PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22034285-2	2011	The time-dependent changes in cellular GSH induced by tBHP were monitored as a measure of GSH recovery capacity (GRC), of which glutathione reductase (GR)-mediated glutathione redox cycling and gamma-glutamate cysteine ligase (GCL)-mediated GSH synthesis were found to play an essential role.	tert-Butylhydroperoxide	54-58	glutathione-disulfide reductase	Rattus norvegicus	128-149	
23690869-2	2013	tert-butyl hydroperoxide caused a significant (P < 0.05) elevation in conjugated dienes (CD) and malondialdehyde (MDA) levels, significantly (P < 0.05) decreased reduced glutathione (GSH) and GSH : GSSG ratio, and induced varying changes in activities of catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase in the blood and liver.	tert-Butylhydroperoxide	0-24	glutathione-disulfide reductase	Rattus norvegicus	321-342	
22034285-2	2011	The time-dependent changes in cellular GSH induced by tBHP were monitored as a measure of GSH recovery capacity (GRC), of which glutathione reductase (GR)-mediated glutathione redox cycling and gamma-glutamate cysteine ligase (GCL)-mediated GSH synthesis were found to play an essential role.	tert-Butylhydroperoxide	54-58	glutathione-disulfide reductase	Rattus norvegicus	113-115	
2143896-7	1990	Oxidation of pyridine nucleotides, induced by tbh through the concerted action of glutathione peroxidase, glutathione reductase and the energy-linked transhydrogenase, was not affected by up to 50 microM-HNE.	tert-Butylhydroperoxide	46-49	glutathione-disulfide reductase	Rattus norvegicus	106-127	
3087771-1	1986	The administration to rats of either t-butyl hydroperoxide or phenobarbital, compounds that are metabolized through detoxification processes, produces an increase in specific activity of the NADPH-consuming enzymes, glutathione reductase and NADPH-cytochrome c reductase.	tert-Butylhydroperoxide	37-58	glutathione-disulfide reductase	Rattus norvegicus	216-237	
3726880-1	1986	Metabolism of tert-butyl hydroperoxide (TBHP, 2.0 mM) by glutathione peroxidase within isolated rat hepatocytes caused a rapid oxidation of intracellular reduced glutathione and ultimately NADPH through glutathione reductase.	tert-Butylhydroperoxide	14-38	glutathione-disulfide reductase	Rattus norvegicus	203-224	
3726880-1	1986	Metabolism of tert-butyl hydroperoxide (TBHP, 2.0 mM) by glutathione peroxidase within isolated rat hepatocytes caused a rapid oxidation of intracellular reduced glutathione and ultimately NADPH through glutathione reductase.	tert-Butylhydroperoxide	40-44	glutathione-disulfide reductase	Rattus norvegicus	203-224	
6692829-2	1984	In the present study freshly isolated rat hepatocytes treated with the glutathione reductase inhibitor BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) were used to investigate the metabolism of tert-butyl hydroperoxide and of hydrogen peroxide formed in different intracellular compartments.	tert-Butylhydroperoxide	190-214	glutathione-disulfide reductase	Rattus norvegicus	71-92