subfamily C member 2	Rattus norvegicus	380-421	
30538149-5	2019	During this time period, HO-1 induction fully prevented the pro-oxidant tert-butylhydroperoxide (tBuOOH)-induced drop in bile flow, and in the biliary excretion of bile salts and glutathione, the two main driving forces of bile flow; this was associated with preservation of the membrane localization of their respective canalicular transporters, bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2), which are otherwise endocytosed by OS.	tert-Butylhydroperoxide	97-103	ATP binding cassette subfamily C member 2	Rattus norvegicus	423-427	
27913845-1	2017	In previous studies, we showed that the pro-oxidant model agent tert-butyl hydroperoxide (tBuOOH) induces alterations in hepatocanalicular secretory function by activating Ca2+-dependent protein kinase C isoforms (cPKC), via F-actin disorganization followed by endocytic internalization of canalicular transporters relevant to bile formation (Mrp2, Bsep).	tert-Butylhydroperoxide	64-88	ATP binding cassette subfamily C member 2	Rattus norvegicus	343-347	
18787061-3	2008	In this study, we demonstrated that decreased canalicular expression of Mrp2 induced by tertiary-butyl hydroperoxide (t-BHP) was recovered to the canalicular membrane by the replenishment of GSH by GSH-ethyl ester, a cell-permeable form of GSH.	tert-Butylhydroperoxide	88-116	ATP binding cassette subfamily C member 2	Rattus norvegicus	72-76	
18787061-3	2008	In this study, we demonstrated that decreased canalicular expression of Mrp2 induced by tertiary-butyl hydroperoxide (t-BHP) was recovered to the canalicular membrane by the replenishment of GSH by GSH-ethyl ester, a cell-permeable form of GSH.	tert-Butylhydroperoxide	118-123	ATP binding cassette subfamily C member 2	Rattus norvegicus	72-76	
34303734-8	2021	Subsequent incubation with N-Acetyl-L-cysteine (NAC, 1 mM) reestablished GSH content and reverted concomitantly the alteration in Mrp2 localization and function induced by TBH.	tert-Butylhydroperoxide	172-175	ATP binding cassette subfamily C member 2	Rattus norvegicus	130-134	
21839169-6	2011	We detected a significant decrease in the amount of p-radixin that co-immunoprecipitated with Mrp2 after tertiary-butylhydroperoxide (t-BHP) treatment.	tert-Butylhydroperoxide	134-139	ATP binding cassette subfamily C member 2	Rattus norvegicus	94-98	
21839169-8	2011	A PKC and protein phosphatase (PP)-1/2A inhibitor, but not a PP-2A selective inhibitor, prevented the t-BHP-induced decrease of p-radixin and subsequent canalicular Mrp2 localization.	tert-Butylhydroperoxide	102-107	ATP binding cassette subfamily C member 2	Rattus norvegicus	165-169