PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27099245-3 2016 OBJECTIVE: We determined the effects of sucrose, fructose, and sucralose on triglyceride, glucose, and insulin in an acute study in healthy, overweight, and obese individuals. Sucrose 40-47 insulin Homo sapiens 103-110 25697639-0 2015 Effect of sucrose consumption on serum insulin, serum cortisol and insulin sensitivity in migraine: evidence of sex differences. Sucrose 10-17 insulin Homo sapiens 39-46 26085100-5 2015 The development of hepatic steatosis and insulin resistance in CBA/J mice on a sucrose-enriched diet was paralleled by increased hepatic expression of the transcription factor Ppargamma and its target gene Cd36 whereas that of genes implicated in lipogenesis, fatty acid oxidation, and VLDL secretion was unaltered. Sucrose 79-86 insulin Homo sapiens 41-48 25697639-0 2015 Effect of sucrose consumption on serum insulin, serum cortisol and insulin sensitivity in migraine: evidence of sex differences. Sucrose 10-17 insulin Homo sapiens 67-74 25030779-8 2014 In contrast, glucagon-like peptide 1 (GLP-1) was ~64% higher (P < 0.001) after isomaltulose ingestion, which results in an increased insulin-to-glucagon ratio (P < 0.001) compared with sucrose. Sucrose 191-198 insulin Homo sapiens 136-143 25180545-2 2014 Insulin-loaded PLGA nanoparticles with a size around 450 nm were dehydrated using a standard freeze-drying cycle, using trehalose, glucose, sucrose, fructose, and sorbitol at 10% (w/v) as cryoprotectants. Sucrose 140-147 insulin Homo sapiens 0-7 25569521-5 2015 Reduced HISS release accounts for the insulin resistance that occurs with aging and is made worse by physical inactivity and diets high in sucrose or fat. Sucrose 139-146 insulin Homo sapiens 38-45 25515398-7 2014 RESULTS: Glucose and sucrose supplementation initially resulted in a significant increase in glucose and insulin levels compared to fructose supplementation and returned to near baseline values within 2 hours. Sucrose 21-28 insulin Homo sapiens 105-112 25030779-10 2014 Insulin action was enhanced after isomaltulose compared with sucrose (P = 0.013). Sucrose 61-68 insulin Homo sapiens 0-7 23337559-6 2013 In both patients and controls, the increase in the level of C-peptide after honey was significant when compared with either glucose or sucrose (P < 0.01). Sucrose 135-142 insulin Homo sapiens 60-69 24411482-2 2014 Using an animal model of AD, here we show that high sucrose intake induces obesity with changes in central and peripheral insulin signaling. Sucrose 52-59 insulin Homo sapiens 122-129 23363580-13 2013 However, reductions in fasting glucose, one hour insulin and insulin area under the curve with the low sucrose diet on glucose tolerance testing may indicate a beneficial effect and further work is required to determine if this is the case. Sucrose 103-110 insulin Homo sapiens 61-68 23507897-8 2012 After freeze-drying with cryoprotectants, the amount of insulin released was higher for trehalose and lower for sucrose, glucose, fructose and sorbitol comparatively to freeze-dried PLGA-NP with no cryoprotectant added. Sucrose 112-119 insulin Homo sapiens 56-63 22038462-8 2012 When a bun or sucrose and milk were consumed together with coffee, lower GI values and insulin responses were observed, reflecting the carbohydrate quality and protein content of the accompaniments. Sucrose 14-21 insulin Homo sapiens 87-94 24485339-5 2013 While C-peptide and glucose were unaffected, a short-term increase in insulin was observed after the sucrose, but not after the aspartate or placebo. Sucrose 101-108 insulin Homo sapiens 70-77 21799667-7 2011 RESULTS: After 10 weeks postprandial glucose, insulin, lactate, triglyceride, leptin, glucagon, and GLP-1 were all significantly higher in the sucrose compared with the sweetener group. Sucrose 143-150 insulin Homo sapiens 46-53 22854401-1 2012 BACKGROUND: Sucrose induces high postprandial glucose and insulin responses. Sucrose 12-19 insulin Homo sapiens 58-65 22854401-8 2012 RESULTS: In comparison with sucrose alone, ingestion of sucrose with whole berries resulted in reduced glucose and insulin concentrations during the first 30 min and a slower decline during the second hour and a significantly improved glycemic profile. Sucrose 56-63 insulin Homo sapiens 115-122 21635573-6 2012 It was concluded that dextrose and sucrose have the potential to stimulate fast and high insulin peaks, especially when combined with additional lactose. Sucrose 35-42 insulin Homo sapiens 89-96 22572647-7 2012 Insulin signaling increased during EAA+sucrose ingestion in both groups (P < 0.05). Sucrose 39-46 insulin Homo sapiens 0-7 21677059-12 2011 CONCLUSIONS: l-Arabinose inhibits sucrase activity from Caco-2 cells; 4% l-arabinose in sucrose beverages reduces postprandial glucose, insulin, and C-peptide responses and enhances the GLP-1 response in humans without gastrointestinal adverse effects. Sucrose 88-95 insulin Homo sapiens 136-143 20851729-5 2010 The results showed a significant alteration in serum insulin and plasma glucose following sucrose ingestion in the migraine and non-migraine groups. Sucrose 90-97 insulin Homo sapiens 53-60 20851729-6 2010 In addition, significant group differences were observed in the level of serum insulin, serum DHEAS, and the cortisol:DHEAS ratio with migraine