PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10590231-3 1999 This study investigated whether the mutational hot spots of the Apc and p53 genes for human colorectal cancer are mutated in dimethylhydrazine-induced colorectal neoplasms and whether dietary folate can modulate mutations in these regions. Dimethylhydrazines 125-142 tumor protein p53 Homo sapiens 72-75 10590231-12 1999 These data suggest that in the dimethylhydrazine rat model of colorectal cancer, the Apc gene is mutated in early stages, albeit to a lesser degree than observed in human colorectal cancer, whereas the mutational hot spot of the p53 gene for human colorectal cancer is not commonly mutated. Dimethylhydrazines 31-48 tumor protein p53 Homo sapiens 229-232