PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29514434-4 2018 The correlation analysis results indicated that the methylation frequency of CpG_2 significantly correlated with CD4 mRNA expression in the DP and Landrace combined population, though it did not reach significance level in DP and Landrace separately. dp 140-142 CD4 molecule Homo sapiens 113-116 29424790-10 2018 Vaginal tissue TFV concentrations were significantly positively correlated with vaginal epithelial thickness, whereas vaginal tissue TFV-DP concentrations were positively correlated with density of vaginal CD4 and CD8 immune cells. dp 137-139 CD4 molecule Homo sapiens 206-209 26126194-4 2015 In HSCT, strong alloreactive potential of naive T cells causes concerns for graft-versus-host disease while additional HLA-DP matching is suggested to prevent CD4 alloreactivity. dp 123-125 CD4 molecule Homo sapiens 159-162 27067196-6 2016 Children randomly assigned to receive DP had higher frequencies of blood-stage specific CD4(+) T cells coproducing interleukin-2 and tumor necrosis factor alpha (P = .003), which were associated with protection from subsequent clinical malaria and parasitemia, and fewer blood-stage specific CD4(+) T cells coproducing interleukin-10 and interferon gamma (P = .001), which were associated with increased risk of malaria. dp 38-40 CD4 molecule Homo sapiens 88-91 27067196-6 2016 Children randomly assigned to receive DP had higher frequencies of blood-stage specific CD4(+) T cells coproducing interleukin-2 and tumor necrosis factor alpha (P = .003), which were associated with protection from subsequent clinical malaria and parasitemia, and fewer blood-stage specific CD4(+) T cells coproducing interleukin-10 and interferon gamma (P = .001), which were associated with increased risk of malaria. dp 38-40 CD4 molecule Homo sapiens 292-295 24462895-6 2014 Structural homology modeling suggested specific amino acid residues in the alpha chain, in particular position 31, to impact CD4+ T cell allorecognition of HLA-DP. dp 160-162 CD4 molecule Homo sapiens 125-128 25003630-4 2014 We found that the expression of hundreds of LncRNAs significantly changed in each process of developmental transition, including DN into DP, DP into CD4+CD8-, and CD4+CD8- into activated CD4+ T cells. dp 141-143 CD4 molecule Homo sapiens 149-152 22224408-10 2012 As T cell binding is not restricted to the polymorphic groove and polymorphism in the beta2 domain of the DP molecule affects CD4 interaction, full-length polymorphism should be considered to determine immunogenicity. dp 106-108 CD4 molecule Homo sapiens 126-129 24150275-7 2014 QOL, CD4 percentage and CD4/CD8 ratio were significantly lower in the DP group. dp 70-72 CD4 molecule Homo sapiens 5-8 24150275-7 2014 QOL, CD4 percentage and CD4/CD8 ratio were significantly lower in the DP group. dp 70-72 CD4 molecule Homo sapiens 24-27 23793512-7 2013 In addition, we describe the transcription factors implicated in the regulation of coreceptor gene expression and discuss how these factors are integrated into the transcription factor network that regulates CD4/CD8 cell-fate choice of DP thymocytes. dp 236-238 CD4 molecule Homo sapiens 208-211 22425249-6 2012 These studies identify an important role for E proteins in the activation of CD4(+) lineage differentiation as thymocytes undergo the DP to SP transition. dp 134-136 CD4 molecule Homo sapiens 77-80 16236130-8 2005 Collectively, these results indicate that the efficiency of DP to CD4 SP transit is a frequency dependent process, which determines (1) the steady-state size of the peripheral T cell compartment and (2) the threshold for homeostatic expansion of peripheral CD4 T cells. dp 60-62 CD4 molecule Homo sapiens 66-69 18171694-9 2008 Finally, the increase in the apoptosis of DP cells was associated with a consequent decrease in the positive selection, as indicated by the reduction of both ERK phosphorylation in DP cells and single-positive (SP, CD4(+) or CD8(+)) cell outcome. dp 42-44 CD4 molecule Homo sapiens 215-218 17090688-8 2007 Collectively, these data indicate