PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21839169-6 2011 We detected a significant decrease in the amount of p-radixin that co-immunoprecipitated with Mrp2 after tertiary-butylhydroperoxide (t-BHP) treatment. tert-Butylhydroperoxide 105-132 ATP binding cassette subfamily C member 2 Rattus norvegicus 94-98 10937881-0 2000 Retrieval of the mrp2 gene encoded conjugate export pump from the canalicular membrane contributes to cholestasis induced by tert-butyl hydroperoxide and chloro-dinitrobenzene. tert-Butylhydroperoxide 125-149 ATP binding cassette subfamily C member 2 Rattus norvegicus 17-21 10937881-2 2000 In this study we have characterized the short-term effects of tert-butyl hydroperoxide (t-BOOH)- and 1-chloro-2,4-dinitrobenzene (CDNB) on the mrp2 gene encoded canalicular export pump (Mrp2). tert-Butylhydroperoxide 62-86 ATP binding cassette subfamily C member 2 Rattus norvegicus 143-147 10937881-2 2000 In this study we have characterized the short-term effects of tert-butyl hydroperoxide (t-BOOH)- and 1-chloro-2,4-dinitrobenzene (CDNB) on the mrp2 gene encoded canalicular export pump (Mrp2). tert-Butylhydroperoxide 62-86 ATP binding cassette subfamily C member 2 Rattus norvegicus 186-190 30538149-5 2019 During this time period, HO-1 induction fully prevented the pro-oxidant tert-butylhydroperoxide (tBuOOH)-induced drop in bile flow, and in the biliary excretion of bile salts and glutathione, the two main driving forces of bile flow; this was associated with preservation of the membrane localization of their respective canalicular transporters, bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2), which are otherwise endocytosed by OS. tert-Butylhydroperoxide 72-95 ATP binding cassette subfamily C member 2 Rattus norvegicus 380-421 30538149-5 2019 During this time period, HO-1 induction fully prevented the pro-oxidant tert-butylhydroperoxide (tBuOOH)-induced drop in bile flow, and in the biliary excretion of bile salts and glutathione, the two main driving forces of bile flow; this was associated with preservation of the membrane localization of their respective canalicular transporters, bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2), which are otherwise endocytosed by OS. tert-Butylhydroperoxide 72-95 ATP binding cassette subfamily C member 2 Rattus norvegicus 423-427 30538149-5 2019 During this time period, HO-1 induction fully prevented the pro-oxidant tert-butylhydroperoxide (tBuOOH)-induced drop in bile flow, and in the biliary excretion of bile salts and glutathione, the two main driving forces of bile flow; this was associated with preservation of the membrane localization of their respective canalicular transporters, bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2), which are otherwise endocytosed by OS. tert-Butylhydroperoxide 97-103 ATP binding cassette subfamily C member 2 Rattus norvegicus 380-421 30538149-5 2019 During this time period, HO-1 induction fully prevented the pro-oxidant tert-butylhydroperoxide (tBuOOH)-induced drop in bile flow, and in the biliary excretion of bile salts and glutathione, the two main driving forces of bile flow; this was associated with preservation of the membrane localization of their respective canalicular transporters, bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2), which are otherwise endocytosed by OS. tert-Butylhydroperoxide 97-103 ATP binding cassette subfamily C member 2 Rattus norvegicus 423-427 27913845-1 2017 In previous studies, we showed that the pro-oxidant model agent tert-butyl hydroperoxide (tBuOOH) induces alterations in hepatocanalicular secretory function by activating Ca2+-dependent protein kinase C isoforms (cPKC), via F-actin disorganization followed by endocytic internalization of canalicular transporters relevant to bile formation (Mrp2, Bsep). tert-Butylhydroperoxide 64-88 ATP binding cassette subfamily C member 2 Rattus norvegicus 343-347 18787061-3 2008 In this study, we demonstrated that decreased canalicular expression of Mrp2 induced by tertiary-butyl hydroperoxide (t-BHP) was recovered to the canalicular membrane by the replenishment of GSH by GSH-ethyl ester, a cell-permeable form of GSH. tert-Butylhydroperoxide 88-116 ATP binding cassette subfamily C member 2 Rattus norvegicus 72-76 18787061-3 2008 In this study, we demonstrated that decreased canalicular expression of Mrp2 induced by tertiary-butyl hydroperoxide (t-BHP) was recovered to the canalicular membrane by the replenishment of GSH by GSH-ethyl ester, a cell-permeable form of GSH. tert-Butylhydroperoxide 118-123 ATP binding cassette subfamily C member 2 Rattus norvegicus 72-76 34303734-8 2021 Subsequent incubation with N-Acetyl-L-cysteine (NAC, 1 mM) reestablished GSH content and reverted concomitantly the alteration in Mrp2 localization and function induced by TBH. tert-Butylhydroperoxide 172-175 ATP binding cassette subfamily C member 2 Rattus norvegicus 130-134 21839169-6 2011 We detected a significant decrease in the amount of p-radixin that co-immunoprecipitated with Mrp2 after tertiary-butylhydroperoxide (t-BHP) treatment. tert-Butylhydroperoxide 134-139 ATP binding cassette subfamily C member 2 Rattus norvegicus 94-98 21839169-8 2011 A PKC and protein phosphatase (PP)-1/2A inhibitor, but not a PP-2A selective inhibitor, prevented the t-BHP-induced decrease of p-radixin and subsequent canalicular Mrp2 localization. tert-Butylhydroperoxide 102-107 ATP binding cassette subfamily C member 2 Rattus norvegicus 165-169