participants on average recording a higher sucrose-induced serum insulin level and lower DHEAS level and cortisol:DHEAS ratio when group data was compared. Sucrose 187-194 insulin Homo sapiens 209-216 20851729-7 2010 It was concluded that while sucrose consumption may potentiate serum insulin in migraineurs this does not result in the development of sucrose-induced hypoglycemia in migraine or non-migraine participants. Sucrose 28-35 insulin Homo sapiens 69-76 19083105-6 2009 Fasting insulin and/or glucose were positively associated with body mass index (BMI), height, and dietary total and saturated fat and inversely associated with serum high-density lipoprotein cholesterol (HDL) and dietary available carbohydrates, sucrose, and alcohol. Sucrose 246-253 insulin Homo sapiens 8-15 20934606-1 2010 Fructose- or sucrose-rich diets can cause insulin resistance and increase the risk of cardiovascular disease. Sucrose 13-20 insulin Homo sapiens 42-49 20934606-3 2010 We hypothesize that fructose and sucrose induce insulin resistance via effects on adipokine gene expression in adipocytes. Sucrose 33-40 insulin Homo sapiens 48-55 19270448-6 2009 RESULTS: The main finding was that both plasma glucose and plasma insulin concentrations were transiently but markedly increased after sucrose test meals compared to isomaltulose or starch meals. Sucrose 135-142 insulin Homo sapiens 66-73 19221011-5 2009 GLP-1, GIP, and insulin also increased after sucrose (P=0.0001) but not after either load of sucralose or saline. Sucrose 45-52 insulin Homo sapiens 16-23 19207533-2 2009 In animal studies, sugars, particularly sucrose and fructose, have been shown to decrease insulin sensitivity, with potential association with an induced hypertriglyceridemia. Sucrose 40-47 insulin Homo sapiens 90-97 19043980-9 2008 In addition, carbohydrate and sucrose intake presented a positive and significant correlation with insulin concentration and HOMA-IR at 180 min postprandial, after adjusting for energy intake and % TBF (p<0.05). Sucrose 30-37 insulin Homo sapiens 99-106 18556090-7 2008 A significant increase of plasma insulin concentration was apparent after stimulation with sucrose and saccharin. Sucrose 91-98 insulin Homo sapiens 33-40 17828323-7 2007 Glucose from sucrose and starch increase blood glucose levels and stimulate insulin secretion. Sucrose 13-20 insulin Homo sapiens 76-83 18469239-8 2008 In the men in whom the effects of 4 sweeteners were compared, the 24-h glucose and insulin responses induced by HFCS and sucrose were intermediate between the lower responses during consumption of fructose and the higher responses during glucose. Sucrose 121-128 insulin Homo sapiens 83-90 12862206-5 2003 Homeostasis model assessment-insulin resistance (HOMA-IR) index, plasma levels of leptin, and leptin mRNA in mesenteric adipose tissue were significantly greater in the sucrose-rich chow fed animals than in the standard chow fed animals, and significantly lower in the ARA-treated sucrose-rich chow fed animals than in the sucrose-rich chow fed animals in both SHR and WKY. Sucrose 169-176 insulin Homo sapiens 29-36 17130505-1 2006 The long-term impact of dietary carbohydrate type, in particular sucrose, on insulin resistance and the development of diabetes and atherosclerosis is not established. Sucrose 65-72 insulin Homo sapiens 77-84 16648298-1 2006 Administration of a sucrose-rich diet (SRD) to normal hamsters induces an insulin-resistant state and a significant increase of insulin secretion and beta-cell mass. Sucrose 20-27 insulin Homo sapiens 74-81 16965239-3 2006 We investigated interactions between foods (dairy products, red and processed meat, and whole and refined grains) and dietary patterns (sucrose-to-fiber ratio and glycemic index) associated with insulin resistance with the FokI polymorphism of the VDR gene and colon and rectal cancer risk. Sucrose 136-143 insulin Homo sapiens 195-202 14675555-3 2004 A diet high in sucrose or fructose can give rise to hyperlipidemia, insulin resistance and hypertension. Sucrose 15-22 insulin Homo sapiens 68-75 17260532-1 2007 OBJECTIVE: The purpose of this study was to investigate the effect of high sucrose diet (HD) and high fat diet (RFD) ingested under free-living conditions, on insulin homeostasis, verifies the association between insulin resistance and body composition as well. Sucrose 75-82 insulin Homo sapiens 159-166 16720893-9 2006 In animal studies, n-3 unsaturated fatty acids have been shown to enhance insulin sensitivity and fructose and sucrose to increase insulin resistance. Sucrose 111-118 insulin Homo sapiens 131-138 15962882-1 2005 Sweets release opiates which stimulates the appetite for sucrose--insulin can depress it]. Sucrose 57-64 insulin Homo sapiens 66-73 15962882-8 2005 Insulin has been shown to decrease sucrose intake by blocking the opioid response. Sucrose 35-42 insulin Homo sapiens 0-7 14522751-3 2003 Research on animals, particularly rodents, has shown a clear and consistent effect of high-sucrose and high-fructose diets in decreasing insulin sensitivity. Sucrose 91-98 insulin Homo sapiens 137-144 14522751-7 2003 However, the pattern of postprandial glucose and insulin responses elicited by sucrose and fructose differs substantially from that elicited by starches, with lower troughs elicited by sucrose and fructose 2-3 h