PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15934077-8 2005 Furthermore, in SLE patients whose SLEDAI scores were >12 despite taking >0.5 mg/kg/day of prednisolone, P-gp expression on lymphocytes was markedly increased, and intracellular dexamethasone in their PBMCs was significantly decreased. Prednisolone 97-109 ATP binding cassette subfamily B member 1 Homo sapiens 111-115 11913542-10 2002 These results appear to suggest that methylprednisolone, prednisolone, and hydrocortisone interact with MDR1 as the substrates. Prednisolone 43-55 ATP binding cassette subfamily B member 1 Homo sapiens 104-108 12948018-11 2003 For structurally diverse P-gp substrates (acebutolol, colchicine, digoxin, etoposide, methylprednisolone, prednisolone, quinidine, and talinolol) apparent Km was approximately 3 to 8-fold greater in absorptive vs. secretory transport direction, whereas apparent J(max) was somewhat similar in both transport directions. Prednisolone 92-104 ATP binding cassette subfamily B member 1 Homo sapiens 25-29 12379510-0 2002 The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone. Prednisolone 74-86 ATP binding cassette subfamily B member 1 Homo sapiens 35-49 12379510-1 2002 In the present study, we have investigated the role of the multidrug resistance (mdr) P-glycoprotein (Pgp) at the blood-brain barrier in hampering the access of the synthetic glucocorticoid, prednisolone. Prednisolone 191-203 ATP binding cassette subfamily B member 1 Homo sapiens 86-100 12379510-1 2002 In the present study, we have investigated the role of the multidrug resistance (mdr) P-glycoprotein (Pgp) at the blood-brain barrier in hampering the access of the synthetic glucocorticoid, prednisolone. Prednisolone 191-203 ATP binding cassette subfamily B member 1 Homo sapiens 102-105 12379510-3 2002 In vitro, in stably transfected LLC-PK1 monolayers the human MDR1 P-glycoprotein was able to transport prednisolone present at a micromolar concentration. Prednisolone 103-115 ATP binding cassette subfamily B member 1 Homo sapiens 66-80 12379510-6 2002 The ability of Pgp to export the synthetic glucocorticoid, prednisolone, suggests that uptake of prednisolone in the human brain is impaired, leading to a discrepancy between central and peripheral actions. Prednisolone 59-71 ATP binding cassette subfamily B member 1 Homo sapiens 15-18 12379510-6 2002 The ability of Pgp to export the synthetic glucocorticoid, prednisolone, suggests that uptake of prednisolone in the human brain is impaired, leading to a discrepancy between central and peripheral actions. Prednisolone 97-109 ATP binding cassette subfamily B member 1 Homo sapiens 15-18 29377275-0 2018 Regulatory effect of resveratrol and prednisolone on MDR1 gene expression in acute lymphoblastic leukemia cell line (CCRF-CEM): An epigenetic perspective. Prednisolone 37-49 ATP binding cassette subfamily B member 1 Homo sapiens 53-57 34157499-4 2021 Furthermore, increase in mRNA expression of selected proteins with multidrug resistance potential (MDR1, BCRP, LRP, MT) was observed after prednisolone pre-treatment. Prednisolone 139-151 ATP binding cassette subfamily B member 1 Homo sapiens 99-103 34603785-0 2021 Assessment of the Link of ABCB1 and NR3C1 gene polymorphisms with the prednisolone resistance in pediatric nephrotic syndrome patients of Bangladesh: A genotype and haplotype approach. Prednisolone 70-82 ATP binding cassette subfamily B member 1 Homo sapiens 26-31 34603785-3 2021 Objectives: This study aimed to identify the association of ABCB1 (1236C > T, 2677G > T, 3435C > T), NR3C1 (rs10482634, rs6877893), and CYP3A5 (CYP3A5*3) gene polymorphism as well as sociodemographic and clinicopathological parameters with the risk of developing prednisolone resistance in pediatric patients with nephrotic syndrome. Prednisolone 263-275 ATP binding cassette subfamily B member 1 Homo sapiens 60-65 34603785-12 2021 CTC and TGT haplotypes of ABCB1 and GA haplotype of NR3C1 were also associated with the increased risk of pediatric prednisolone resistance (OR = 4.47, p = 0.0003; OR = 2.71, p = 0.03; and OR = 4.22, p = 0.022, consecutively). Prednisolone 116-128 ATP binding cassette subfamily B member 1 Homo sapiens 26-31 30996113-6 2019 The ABCB1 rs2032582 mutant homozygote had a protective effect in the methylprednisolone/prednisolone renal transplant population. Prednisolone 75-87 ATP binding cassette subfamily B member 1 Homo sapiens 4-9 34603785-14 2021 Conclusion: Our findings showed a significant association of ABCB1 and NR3C1 gene polymorphisms with prednisolone resistant pediatric nephrotic syndrome. Prednisolone 101-113 ATP binding cassette subfamily B member 1 Homo sapiens 61-66 29377275-6 2018 We evaluated