PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31229844-2	2019	The core fucosylation is dramatically up-regulated at the transition from CD4-CD8- (DN) to CD4+CD8+ (DP) in the thymic development.	dp	101-103	CD4 antigen	Mus musculus	74-77	
33428991-5	2021	This phenomenon might be explained by an inhibition of the DN-to-DP-cell transition and stimulation of DP cell conversion into CD4+ /CD8+ SP thymocytes.	dp	103-105	CD4 antigen	Mus musculus	127-130	
31229844-2	2019	The core fucosylation is dramatically up-regulated at the transition from CD4-CD8- (DN) to CD4+CD8+ (DP) in the thymic development.	dp	101-103	CD4 antigen	Mus musculus	91-94	
29310022-6	2018	Genetic studies suggested that the altered balance between transcription factors T-bet, Runx3, and Th-POK underlies the induction of the DP-IEL-like phenotype in Eed-deficient CD4+ cells.	dp	137-139	CD4 antigen	Mus musculus	176-179	
22927977-4	2012	CONCLUSION/SIGNIFICANCE: This study shows that the developmental dynamics of DN iNKT cells in DP(dim) are very rapid and that it takes less than 1 day to down-regulate CD4 and CD8 and become DN.	dp	94-96	CD4 antigen	Mus musculus	168-171	
24592261-10	2014	In the post-DP compartment, 91.7% undergo death by negative selection, 4.7% become CD4 SP, and 3.6% become CD8 SP.	dp	12-14	CD4 antigen	Mus musculus	83-86	
23093039-16	2012	Our lab has developed the HY(cd4) model, in which the transgenic HY TCRalpha is conditionally expressed at the DP stage, allowing negative selection to occur during the DP to SP transition as occurs in wildtype mice(10).	dp	111-113	CD4 antigen	Mus musculus	29-32	
15792999-2	2005	Intrathymic precursor transfer experiments and the identification of CD4(+)8+ double-positive (DP), V alpha 14J alpha 18 natural T (iNKT) cells suggest that commitment to this lineage might occur at the DP stage.	dp	95-97	CD4 antigen	Mus musculus	69-72	
20599940-4	2010	This occurs at the transition from a double positive (DP) to a single positive (SP) phenotype, resulting in higher numbers of CD4 and CD8 SP cells, and to a lesser extent at the transition from double negative (DN) to DP cells.	dp	54-56	CD4 antigen	Mus musculus	126-129	
17911179-8	2008	Finally, in competitive reaggregation thymic organ cultures, CCR9(-/-) preselection DP thymocytes were disadvantaged significantly in their ability to generate CD4 single-positive (SP) thymocytes, a finding that correlated with a reduced ability to form TCR-MHC-dependent conjugates with thymic epithelial cells.	dp	84-86	CD4 antigen	Mus musculus	160-163	
9881968-5	1998	Activation of the Notch signaling pathway also upregulated a number of other markers that, like steroid resistance, correlate with DP maturation into both the CD4 and CD8 lineages.	dp	131-133	CD4 antigen	Mus musculus	159-162	
10975810-5	2000	Production of CD4+ T cells required TCR signaling in the reaggregates, indicating that transient recognition of self-ligands by DP is inadequate for full differentiation.	dp	128-130	CD4 antigen	Mus musculus	14-17	
11097211-5	2000	Examination of the CD4/CD8 populations in dy/dy thymi showed large relative increases in the DN (CD4- CD8-) and SP (CD4+ CD8-, CD4- CD8+) populations and a significant decrease in the DP (CD4+ CD8+) population.	dp	184-186	CD4 antigen	Mus musculus	19-22	
10477603-6	1999	Specifically, a dramatic increase in the CD4low/-CD8+CD5lowHSA+TCRlow/- immature single positive population and a concomitant decrease in the subsequent DP population are observed.	dp	153-155	CD4 antigen	Mus musculus	41-44	
14768939-6	2003	These thymic SP and DP populations with reduced levels of CD4 and/or CD8 markers had a lower rate of apoptosis in the tg than in the non-tg mice.	dp	20-22	CD4 antigen	Mus musculus	58-61	
9144482-10	1997	Even in a viable DP population, high incidences of DNA strand breaks were detected in the CD4(low)CD8(low) compartment.	dp	17-19	CD4 antigen	Mus musculus	90-93	
8671594-7	1996	The size of the F3Ag- DP subset is positively correlated with the efficacy of positive selection into the CD4(+) SP compartment.	dp	22-24	CD4 antigen	Mus musculus	106-109