after eating. Sucrose 79-86 insulin Homo sapiens 49-56 10917906-0 2000 Blood glucose and insulin concentrations are reduced in humans administered sucrose with inosine or adenosine. Sucrose 76-83 insulin Homo sapiens 18-25 11694656-6 2001 Many studies indicate that dietary patterns that stimulate insulin resistance or secretion, including high consumption of sucrose, various sources of starch, a high glycemic index and high saturated fatty acid intake, are associated with a higher risk of colon cancer. Sucrose 122-129 insulin Homo sapiens 59-66 12387299-7 2002 Thus, blood glucose and insulin levels in humans after oral administration rise slower and reach lower maxima than after sucrose administration. Sucrose 121-128 insulin Homo sapiens 24-31 10917906-5 2000 The total increases in the areas under the plasma glucose and serum insulin concentration curves for 3 h after administration of the same amount of sucrose with inosine were also significantly less than those when the volunteers were administered sucrose alone. Sucrose 148-155 insulin Homo sapiens 68-75 10917906-4 2000 The initial increase in plasma glucose and serum insulin concentrations at 30 min after loading sucrose (50 g) alone were significantly reduced by co-administration of inosine (2.5 and 1.0 g) or adenosine (2.5 g). Sucrose 96-103 insulin Homo sapiens 49-56 10917906-5 2000 The total increases in the areas under the plasma glucose and serum insulin concentration curves for 3 h after administration of the same amount of sucrose with inosine were also significantly less than those when the volunteers were administered sucrose alone. Sucrose 247-254 insulin Homo sapiens 68-75 9530253-10 1998 Sucrose-induced insulin resistance was reversed in rats that were switched back to the starch diet (GIR, 18.6 +/- 3.0). Sucrose 0-7 insulin Homo sapiens 16-23 9881888-1 1998 OBJECTIVE: To determine the plasma glucose and insulin responses of various doses of glucose, sucrose, fructose and white bread in normal human subjects. Sucrose 94-101 insulin Homo sapiens 47-54 9530253-7 1998 In study 1, the presence of the fish oil in the high-sucrose diet prevented the development of insulin resistance. Sucrose 53-60 insulin Homo sapiens 95-102 10805502-11 2000 Furthermore, increased leptin concentrations were found after a sucrose-rich diet in both groups, possibly related to larger postprandial insulin peaks on this diet. Sucrose 64-71 insulin Homo sapiens 138-145 9625092-3 1998 This study aimed to assess the acute (24 h) effects of a high-sucrose compared with a high-starch diet on insulin sensitivity and to identify changes in blood metabolites that might lead to altered insulin sensitivity. Sucrose 62-69 insulin Homo sapiens 106-113 9616209-9 1998 In non-equilibrium fractions, insulin led to small GLUT4 decrements in the 25 and 28% sucrose fractions and increased GLUT4 in the 32% sucrose fraction by 2.8-fold over basal in insulin-sensitive but only by 1.5-fold in both insulin-resistant and diabetic subgroups. Sucrose 86-93 insulin Homo sapiens 30-37 9616209-9 1998 In non-equilibrium fractions, insulin led to small GLUT4 decrements in the 25 and 28% sucrose fractions and increased GLUT4 in the 32% sucrose fraction by 2.8-fold over basal in insulin-sensitive but only by 1.5-fold in both insulin-resistant and diabetic subgroups. Sucrose 135-142 insulin Homo sapiens 30-37 9062523-10 1997 Only the consumption of the sucrose tablet was followed by a postabsorptive increase in plasma glucose and insulin concentrations starting 17 and 19 min, respectively, after the beginning of sucking. Sucrose 28-35 insulin Homo sapiens 107-114 9507911-4 1998 Peak plasma glucose, insulin, and glucose-dependent insulinotropic polypeptide (GIP) responses were reduced when sucrose was given with acarbose. Sucrose 113-120 insulin Homo sapiens 21-28 2037862-3 1991 Insulin was positively correlated with serum glucose, body mass index (BMI), skinfold thickness, waist/hip ratio and sucrose intake, and negatively correlated with heavy physical activity score, treadmill exercise duration, and magnesium intake (each p less than 0.01). Sucrose 117-124 insulin Homo sapiens 0-7 8578189-6 1995 The sucrose-related increments in glucose, insulin, C-peptide, and gastric inhibitory polypeptide (GIP) and the suppression of glucagon were only marginally affected by acarbose administration. Sucrose 4-11 insulin Homo sapiens 43-50 8352474-0 1993 Raised dietary intake of N-3 polyunsaturated fatty acids in high sucrose-induced insulin resistance. Sucrose 65-72 insulin Homo sapiens 81-88 7748193-7 1995 Results with insulin showed slight effects (20-30% impairment) on uptake of the ligand in the presence of sucrose. Sucrose 106-113 insulin Homo sapiens 13-20 8386623-3 1993 The incorporation of lectin-purified insulin receptors was assessed by cosedimentation of 125I-insulin binding and [32P]phospholipids in a sucrose gradient. Sucrose 139-146 insulin Homo sapiens 37-44 2037862-4 1991 After adjustment for other covariates, the positive association of insulin with waist/hip ratio, skinfold thickness, and sucrose intake remained in the group as a whole, as did the negative associations with magnesium and treadmill duration. Sucrose 121-128 insulin Homo sapiens 67-74 1771173-7 1991 Following sucrose alone, the high mean ratio increased 19% at 2.5 h. Sucrose