PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30538798-8	2018	Further studies have shown that HCEA inhibits t-BHP-induced apoptosis by increasing B-cell lymphoma-2 (BCL-2) activity and decreasing caspase-3 and caspase-9 activity.	tert-Butylhydroperoxide	46-51	caspase 3	Rattus norvegicus	134-143	
27109168-7	2017	The activity of apoptosis executioner caspase-3 was significantly increased in the SeT of WT rats treated with 250 muM of TBHP or 10 muM of Cd, an effect not seen in Tg-RGN animals.	tert-Butylhydroperoxide	122-126	caspase 3	Rattus norvegicus	38-47	
24231470-6	2014	The down-regulated Bcl-2 mRNA level and up-regulated Bax, Caspase-9, and Caspase-3 mRNA expression induced by H2O2 or t-BHP could be restored by EPA-enriched PL pretreatment.	tert-Butylhydroperoxide	118-123	caspase 3	Rattus norvegicus	73-82	
24614978-6	2014	tBOOH-induced apoptosis, as shown by flow cytometry of annexin V/propidium iodide, mitochondrial release of cytochrome c, activation of caspase-3 and increase in the Bax-to-Bcl-xL ratio, and the Ca2+/CaM/CaMKII signaling antagonists fully prevented these effects.	tert-Butylhydroperoxide	0-5	caspase 3	Rattus norvegicus	136-145	
15569404-7	2004	RESULTS: Exposure of tBHP 100 micromol/L to neurons for 60 min resulted in DYm loss and cytochrome c release from mitochondria and subsequent activation of caspase-3 and PARP cleavation, and cell apoptosis.	tert-Butylhydroperoxide	21-25	caspase 3	Rattus norvegicus	156-165	
12181751-8	2002	Collectively, these results show that TBH-induced GSSG elevation is associated with the disruption of mitochondrial integrity, activation of caspase-3 and cell apoptosis.	tert-Butylhydroperoxide	38-41	caspase 3	Rattus norvegicus	141-150