PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33196058-4 2020 ACE2 is integral to the renin-angiotensin-aldosterone system (RAAS), and SARS-CoV-2 down-regulates protein expression levels of ACE2. Aldosterone 42-53 angiotensin converting enzyme 2 Homo sapiens 0-4 33196058-4 2020 ACE2 is integral to the renin-angiotensin-aldosterone system (RAAS), and SARS-CoV-2 down-regulates protein expression levels of ACE2. Aldosterone 42-53 angiotensin converting enzyme 2 Homo sapiens 128-132 32089050-2 2020 Reduced angiotensin converting enzyme 2 activity from the counter angiotensin converting enzyme 2 /angiotensin-(1-7)/Mas receptor axis of the renin angiotensin aldosterone system has been reported in people with pre-hypertension, type 2 diabetes mellitus and chronic renal disease. Aldosterone 160-171 angiotensin converting enzyme 2 Homo sapiens 8-39 32089050-2 2020 Reduced angiotensin converting enzyme 2 activity from the counter angiotensin converting enzyme 2 /angiotensin-(1-7)/Mas receptor axis of the renin angiotensin aldosterone system has been reported in people with pre-hypertension, type 2 diabetes mellitus and chronic renal disease. Aldosterone 160-171 angiotensin converting enzyme 2 Homo sapiens 66-97 32984543-4 2020 There is clear evidence that, by targeting the angiotensin-converting enzyme II (ACE2) -its natural receptor-, SARS-CoV-2 would mainly affect the renin-angiotensin-aldosterone system (RAAS), whose imbalance triggers diverse symptomatology-associated pathological processes. Aldosterone 164-175 angiotensin converting enzyme 2 Homo sapiens 81-85 31165585-0 2019 Both aldosterone and spironolactone can modulate the intracellular ACE/ANG II/AT1 and ACE2/ANG (1-7)/MAS receptor axes in human mesangial cells. Aldosterone 5-16 angiotensin converting enzyme 2 Homo sapiens 86-90 31430320-4 2019 Angiotensin I-converting enzymes, ACE and ACE2, are key regulators of blood pressure that have counterbalance roles by acting on vasoactive peptides from Renin-Angiotensin-Aldosterone System (RAAS). Aldosterone 172-183 angiotensin converting enzyme 2 Homo sapiens 42-46 34667599-4 2021 Angiotensin-converting enzyme 2 is an essential component of the renin-angiotensin-aldosterone system and the target receptor that mediates SARS-CoV-2 entry to the cell. Aldosterone 83-94 angiotensin converting enzyme 2 Homo sapiens 0-31 34667599-5 2021 This led to speculations that major renin-angiotensin-aldosterone system inhibitors, such as angiotensin receptor blockers and angiotensin-converting enzyme inhibitors might affect the course of the disease, since their administration enhances angiotensin-converting enzyme (ACE)2 expression. Aldosterone 54-65 angiotensin converting enzyme 2 Homo sapiens 275-280 34806090-3 2021 The binding of SARS-CoV-2 to the angiotensin-converting enzyme 2 (ACE2) leads to deregulation of the renin-angiotensin-aldosterone system (RAAS) through down-regulation of ACE2 with subsequent increment of the harmful Ang II serum levels and reduction of the protective Ang-(1-7). Aldosterone 119-130 angiotensin converting enzyme 2 Homo sapiens 33-64 34806090-3 2021 The binding of SARS-CoV-2 to the angiotensin-converting enzyme 2 (ACE2) leads to deregulation of the renin-angiotensin-aldosterone system (RAAS) through down-regulation of ACE2 with subsequent increment of the harmful Ang II serum levels and reduction of the protective Ang-(1-7). Aldosterone 119-130 angiotensin converting enzyme 2 Homo sapiens 66-70 34806090-3 2021 The binding of SARS-CoV-2 to the angiotensin-converting enzyme 2 (ACE2) leads to deregulation of the renin-angiotensin-aldosterone system (RAAS) through down-regulation of ACE2 with subsequent increment of the harmful Ang II serum levels and reduction of the protective Ang-(1-7). Aldosterone 119-130 angiotensin converting enzyme 2 Homo sapiens 172-176 34176080-1 2021 Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with hypertension, renin-angiotensin-aldosterone system pathway, and other cardiovascular system disorders. Aldosterone 118-129 angiotensin converting enzyme 2 Homo sapiens 55-59 34884604-1 2021 Alternative branches of the classical renin-angiotensin-aldosterone system (RAS) represent an important cascade in which angiotensin 2 (AngII) undergoes cleavage via the action