PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35074928-5	2022	Mechanistically, stabilization of wild-type p53 and induction of the p53 target gene CDKN1A (p21) leads to decreased expression of the ribonucleotide reductase (RNR) subunits RRM1 and RRM2 RNR is the rate-limiting enzyme of de novo nucleotide synthesis that reduces ribonucleotides to deoxyribonucleotides in a glutathione-dependent manner.	Glutathione	311-322	ribonucleotide reductase catalytic subunit M1	Homo sapiens	175-179	
26485711-4	2015	Here, we report that the production of 1O2 by UVA radiation leads to a transient inhibition of replication fork velocity, a transient decrease in the dNTP pool, a quickly reversible GSH-dependent oxidation of the RRM1 subunit of ribonucleotide reductase and sustained inhibition of origin firing.	Glutathione	182-185	ribonucleotide reductase catalytic subunit M1	Homo sapiens	213-217	
26028097-1	2015	BACKGROUND: Previous studies showed that genetic polymorphisms of glutathione S-transferase P1 (GSTP1) were involved in glutathione metabolism and genetic polymorphisms of ribonucleotide reductase (RRM1) were correlated with DNA synthesis.	Glutathione	66-77	ribonucleotide reductase catalytic subunit M1	Homo sapiens	198-202