PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19101551-0 2009 Glutathione redox regulates TGF-beta-induced fibrogenic effects through Smad3 activation. Glutathione 0-11 SMAD family member 3 Homo sapiens 72-77 19101551-3 2009 In human lung fibroblasts or bronchial smooth muscle cells, we demonstrated that an increase in the intracellular glutathione level suppressed TGF-beta1-induced phosphorylation of Smad3, while inhibiting TGF-beta1-induced expressions of CTGF, collagen type1, fibronectin and transformation into myofibroblasts, which are characterized by the expression of alpha-smooth muscle actin. Glutathione 114-125 SMAD family member 3 Homo sapiens 180-185 19101551-4 2009 These data indicate that the intracellular glutathione redox status regulates TGF-beta-induced fibrogenic effects through Smad3 activation. Glutathione 43-54 SMAD family member 3 Homo sapiens 122-127 12902338-9 2003 Glutathione S-transferase pull-down assays demonstrated that several regions of the LBD could mediate GR-Smad3 physical interaction. Glutathione 0-11 SMAD family member 3 Homo sapiens 105-110 12161428-12 2002 Also, a glutathione S-transferase-fused SMAD3 directly binds to in vitro synthesized NKX2.1 or HNF-3, demonstrating protein-protein interactions between SMAD3 and the two transcriptional factors. Glutathione 8-19 SMAD family member 3 Homo sapiens 40-45 12161428-12 2002 Also, a glutathione S-transferase-fused SMAD3 directly binds to in vitro synthesized NKX2.1 or HNF-3, demonstrating protein-protein interactions between SMAD3 and the two transcriptional factors. Glutathione 8-19 SMAD family member 3 Homo sapiens 153-158 12917425-8 2003 Glutathione S-transferase pull-down assays showed that YB-1 binds to the MH1 domain of Smad3, whereas the central and carboxyl-terminal regions of YB-1 were required for its interaction with Smad3. Glutathione 0-11 SMAD family member 3 Homo sapiens 87-92 9843964-5 1998 Electrophoretic mobility-shift assays using recombinant glutathione S-transferase-SMAD fusion proteins indicate that both SMAD4 and C-terminally truncated SMAD3, but not SMAD2, can bind the COL7A1 SBS. Glutathione 56-67 SMAD family member 3 Homo sapiens 155-160