PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29803556-2 2018 CBS resides at the intersection of transmethylation, transsulfuration, and remethylation pathways, thus lack of CBS fundamentally blocks Hcy degradation; an essential step in glutathione synthesis. Glutathione 175-186 cystathionine beta-synthase Mus musculus 0-3 22096601-6 2011 Although NAC treatment in TgI278T Cbs(-/-) mice caused significant increase in serum tCys and liver GSH, there was no increase in body fat content or in liver Scd-1 levels. Glutathione 100-103 cystathionine beta-synthase Mus musculus 34-37 29803556-2 2018 CBS resides at the intersection of transmethylation, transsulfuration, and remethylation pathways, thus lack of CBS fundamentally blocks Hcy degradation; an essential step in glutathione synthesis. Glutathione 175-186 cystathionine beta-synthase Mus musculus 112-115 22215680-3 2012 Cystathionine gamma-lyase (CSE) and cystathionine beta-synthase are critical enzymes in the transsulfuration pathway, which also regulate cellular redox status by modulating glutathione (GSH) levels. Glutathione 174-185 cystathionine beta-synthase Mus musculus 36-63 28759161-5 2017 However, when cystathionine beta-synthase expression was inhibited by interference RNA in hepatocytes, the effects of serine supplementation on the improvement of glutathione synthesis and the alleviation of oxidative stress were diminished. Glutathione 163-174 cystathionine beta-synthase Mus musculus 14-41 26304691-1 2015 While N-acetyl-p-benzoquinoneimine (NAPQI), an electrophilic metabolite of acetaminophen (APAP), has been found to undergo GSH conjugation associated with its detoxification, interaction of NAPQI with nucleophilic per- and polysulfides produced by cystathionine gamma-lyase (CSE), cystathionine beta-synthase, and/or other enzymes is not known. Glutathione 123-126 cystathionine beta-synthase Mus musculus 281-308 23807810-8 2013 Cystathionine beta-synthase was induced, but cysteine dioxygenase was downregulated, both of which would contribute to the elevation of cysteine and its product, glutathione, in liver. Glutathione 162-173 cystathionine beta-synthase Mus musculus 0-27 28232079-9 2017 Under oxidizing conditions, an increase in cystathionine beta-synthase activity might indirectly result in an increase in the antioxidant glutathione level; this was reflected by the increased GSH/GSSG ratio in the liver, but not in the brain, where a trace activity of gamma-cystathionase is normally detected. Glutathione 138-149 cystathionine beta-synthase Mus musculus 43-70 28232079-9 2017 Under oxidizing conditions, an increase in cystathionine beta-synthase activity might indirectly result in an increase in the antioxidant glutathione level; this was reflected by the increased GSH/GSSG ratio in the liver, but not in the brain, where a trace activity of gamma-cystathionase is normally detected. Glutathione 193-196 cystathionine beta-synthase Mus musculus 43-70 23470016-1 2013 UNLABELLED: Abstract Purpose: Cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration metabolic pathway, converts homocysteine to cystathionine, which is converted to cysteine required for the synthesis of major retinal antioxidant glutathione (GSH). Glutathione 248-259 cystathionine beta-synthase Mus musculus 30-57 23470016-1 2013 UNLABELLED: Abstract Purpose: Cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration metabolic pathway, converts homocysteine to cystathionine, which is converted to cysteine required for the synthesis of major retinal antioxidant glutathione (GSH). Glutathione 248-259 cystathionine beta-synthase Mus musculus 59-62 23470016-1 2013 UNLABELLED: Abstract Purpose: Cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration metabolic pathway, converts homocysteine to cystathionine, which is converted to cysteine required for the synthesis of major retinal antioxidant glutathione (GSH). Glutathione 261-264 cystathionine beta-synthase Mus musculus 30-57 23470016-1 2013 UNLABELLED: Abstract Purpose: Cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration metabolic pathway, converts homocysteine to cystathionine, which is converted to cysteine required for the synthesis of major retinal antioxidant glutathione (GSH). Glutathione 261-264 cystathionine beta-synthase Mus musculus 59-62 23470016-15 2013 These findings set the stage to investigate the role of CBS and the transsulfuration pathway in the generation of GSH in mouse retina. Glutathione 114-117 cystathionine beta-synthase Mus musculus 56-59 22215680-3 2012 Cystathionine gamma-lyase (CSE) and cystathionine beta-synthase are critical enzymes in the transsulfuration pathway, which also regulate cellular redox status by modulating glutathione (GSH) levels. Glutathione 187-190 cystathionine beta-synthase Mus musculus 36-63 22021075-3 2011 Cystathionine beta-synthase (Cbs) catalyzes the first step in the trans-sulfuration of homocysteine to cysteine, which is estimated to provide ~50% of cysteine for hepatic glutathione biosynthesis. Glutathione 172-183 cystathionine beta-synthase Mus musculus 0-27 22021075-3 2011 Cystathionine beta-synthase (Cbs) catalyzes the first step in the trans-sulfuration of homocysteine to cysteine, which is estimated to provide ~50% of cysteine for hepatic glutathione biosynthesis. Glutathione 172-183 cystathionine beta-synthase Mus musculus 29-32 22021075-7 2011 However, Cbs(+/-) mice with diet-induced obesity had greater glucose intolerance and lower total and reduced glutathione levels in the heart, accompanied by lower plasma cysteine levels compared with Cbs(+/+) mice. Glutathione 109-120 cystathionine beta-synthase Mus musculus 9-12 22021075-9 2011 This study suggests a novel role for Cbs in maintaining the cardiac glutathione pool and protecting against cardiac lipid accumulation and oxidative stress during diet-induced obesity in mice. Glutathione 68-79 cystathionine beta-synthase Mus musculus 37-40