PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31047919-0 2019 Targeting PSD95-nNOS interaction by Tat-N-dimer peptide during status epilepticus is neuroprotective in MAM-pilocarpine rat model. methylazoxymethanol 104-107 discs large MAGUK scaffold protein 4 Rattus norvegicus 10-15 31047919-4 2019 We took advantage of this promising approach to verify whether early administration of a neuroprotective NMDAR-PSD95-nNOS PPI inhibitor preserves the brain from SE-induced damage in a model of acquired cortical dysplasia, the methylazoxymethanol (MAM)/pilocarpine rat. methylazoxymethanol 226-245 discs large MAGUK scaffold protein 4 Rattus norvegicus 111-116 31047919-4 2019 We took advantage of this promising approach to verify whether early administration of a neuroprotective NMDAR-PSD95-nNOS PPI inhibitor preserves the brain from SE-induced damage in a model of acquired cortical dysplasia, the methylazoxymethanol (MAM)/pilocarpine rat. methylazoxymethanol 247-250 discs large MAGUK scaffold protein 4 Rattus norvegicus 111-116 31047919-6 2019 We demonstrated that SE rapidly induces NMDAR activation, nNOS membrane translocation, PSD95-nNOS molecular interaction associated with neuronal and glial peroxynitrite accumulation in the neocortex of MAM-pilocarpine rats. methylazoxymethanol 202-205 discs large MAGUK scaffold protein 4 Rattus norvegicus 87-92 31047919-8 2019 Early administration of a cell-penetrating Tat-N-dimer peptide inhibitor of NMDAR-PSD95-nNOS PPI during SE significantly rescued the MAM-pilocarpine rats from SE-induced mortality, reduced the number of degenerating neurons, decreased neuronal c-fos activation, peroxynitrite formation and cytoskeletal degradation and prevented astrogliosis. methylazoxymethanol 133-136 discs large MAGUK scaffold protein 4 Rattus norvegicus 82-87