of the angiotensin-converting enzyme 2 (ACE2) with subsequent production of Ang(1-7) and other related metabolites eliciting its effects via Mas receptor activation. Aldosterone 56-67 angiotensin converting enzyme 2 Homo sapiens 184-215 34884604-1 2021 Alternative branches of the classical renin-angiotensin-aldosterone system (RAS) represent an important cascade in which angiotensin 2 (AngII) undergoes cleavage via the action of the angiotensin-converting enzyme 2 (ACE2) with subsequent production of Ang(1-7) and other related metabolites eliciting its effects via Mas receptor activation. Aldosterone 56-67 angiotensin converting enzyme 2 Homo sapiens 217-221 34673795-2 2021 As the SARS-CoV2 virus enters cells via the angiotensin-converting enzyme receptor II (ACE2), drugs which interact with the renin angiotensin aldosterone system (RAAS) were suspected to influence disease severity. Aldosterone 142-153 angiotensin converting enzyme 2 Homo sapiens 87-91 34867390-2 2021 However, ACE2 also converts angiotensin II into angiotensin-(1-7) and counterbalances the renin-angiotensin-aldosterone system, with resultant protective effects in the cardiovascular system. Aldosterone 108-119 angiotensin converting enzyme 2 Homo sapiens 9-13 34869917-1 2021 Aims: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the ACE2 component of the renin-angiotensin aldosterone system (RAAS) and infects the human cells. Aldosterone 124-135 angiotensin converting enzyme 2 Homo sapiens 84-88 34420372-7 2021 P-ACE2 was significantly lower in subjects treated with renin-angiotensin-aldosterone system inhibitors than in those not treated with renin-angiotensin-aldosterone system inhibitors, but there was no significant difference in U-ACE2 between the groups. Aldosterone 74-85 angiotensin converting enzyme 2 Homo sapiens 2-6 34392451-5 2021 SARS-CoV-2 cell entry through angiotensin-converting enzyme 2 (ACE2) may enhance the activity of renin-angiotensin-aldosterone system (RAAS) classical axis and further leading to over production of aldosterone. Aldosterone 115-126 angiotensin converting enzyme 2 Homo sapiens 30-61 34392451-5 2021 SARS-CoV-2 cell entry through angiotensin-converting enzyme 2 (ACE2) may enhance the activity of renin-angiotensin-aldosterone system (RAAS) classical axis and further leading to over production of aldosterone. Aldosterone 115-126 angiotensin converting enzyme 2 Homo sapiens 63-67 34392451-5 2021 SARS-CoV-2 cell entry through angiotensin-converting enzyme 2 (ACE2) may enhance the activity of renin-angiotensin-aldosterone system (RAAS) classical axis and further leading to over production of aldosterone. Aldosterone 198-209 angiotensin converting enzyme 2 Homo sapiens 30-61 34392451-5 2021 SARS-CoV-2 cell entry through angiotensin-converting enzyme 2 (ACE2) may enhance the activity of renin-angiotensin-aldosterone system (RAAS) classical axis and further leading to over production of aldosterone. Aldosterone 198-209 angiotensin converting enzyme 2 Homo sapiens 63-67 34406302-4 2021 In such patients there is an overactivation of renin-angiotensin-aldosterone system, which promotes an increase in the expression of angiotensin-converting enzyme - 2 that acts as a receptor for the SPIKE protein expressed by the virus and enables the interaction between the host cell and Severe Acute Respiratory Syndrome Coronavirus 2. Aldosterone 65-76 angiotensin converting enzyme 2 Homo sapiens 133-166 34501332-3 2021 Based on this purported ACE2 double function, it has been put forward that the benefit from ACE2 upregulation with renin-angiotensin-aldosterone system inhibitors (RAASi) counterbalances COVID-19 risks due to counter-regulatory RAS axis amplification. Aldosterone 133-144 angiotensin converting enzyme 2 Homo sapiens 24-28 34501332-3 2021 Based on this purported ACE2 double function, it has been put forward that the benefit from ACE2 upregulation with renin-angiotensin-aldosterone system inhibitors (RAASi) counterbalances COVID-19 risks due to counter-regulatory RAS axis amplification. Aldosterone 133-144 angiotensin converting enzyme 2 Homo sapiens 92-96 34195577-1 2021 Background: The SARS-CoV-2 virus enters cells via Angiotensin-converting enzyme 2 (ACE2), disrupting the renin-angiotensin-aldosterone axis, potentially