PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21632243-1 2011 The incorporation of R,R-1,2-diaminocyclohexane at C4 in a series of 2,4-diaminopyrimidines led to a number of ALK inhibitors in which optimized activity was achieved by conversion of the 2-amino group into a methanesulfonamide. r,r-1,2-diaminocyclohexane 21-47 anaplastic lymphoma kinase Mus musculus 111-114