PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14499631-5 2003 MnSOD activity was strongly induced in virally transformed WI-38 cells by treatment with the herbicide paraquat or inhibition of GSH synthesis with BSO. Glutathione 129-132 superoxide dismutase 2 Homo sapiens 0-5 15130278-4 2004 Overexpression of MnSOD resulted in a seven- to eightfold increase in reduced glutathione (GSH), 18- to 26-fold increase in oxidized glutathione (GSSG), and a two- to threefold decrease in the ratio of GSH to GSSG. Glutathione 78-89 superoxide dismutase 2 Homo sapiens 18-23 15130278-4 2004 Overexpression of MnSOD resulted in a seven- to eightfold increase in reduced glutathione (GSH), 18- to 26-fold increase in oxidized glutathione (GSSG), and a two- to threefold decrease in the ratio of GSH to GSSG. Glutathione 91-94 superoxide dismutase 2 Homo sapiens 18-23 15130278-4 2004 Overexpression of MnSOD resulted in a seven- to eightfold increase in reduced glutathione (GSH), 18- to 26-fold increase in oxidized glutathione (GSSG), and a two- to threefold decrease in the ratio of GSH to GSSG. Glutathione 133-144 superoxide dismutase 2 Homo sapiens 18-23 15130278-4 2004 Overexpression of MnSOD resulted in a seven- to eightfold increase in reduced glutathione (GSH), 18- to 26-fold increase in oxidized glutathione (GSSG), and a two- to threefold decrease in the ratio of GSH to GSSG. Glutathione 202-205 superoxide dismutase 2 Homo sapiens 18-23 15130278-5 2004 MnSOD-overexpressing cells showed an increase in sensitivity to the cytotoxicity of buthionine sulfoximine, a glutathione-depleting agent, and vitamin C, but a decrease in sensitivity to sodium selenite. Glutathione 110-121 superoxide dismutase 2 Homo sapiens 0-5 14967442-8 2004 CONCLUSIONS: Manganese superoxide dismutase overexpression protects 2C6 cells from irradiation damage by scavenging ROS that readily interact with major endogenous antioxidants--ascorbate and GSH--in nontransfected hematopoietic 32D cl 3 cells. Glutathione 192-195 superoxide dismutase 2 Homo sapiens 13-43 15051313-4 2004 A network of intramitochondrial antioxidants consisting of the enzymes Mn-superoxide dismutase and glutathione peroxidase and of the reductants NADH(2), ubiquinol and reduced glutathione, is operative in minimizing the potentially harmful effects of O(2)(-), NO, H(2)O(2) and ONOO(-). Glutathione 99-110 superoxide dismutase 2 Homo sapiens 71-94 17395009-6 2007 On the other hand, glutathione, known to react with both peroxynitrite and nitrogen dioxide, totally protected MnSOD from inactivation and nitration on addition of authentic peroxynitrite but, notably, it was only partially inhibitory in the presence of the more biologically relevant J*NO and JO(2)(*-). Glutathione 19-30 superoxide dismutase 2 Homo sapiens 111-116 17395009-9 2007 Our results help to rationalize MnSOD tyrosine nitration observed in inflammatory conditions in vivo in the presence of low molecular weight scavengers such as glutathione that otherwise would completely consume nitrogen dioxide and prevent nitration reactions. Glutathione 160-171 superoxide dismutase 2 Homo sapiens 32-37 16910775-8 2006 MnSOD overexpression did prevent radiation-induced decreases in total glutathione content, which correlated with radioresistance and enhanced G(2) accumulation. Glutathione 70-81 superoxide dismutase 2 Homo sapiens 0-5 9409551-5 1997 In HHL rabbits, MnSOD activity and GSH concentration were significantly increased in atherosclerotic intima compared to the media of the aorta, but significantly decreased (P<0.01) in larger plaques compared with smaller ones, resulting in a significant inverse correlation of MnSOD activity (r=-0.67, P<0.001) and GSH concentration (r=-0.57, P<0.01) with plaque size. Glutathione 321-324 superoxide dismutase 2 Homo sapiens 16-21 9518260-10 1998 Subsequent thiol redox modulation studies showed that only the normal fibroblast cultures showed a potentiation of TNF-alpha-mediated MnSOD upregulation following GSH depletion. Glutathione 163-166 superoxide dismutase 2 Homo sapiens 134-139 9518260-11 1998 In addition, provision of the GSH precursor, N-acetylcysteine during TNF-alpha challenge only diminished MnSOD activity and mitochondrial compartmentalization in the AIDS-KS cells, a finding that likely reflects the lower levels of reduced thiols in this cellular population. Glutathione 30-33 superoxide dismutase 2 Homo sapiens 105-110 11672836-5 2001 MnSOD increased in hippocampus at 24, 48 and 72 h after ischemia, coincident with the marked reduction in the activity of glutathione-related enzymes. Glutathione 122-133 superoxide dismutase 2 Homo sapiens 0-5 10962132-5 2000 Upregulation of Mn-SOD in the mitochondria in the course of the induction of i-NOS and, compared to the astrocytes, higher GSH levels in the microglial cells probably explain the resistance of the cultures against nitrosative stress. Glutathione 123-126 superoxide dismutase 2 Homo sapiens 16-22 