contributing to lung injury. Aldosterone 123-134 angiotensin converting enzyme 2 Homo sapiens 50-81 34356070-4 2021 It is known that angiotensin-converting enzyme 2 (ACE2), an important counter-regulatory component of the renin-angiotensin-aldosterone system (RAAS), is expressed in the airways. Aldosterone 124-135 angiotensin converting enzyme 2 Homo sapiens 17-48 34356070-4 2021 It is known that angiotensin-converting enzyme 2 (ACE2), an important counter-regulatory component of the renin-angiotensin-aldosterone system (RAAS), is expressed in the airways. Aldosterone 124-135 angiotensin converting enzyme 2 Homo sapiens 50-54 34195577-1 2021 Background: The SARS-CoV-2 virus enters cells via Angiotensin-converting enzyme 2 (ACE2), disrupting the renin-angiotensin-aldosterone axis, potentially contributing to lung injury. Aldosterone 123-134 angiotensin converting enzyme 2 Homo sapiens 83-87 34177593-2 2021 SARS-CoV-2 uses as a receptor angiotensin-converting enzyme 2 (ACE-2), a critical member of the renin-angiotensin-aldosterone system (RAAS) involved in the regulation of blood pressure and fluid system. Aldosterone 114-125 angiotensin converting enzyme 2 Homo sapiens 30-61 34177593-2 2021 SARS-CoV-2 uses as a receptor angiotensin-converting enzyme 2 (ACE-2), a critical member of the renin-angiotensin-aldosterone system (RAAS) involved in the regulation of blood pressure and fluid system. Aldosterone 114-125 angiotensin converting enzyme 2 Homo sapiens 63-68 34642634-2 2021 Renin-angiotensin-aldosterone system (RAAS) inhibitors have been reported to increase ACE2 in type 2 pneumocyte pulmonary tissue. Aldosterone 18-29 angiotensin converting enzyme 2 Homo sapiens 86-90 34718258-6 2021 General mechanisms of multi-system dysfunction and multi-organ damage reported in COVID-19 are probably related to ubiquitous expression of ACE2 in many tissues and its important role in the renin-angiotensin-aldosterone system (RAAS) functioning. Aldosterone 209-220 angiotensin converting enzyme 2 Homo sapiens 140-144 34596976-0 2021 Influence of renin-angiotensin-aldosterone system inhibitors on plasma levels of angiotensin-converting enzyme 2. Aldosterone 31-42 angiotensin converting enzyme 2 Homo sapiens 81-112 34862332-3 2022 Although renin-angiotensin-aldosterone-system (RAAS) blockers have been suggested to upregulate ACE2, their use in COVID-19 patients is now considered well tolerated. Aldosterone 27-38 angiotensin converting enzyme 2 Homo sapiens 96-100 35173799-3 2022 Numerous studies have elucidated the presence of many components of the renin-angiotensin-aldosterone system (RAAS) in the eye, including the ACE2 receptor. Aldosterone 90-101 angiotensin converting enzyme 2 Homo sapiens 142-146 34997794-2 2022 Published data revealed associations of COVID-19 susceptibility and severity with host genetic polymorphisms in renin-angiotensin-aldosterone system (RAAS)-related genes including angiotensin-converting enzyme (ACE)1, ACE2, and transmembrane protease (TMPRSS)2. Aldosterone 130-141 angiotensin converting enzyme 2 Homo sapiens 218-222 35393089-1 2022 BACKGROUND: SARS-CoV-2 uses Angiotensin-Converting Enzyme 2 as a viral gateway to the cell and could interact with the renin-angiotensin-aldosterone system. Aldosterone 137-148 angiotensin converting enzyme 2 Homo sapiens 28-59 33964216-2 2021 The aim of this review is to provide a new look at the data already available for COVID-19, exploring it as a transient molecular disease that causes negative regulation of ACE-2 (angiotensin-converting enzyme 2) and, consequently, deregulates the renin-angiotensin-aldosterone system (RAAS), promoting important changes in the microcirculatory environment. Aldosterone 266-277 angiotensin converting enzyme 2 Homo sapiens 173-178 34010445-3 2021 Firstly, the virus SARS-CoV-2 responsible for the Covid-19 infection uses an important renin-angiotensin system element - angiotensin-converting enzyme 2 (ACE2) - as a receptor protein for the entry into target cells and, in consequence, disturbs the function of the main (circulating) renin-angiotensin-aldosterone system (RAAS) and of the local renin-angiotensin system (RAS) localized in different tissues and organs. Aldosterone 304-315 angiotensin converting enzyme 2 Homo sapiens 