PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20799892-1	2010	The acetyl-CoA carboxylase isoform ACC2 expressed in the liver generates malonyl-CoA, which primarily regulates fatty acid oxidation through inhibition of the mitochondrial carrier carnitine palmitoyl-CoA transferase-I.	Malonyl Coenzyme A	73-84	acetyl-CoA carboxylase beta	Homo sapiens	35-39	
28768177-2	2017	To determine if reducing lipogenesis functions similarly in humans, we developed MK-4074, a liver-specific inhibitor of acetyl-CoA carboxylase (ACC1) and (ACC2), enzymes that produce malonyl-CoA for fatty acid synthesis.	Malonyl Coenzyme A	183-194	acetyl-CoA carboxylase beta	Homo sapiens	155-159	
24650564-8	2014	The silence of ACC2 in HK-2 cells led to restored cell morphology with less lipid deposition and less malonyl-CoA content, which resulted from faster beta-oxidation rate.	Malonyl Coenzyme A	102-113	acetyl-CoA carboxylase beta	Homo sapiens	15-19	
21184748-1	2011	Acetyl CoA carboxylase (ACC1 and ACC2) generates malonyl CoA, a substrate for de novo lipogenesis (DNL) and an inhibitor of mitochondrial fatty acid beta-oxidation (FAO).	Malonyl Coenzyme A	49-60	acetyl-CoA carboxylase beta	Homo sapiens	33-37	
19236960-2	2009	The present study describes the steady-state kinetic analysis of a purified recombinant human form of the enzyme, namely ACC2, using a novel LC/MS/MS assay to directly measure malonyl-CoA formation.	Malonyl Coenzyme A	176-187	acetyl-CoA carboxylase beta	Homo sapiens	121-125	
20602615-7	2010	The acetyl coenzyme A carboxylase beta enzyme synthesizes malonyl coenzyme A, an essential substrate for hepatic fatty acid synthesis and an inhibitor of fatty acid oxidation.	Malonyl Coenzyme A	58-76	acetyl-CoA carboxylase beta	Homo sapiens	4-38	
20139635-3	2010	Acetyl-CoA carboxylase (ACC), consisting of two isoenzymes ACC1 and ACC2, mediates the conversion from acetyl-CoA to malonyl-CoA, and thus plays a key role for the regulation of lipogenesis.	Malonyl Coenzyme A	117-128	acetyl-CoA carboxylase beta	Homo sapiens	68-72	
18452391-6	2008	Using this detection method for CoA, we measured the activity of sequential enzymes in the fatty acid synthesis pathway to develop an ACC2/FAS-coupled assay where ACC2 produces malonyl-CoA from acetyl-CoA.	Malonyl Coenzyme A	177-188	acetyl-CoA carboxylase beta	Homo sapiens	134-138	
19047759-2	2009	Acetyl-CoA carboxylases 1 and 2 (ACC1 and ACC2) catalyze the synthesis of malonyl-CoA, the substrate for fatty acid synthesis and the regulator of fatty acid oxidation.	Malonyl Coenzyme A	74-85	acetyl-CoA carboxylase beta	Homo sapiens	42-46	
18452391-6	2008	Using this detection method for CoA, we measured the activity of sequential enzymes in the fatty acid synthesis pathway to develop an ACC2/FAS-coupled assay where ACC2 produces malonyl-CoA from acetyl-CoA.	Malonyl Coenzyme A	177-188	acetyl-CoA carboxylase beta	Homo sapiens	163-167	
19190759-1	2009	Acetyl-CoA carboxylases ACC1 and ACC2 catalyze the carboxylation of acetyl-CoA to malonyl-CoA, regulating fatty-acid synthesis and oxidation, and are potential targets for treatment of metabolic syndrome.	Malonyl Coenzyme A	82-93	acetyl-CoA carboxylase beta	Homo sapiens	33-37	
32487689-3	2020	Mechanistically, Snail suppresses mitochondrial ACC2 (ACACB) by binding to a series of E-boxes located in its proximal promoter, resulting in decreased malonyl-CoA level.	Malonyl Coenzyme A	152-163	acetyl-CoA carboxylase beta	Homo sapiens	48-52	
