PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29850524-4 2018 The current study aims to investigate how miRNAs regulate Wnt/beta-catenin to control HF inductivity of DP cells by performing microarray analysis in early- and late-passage DP cells and transfecting with miRNAs inhibitor or mimic. dp 104-106 catenin beta 1 Homo sapiens 62-74 34099599-6 2021 These results correlated with not only the increased nuclear translocation of beta-catenin following the treatment of the DP spheres with Rg4, but also the significant elevation of mRNA expression of the downstream target genes of the WNT/beta-catenin pathway, including WNT5A, beta-catenin, and LEF1. dp 122-124 catenin beta 1 Homo sapiens 78-90 34099599-6 2021 These results correlated with not only the increased nuclear translocation of beta-catenin following the treatment of the DP spheres with Rg4, but also the significant elevation of mRNA expression of the downstream target genes of the WNT/beta-catenin pathway, including WNT5A, beta-catenin, and LEF1. dp 122-124 catenin beta 1 Homo sapiens 239-251 34099599-6 2021 These results correlated with not only the increased nuclear translocation of beta-catenin following the treatment of the DP spheres with Rg4, but also the significant elevation of mRNA expression of the downstream target genes of the WNT/beta-catenin pathway, including WNT5A, beta-catenin, and LEF1. dp 122-124 catenin beta 1 Homo sapiens 278-290 31221480-5 2019 Herein, we assessed effects of the canonical Wnt/beta-catenin signaling activator CHIR99021 and found that it enhanced the expression of DP signature genes associated with hair-inducing ability. dp 137-139 catenin beta 1 Homo sapiens 49-61 30609881-6 2019 The activation of the wingless and INT-1 (Wnt)/beta-catenin signaling pathway, which is associated with hair growth induction in the DP, was evaluated using the T cell-specific transcription factor and lymphoid enhancer-binding factor (TCF/LEF) transcription factor reporter assay; results indicated significantly increased luciferase activity. dp 133-135 catenin beta 1 Homo sapiens 47-59 29741358-14 2018 Taken together, these results demonstrate the nanofibrous engineered matrix strongly supports odontoblastic differentiation of DP-MSCs by enhancing Wnt/beta-catenin signaling. dp 127-129 catenin beta 1 Homo sapiens 152-164 27450439-2 2016 In this issue of The FEBS Journal, Zhang and colleagues show that enhancing the beta-catenin signalling pathway in DP cells allows faster and denser hair growth, providing a potential target for hair loss treatments and for improving hair regeneration techniques. dp 115-117 catenin beta 1 Homo sapiens 80-92 27472703-12 2016 On the other hand, we suppressed the Wnt signaling by XAV939 in nonbalding DP cells, which displayed that the level of beta-catenin and LEF1 was significantly inhibited; however, the level of active TGF-beta1 and the phosphorylation of Smad2 and Akt were up-regulated. dp 75-77 catenin beta 1 Homo sapiens 119-131 19124718-7 2009 These data are consistent with a model in which post-beta-selection, pre-TCR-induced beta-catenin expression must return to background levels for efficient transition to the DP stage. dp 174-176 catenin beta 1 Homo sapiens 85-97 25951188-5 2015 We found that the short-term coculture with DP cells enhanced both Wnt/beta-catenin signaling, a signaling cascade key to HF development, and upregulated the expression of HF-specific genes, including K6, K16, K17, and K75, in keratinocytes, indicating that these cells were poised toward a HF fate. dp 44-46 catenin beta 1 Homo sapiens 71-83 23489428-3 2013 Treatment with Wnt5a resulted in attenuation of Wnt3a-mediated elevation of beta-catenin signalling, which was increased by Wnt5a siRNA transfection in cultured DP cells, as examined by reporter assay. dp 161-163 catenin beta 1 Homo sapiens 76-88 21098273-4 2010 beta-Catenin activity in the DP suppresses Agouti expression and activates Corin, a negative regulator of Agouti activity. dp 29-31 catenin beta 1 Homo sapiens 0-12 21098273-5 2010 In addition, beta-catenin activity in the DP regulates melanocyte activity by a mechanism that is independent of both Agouti and Corin. dp 42-44 catenin beta 1 Homo sapiens 13-25 21098273-6 2010 The coordinate and inverse regulation of Agouti and Corin renders pelage pigmentation sensitive to changes in beta-catenin activity in the DP that do not alter pelage structure. dp 139-141 catenin beta 1 Homo sapiens 110-122 19141591-8 2009 Whereas DP cells from both scalp regions expressed AR protein, the expression levels of AR and cotranslocation with beta-catenin, a downstream Wnt signaling molecule, were higher in DP cells of AGA patients than in DP cells from non-AGA males. dp 182-184 catenin beta 1 Homo sapiens 116-128 15292489-8 2004 Since the beta-catenin signaling pathway has been implicated in hair follicle development, we examined the role of beta-catenin in our system and demonstrated that beta-catenin/lef-1 signaling is required for DP-induced hair differentiation. dp 209-211 catenin beta 1 Homo sapiens 10-22 17317856-3 2007 We show here that activated beta-catenin stalls the developmental transition from the double-positive (DP) to the single-positive (SP) thymocyte stage and predisposes DP thymocytes to transformation. dp 103-105 catenin beta 1 Homo sapiens 28-40 17317856-4 2007 beta-Catenin-induced thymic lymphomas have a leukemic arrest at the early DP stage. dp 74-76 catenin beta 1 Homo sapiens 0-12 15292489-8 2004 Since the beta-catenin signaling pathway has been implicated in hair follicle development, we examined the role of beta-catenin in our system and demonstrated that beta-catenin/lef-1 signaling is required for DP-induced hair differentiation. dp 209-211 catenin beta 1 Homo sapiens 115-127 15292489-8 2004 Since the beta-catenin signaling pathway has been implicated in hair follicle development, we examined the role of beta-catenin in our system and demonstrated that beta-catenin/lef-1 signaling is required for DP-induced hair differentiation. dp 209-211 catenin beta 1 Homo sapiens 115-127