155-159 35176079-5 2022 Angiotensin-1 converting enzyme 2 (ACE2), is the key regulator of blood pressure in the Renin-Angiotensin-Aldosterone System that hydrolyzes angiotensin II (vasoconstrictor) into angiotensin 1-7 (vasodilator). Aldosterone 106-117 angiotensin converting enzyme 2 Homo sapiens 0-33 35176079-5 2022 Angiotensin-1 converting enzyme 2 (ACE2), is the key regulator of blood pressure in the Renin-Angiotensin-Aldosterone System that hydrolyzes angiotensin II (vasoconstrictor) into angiotensin 1-7 (vasodilator). Aldosterone 106-117 angiotensin converting enzyme 2 Homo sapiens 35-39 34010445-4 2021 The binding of SARS-CoV-2 to ACE2 leads to the down-regulation of this enzyme and, in the aftermath, to the excess of angiotensin II and aldosterone. Aldosterone 137-148 angiotensin converting enzyme 2 Homo sapiens 29-33 34035891-2 2021 Renin-angiotensin-aldosterone system (RAAS) blockers enhance the expression of ACE2, the binding receptor of SARS-CoV-2, and can enhance viral infectivity. Aldosterone 18-29 angiotensin converting enzyme 2 Homo sapiens 79-83 33964216-2 2021 The aim of this review is to provide a new look at the data already available for COVID-19, exploring it as a transient molecular disease that causes negative regulation of ACE-2 (angiotensin-converting enzyme 2) and, consequently, deregulates the renin-angiotensin-aldosterone system (RAAS), promoting important changes in the microcirculatory environment. Aldosterone 266-277 angiotensin converting enzyme 2 Homo sapiens 180-211 33714595-7 2021 On the basis of our review of the published literature, we speculate that several unifying cutaneous and systemic mechanisms may explain COVID-19-associated pernio: (1) SARS-CoV-2 cell infection occurs through the cellular receptor angiotensin-converting enzyme 2 mediated by transmembrane protease serine 2, subsequently affecting the renin-angiotensin-aldosterone system with an increase in the vasoconstricting, pro-inflammatory, and prothrombotic angiotensin II pathway. Aldosterone 354-365 angiotensin converting enzyme 2 Homo sapiens 232-263 33539861-1 2021 Membrane-bound angiotensin-converting enzyme 2 (ACE2) is important in regulation of the renin-angiotensin-aldosterone system, but the association of cleaved soluble ACE2 (sACE2) with cardiovascular disease (CVD) is unclear. Aldosterone 106-117 angiotensin converting enzyme 2 Homo sapiens 15-46 33539861-1 2021 Membrane-bound angiotensin-converting enzyme 2 (ACE2) is important in regulation of the renin-angiotensin-aldosterone system, but the association of cleaved soluble ACE2 (sACE2) with cardiovascular disease (CVD) is unclear. Aldosterone 106-117 angiotensin converting enzyme 2 Homo sapiens 48-52 33458761-5 2021 ACE2 usually converts Angiotensin I in the renin-angiotensin-aldosterone system to Angiotensin II, which affects blood pressure levels. Aldosterone 61-72 angiotensin converting enzyme 2 Homo sapiens 0-4 33422689-1 2021 Angiotensin-converting enzyme 2 (ACE2) is an important player of the renin-angiotensin-aldosterone system (RAAS) in regulating the conversion of angiotensin II into angiotensin (1-7). Aldosterone 87-98 angiotensin converting enzyme 2 Homo sapiens 0-31 33422689-1 2021 Angiotensin-converting enzyme 2 (ACE2) is an important player of the renin-angiotensin-aldosterone system (RAAS) in regulating the conversion of angiotensin II into angiotensin (1-7). Aldosterone 87-98 angiotensin converting enzyme 2 Homo sapiens 33-37 33657582-0 2021 Aldosterone and cortisol synthesis regulation by angiotensin-(1-7) and angiotensin-converting enzyme 2 in the human adrenal cortex. Aldosterone 0-11 angiotensin converting enzyme 2 Homo sapiens 71-102 32917504-3 2021 We hypothesized that the renal abundance of angiotensin-converting enzyme (ACE) 2, the cell surface receptor for SARS-CoV-2, may be modulated by diabetes and agents that block the renin-angiotensin-aldosterone system (RAAS). Aldosterone 198-209 angiotensin converting enzyme 2 Homo sapiens 44-81 33563197-4 2021 Even though ACE-2 is significant in the renin-angiotensin-aldosterone system (RAAS) regulation that exhibits protection to various organs, they play a significant role in COVID-19 disease pathogenesis. Aldosterone 58-69 angiotensin converting enzyme 2 Homo sapiens 12-17 