PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29514209-0	2018	Gene of the transcriptional activator MET4 is involved in regulation of glutathione biosynthesis in the methylotrophic yeast Ogataea (Hansenula) polymorpha.	Glutathione	72-83	Met4p	Saccharomyces cerevisiae S288C	38-42	
29514209-3	2018	In this study, a competitive O. polymorpha glutathione producer was constructed by overexpression of the GSH2 gene, encoding gamma-glutamylcysteine synthetase, the first enzyme involved in glutathione biosynthesis, and the MET4 gene coding for central regulator of sulfur metabolism.	Glutathione	43-54	Met4p	Saccharomyces cerevisiae S288C	223-227	
29514209-3	2018	In this study, a competitive O. polymorpha glutathione producer was constructed by overexpression of the GSH2 gene, encoding gamma-glutamylcysteine synthetase, the first enzyme involved in glutathione biosynthesis, and the MET4 gene coding for central regulator of sulfur metabolism.	Glutathione	189-200	Met4p	Saccharomyces cerevisiae S288C	223-227	
29514209-4	2018	Overexpression of MET4 gene in the background of overexpressed GSH2 gene resulted in 5-fold increased glutathione production during shake flask cultivation as compared to the wild-type strain, reaching 2167 mg L-1.	Glutathione	102-113	Met4p	Saccharomyces cerevisiae S288C	18-22	
29514209-6	2018	Obtained results suggest involvement of Met4 transcriptional activator in regulation of GSH synthesis in the methylotrophic yeast O. polymorpha.	Glutathione	88-91	Met4p	Saccharomyces cerevisiae S288C	40-44	
17327492-8	2007	Taken together, our data reveal that arsenite-exposed cells channel a large part of assimilated sulfur into glutathione biosynthesis, and we provide evidence that the transcriptional regulators Yap1p and Met4p control this response in concert.	Glutathione	108-119	Met4p	Saccharomyces cerevisiae S288C	204-209	
15689486-6	2005	Cadmium-activated Met4 induced glutathione biosynthesis as well as genes involved in sulfuramino acid synthesis.	Glutathione	31-42	Met4p	Saccharomyces cerevisiae S288C	18-22	
14514673-0	2003	Coupling of the transcriptional regulation of glutathione biosynthesis to the availability of glutathione and methionine via the Met4 and Yap1 transcription factors.	Glutathione	46-57	Met4p	Saccharomyces cerevisiae S288C	129-133	
14514673-0	2003	Coupling of the transcriptional regulation of glutathione biosynthesis to the availability of glutathione and methionine via the Met4 and Yap1 transcription factors.	Glutathione	94-105	Met4p	Saccharomyces cerevisiae S288C	129-133	
14514673-2	2003	Here, we show that the Yap1 and Met4 transcription factors regulate the expression of gamma-glutamylcysteine synthetase (GSH1), encoding the rate-limiting enzyme in glutathione biosynthesis to prevent the damaging effects of glutathione depletion.	Glutathione	165-176	Met4p	Saccharomyces cerevisiae S288C	32-36	
14514673-2	2003	Here, we show that the Yap1 and Met4 transcription factors regulate the expression of gamma-glutamylcysteine synthetase (GSH1), encoding the rate-limiting enzyme in glutathione biosynthesis to prevent the damaging effects of glutathione depletion.	Glutathione	225-236	Met4p	Saccharomyces cerevisiae S288C	32-36	
14514673-6	2003	In contrast, the Yap1-mediated effect is unaffected, indicating that Met4 acts via Cbf1 to regulate the Yap1-mediated induction of GSH1 expression in response to glutathione depletion.	Glutathione	162-173	Met4p	Saccharomyces cerevisiae S288C	69-73	
14514673-9	2003	These results indicate that the Yap1-dependent activation of GSH1 expression in response to glutathione depletion is regulated by the sulfur status of the cell through a specific Met4-dependent mechanism.	Glutathione	92-103	Met4p	Saccharomyces cerevisiae S288C	179-183	
12406228-0	2002	Glutathione regulates the expression of gamma-glutamylcysteine synthetase via the Met4 transcription factor.	Glutathione	0-11	Met4p	Saccharomyces cerevisiae S288C	82-86	
12406228-7	2002	Furthermore, this mechanism normally operates to regulate GSH biosynthesis in the cell, as GSH1 promoter activity is induced in a Met4-dependent manner in a gsh1 mutant which is devoid of GSH, and the addition of exogenous GSH represses GSH1 expression.	Glutathione	58-61	Met4p	Saccharomyces cerevisiae S288C	130-134	
12406228-7	2002	Furthermore, this mechanism normally operates to regulate GSH biosynthesis in the cell, as GSH1 promoter activity is induced in a Met4-dependent manner in a gsh1 mutant which is devoid of GSH, and the addition of exogenous GSH represses GSH1 expression.	Glutathione	91-94	Met4p	Saccharomyces cerevisiae S288C	130-134	
12406228-7	2002	Furthermore, this mechanism normally operates to regulate GSH biosynthesis in the cell, as GSH1 promoter activity is induced in a Met4-dependent manner in a gsh1 mutant which is devoid of GSH, and the addition of exogenous GSH represses GSH1 expression.	Glutathione	91-94	Met4p	Saccharomyces cerevisiae S288C	130-134	
12406228-10	2002	In summary, GSH biosynthesis is regulated in parallel with sulphate assimilation by activity of the Met4 protein, but GSH1-specific mechanisms exist that respond to GSH availability.	Glutathione	12-15	Met4p	Saccharomyces cerevisiae S288C	100-104