PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12356421-1 2002 The effects of sodium taurocholate (NaTC) on the absorption of inhaled insulin was investigated using both in vivo and in vitro experiments. natc 36-40 insulin Homo sapiens 71-78 15464833-7 2004 In conclusion, the permeability of insulin was increased across Caco-2 cell monolayer when the liposome sodium taurocholate (NaTC) formulation was used. natc 125-129 insulin Homo sapiens 35-42 12356421-4 2002 In a similar concentration interval (20-25 mM) NaTC decreased the transepithelial electrical resistance (TEER) across Caco-2 cell monolayers leading to an increased permeability of insulin. natc 47-51 insulin Homo sapiens 181-188 12356421-6 2002 Furthermore, we show that NaTC in the concentration range 2-15 mM gradually decreases the aggregation state of insulin, i.e., produces mono- or dimeric insulin from hexameric insulin. natc 26-30 insulin Homo sapiens 111-118 12356421-6 2002 Furthermore, we show that NaTC in the concentration range 2-15 mM gradually decreases the aggregation state of insulin, i.e., produces mono- or dimeric insulin from hexameric insulin. natc 26-30 insulin Homo sapiens 152-159 12356421-6 2002 Furthermore, we show that NaTC in the concentration range 2-15 mM gradually decreases the aggregation state of insulin, i.e., produces mono- or dimeric insulin from hexameric insulin. natc 26-30 insulin Homo sapiens 152-159 12356421-7 2002 In conclusion, NaTC increases the bioavailability of nebulized insulin, increases the permeability of insulin across Caco-2 cell monolayers, and decreases the aggregation state of insulin at similar concentrations. natc 15-19 insulin Homo sapiens 63-70 12356421-7 2002 In conclusion, NaTC increases the bioavailability of nebulized insulin, increases the permeability of insulin across Caco-2 cell monolayers, and decreases the aggregation state of insulin at similar concentrations. natc 15-19 insulin Homo sapiens 102-109 12356421-7 2002 In conclusion, NaTC increases the bioavailability of nebulized insulin, increases the permeability of insulin across Caco-2 cell monolayers, and decreases the aggregation state of insulin at similar concentrations. natc 15-19 insulin Homo sapiens 102-109 12356421-8 2002 We suggest that the main mechanisms behind the absorption enhancement of inhaled insulin by NaTC are the production of insulin monomers and an opening of tight junctions between adjacent airway epithelial cells. natc 92-96 insulin Homo sapiens 81-88 12356421-8 2002 We suggest that the main mechanisms behind the absorption enhancement of inhaled insulin by NaTC are the production of insulin monomers and an opening of tight junctions between adjacent airway epithelial cells. natc 92-96 insulin Homo sapiens 119-126