32691370-1 2021 Angiotensin-converting enzyme 2 (ACE2) plays an important role as a member of the renin-angiotensin-aldosterone system (RAAS) in regulating the conversion of angiotensin II (Ang II) into angiotensin (1-7) (Ang [1-7]). Aldosterone 100-111 angiotensin converting enzyme 2 Homo sapiens 0-31 33275540-4 2021 ACE2 is crucial for maintaining tissue homeostasis and negatively regulates the renin-angiotensin-aldosterone system (RAAS) in the humans. Aldosterone 98-109 angiotensin converting enzyme 2 Homo sapiens 0-4 32691370-1 2021 Angiotensin-converting enzyme 2 (ACE2) plays an important role as a member of the renin-angiotensin-aldosterone system (RAAS) in regulating the conversion of angiotensin II (Ang II) into angiotensin (1-7) (Ang [1-7]). Aldosterone 100-111 angiotensin converting enzyme 2 Homo sapiens 33-37 33584343-4 2021 ACE2 has extensive biological activities as a component of the renin-angiotensin-aldosterone system (RAAS) and plays a pivotal role as counter-regulator of angiotensin II (Ang II) activity by converting the latter to Ang (1-7). Aldosterone 81-92 angiotensin converting enzyme 2 Homo sapiens 0-4 33537555-4 2021 The renin-angiotensin-aldosterone system (RAAS) is strictly involved in COVID-19 because angiotensin converting enzyme 2 (ACE2) is the host receptor for SARS-CoV-2 and also converts pro-inflammatory angiotensin (Ang) II into anti-inflammatory Ang(1-7). Aldosterone 22-33 angiotensin converting enzyme 2 Homo sapiens 89-120 32522617-3 2021 ACE2 is a part of Renin-Angiotensin-Aldosterone System, which is expressed in several organs that opposes the angiotensin (Ang) II functions by converting Ang II to Ang (1-7), the one with vasodilation effects. Aldosterone 36-47 angiotensin converting enzyme 2 Homo sapiens 0-4 33387941-3 2021 Angiotensin-converting enzyme 2 (ACE2), an important component of the renin-angiotensin-aldosterone system (RAAS), displays circadian rhythmicity. Aldosterone 88-99 angiotensin converting enzyme 2 Homo sapiens 0-31 33387941-3 2021 Angiotensin-converting enzyme 2 (ACE2), an important component of the renin-angiotensin-aldosterone system (RAAS), displays circadian rhythmicity. Aldosterone 88-99 angiotensin converting enzyme 2 Homo sapiens 33-37 33039544-3 2021 Incidentally, the renin-angiotensin-aldosterone system (RAAS) is integral to physiologic control of both ACE and ACE2 expression, and is an essential system utilized by SARS-CoV-2, albeit with varying schools of thought on how it can affect viral entry. Aldosterone 36-47 angiotensin converting enzyme 2 Homo sapiens 113-117 33188364-4 2021 Angiotensin-converting enzyme 2 (ACE2), which is part of the renin-angiotensin-aldosterone system (RAAS), is the main entry receptor for SARS-CoV-2; although dipeptidyl peptidase 4 (DPP4) might also act as a binding target. Aldosterone 79-90 angiotensin converting enzyme 2 Homo sapiens 0-31 33188364-4 2021 Angiotensin-converting enzyme 2 (ACE2), which is part of the renin-angiotensin-aldosterone system (RAAS), is the main entry receptor for SARS-CoV-2; although dipeptidyl peptidase 4 (DPP4) might also act as a binding target. Aldosterone 79-90 angiotensin converting enzyme 2 Homo sapiens 33-37 33537555-4 2021 The renin-angiotensin-aldosterone system (RAAS) is strictly involved in COVID-19 because angiotensin converting enzyme 2 (ACE2) is the host receptor for SARS-CoV-2 and also converts pro-inflammatory angiotensin (Ang) II into anti-inflammatory Ang(1-7). Aldosterone 22-33 angiotensin converting enzyme 2 Homo sapiens 122-126 32809116-8 2020 In this paper, we also review the pathogenesis of SARS-CoV-2 infection and how it worsens CVD and postulate that the differences in modulation of the renin-angiotensin-aldosterone system (RAAS) axis which controls angiotensin-converting enzyme (ACE)/ACE2 balance may be an important determinant of COVID-19 outcomes in Africa. Aldosterone 168-179 angiotensin converting enzyme 2 Homo sapiens 250-254 32442259-0 2020 Renin-angiotensin-aldosterone system inhibitors impact on COVID-19 mortality: What"s next for ACE2? Aldosterone 18-29 angiotensin converting enzyme 2 Homo sapiens 94-98 33443121-3 2020 ACE2 is part of the counter-regulatory renin-angiotensin-aldosterone system and is also expressed in the lower respiratory tract along