32781281-3 2021 After exposure to Cr(III), loss of sodA not only led to the excessive generation of ROS, but also enhanced the level of lipid peroxidation and reduced the GSH level, indicating that the deficiency of Mn-SOD decreased the bacterial resistance ability against Cr(III). Glutathione 155-158 superoxide dismutase 2 Homo sapiens 200-206 7859743-8 1995 Decreased Mn-SOD expression was associated with decreased levels of glutathione and a lower ratio of reduced:oxidized glutathione. Glutathione 68-79 superoxide dismutase 2 Homo sapiens 10-16 7859743-8 1995 Decreased Mn-SOD expression was associated with decreased levels of glutathione and a lower ratio of reduced:oxidized glutathione. Glutathione 118-129 superoxide dismutase 2 Homo sapiens 10-16 33672092-6 2021 We summarize the association findings between drug hypersensitivity reactions and variants in the genes that encode the enzymes related to the redox system such as enzymes related to glutathione: Glutathione S-transferase (GSTM1, GSTP, GSTT1) and glutathione peroxidase (GPX1), thioredoxin reductase (TXNRD1 and TXNRD2), superoxide dismutase (SOD1, SOD2, and SOD3), catalase (CAT), aldo-keto reductase (AKR), and the peroxiredoxin system (PRDX1, PRDX2, PRDX3, PRDX4, PRDX5, PRDX6). Glutathione 183-194 superoxide dismutase 2 Homo sapiens 349-353 25576182-4 2015 There is a growing consensus that the mitochondrial SOD isoform - SOD2 and GSH are critical for the cellular antioxidant defense. Glutathione 75-78 superoxide dismutase 2 Homo sapiens 52-55 29158541-8 2018 Concurrently, in samples from children with obesity, we found decreased SOD2 activity and redox state imbalance highlighted by decreased reduced glutathione/oxidized glutathione (GSH/GSSG) ratio and significant increases in protein carbonylation. Glutathione 145-156 superoxide dismutase 2 Homo sapiens 72-76 23212700-6 2013 SOD2Val16Ala polymorphism was associated with dopamine plasma concentration and blood concentration ratio between reduced and oxidised form of glutathione, while GPX1Pro200Leu was related with concentration of reduced glutathione. Glutathione 143-154 superoxide dismutase 2 Homo sapiens 0-4 25522270-6 2014 Moreover, the enzymatic activities of isocitrate dehydrogenase 2 (IDH2), glutathione peroxidase (GSH-Px) and manganese superoxide dismutase (SOD2) as well as deacetylation of SOD2 were increased by RSV pretreatment, suggesting RSV notably enhanced mtROS scavenging in t-BHP-induced endothelial cells. Glutathione 97-100 superoxide dismutase 2 Homo sapiens 141-145 23212700-6 2013 SOD2Val16Ala polymorphism was associated with dopamine plasma concentration and blood concentration ratio between reduced and oxidised form of glutathione, while GPX1Pro200Leu was related with concentration of reduced glutathione. Glutathione 218-229 superoxide dismutase 2 Homo sapiens 0-4 19424927-6 2009 Also they, as well as glutathione itself, slightly increased MnSOD activity in human brain mitochondria and inhibited oxidative burst caused by neutrophil NAD(P)H oxidase. Glutathione 22-33 superoxide dismutase 2 Homo sapiens 61-66 20059731-5 2010 Superoxide radicals produced are quickly scavenged by superoxide dismutase (MnSOD), and the resulting H(2)O(2) is detoxified by peroxiredoxin-thioredoxin system or by the enzymes of ascorbate-glutathione cycle, found in the mitochondrial matrix. Glutathione 192-203 superoxide dismutase 2 Homo sapiens 76-81 20018168-4 2010 Protein expression and enzymatic activity of MnSOD and catalase were increased in thermotolerant cells, as well as intracellular glutathione levels and gamma-glutamylcysteine synthetase expression. Glutathione 129-140 superoxide dismutase 2 Homo sapiens 45-50 20538313-3 2010 Our results show that within the initial 48 h of infection the expression of the mitochondrial superoxide dismutase (MnSOD) is significantly increased, which correlates with a decrease in reactive oxygen species production, and with a lack of cellular glutathione depletion. Glutathione 252-263 superoxide dismutase 2 Homo sapiens 81-115 20712757-3 2010 METHODS: Four candidate genes were selected a priori from two different steps in the oxidative stress pathway, specifically the synthesis of glutathione [catalytic subunit of glutamate cysteine ligase (GCLC) and regulatory subunit of glutamate cysteine ligase (GCLM)] and the removal of reactive oxygen species [superoxide dismutase 2 (SOD2) and glutathione peroxidase 3 (GPX3)]. Glutathione 141-152 superoxide dismutase 2 Homo sapiens 312-334 20712757-3 2010 METHODS: Four candidate genes were selected a priori from two different steps in the oxidative stress pathway, specifically the synthesis of glutathione [catalytic subunit of glutamate cysteine ligase (GCLC) and regulatory subunit of glutamate cysteine ligase (GCLM)] and the removal of reactive oxygen species [superoxide dismutase 2 (SOD2) and glutathione peroxidase 3 (GPX3)]. Glutathione 141-152 superoxide dismutase 2 Homo sapiens 336-340