PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34134572-6 2021 The IC50 value of compound 20 against acetylcholinesterase inhibition (0.086 +- 0.01 micromol L-1) is similar to donepezil (0.085 +- 0.01 micromol L-1) and is better than baicalein (0.404 +- 0.04 micromol L-1). baicalein 171-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 35053900-0 2022 Inhibitory Mechanism of Baicalein on Acetylcholinesterase: Inhibitory Interaction, Conformational Change, and Computational Simulation. baicalein 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 35053900-4 2022 In the current study, baicalein, a typical bioactive flavonoid, was found to inhibit AChE competitively, with an associated IC50 value of 6.42 +- 0.07 microM, through a monophasic kinetic process. baicalein 22-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 35053900-5 2022 The AChE fluorescence quenching by baicalein was a static process. baicalein 35-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 35053900-8 2022 Molecular docking revealed that baicalein predominated at the active site of AChE, likely tightening the gorge entrance and preventing the substrate from entering and binding with the enzyme, resulting in AChE inhibition. baicalein 32-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 35053900-8 2022 Molecular docking revealed that baicalein predominated at the active site of AChE, likely tightening the gorge entrance and preventing the substrate from entering and binding with the enzyme, resulting in AChE inhibition. baicalein 32-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 205-209 35053900-10 2022 The current study provides an insight into the molecular-level mechanism of baicalein interaction with AChE, which may offer new ideas for the research and development of anti-AD functional foods and drugs. baicalein 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107