increased the Phe/LNAA value due to an insulin-mediated decrease in the plasma LNAA, while aspartame increased the ratio by increasing the plasma Phe concentration. Sucrose 69-76 insulin Homo sapiens 116-123 33769519-5 2021 KEY FINDINGS: The addition of cryoprotectants (1% sucrose) in lyophilisation improved the stability of nanoparticles, enhanced the encapsulation efficiency, and ameliorated the pre-mature release of insulin at acidic pH. Sucrose 50-57 insulin Homo sapiens 199-206 2103901-0 1990 Recovery from insulin-induced hypoglycemia after saccharose or glucose administration. Sucrose 49-59 insulin Homo sapiens 14-21 33813244-0 2021 Lower versus standard sucrose dose for treating hypoglycemia in patients with type 1 diabetes mellitus in therapy with predictive low glucose suspend (PLGS) augmented insulin pumps: A randomized crossover trial in Santiago, Chile. Sucrose 22-29 insulin Homo sapiens 167-174 34265055-0 2021 Consuming Sucrose- or HFCS-Sweetened Beverages Increases Hepatic Lipid and Decreases Insulin Sensitivity in Adults. Sucrose 10-17 insulin Homo sapiens 85-92 34265055-14 2021 CONCLUSIONS: Consumption of both sucrose- and HFCS-SB induced detrimental changes in hepatic lipid, insulin sensitivity, and circulating lipids, lipoproteins and uric acid in 2 weeks. Sucrose 33-40 insulin Homo sapiens 100-107 35598544-7 2022 At the 60th minute, insulin secretion (0.80 +- 0.27 pg/dl) after the sucrose trial was found significantly higher than the saccharin trial (0.53 +- 0.09 pg/dl) and water (0.49 +- 0.06 pg/dl) (p < 0.05). Sucrose 69-76 insulin Homo sapiens 20-27 34072006-5 2021 Sucrose ingestion induced greater blood glucose concentration and insulin secretion at the pre-exercise state, compared with isomaltulose and/or water trials, with no differences during exercise in blood glucose. Sucrose 0-7 insulin Homo sapiens 66-73 34414452-10 2021 Starch- and sucrose-reduced diets lead to decreased levels of C-peptide, insulin, gastric inhibitory peptide, leptin and weight reduction. Sucrose 12-19 insulin Homo sapiens 73-80 34581796-15 2021 Sucrose vs sucralose was associated with greater production of circulating glucose, insulin, and glucagon-like peptide-1 and suppression of acyl-ghrelin, but no differences were found for peptide YY or leptin. Sucrose 0-7 insulin Homo sapiens 84-91 35448469-8 2022 Therefore, whey protein co-ingestion with sucrose suppresses glucose levels and increases insulin levels as opposed to the sucrose ingestion, but does not affect amino acid absorption of whey protein, indicating that this co-ingestion may not be a problem for protein supplementation. Sucrose 42-49 insulin Homo sapiens 90-97 35380611-4 2022 Previous animal studies have shown that high sucrose/fructose consumption causes insulin resistance in the liver, skeletal muscle and consequent hyperglycemia, mainly because of fructose-induced de novo hepatic lipogenesis. Sucrose 45-52 insulin Homo sapiens 81-88 2758952-1 1989 Fructose is credited with some advantages over sucrose: it causes less of an increment in plasma glucose and insulin response, and the taste is sweeter. Sucrose 47-54 insulin Homo sapiens 109-116 3042485-0 1988 Effect of acarbose on glucose and insulin response to sucrose load in reactive hypoglycemia. Sucrose 54-61 insulin Homo sapiens 34-41 2735674-6 1989 When fructose diets were used, there was a decrease in sucrose intake, which may help keep serum glucose and insulin responses within a normal range. Sucrose 55-62 insulin Homo sapiens 109-116 3055929-4 1988 Insulin was higher after High Starch and High Sucrose than after High Protein. Sucrose 46-53 insulin Homo sapiens 0-7 2655436-5 1989 Acarbose 100 mg markedly decreased absorption of sucrose, resulting in inhibition of plasma elevation of glucose and insulin and in enhancement of enteroglucagon release. Sucrose 49-56 insulin Homo sapiens 117-124 3304593-4 1987 Following sucrose ingestion, both in the nonobese and obese, there were significant (p less than 0.001) increases in the following: glucose, gastric inhibitory polypeptide, insulin, VO2, and respiratory quotient. Sucrose 10-17 insulin Homo sapiens 173-180 3302136-2 1987 Fasted subjects consumed a beverage containing 2 g sucrose/kg, and urine and blood samples were taken at intervals during the next 3 h. As a result of sucrose consumption there were significant increases in serum insulin and decreases in serum phosphorus, but no change in serum total or filterable calcium, zinc, sodium or potassium. Sucrose 151-158 insulin Homo sapiens 213-220 3302136-3 1987 Urine calcium peaked at 1.5 h and was significantly increased from 10 through 2.5 h. Sucrose-induced increases in serum insulin and urine calcium were highly variable among subjects, and within the group were significantly correlated (r = 0.82, P less than 0.01). Sucrose 85-92 insulin Homo sapiens 120-127 3302136-6 1987 The effects of sucrose on urinary calcium are consistent with the hypothesis that insulin inhibits renal calcium reabsorption. Sucrose 15-22 insulin Homo sapiens 82-89 2423368-2 1986 These hypotheses were tested by measuring insulin release in sucrose media devoid of monovalent ions. Sucrose 61-68 insulin Homo sapiens 42-49 3313140-8 1987 Stone formers with an exaggerated urinary risk factor response to sucrose were found to have abnormally high and sustained blood