PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32449150-0 2020 Farnesol attenuates oxidative stress and liver injury and modulates fatty acid synthase and acetyl-CoA carboxylase in high cholesterol-fed rats. Farnesol 0-8 fatty acid synthase Rattus norvegicus 68-87 32449150-2 2020 This study investigated the protective effect of farnesol (FAR), a sesquiterpene alcohol, against liver injury in high cholesterol diet (HCD)-fed rats, and its modulatory effect on fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC). Farnesol 49-57 fatty acid synthase Rattus norvegicus 202-205 18509688-0 2008 Farnesol decreases serum triglycerides in rats: identification of mechanisms including up-regulation of PPARalpha and down-regulation of fatty acid synthase in hepatocytes. Farnesol 0-8 fatty acid synthase Rattus norvegicus 137-156 18509688-7 2008 Farnesol did not change SREBP-1c mRNA levels, but significantly down-regulated fatty acid synthase (FAS) mRNA and protein levels and activity, indicating that attenuated lipogenesis may also contribute to hypotriglyceridemic effects of farnesol in vivo. Farnesol 0-8 fatty acid synthase Rattus norvegicus 79-98 18509688-7 2008 Farnesol did not change SREBP-1c mRNA levels, but significantly down-regulated fatty acid synthase (FAS) mRNA and protein levels and activity, indicating that attenuated lipogenesis may also contribute to hypotriglyceridemic effects of farnesol in vivo. Farnesol 0-8 fatty acid synthase Rattus norvegicus 100-103 18509688-8 2008 Rescue experiments revealed that down-regulation of FAS by farnesol was not related to activation of PPARalpha, but rather was caused by a 9-cis retinoic acid mediated mechanism that involved down-regulation of retinoid X receptor beta. Farnesol 59-67 fatty acid synthase Rattus norvegicus 52-55