that Rac1 is critical in differentiation of CD4-SP from the DP cell line by preventing TCR-induced apoptosis via Bcl-2 up-regulation. dp 94-96 CD4 molecule Homo sapiens 78-81 16236130-8 2005 Collectively, these results indicate that the efficiency of DP to CD4 SP transit is a frequency dependent process, which determines (1) the steady-state size of the peripheral T cell compartment and (2) the threshold for homeostatic expansion of peripheral CD4 T cells. dp 60-62 CD4 molecule Homo sapiens 257-260 12370367-2 2002 Accordingly, expression of a human CD4 (hCD4) transgene beginning at the DP stage has been shown to restore normal T cell development and function in CD4-deficient mice. dp 73-75 CD4 molecule Homo sapiens 35-38 15588377-3 2004 Proportions and intensities of Fas expression were increased in CD4 single-positive (SP) (CD4(+) CD8(-)), CD8 SP (CD8(+) CD4(-) ), and CD4(+) CD8(+) double-positive (DP) lymphocytes in AITD thyroids compared to those in blood, and were much higher in CD4(+) (CD4 SP and DP) lymphocytes than in CD8 SP lymphocytes in the thyroid. dp 166-168 CD4 molecule Homo sapiens 64-67 15044085-4 2004 Here, we show that CD4(+) and CD8(+) T cells producing IFN-gamma and IL-2 were reduced by DP-mediated signals, while CRTH2-mediated signals enhanced IL-2, IL-4, IL-5, and IL-13 production by Th2 cells. dp 90-92 CD4 molecule Homo sapiens 19-22 12370367-2 2002 Accordingly, expression of a human CD4 (hCD4) transgene beginning at the DP stage has been shown to restore normal T cell development and function in CD4-deficient mice. dp 73-75 CD4 molecule Homo sapiens 40-44 12370367-2 2002 Accordingly, expression of a human CD4 (hCD4) transgene beginning at the DP stage has been shown to restore normal T cell development and function in CD4-deficient mice. dp 73-75 CD4 molecule Homo sapiens 41-44 11339367-4 2000 Several critical events of T lymphocyte maturation such as TCRalpha gene recombination, positive and negative selection, and CD4/CD8 lineage commitment occur around the DP stage. dp 169-171 CD4 molecule Homo sapiens 125-128 12116348-4 2002 METHODS: We introduced "PanLeucogating," i.e., we used total leucocytes as the common denominator for improving the precision of DP absolute CD4 counting. dp 129-131 CD4 molecule Homo sapiens 141-144 12116348-8 2002 A particularly high correlation and comparable precision of absolute CD4 counts were observed between the SP volumetric method and DP PanLeucogating (R(2) = 0.990; bias 6 +/- SD 17%). dp 131-133 CD4 molecule Homo sapiens 69-72 10820233-6 2000 These data indicate that the translating ability of the c-fos gene is up-regulated in the thymic positive selection process, from nonselected DP to CD4+8- single positive cells through positively selected DP cells. dp 142-144 CD4 molecule Homo sapiens 148-151 10820233-6 2000 These data indicate that the translating ability of the c-fos gene is up-regulated in the thymic positive selection process, from nonselected DP to CD4+8- single positive cells through positively selected DP cells. dp 205-207 CD4 molecule Homo sapiens 148-151 9756725-3 1998 In these subjects, with a mean age of about 64 years, expansions of CD4(+) cells with the same TCRBV family specificity as in the respective DP cells also were consistently detected. dp 141-143 CD4 molecule Homo sapiens 68-71 10552959-3 1999 In contrast to mice, progression to the DP compartment occurs in humans via a CD4(+) CD8(-) intermediate stage. dp 40-42 CD4 molecule Homo sapiens 78-81 8494827-6 1993 These data suggest that the alternation of CD4/CD8 expression from DP to SP is dependent on PKC activation. dp 67-69 CD4 molecule Homo sapiens 43-46 8494827-10 1993 CsA may block the transition from DP to SP by inhibition of CD4/CD8 down-regulation induced by PKC activation. dp 34-36 CD4 molecule Homo sapiens 60-63 2575597-7 1989 To investigate whether HLA class II antigens other than DR (i.e., DQ or DP) activate CD4+ cells to IL2 secretion, we analyzed a set of HLA-A,B,C and -DR,DQ-identical responder-stimulator cells which differed only in DP antigens. dp 72-74 CD4 molecule Homo sapiens 85-88