the effect of resveratrol and prednisolone on DNA methylation patterns of MDR1 gene promoter in the CCRF-CEM cell line as a representative for acute lymphoblastic leukemia. Prednisolone 43-55 ATP binding cassette subfamily B member 1 Homo sapiens 87-91 29377275-7 2018 The study was aimed to clarify whether the MDR1 gene expression is regulated via DNA promoter methylation as a potential underlying mechanism, following exposure to resveratrol and prednisolone. Prednisolone 181-193 ATP binding cassette subfamily B member 1 Homo sapiens 43-47 29377275-9 2018 Unchanged status of DNA methylation of MDR1 gene may suggest that Resveratrol and Prednisolone causes the gene expression changes through a distinct mechanism which requires further studies to be understood. Prednisolone 82-94 ATP binding cassette subfamily B member 1 Homo sapiens 39-43 23731729-9 2013 Treatment with 2.5 ng/ml cylosporin A and10-6 M prednisolone resulted in synergistic inhibition of pro-inflammatory cytokines in Pgp1 + cells (p < 0.05 for all). Prednisolone 48-60 ATP binding cassette subfamily B member 1 Homo sapiens 129-133 29352737-7 2018 The addition of 2 5 ng/ml cyclosporin A and 1 microM prednisolone inhibit IFN-gamma/TNF-alpha production significantly by CD8+ Pgp+ T cells from BOS patients. Prednisolone 53-65 ATP binding cassette subfamily B member 1 Homo sapiens 127-130 29352737-8 2018 The addition of 10 microM Compound A and 1 microM prednisolone inhibit IFN-gamma/TNF-alpha production significantly by CD8+ Pgp- T cells from BOS patients. Prednisolone 50-62 ATP binding cassette subfamily B member 1 Homo sapiens 124-127 28807771-4 2017 Furthermore, prednisolone induces the development of MDR1+Th17.1 cells, whereas 1alpha,25-(OH)2D3 acts as an anti-inflammatory, leading to diminished percentages of proinflammatory MDR1+Th17.1 cells in the presence of prednisolone after stimulation with the TLR4-ligand S100A8/S100A9. Prednisolone 13-25 ATP binding cassette subfamily B member 1 Homo sapiens 53-57 27771052-7 2016 For in vitro and in vivo studies, these surfactants enhanced the intestinal absorption of quinidine and prednisolone, 2 P-gp substrates. Prednisolone 104-116 ATP binding cassette subfamily B member 1 Homo sapiens 120-124 22546724-2 2012 In lymphocytes, two glucocorticoids, prednisone and prednisolone, have been shown to induce ABCB1 activity. Prednisolone 52-64 ATP binding cassette subfamily B member 1 Homo sapiens 92-97 24617050-10 2013 Steroids low responders whose SLEDAI were > or = 11 while receiving 1 mg/Kg/day of prednisolone demonstrated higher P-gp1 functions in CD 5+ and CD 7+ lymphocytes compared to high responders whose SLEDAI were < 11 while receiving < 1 mg/Kg/day of prednisolone. Prednisolone 86-98 ATP binding cassette subfamily B member 1 Homo sapiens 119-124 22016125-10 2011 Methylprednisolone and prednisolone may also be affected by substances that modulate CYP3A4 and P-glycoprotein. Prednisolone 6-18 ATP binding cassette subfamily B member 1 Homo sapiens 96-110 19352661-0 2009 Changes in the MDR1 gene expression after short-term ex vivo therapy with prednisolone have prognostic impact in childhood acute lymphoblastic leukemia. Prednisolone 74-86 ATP binding cassette subfamily B member 1 Homo sapiens 15-19 19352661-4 2009 In this study, we have shown that changes in the expression of MDR1 gene after short-term incubation of lymphoblasts with prednisolone may have prognostic value in pediatric de novo ALL patients. Prednisolone 122-134 ATP binding cassette subfamily B member 1 Homo sapiens 63-67 18502461-6 2008 The plasma concentrations of prednisolone in recipients having both ABCB1 3435CC and CYP3A5*3/*3 genotypes tended to be higher than those having both ABCB1 3435TT and CYP3A5*3/*3 genotypes. Prednisolone 29-41 ATP binding cassette subfamily B member 1 Homo sapiens 68-73 19101657-6 2009 There was a significant correlation between P-gp function in CD3(+) (r=0.55, p=0.014) or CD4(+) (r=0.48, p=0.034) T cells and the total dose of prednisolone for treatment. Prednisolone 144-156 ATP binding cassette subfamily B member 1 Homo sapiens 44-48 19101657-7 2009 P-gp function on CD4(+) T cells in MG patients who showed low responses to prednisolone therapy (n=8) was higher than that in patients who showed relatively high responses to prednisolone therapy (n=10) (p=0.045). Prednisolone 75-87 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 19101657-7 2009 P-gp function on CD4(+) T cells in MG patients who showed low responses to prednisolone therapy (n=8) was higher than that in patients who showed relatively high responses to prednisolone therapy (n=10) (p=0.045). Prednisolone 175-187 ATP binding cassette subfamily B member 1 Homo sapiens 0-4