PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28512249-3 2017 Metabolic profiling revealed that depletion of p62 in Tsc2-null cells decreased intracellular glutamine, glutamate, and glutathione (GSH). Glutathione 120-131 TSC complex subunit 2 Mus musculus 54-58 28512249-3 2017 Metabolic profiling revealed that depletion of p62 in Tsc2-null cells decreased intracellular glutamine, glutamate, and glutathione (GSH). Glutathione 133-136 TSC complex subunit 2 Mus musculus 54-58 28512249-7 2017 These mitochondrial phenotypes were rescued by addition of exogenous GSH and overexpression of Sod2, which suppressed indices of mitochondrial damage and promoted growth of Tsc2-null cells. Glutathione 69-72 TSC complex subunit 2 Mus musculus 173-177 28512249-8 2017 Finally, p62 depletion sensitized Tsc2-null cells to both oxidative stress and direct inhibition of GSH biosynthesis by buthionine sulfoximine. Glutathione 100-103 TSC complex subunit 2 Mus musculus 34-38