levels of insulin following a standard glucose test meal. Sucrose 66-73 insulin Homo sapiens 139-146 3313140-9 1987 Where sucrose or sucrose products are in abundance, quite apart from its effect in increasing urinary risk factors in the population in general, there is particular vulnerability of a significant sub group within the population with this type of insulin response. Sucrose 6-13 insulin Homo sapiens 246-253 3313140-9 1987 Where sucrose or sucrose products are in abundance, quite apart from its effect in increasing urinary risk factors in the population in general, there is particular vulnerability of a significant sub group within the population with this type of insulin response. Sucrose 17-24 insulin Homo sapiens 246-253 3021769-4 1986 Insulin-dependent autophosphorylation of alpha beta dimers isolated from low ionic strength sucrose density gradients was minimal and was always accompanied by reoxidation of dimers to the tetrameric holoreceptor. Sucrose 92-99 insulin Homo sapiens 0-7 3710313-2 1986 SHR treated with 10% sucrose solution as drinking water for 3 months exhibited an impaired glucose tolerance with higher serum insulin levels and a reduction of sigma delta IRI/sigma delta BS. Sucrose 21-28 insulin Homo sapiens 127-134 3512562-10 1986 Insulin increases the rate of sucrose efflux from both compartments as well as the rate of transfer from the first compartment to the second compartment by about 2-fold. Sucrose 30-37 insulin Homo sapiens 0-7 3525270-0 1986 The effects of sucrose meal on insulin requirement in IDDM and its modulation by acarbose. Sucrose 15-22 insulin Homo sapiens 31-38 3525270-1 1986 The purpose of the present study was to evaluate the insulin requirement in response to sucrose meal in IDDM and its modulation by a disaccharidase inhibitor, Acarbose. Sucrose 88-95 insulin Homo sapiens 53-60 3517560-5 1986 Mean plasma glucose, fructose, and insulin were reduced by both drugs during the first two hours following the sucrose load and led to a decrease of the suprabasal glucose oxidation (oxidation above baseline) during the first two hours of the test. Sucrose 111-118 insulin Homo sapiens 35-42 3524617-6 1986 Dietary sucrose seems to cause a degree of insulin resistance. Sucrose 8-15 insulin Homo sapiens 43-50 3517111-9 1986 The sucrose diet generally gave lower insulin levels in response to the glucose load. Sucrose 4-11 insulin Homo sapiens 38-45 3537075-8 1986 No differences occurred in fasting serum insulin or serum cholesterol levels, but postprandial insulin levels were higher in high sucrose-carbohydrate diets. Sucrose 130-137 insulin Homo sapiens 95-102 4084539-5 1985 Sucrose gradient centrifugation of insulin receptors incorporated at various protein to phospholipid mole ratios demonstrated that the insulin receptors were inserted into the phospholipid bilayer structure in a concentration-dependent manner. Sucrose 0-7 insulin Homo sapiens 35-42 4084539-5 1985 Sucrose gradient centrifugation of insulin receptors incorporated at various protein to phospholipid mole ratios demonstrated that the insulin receptors were inserted into the phospholipid bilayer structure in a concentration-dependent manner. Sucrose 0-7 insulin Homo sapiens 135-142 3967778-6 1985 The form of CHO (i.e., glucose, fructose, sucrose) ingested may produce different blood glucose and insulin responses, but the rate of muscle glycogen resynthesis is about the same regardless of the structure. Sucrose 42-49 insulin Homo sapiens 100-107 6759077-0 1982 The role of gastric inhibitory polypeptide in the augmented insulin response to sucrose. Sucrose 80-87 insulin Homo sapiens 60-67 3906452-4 1985 A finite segment of the population characterized by high levels of triglycerides and insulin may be at a substantially higher risk than is the general population from the present level of intake of sucrose or fructose. Sucrose 198-205 insulin Homo sapiens 85-92 7048890-1 1982 We studied the acute effects of oral ingestion of fructose and sucrose sweetened cakes and ice creams on postprandial serum glucose and insulin responses in 10 normal subjects, six subjects with impaired glucose tolerance, and 10 noninsulin-dependent diabetic subjects. Sucrose 63-70 insulin Homo sapiens 136-143 6489578-0 1984 [Plasma glucose and C-peptide after ingestion of sucrose and starch in controlled insulin-dependent diabetics. Sucrose 49-56 insulin Homo sapiens 20-29 6381959-6 1984 It is concluded that the rise in CHO oxidation and in plasma glucose and insulin levels is markedly reduced when sucrose is replaced by an equal weight of isomalt. Sucrose 113-120 insulin Homo sapiens 73-80 6143305-2 1984 The addition of naloxone to a meal consisting of 50 g sucrose dissolved in 200 ml water augmented the rise of plasma insulin levels significantly during the first 30 min after its ingestion and reduced the rise in plasma insulin and pancreatic polypeptide and elevated glucagon levels during the last 30 min of the experimental period. Sucrose 54-61 insulin Homo sapiens 117-124 6143305-3 1984 When sucrose was dissolved in 200 ml cream the addition of naloxone augmented the postprandial rise of insulin levels between 15 and 60 min after ingestion of the meal and elicited an increase of plasma SLI and PP levels throughout the entire experimental period which indicates that post-prandial