the alveolar epithelium. Aldosterone 57-68 angiotensin converting enzyme 2 Homo sapiens 0-4 32657529-11 2020 Higher serum aldosterone (ss=0.11 (SE 0.04;p<0.01) and urine AGT (ss=0.32 (SE 0.07;p<0.01) significantly associated with ACR and urine ACE2 (ss=0.21 (SE 0.13;p<0.03). Aldosterone 13-24 angiotensin converting enzyme 2 Homo sapiens 135-139 32966970-4 2020 ACE2 is an established component of the "protective arm" of the renin-angiotensin-aldosterone-system (RAAS) that opposes ACE/angiotensin II (ANG II) pressor and tissue remodelling actions. Aldosterone 82-93 angiotensin converting enzyme 2 Homo sapiens 0-4 33171852-2 2020 The virus SARS-CoV-2 employs the Angiotensin-converting enzyme 2 (ACE2), a component of the RAAS (Renin-Angiotensin-Aldosterone System) system, as a receptor for entry into the cells. Aldosterone 116-127 angiotensin converting enzyme 2 Homo sapiens 33-64 33171852-2 2020 The virus SARS-CoV-2 employs the Angiotensin-converting enzyme 2 (ACE2), a component of the RAAS (Renin-Angiotensin-Aldosterone System) system, as a receptor for entry into the cells. Aldosterone 116-127 angiotensin converting enzyme 2 Homo sapiens 66-70 32981365-1 2020 ACE2 (angiotensin-converting enzyme 2) is a key component of the renin-angiotensin-aldosterone system. Aldosterone 83-94 angiotensin converting enzyme 2 Homo sapiens 0-4 32981365-1 2020 ACE2 (angiotensin-converting enzyme 2) is a key component of the renin-angiotensin-aldosterone system. Aldosterone 83-94 angiotensin converting enzyme 2 Homo sapiens 6-37 32853823-4 2020 The problem here is that in addition to be a receptor for the SARS-CoV-2 entry into the host cells, ACE2 acts as a key component of the renin-angiotensin-aldosterone system (RAAS) aimed at the generation of a cascade of vasoactive peptides coordinating several physiological processes. Aldosterone 154-165 angiotensin converting enzyme 2 Homo sapiens 100-104 33254506-5 2020 The angiotensin converting enzyme-2 (ACE-2), a component in the renin-angiotensin-aldosterone system (RAAS), plays as cell surface receptors for SARS-CoV-2. Aldosterone 82-93 angiotensin converting enzyme 2 Homo sapiens 4-35 33254506-5 2020 The angiotensin converting enzyme-2 (ACE-2), a component in the renin-angiotensin-aldosterone system (RAAS), plays as cell surface receptors for SARS-CoV-2. Aldosterone 82-93 angiotensin converting enzyme 2 Homo sapiens 37-42 33082849-4 2020 Angiotensin converting enzyme-2 (ACE-2) mediated cellular entry of SARS-Cov2 leads to receptor shedding of ACE-2 and disrupts the renin angiotensin aldosterone axis (RAAS). Aldosterone 148-159 angiotensin converting enzyme 2 Homo sapiens 0-31 32933039-1 2020 BACKGROUND: In COVID-19 patients, aldosterone via angiotensin-converting enzyme-2 deregulation may be responsible for systemic and pulmonary vasoconstriction, inflammation, and oxidative organ damage. Aldosterone 34-45 angiotensin converting enzyme 2 Homo sapiens 50-81 33082849-4 2020 Angiotensin converting enzyme-2 (ACE-2) mediated cellular entry of SARS-Cov2 leads to receptor shedding of ACE-2 and disrupts the renin angiotensin aldosterone axis (RAAS). Aldosterone 148-159 angiotensin converting enzyme 2 Homo sapiens 33-38 32922297-3 2020 ACE2 serves as an endogenous inhibitor of inflammatory signals associated with four major regulator systems: the renin-angiotensin-aldosterone system (RAAS), the complement system, the coagulation cascade, and the kallikrein-kinin system (KKS). Aldosterone 131-142 angiotensin converting enzyme 2 Homo sapiens 0-4 32654557-2 2020 There have been concerns on whether alterations of ACE2 expression by renin-angiotensin-aldosterone system (RAAS) inhibitors would contribute to the infectivity and severity of coronavirus disease 2019 (COVID-19). Aldosterone 88-99 angiotensin converting enzyme 2 Homo sapiens 51-55 32544563-6 2020 The virus-mediated down-regulation of ACE2 causes a burst of inflammatory cytokine release through dysregulation of the renin-angiotensin-aldosterone system (ACE/angiotensin II/AT1R axis), attenuation of Mas receptor (ACE2/MasR axis), increased activation of [des-Arg9]-bradykinin (ACE2/bradykinin B1R/DABK axis), and activation of the complement system including C5a and C5b-9 components. Aldosterone 138-149 angiotensin converting enzyme 