PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35074928-5 2022 Mechanistically, stabilization of wild-type p53 and induction of the p53 target gene CDKN1A (p21) leads to decreased expression of the ribonucleotide reductase (RNR) subunits RRM1 and RRM2 RNR is the rate-limiting enzyme of de novo nucleotide synthesis that reduces ribonucleotides to deoxyribonucleotides in a glutathione-dependent manner. Glutathione 311-322 ribonucleotide reductase catalytic subunit M1 Homo sapiens 175-179 26485711-4 2015 Here, we report that the production of 1O2 by UVA radiation leads to a transient inhibition of replication fork velocity, a transient decrease in the dNTP pool, a quickly reversible GSH-dependent oxidation of the RRM1 subunit of ribonucleotide reductase and sustained inhibition of origin firing. Glutathione 182-185 ribonucleotide reductase catalytic subunit M1 Homo sapiens 213-217 26028097-1 2015 BACKGROUND: Previous studies showed that genetic polymorphisms of glutathione S-transferase P1 (GSTP1) were involved in glutathione metabolism and genetic polymorphisms of ribonucleotide reductase (RRM1) were correlated with DNA synthesis. Glutathione 66-77 ribonucleotide reductase catalytic subunit M1 Homo sapiens 198-202