levels of insulin, glucagon, PP and SLI are modulated via endogenous opiate receptors during the ingestion of carbohydrate and fat test meals and that this effect depends on the composition of the ingested nutrients. Sucrose 5-12 insulin Homo sapiens 103-110 6143305-3 1984 When sucrose was dissolved in 200 ml cream the addition of naloxone augmented the postprandial rise of insulin levels between 15 and 60 min after ingestion of the meal and elicited an increase of plasma SLI and PP levels throughout the entire experimental period which indicates that post-prandial levels of insulin, glucagon, PP and SLI are modulated via endogenous opiate receptors during the ingestion of carbohydrate and fat test meals and that this effect depends on the composition of the ingested nutrients. Sucrose 5-12 insulin Homo sapiens 308-315 6350543-2 1983 Carbohydrate-sensitivity was based on an abnormal insulin response to a sucrose load. Sucrose 72-79 insulin Homo sapiens 50-57 6350543-8 1983 At 1 hour, the carbohydrate-sensitive men given sucrose had significantly higher insulin levels than carbohydrate-sensitive men given invert sugar (disaccharide effect). Sucrose 48-55 insulin Homo sapiens 81-88 6574482-5 1983 Activation proceeds unabated in the presence of soybean trypsin inhibitor at 0.1 mg/ml and the activated, insulin-independent, protein kinase sediments in 5-20% sucrose gradients at the same position as the unmodified receptor. Sucrose 161-168 insulin Homo sapiens 106-113 6758860-3 1982 Fractionation of a sucrose homogenate of skeletal muscle demonstrated that 97% of the total neutral insulin degrading activity was in the 100 000 x g supernatant with no detectable glutathione-insulin transhydrogenase activity. Sucrose 19-26 insulin Homo sapiens 100-107 6759077-1 1982 To evaluate the role of gastric inhibitory polypeptide (GIP) in the augmented insulin response to sucrose, seven normal volunteers ingested four separate meals of 100 g sucrose (S), 50 g glucose (G), 50 g fructose (F), and 50 g glucose + 50 g fructose (G + F). Sucrose 98-105 insulin Homo sapiens 78-85 6759077-9 1982 The augmentation of insulin to S in the first hour may result from fructose, extra glucose equivalent of the sucrose test solution, or from endocrine mechanisms other than those subserved by GIP. Sucrose 109-116 insulin Homo sapiens 20-27 7016781-8 1981 BAY g 5421 caused a significant decrease of plasma insulin after a 100 g sucrose tolerance test as compared to placebo. Sucrose 73-80 insulin Homo sapiens 51-58 7044093-7 1982 Insulin and glucose levels were positively correlated with total caloric consumption and insulin was also positively correlated with sucrose consumption (p less than 0.05). Sucrose 133-140 insulin Homo sapiens 0-7 7044093-7 1982 Insulin and glucose levels were positively correlated with total caloric consumption and insulin was also positively correlated with sucrose consumption (p less than 0.05). Sucrose 133-140 insulin Homo sapiens 89-96 7024026-5 1981 Sucrose, in contrast, induced a greater post-prandial rise in blood glucose levels despite counter-regulation by the glucose-controlled insulin infusion system. Sucrose 0-7 insulin Homo sapiens 136-143 7016892-2 1981 In 10 normal subjects, the ingestion of a solid-liquid meal with sucrose in the liquid part elicited a significantly greater increase in the plasma insulin and glucose levels during the first 20 min than did the ingestion of the same meal in homogenized form. Sucrose 65-72 insulin Homo sapiens 148-155 7016892-5 1981 In response to the liquid-sucrose meal, mean postprandial plasma insulin levels were significantly higher than those observed in response to the solid-sucrose meal (110 +/- 11.3 vs. 80 +/- 8.5 microunits/ml; P less than 0.01) as were plasma glucagon levels (284 +/- 12.2 vs. 198 +/- 8.2 pg/ml; P less than 0.001). Sucrose 26-33 insulin Homo sapiens 65-72 7016892-7 1981 The present data demonstrate that the ingestion of sucrose in the liquid part of a meal results in a significant elevation of plasma insulin concentrations compared to the ingestion of sucrose in the solid part of the meal. Sucrose 51-58 insulin Homo sapiens 133-140 7038409-6 1982 Such "sucrose-induced hyperinsulinism" leads to formation of insulin antibodies. Sucrose 6-13 insulin Homo sapiens 27-34 7030048-0 1981 Serum insulin and glucose in hyperinsulinemic subjects fed three different levels of sucrose. Sucrose 85-92 insulin Homo sapiens 6-13 7030048-6 1981 Fasting serum insulin levels increased with the sucrose content of the diet and were significantly higher in men than in women. Sucrose 48-55 insulin Homo sapiens 14-21 7030048-9 1981 When compared to the insulin response to a sucrose load (2 g/kg body weight) after consuming the 5% sucrose diet, serum insulin was significantly higher at 1 h after the 18% sucrose diet and at 0.5, 1, 2, and 3 h after the 33% sucrose diet. Sucrose 43-50 insulin Homo sapiens 21-28 7030048-9 1981 When compared to the insulin response to a sucrose load (2 g/kg body weight) after consuming the 5% sucrose diet, serum insulin was significantly higher at 1 h after the 18% sucrose diet and at 0.5, 1, 2, and 3 h after the 33% sucrose diet. Sucrose 43-50 insulin Homo sapiens 120-127 7030048-9 1981 When compared to the insulin response to a sucrose load (2 g/kg body weight) after consuming the 