PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10652599-0 1999 Mutant p53 mediated induction of cell cycle arrest and apoptosis at G1 phase by 9-hydroxyellipticine. 9-hydroxyellipticine 80-100 tumor protein p53 Homo sapiens 7-10 12570841-1 2003 The hydroxy group in 9-hydroxyellipticines increases the apparent affinity for DNA, stabilisation of toposiomerase II-DNA cleavable complex, oxidation to reactive quinone-imine intermediates, phosphorylation of p53 suppressor proteins and cytotoxicity relative to the parent ellipticines. 9-hydroxyellipticine 21-42 tumor protein p53 Homo sapiens 211-214 11724337-0 2001 9-Hydroxyellipticine alters the conformation and DNA binding characteristics of mutated p53 protein. 9-hydroxyellipticine 0-20 tumor protein p53 Homo sapiens 88-91 11724337-3 2001 We examined whether 9-hydroxyellipticine (9HE), a cytotoxic agent, affected the tertiary structure of mutant p53 and DNA binding characteristics. 9-hydroxyellipticine 20-40 tumor protein p53 Homo sapiens 109-112 11724337-3 2001 We examined whether 9-hydroxyellipticine (9HE), a cytotoxic agent, affected the tertiary structure of mutant p53 and DNA binding characteristics. 9-hydroxyellipticine 42-45 tumor protein p53 Homo sapiens 109-112 10737712-0 2000 Diverse effects of 9-hydroxyellipticine on the chemosensitivity of human pancreatic cancer cells harboring p53 mutations. 9-hydroxyellipticine 19-39 tumor protein p53 Homo sapiens 107-110 10737712-1 2000 Recently, it has been shown that 9-hydroxyellipticine (9-HE), an antitumor alkaloid has a unique property of restoring functional wild-type (wt) p53 activity via inhibition of mutant (mt) p53 protein phosphorylation. 9-hydroxyellipticine 33-53 tumor protein p53 Homo sapiens 145-148 10737712-1 2000 Recently, it has been shown that 9-hydroxyellipticine (9-HE), an antitumor alkaloid has a unique property of restoring functional wild-type (wt) p53 activity via inhibition of mutant (mt) p53 protein phosphorylation. 9-hydroxyellipticine 33-53 tumor protein p53 Homo sapiens 188-191 10737712-1 2000 Recently, it has been shown that 9-hydroxyellipticine (9-HE), an antitumor alkaloid has a unique property of restoring functional wild-type (wt) p53 activity via inhibition of mutant (mt) p53 protein phosphorylation. 9-hydroxyellipticine 55-59 tumor protein p53 Homo sapiens 145-148 10737712-1 2000 Recently, it has been shown that 9-hydroxyellipticine (9-HE), an antitumor alkaloid has a unique property of restoring functional wild-type (wt) p53 activity via inhibition of mutant (mt) p53 protein phosphorylation. 9-hydroxyellipticine 55-59 tumor protein p53 Homo sapiens 188-191 10737712-3 2000 Exposure of cells to 9-HE at a relatively low concentration of 1 microM induced almost no cell death but was sufficient to restore wt p53 activity, as evidenced by an induction of endogenous p21WAF1/CIP1 concomitant with G1 and G2/M arrests in cell-cycle progression. 9-hydroxyellipticine 21-25 tumor protein p53 Homo sapiens 134-137 10737712-6 2000 These effects of 9-HE were specific for several cell lines containing mt p53 and were not observed in p53-negative or wt p53 expressing cells. 9-hydroxyellipticine 17-21 tumor protein p53 Homo sapiens 73-76 10652599-2 1999 Although in many cancer cells p53 is frequently mutated and loses its functions, we have proposed that mutant p53 may be involved in the anticancer mechanism of 9-hydroxy ellipticine (9HE). 9-hydroxyellipticine 161-182 tumor protein p53 Homo sapiens 30-33 10652599-2 1999 Although in many cancer cells p53 is frequently mutated and loses its functions, we have proposed that mutant p53 may be involved in the anticancer mechanism of 9-hydroxy ellipticine (9HE). 9-hydroxyellipticine 161-182 tumor protein p53 Homo sapiens 110-113 10652599-2 1999 Although in many cancer cells p53 is frequently mutated and loses its functions, we have proposed that mutant p53 may be involved in the anticancer mechanism of 9-hydroxy ellipticine (9HE). 9-hydroxyellipticine 184-187 tumor protein p53 Homo sapiens 30-33 10652599-2 1999 Although in many cancer cells p53 is frequently mutated and loses its functions, we have proposed that mutant p53 may be involved in the anticancer mechanism of 9-hydroxy ellipticine (9HE). 9-hydroxyellipticine 184-187 tumor protein p53 Homo sapiens 110-113 9883907-2 1998 We hypothesized that 9-hydroxyellipticine (9-HE), an antitumor alkaloid, would inhibit telomerase activity because the drug has a unique mechanism of inhibiting phosphorylation of mutant p53 protein via inhibition of protein kinases, thereby restoring wild-type p53 function. 9-hydroxyellipticine 21-41 tumor protein p53 Homo sapiens 187-190 9883907-2 1998 We hypothesized that 9-hydroxyellipticine (9-HE), an antitumor alkaloid, would inhibit telomerase activity because the drug has a unique mechanism of inhibiting phosphorylation of mutant p53 protein via inhibition of protein kinases, thereby restoring wild-type p53 function. 9-hydroxyellipticine 21-41 tumor protein p53 Homo sapiens 262-265 9883907-2 1998 We hypothesized that 9-hydroxyellipticine (9-HE), an antitumor alkaloid, would inhibit telomerase activity because the drug has a unique mechanism of inhibiting phosphorylation of mutant p53 protein via inhibition of protein kinases, thereby restoring wild-type p53 function. 9-hydroxyellipticine 43-47 tumor protein p53 Homo sapiens 187-190 9883907-2 1998 We hypothesized that 9-hydroxyellipticine (9-HE), an antitumor alkaloid, would inhibit telomerase activity because the drug has a unique mechanism of inhibiting phosphorylation of mutant p53 protein via inhibition of protein kinases, thereby restoring wild-type p53 function. 9-hydroxyellipticine 43-47 tumor protein p53 Homo sapiens 262-265 9883907-5 1998 We conclude that 9-HE may exert a strong inhibitory effect on telomerase activity possibly through inhibition of protein kinases rather than through restoration of functional wild-type p53. 9-hydroxyellipticine 17-21 tumor protein p53 Homo sapiens 185-188 7591958-0 1995 Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism. 9-hydroxyellipticine 45-65 tumor protein p53 Homo sapiens 14-17 7591958-2 1995 We found that ellipticine and 9-hydroxyellipticine (9HE), antitumor alkaloids, caused selective inhibition of p53 protein phosphorylation in Lewis lung carcinoma and SW480 (human colon cancer cell line) in a concentration-dependent manner from 0.1 to 100 microM. 9-hydroxyellipticine 30-50 tumor protein p53 Homo sapiens 110-113 7591958-2 1995 We found that ellipticine and 9-hydroxyellipticine (9HE), antitumor alkaloids, caused selective inhibition of p53 protein phosphorylation in Lewis lung carcinoma and SW480 (human colon cancer cell line) in a concentration-dependent manner from 0.1 to 100 microM. 9-hydroxyellipticine 52-55 tumor protein p53 Homo sapiens 110-113