PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10903739-5 2000 However, contrary to previous reports using TCR beta-/- mice, a minor population of TCR gamma delta+ DP thymocytes was found within the E beta-/- thymi, which differ in terms of T cell-specific gene expression and V(D)J recombinase activity, from the majority of TCR-, alpha beta lineage-committed DP thymocytes. dp 101-103 T cell receptor alpha variable 6-3 Mus musculus 84-87 15998791-4 2005 The reduced DP and increased DN cellularity typically seen in TCR transgenics was not observed when the alpha chain was expressed at the appropriate stage. dp 12-14 T cell receptor alpha variable 6-3 Mus musculus 62-65 15210747-2 2004 Although ligand-independent signaling is unusual and might be unique to the pre-TCR, it is possible that other TCR complexes such as alphabeta TCR or alphagamma TCR might also be able to signal the DN to DP transition in the absence of ligand engagement if they were expressed on DN thymocytes. dp 204-206 T cell receptor alpha variable 6-3 Mus musculus 80-83 15210747-2 2004 Although ligand-independent signaling is unusual and might be unique to the pre-TCR, it is possible that other TCR complexes such as alphabeta TCR or alphagamma TCR might also be able to signal the DN to DP transition in the absence of ligand engagement if they were expressed on DN thymocytes. dp 204-206 T cell receptor alpha variable 6-3 Mus musculus 111-114 15210747-2 2004 Although ligand-independent signaling is unusual and might be unique to the pre-TCR, it is possible that other TCR complexes such as alphabeta TCR or alphagamma TCR might also be able to signal the DN to DP transition in the absence of ligand engagement if they were expressed on DN thymocytes. dp 204-206 T cell receptor alpha variable 6-3 Mus musculus 111-114 15210747-2 2004 Although ligand-independent signaling is unusual and might be unique to the pre-TCR, it is possible that other TCR complexes such as alphabeta TCR or alphagamma TCR might also be able to signal the DN to DP transition in the absence of ligand engagement if they were expressed on DN thymocytes. dp 204-206 T cell receptor alpha variable 6-3 Mus musculus 111-114 15210747-6 2004 In this way, this study definitively demonstrates that alphabeta TCR can in fact signal the DN to DP transition. dp 98-100 T cell receptor alpha variable 6-3 Mus musculus 65-68 10903739-5 2000 However, contrary to previous reports using TCR beta-/- mice, a minor population of TCR gamma delta+ DP thymocytes was found within the E beta-/- thymi, which differ in terms of T cell-specific gene expression and V(D)J recombinase activity, from the majority of TCR-, alpha beta lineage-committed DP thymocytes. dp 101-103 T cell receptor alpha variable 6-3 Mus musculus 84-87 9203971-5 1997 In mice expressing a transgenic T-cell receptor (TCR) specific for the male antigen presented by H-2Db (H-Y TCR), the up-regulation of TCR, CD5 and CD69 in this large DP population occurred in a major histocompatibility complex (MHC)-restricted manner. dp 167-169 T cell receptor alpha variable 6-3 Mus musculus 32-47 9203971-5 1997 In mice expressing a transgenic T-cell receptor (TCR) specific for the male antigen presented by H-2Db (H-Y TCR), the up-regulation of TCR, CD5 and CD69 in this large DP population occurred in a major histocompatibility complex (MHC)-restricted manner. dp 167-169 T cell receptor alpha variable 6-3 Mus musculus 49-52 9203971-5 1997 In mice expressing a transgenic T-cell receptor (TCR) specific for the male antigen presented by H-2Db (H-Y TCR), the up-regulation of TCR, CD5 and CD69 in this large DP population occurred in a major histocompatibility complex (MHC)-restricted manner. dp 167-169 T cell receptor alpha variable 6-3 Mus musculus 108-111 9203971-5 1997 In mice expressing a transgenic T-cell receptor (TCR) specific for the male antigen presented by H-2Db (H-Y TCR), the up-regulation of TCR, CD5 and CD69 in this large DP population occurred in a major histocompatibility complex (MHC)-restricted manner. dp 167-169 T cell receptor alpha variable 6-3 Mus musculus 108-111 8921432-5 1996 We found that TCR expression was high in the thymocytes that had recently transited into the DP stage but then gradually decreased on DP cells if they were not selected by TCR interaction with MHC molecules. dp 93-95 T cell receptor alpha variable 6-3 Mus musculus 14-17 8921432-5 1996 We found that TCR expression was high in the thymocytes that had recently transited into the DP stage but then gradually decreased on DP cells if they were not selected by TCR interaction with MHC molecules. dp 134-136 T cell receptor alpha variable 6-3 Mus musculus 14-17 8828007-5 1996 However, specific depletion of the DP subset occurred within 24 hr when thymocytes were incubated in the presence of both anti-TCR and the immunosuppressant cyclosporin A (CsA). dp 35-37 T cell receptor alpha variable 6-3 Mus musculus 127-130 1716278-4 1991 Comparison of Tcr alpha, beta levels of thymocytes and IEL revealed that whereas the majority of DP thymocytes expressed low Tcr levels, DP IEL expressed high, mature T cell levels of Tcr. dp 97-99 T cell receptor alpha variable 6-3 Mus musculus 125-128 18207026-4 2008 Exogenous GC analogue treatment or TcR stimulation alone lead to marked DP cell depletion, coupled with a significant increase of early apoptotic cell ratio (AnnexinV staining), marked abrogation of the mitochondrial function in DP cells (CMXRos staining), and significant decrease in the Bcl-2(high) DP thymocyte numbers, respectively. dp 72-74 T cell receptor alpha variable 6-3 Mus musculus 35-38 18207026-4 2008 Exogenous GC analogue treatment or TcR stimulation alone lead to marked DP cell depletion, coupled with a significant increase of early apoptotic cell ratio (AnnexinV staining), marked abrogation of the mitochondrial function in DP cells (CMXRos staining), and significant decrease in the Bcl-2(high) DP thymocyte numbers, respectively. dp 229-231 T cell receptor alpha variable 6-3 Mus musculus 35-38 18207026-4 2008 Exogenous GC analogue treatment or TcR stimulation alone lead to marked DP cell depletion, coupled with a significant increase of early apoptotic cell ratio (AnnexinV staining), marked abrogation of the mitochondrial function in DP cells (CMXRos staining), and significant decrease in the Bcl-2(high) DP thymocyte numbers, respectively. dp 229-231 T cell receptor alpha variable 6-3 Mus musculus 35-38 23267019-7 2013 Our results indicate that Nck is recruited to the TCR in an inducible manner in DP thymocytes, and that this recruitment is required for the activation of early TCR-dependent events. dp 80-82 T cell receptor alpha variable 6-3 Mus musculus 50-53 23267019-7 2013 Our results indicate that Nck is recruited to the TCR in an inducible manner in DP thymocytes, and that this recruitment is required for the activation of early TCR-dependent events. dp 80-82 T cell receptor alpha variable 6-3 Mus musculus 161-164