5% sucrose diet, serum insulin was significantly higher at 1 h after the 18% sucrose diet and at 0.5, 1, 2, and 3 h after the 33% sucrose diet. Sucrose 100-107 insulin Homo sapiens 120-127 7030048-9 1981 When compared to the insulin response to a sucrose load (2 g/kg body weight) after consuming the 5% sucrose diet, serum insulin was significantly higher at 1 h after the 18% sucrose diet and at 0.5, 1, 2, and 3 h after the 33% sucrose diet. Sucrose 100-107 insulin Homo sapiens 120-127 7030048-9 1981 When compared to the insulin response to a sucrose load (2 g/kg body weight) after consuming the 5% sucrose diet, serum insulin was significantly higher at 1 h after the 18% sucrose diet and at 0.5, 1, 2, and 3 h after the 33% sucrose diet. Sucrose 100-107 insulin Homo sapiens 120-127 6275467-7 1981 125I-insulin was less degraded by partially purified placental plasma membranes than by a microsomal-membrane preparation obtained without differential centrifugation in sucrose linear gradient. Sucrose 170-177 insulin Homo sapiens 5-12 7024026-6 1981 Insulin requirement after sucrose significantly exceeded (p less than 0.01) that after xylitol or starch during the first 60 min and 2 h respectively. Sucrose 26-33 insulin Homo sapiens 0-7 7034156-0 1981 Response of serum levels of gastric inhibitory polypeptide and insulin to sucrose ingestion during long-term application of acarbose. Sucrose 74-81 insulin Homo sapiens 63-70 6998274-8 1980 These results suggest that the increases in insulin levels observed after sucrose feeding may be mediated by an effect on the enteric hormone gastric inhibitory polypeptide. Sucrose 74-81 insulin Homo sapiens 44-51 6986758-7 1980 We conclude that fructose seems to be responsible for the impaired insulin binding and insulin sensitivity induced by sucrose. Sucrose 118-125 insulin Homo sapiens 67-74 7008368-3 1980 Sucrose produced the steepest BG increase and the greatest insulin requirement in order to return to baseline BG levels. Sucrose 0-7 insulin Homo sapiens 59-66 6989226-9 1980 Levels of serum glucagon and responses of serum glucose and insulin to sucrose load were significantly higher in OC users than in controls. Sucrose 71-78 insulin Homo sapiens 60-67 6989226-14 1980 After 3 weeks on the diet, the glucose and insulin responses of the OC users, but not of the controls, were significantly greater on the sucrose than on the starch diet. Sucrose 137-144 insulin Homo sapiens 43-50 6989226-15 1980 The response of the insulin/glucagon ratio to the sucrose load was not significantly affected by the OC use. Sucrose 50-57 insulin Homo sapiens 20-27 6990183-8 1980 The mechanism of action of the low-fat, low-sucrose diet seems for the greatest part to be a normalization of the insulin sensitivity, which is partly caused by a normalization of the cellular insulin binding. Sucrose 44-51 insulin Homo sapiens 114-121 6990183-8 1980 The mechanism of action of the low-fat, low-sucrose diet seems for the greatest part to be a normalization of the insulin sensitivity, which is partly caused by a normalization of the cellular insulin binding. Sucrose 44-51 insulin Homo sapiens 193-200 6986758-1 1980 We have studied whether the sucrose-induced reduction of insulin sensitivity and cellular insulin binding in normal man is related to the fructose or the glucose moiety. Sucrose 28-35 insulin Homo sapiens 57-64 6995516-5 1980 Plasma glucose and insulin peaks were both significantly lower after fructose ingestion as compared with glucose and sucrose. Sucrose 117-124 insulin Homo sapiens 19-26 5101782-0 1971 Diurnal fluctuations in triglyceride, free fatty acids, and insulin during sucrose consumption and insulin infusion in man. Sucrose 75-82 insulin Homo sapiens 60-67 477874-1 1979 Volunteers experienced sucrose solution as more pleasant 36-48 min after insulin, than after saline control. Sucrose 23-30 insulin Homo sapiens 73-80 672474-6 1978 Experiments have shown that a high consumption of sucrose produces not only the wide range of abnormalities seen in CHD but also an increased blood concentration of insulin and cortisol. Sucrose 50-57 insulin Homo sapiens 165-172 4795809-0 1973 Plasma insulin and carbohydrate metabolism after sucrose ingestion during rest and prolonged aerobic exercise. Sucrose 49-56 insulin Homo sapiens 7-14 4570364-0 1972 Increased levels of plasma insulin and eleven hydroxycorticosteroid induced by sucrose, and their reduction by phenformin. Sucrose 79-86 insulin Homo sapiens 27-34 495537-8 1979 Fasting serum insulin and glucose levels were significantly higher with the sucrose than with the starch diet. Sucrose 76-83 insulin Homo sapiens 14-21 495537-9 1979 The insulin response and the insulin:glucose ratios after a sucrose load (2 g/kg body weight) were greater after the subjects consumed the sucrose diet. Sucrose 60-67 insulin Homo sapiens 29-36 495537-9 1979 The insulin response and the insulin:glucose ratios after a sucrose load (2 g/kg body weight) were greater after the subjects consumed the sucrose diet. Sucrose 139-146 insulin Homo sapiens 4-11 495537-9 1979 The insulin response and the insulin:glucose ratios after a sucrose load (2 g/kg body weight) were greater after the subjects consumed the sucrose diet. Sucrose 139-146 insulin Homo sapiens 29-36 495537-10 1979 Sucrose feeding produced increases in fasting serum