2 Homo sapiens 38-42 32753148-5 2020 Upregulation of ACE2 mediates conversion of angiotensin II (vasoconstrictor) to angiotensin-(1-7) (vasodilator) and contributes to relatively low blood pressures, despite upregulation of other components of the renin-angiotensin-aldosterone system. Aldosterone 229-240 angiotensin converting enzyme 2 Homo sapiens 16-20 32848769-7 2020 The renin-angiotensin-aldosterone system (RAAS) component ACE2 and DPP4 are proteins dysregulated in diabetes. Aldosterone 22-33 angiotensin converting enzyme 2 Homo sapiens 58-62 32418199-3 2020 In human physiology, ACE2 is a pivotal counter-regulatory enzyme to ACE by the breakdown of angiotensin II, the central player in the renin-angiotensin-aldosterone system (RAAS) and the main substrate of ACE2. Aldosterone 152-163 angiotensin converting enzyme 2 Homo sapiens 21-25 32818905-3 2020 ACE2 regulates the protective arm of the renin-angiotensin-aldosterone system (RAAS) that endows anti-hypertensive and anti-inflammatory effects in the cardiovascular and pulmonary systems. Aldosterone 59-70 angiotensin converting enzyme 2 Homo sapiens 0-4 32470515-1 2020 BACKGROUND: Coronavirus disease-2019 (COVID-19) is caused by severe acute respiratory-syndrome coronavirus-2 that interfaces with the renin-angiotensin-aldosterone system (RAAS) through angiotensin-converting enzyme 2. Aldosterone 152-163 angiotensin converting enzyme 2 Homo sapiens 186-217 32708205-1 2020 BACKGROUND: The new coronavirus SARS-CoV-2, responsible for the Covid-19 pandemic, uses the angiotensin converting enzyme type 2 (ACE2), a physiological inhibitor of the renin angiotensin aldosterone system (RAAS), as a cellular receptor to infect cells. Aldosterone 188-199 angiotensin converting enzyme 2 Homo sapiens 130-134 32628137-2 2020 Renin-angiotensin-aldosterone-system (RAAS) inhibitors may increase the expression of angiotensin-converting enzyme 2, which is the receptor for SARSCoV-2 Spike protein. Aldosterone 18-29 angiotensin converting enzyme 2 Homo sapiens 86-117 32446267-3 2020 As the angiotensin-converting enzyme 2 (ACE2) facilitates the entry of coronaviruses into target cells, there have been hypotheses that preexisting use of renin-angiotensin-aldosterone system (RAAS) inhibitors may increase the risk of developing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Aldosterone 173-184 angiotensin converting enzyme 2 Homo sapiens 40-44 32367746-2 2020 Coronavirus binding to ACE2 (angiotensin-converting enzyme 2), a crucial component of the renin-angiotensin-aldosterone system, underlies much of this concern. Aldosterone 108-119 angiotensin converting enzyme 2 Homo sapiens 23-27 32367746-2 2020 Coronavirus binding to ACE2 (angiotensin-converting enzyme 2), a crucial component of the renin-angiotensin-aldosterone system, underlies much of this concern. Aldosterone 108-119 angiotensin converting enzyme 2 Homo sapiens 29-60 32418199-3 2020 In human physiology, ACE2 is a pivotal counter-regulatory enzyme to ACE by the breakdown of angiotensin II, the central player in the renin-angiotensin-aldosterone system (RAAS) and the main substrate of ACE2. Aldosterone 152-163 angiotensin converting enzyme 2 Homo sapiens 204-208 32550040-6 2020 On the other hand, ACE2 negatively regulates the renin-angiotensin-aldosterone system (RAAS) primarily by converting angiotensin II to angiotensin 1-7, which exerts a beneficial effect on coronavirus-induced acute lung injury. Aldosterone 67-78 angiotensin converting enzyme 2 Homo sapiens 19-23 33447763-1 2020 Introduction: Emerging epidemiological studies suggested that Renin-Angiotensin-Aldosterone system (RAAS) inhibitors may increase infectivity and severity of COVID-19 by modulating the expression of ACE2. Aldosterone 80-91 angiotensin converting enzyme 2 Homo sapiens 199-203 32412303-3 2020 Like other coronaviruses, SARS-CoV-2 recognizes human angiotensin-converting enzyme 2 as a cellular receptor that allows it to infect different host cells and likely disrupts renin-angiotensin-aldosterone system homeostasis. Aldosterone 193-204 angiotensin converting enzyme 2 Homo sapiens 54-85 32421367-4 2020 The main host receptor of the SARS-CoV-2 is angiotensin converting enzyme 2 (ACE2), a major component of the renin-angiotensin-aldosterone system (RAAS). Aldosterone 127-138 angiotensin converting enzyme 2 Homo sapiens 44-75 32421367-4 2020 The main host receptor of the SARS-CoV-2 is angiotensin converting enzyme 2 (ACE2), a major component of the renin-angiotensin-aldosterone system (RAAS). Aldosterone 127-138 angiotensin converting enzyme 2 Homo sapiens 77-81 32574273-6 2020 ACE2 is part of the wider renin-angiotensin-aldosterone system (RAAS) and is upregulated via compounds, which inhibits the classical ACE, thereby plasma aldosterone and aldosterone receptor (MR) activation. Aldosterone 44-55 angiotensin converting enzyme 2 Homo sapiens 0-4 32301766-4 2020 In addition, renin-angiotensin aldosterone system inhibitors reduce adverse atherosclerotic cardiovascular disease, heart failure, and chronic kidney disease outcomes, but may increase ACE2 levels. Aldosterone 31-42 angiotensin converting enzyme 2 Homo sapiens 185-189 32387238-4 2020 SARS-CoV-2 has a major impact on the Renin Angiotensin Aldosterone System (RAAS), through its binding to the membrane cellular glycoprotein, Angiotensin Converting Enzyme-2 (ACE-2), then infecting cells for replication. Aldosterone 55-66 angiotensin converting enzyme 2 Homo sapiens 141-172 32387238-4 2020 SARS-CoV-2 has a major impact on the Renin Angiotensin Aldosterone System (RAAS), through its binding to the membrane cellular glycoprotein, Angiotensin Converting Enzyme-2 (ACE-2), then infecting cells for replication. Aldosterone 55-66 angiotensin converting enzyme 2 Homo sapiens 174-179 32574273-6 2020 ACE2 is part of the wider renin-angiotensin-aldosterone system (RAAS) and is upregulated via compounds, which inhibits the classical ACE, thereby plasma aldosterone and aldosterone receptor (MR) activation. Aldosterone 153-164 angiotensin converting enzyme 2 Homo sapiens 0-4 32228252-4 2020 ACE2, however, is a key enzymatic component of the renin-angiotensin-aldosterone system (RAAS); ACE2 degrades ANG II, a peptide with multiple actions that promote CVD, and generates Ang-(1-7), which antagonizes the effects of ANG II. Aldosterone 69-80 angiotensin converting enzyme 2 Homo sapiens 0-4 32401442-1 2020 ACE2 is not only an enzyme that counters the effects of the renin-angiotensin-aldosterone system (RAAS) but is also the entry receptor for SARS-CoV-2, the virus of the Covid-19 pandemic. Aldosterone 78-89 angiotensin converting enzyme 2 Homo sapiens 0-4 32435607-4 2020 As a crucial enzyme of renin-angiotensin-aldosterone system (RAAS), ACE2 not only mediates the virus entry but also affects the pathophysiological process of virus-induced acute lung injury (ALI), as well as other organs" damage. Aldosterone 41-52 angiotensin converting enzyme 2 Homo sapiens 68-72 32228252-4 2020 ACE2, however, is a key enzymatic component of the renin-angiotensin-aldosterone system (RAAS); ACE2 degrades ANG II, a peptide with multiple actions that promote CVD, and generates Ang-(1-7), which antagonizes the effects of ANG II. Aldosterone 69-80 angiotensin converting enzyme 2 Homo sapiens 96-100 32354022-4 2020 ACE2 plays an essential role in the renin-angiotensin-aldosterone system (RAAS), which regulates blood pressure and fluid balance. Aldosterone 54-65 angiotensin converting enzyme 2 Homo sapiens 0-4 32314329-2 2020 ACE2 counteracts ACE and angiotensin II in the renin-angiotensin-aldosterone system (RAAS) and has critical functions in the lung and cardiovascular system. Aldosterone 65-76 angiotensin converting enzyme 2 Homo sapiens 0-4 32250244-1 2020 The discovery of angiotensin converting enzyme-2 (ACE-2) as the receptor for SARS- CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) has implicated the renin-angiotensin-aldosterone system in acute respiratory distress syndrome (ARDS) and respiratory failure in patients with coronavirus disease-19 (COVID-19). Aldosterone 176-187 angiotensin converting enzyme 2 Homo sapiens 17-48 32250244-1 2020 The discovery of angiotensin converting enzyme-2 (ACE-2) as the receptor for SARS- CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) has implicated the renin-angiotensin-aldosterone system in acute respiratory distress syndrome (ARDS) and respiratory failure in patients with coronavirus disease-19 (COVID-19). Aldosterone 176-187 angiotensin converting enzyme 2 Homo sapiens 50-55