PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15292489-8 2004 Since the beta-catenin signaling pathway has been implicated in hair follicle development, we examined the role of beta-catenin in our system and demonstrated that beta-catenin/lef-1 signaling is required for DP-induced hair differentiation. dp 209-211 lymphoid enhancer binding factor 1 Homo sapiens 177-182 27472703-12 2016 On the other hand, we suppressed the Wnt signaling by XAV939 in nonbalding DP cells, which displayed that the level of beta-catenin and LEF1 was significantly inhibited; however, the level of active TGF-beta1 and the phosphorylation of Smad2 and Akt were up-regulated. dp 75-77 lymphoid enhancer binding factor 1 Homo sapiens 136-140 23489428-4 2013 In addition, treatment with Wnt5a resulted in repressed Wnt3a-mediated expression of Axin2, EP2 and LEF1 in cultured DP cells, whereas Wnt5a siRNA transfection resulted in increased Wnt3a-mediated expression of the genes in isolated DPs of cultured hair follicles. dp 117-119 lymphoid enhancer binding factor 1 Homo sapiens 100-104 34099599-6 2021 These results correlated with not only the increased nuclear translocation of beta-catenin following the treatment of the DP spheres with Rg4, but also the significant elevation of mRNA expression of the downstream target genes of the WNT/beta-catenin pathway, including WNT5A, beta-catenin, and LEF1. dp 122-124 lymphoid enhancer binding factor 1 Homo sapiens 296-300