16721829-7	2006	In both lean and obese subjects, expression of mitochondrial ACC2 was 20-fold greater than that of cytoplasmic ACC1, consistent with their hypothesized roles in synthesizing malonyl-CoA from acetyl-CoA for CPT1 regulation and lipogenesis, respectively.	Malonyl Coenzyme A	174-185	acetyl-CoA carboxylase beta	Homo sapiens	61-65	
14627750-12	2003	We hypothesize that reduced amount of malonyl-CoA, consequent to reduced ACC2 mRNA, enhancing fatty acid oxidation, causes lowering of the intramyocitic triglyceride depot.	Malonyl Coenzyme A	38-49	acetyl-CoA carboxylase beta	Homo sapiens	73-77	
12642900-3	2003	ACCbeta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine palmitoyl-CoA transferase-1 (CPT-1), which is a rate-limiting enzyme of fatty acid oxidation in mitochondria.	Malonyl Coenzyme A	78-89	acetyl-CoA carboxylase beta	Homo sapiens	0-7	
10677481-8	2000	The association of ACC2 with the mitochondria is consistent with the hypothesis that ACC2 is involved in the regulation of mitochondrial fatty acid oxidation through the inhibition of carnitine palmitoyltransferase 1 by its product malonyl-CoA.	Malonyl Coenzyme A	232-243	acetyl-CoA carboxylase beta	Homo sapiens	19-23	
10677481-8	2000	The association of ACC2 with the mitochondria is consistent with the hypothesis that ACC2 is involved in the regulation of mitochondrial fatty acid oxidation through the inhibition of carnitine palmitoyltransferase 1 by its product malonyl-CoA.	Malonyl Coenzyme A	232-243	acetyl-CoA carboxylase beta	Homo sapiens	85-89	
15955844-6	2005	After the operation, skeletal muscle ACC2 mRNA decreased (P<0.0001) from 452.82+/-76.35 to 182.45+/-40.69% of cyclophilin mRNA as did the malonyl-CoA (from 0.28+/-0.02 to 0.16+/-0.01 nmol x g(-1); P<0.0001).	Malonyl Coenzyme A	141-152	acetyl-CoA carboxylase beta	Homo sapiens	37-41	
15955844-9	2005	In conclusion, the reversion of insulin resistance after BPD might allow reversal of leptin resistance, restoration of leptin pulsatility, and consequent inhibition of ACC2 mRNA expression, translating to a reduced synthesis of malonyl-CoA, which, in turn, results in increased fatty acid oxidation.	Malonyl Coenzyme A	228-239	acetyl-CoA carboxylase beta	Homo sapiens	168-172	
10393092-2	1999	ACC-beta is the predominant isoform expressed in heart and skeletal muscles, in which a major role of malonyl-CoA is probably to regulate fatty acid beta-oxidation.	Malonyl Coenzyme A	102-113	acetyl-CoA carboxylase beta	Homo sapiens	0-8	
35359351-4	2022	ACC2 localizes on the outer membrane of mitochondria and produces malonyl-CoA to regulate the activity of carnitine palmitoyltransferase 1 (CPT1) that involves in the beta-oxidation of fatty acid.	Malonyl Coenzyme A	66-77	acetyl-CoA carboxylase beta	Homo sapiens	0-4	
32487689-3	2020	Mechanistically, Snail suppresses mitochondrial ACC2 (ACACB) by binding to a series of E-boxes located in its proximal promoter, resulting in decreased malonyl-CoA level.	Malonyl Coenzyme A	152-163	acetyl-CoA carboxylase beta	Homo sapiens	54-59	
32487689-4	2020	Malonyl-CoA being a well-known endogenous inhibitor of fatty acid transporter carnitine palmitoyltransferase 1 (CPT1), the suppression of ACC2 by Snail activates CPT1-dependent FAO, generating ATP and decreasing NADPH consumption.	Malonyl Coenzyme A	0-11	acetyl-CoA carboxylase beta	Homo sapiens	138-142