insulin, the insulin:glucose ratio and the insulin response to a sucrose load that were of greater magnitude in a subgroup of nine subjects classified as potentially carbohydrate-sensitive than in normal subjects. Sucrose 0-7 insulin Homo sapiens 52-59 495537-10 1979 Sucrose feeding produced increases in fasting serum insulin, the insulin:glucose ratio and the insulin response to a sucrose load that were of greater magnitude in a subgroup of nine subjects classified as potentially carbohydrate-sensitive than in normal subjects. Sucrose 0-7 insulin Homo sapiens 65-72 495537-10 1979 Sucrose feeding produced increases in fasting serum insulin, the insulin:glucose ratio and the insulin response to a sucrose load that were of greater magnitude in a subgroup of nine subjects classified as potentially carbohydrate-sensitive than in normal subjects. Sucrose 0-7 insulin Homo sapiens 65-72 221604-4 1979 On the other hand, serum free fatty acid levels were slightly increased and serum insulin levels were substantially increased in animals eating the sucrose-lard diet. Sucrose 148-155 insulin Homo sapiens 82-89 756709-0 1978 [Effects of oral glucose, fructose and saccharose loads on blood sugar, insulin and lipids in normal subjects]. Sucrose 39-49 insulin Homo sapiens 72-79 702524-1 1978 Insulin decreased markedly the adenylyl cyclase activity associated with fat cell membranes purified by centrifugation in sucrose gradients. Sucrose 122-129 insulin Homo sapiens 0-7 4551147-0 1972 Insulin biosynthesis: studies of Islet polyribosomes (nascent peptides-sucrose gradient analysis-gel filtration). Sucrose 71-78 insulin Homo sapiens 0-7 5124157-0 1971 Effects of insulin preparations on titrated sucrose regulation. Sucrose 44-51 insulin Homo sapiens 11-18 5101782-11 1971 The data show that when sucrose is eaten for 2 or 3 days, there is a general increase in triglyceride concentration upon which are superimposed major diurnal fluctuations in the concentrations of triglyceride, insulin, and FFA. Sucrose 24-31 insulin Homo sapiens 210-217 31600762-4 2019 Herein, we review evidence that (1) excess sucrose consumption induces AD-associated liver pathologies and brain insulin resistance, (2) chronic stress overdrives activity of locus coeruleus neurons, leading to loss of function (a common event in neurodegeneration), (3) high-sugar diets and stress promote the loss of neuroprotective sex hormones in men and women, and (4) Western dietary trends set the stage for a lithium-deficient state. Sucrose 43-50 insulin Homo sapiens 113-120 13373869-0 1956 Isolation of sucrose and other related oligosaccharides from a partial acid hydrolysate of insulin. Sucrose 13-20 insulin Homo sapiens 91-98 33546941-1 2021 BACKGROUND AND AIM: The overconsumption of sucrose is closely related to sugar-sweetened beverages and one of the main factors associated with the increase of metabolic diseases, such as type 2 diabetes, obesity, and insulin resistance. Sucrose 43-50 insulin Homo sapiens 217-224 33300990-0 2021 Appetite regulating hormones are reduced after oral sucrose vs glucose: influence of obesity, insulin resistance and sex. Sucrose 52-59 insulin Homo sapiens 94-101 33300990-8 2021 RESULTS: Sucrose vs glucose ingestion provoked a less robust rise in glucose (p<0.0001), insulin (p<0.0001), GLP-1 (p<0.0001), and PYY (p=0.02), whereas acyl-ghrelin suppression was similar between the sugars. Sucrose 9-16 insulin Homo sapiens 89-96 31255685-10 2020 Insulin at -20 C under isochoric cooling lost 22% of its function after 15 days and 0.6M sucrose prevented insulin deactivation. Sucrose 89-96 insulin Homo sapiens 107-114 28784181-0 2017 Effectiveness of a low-fructose and/or low-sucrose diet in decreasing insulin resistance (DISFRUTE study): study protocol for a randomized controlled trial. Sucrose 43-50 insulin Homo sapiens 70-77 28899680-9 2017 Sucralose and sucrose exposure elicited similarly significant increases in serum insulin 2min after exposure and significant decreases after 2min in responders in both food forms. Sucrose 14-21 insulin Homo sapiens 81-88 27680107-1 2017 Epidemiological studies indicate that the increased consumption of sugars including sucrose and fructose in beverages correlate with the prevalence of obesity, type-2 diabetes, insulin resistance, hyperinsulinemia, hypertriglyceridemia, and hypertension in humans. Sucrose 84-91 insulin Homo sapiens 177-184 28592611-0 2017 Fructose replacement of glucose or sucrose in food or beverages lowers postprandial glucose and insulin without raising triglycerides: a systematic review and meta-analysis. Sucrose 35-42 insulin Homo sapiens 96-103 28592611-6 2017 Peak postprandial blood triglyceride concentrations did not significantly increase.Conclusions: Strong evidence exists that substituting fructose for glucose or sucrose in food or beverages lowers peak postprandial blood glucose and insulin concentrations. Sucrose 161-168 insulin Homo sapiens 233-240 27620647-5 2016 There was a greater post-prandial excursion in glucose and insulin levels after sucrose than after the erythritol meals. Sucrose 80-87 insulin Homo sapiens 59-66 27581470-2 2016 OBJECTIVE: We aimed to determine the effect of varying the sucrose, RS, and whey protein content of cereal bars on glucose and insulin responses. Sucrose 59-66 insulin Homo sapiens 127-134