PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15184841-3 2004 Activation of the renin-angiotensin system leads to increased synthesis of aldosterone in heart failure. Aldosterone 75-86 renin Homo sapiens 18-23 15310530-4 2004 The pathophysiological mechanisms underpinning these damaging aldosterone-mediated cardiovascular effects are still being elucidated, but prime candidates include cardiomyocyte necrosis and apoptosis, and myocardial fibrosis resulting in adverse cardiac remodelling, coronary vasculopathy, tachyarrhythmia and positive feedback activation of the renin-angiotensin-aldosterone system. Aldosterone 62-73 renin Homo sapiens 346-351 15284285-4 2004 Aldosterone, the principal human mineralocorticoid, is increasingly recognized as playing a significant role in cardiovascular morbidity, and its role in hypertension has recently been reevaluated with studies that suggest that increased aldosterone biosynthesis (as defined by an elevated aldosterone to renin ratio) is a key phenotype in up to 15% of individuals with hypertension. Aldosterone 238-249 renin Homo sapiens 305-310 15284285-7 2004 This review explores the evidence for this and provides a hypothesis linking impaired 11beta-hydroxylation and hypertension with a raised aldosterone to renin ratio. Aldosterone 138-149 renin Homo sapiens 153-158 15086486-8 2004 The dose of agents that block the renin-angiotensin system (RAS) should be adjusted to maximize the fall in plasma aldosterone concentration. Aldosterone 115-126 renin Homo sapiens 34-39 15248825-1 2004 OBJECTIVE: Primary aldosteronism (PA) is characterized by hypertension, hypokalemia and suppressed renin-angiotensin system caused by autonomous aldosterone production. Aldosterone 145-156 renin Homo sapiens 99-104 15134824-2 2004 We have previously reported that polymorphic variation in the 5" promoter region (-344C/T) of the gene encoding aldosterone synthase (CYP11B2) is associated with increased aldosterone metabolite excretion and with hypertension associated with a raised aldosterone to renin ratio (ARR). Aldosterone 112-123 renin Homo sapiens 267-272 15134824-2 2004 We have previously reported that polymorphic variation in the 5" promoter region (-344C/T) of the gene encoding aldosterone synthase (CYP11B2) is associated with increased aldosterone metabolite excretion and with hypertension associated with a raised aldosterone to renin ratio (ARR). Aldosterone 172-183 renin Homo sapiens 267-272 15076164-8 2004 CONCLUSIONS: Our results concur with experimental evidence for participation of endothelin in renal damage of angiotensin-dependent hypertension and for that of an endothelin-aldosterone interaction in low-renin hypertension. Aldosterone 175-186 renin Homo sapiens 206-211 11874420-7 2002 Perturbation of the renin-angiotensin-aldosterone system resulted in appropriately enhanced renin activity but with a subnormal aldosterone response, which appeared to be due to adrenal hyporesponsiveness. Aldosterone 38-49 renin Homo sapiens 20-25 14551679-10 2003 Patients with PAC/renin activity less than 2 had higher total volume of infused fluid, serum creatinine level, and fractional excretion of sodium values; aldosterone and serum creatinine were negatively correlated. Aldosterone 154-165 renin Homo sapiens 18-23 14647005-5 2003 The design of the study was to search for associations between clinical variables of blood pressure regulation pertaining to the renin-angiotensin-aldosterone system (systolic and diastolic blood pressures, urinary excretion of sodium, potassium and aldosterone, plasma renin activity) and a genetic marker at a candidate gene locus - the human insulin gene (INS) RESULTS: We observed significant associations between a variable number of tandem repeats (VNTR) marker (visualized as a biallelic, class I/class III marker system) localized at the 5" end of the human INS gene, and plasma renin activity and urinary sodium, potassium and aldosterone. Aldosterone 147-158 renin Homo sapiens 129-134 12860576-1 2003 BACKGROUND: Although there has been increasing recognition that a substantial part of the cardiovascular, central nervous system, and renal conditions induced by renin-angiotensin-aldosterone system activation reflects an action of aldosterone, the potential influence of therapy designed to block aldosterone has been limited by the fact that spironolactone (until recently the only aldosterone antagonist available) exerts a substantial array of adverse effects. Aldosterone 180-191 renin Homo sapiens 162-167 12860576-1 2003 BACKGROUND: Although there has been increasing recognition that a substantial part of the cardiovascular, central nervous system, and renal conditions induced by renin-angiotensin-aldosterone system activation reflects an action of aldosterone, the potential influence of therapy designed to block aldosterone has been limited by the fact that spironolactone (until recently the only aldosterone antagonist available) exerts a substantial array of adverse effects. Aldosterone 232-243 renin Homo sapiens 162-167 12860576-1 2003 BACKGROUND: Although there has been increasing recognition that a substantial part of the cardiovascular, central nervous system, and renal conditions induced by renin-angiotensin-aldosterone system activation reflects an action of aldosterone, the potential influence of therapy designed to block aldosterone has been limited by the fact that spironolactone (until recently the only aldosterone antagonist available) exerts a substantial array of adverse effects. Aldosterone 232-243 renin Homo sapiens 162-167 12406976-5 2002 The primary combination of renin and aldosterone considered compatible with primary aldosteronism was increased aldosterone for the concomitant renin, defined as aldosterone in the highest quartile predicted by linear regression on renin. Aldosterone 112-123 renin Homo sapiens 144-149 12406976-5 2002 The primary combination of renin and aldosterone considered compatible with primary aldosteronism was increased aldosterone for the concomitant renin, defined as aldosterone in the highest quartile predicted by linear regression on renin. Aldosterone 112-123 renin Homo sapiens 144-149 12163983-12 2002 Renin increased (3.7 +/- 2.3 ng/ml x min vs. 2.3 +/- 1.0 ng/ml x min, p < 0.05) during the total night and aldosterone (3.6 +/- 4.7 ng/ml x min vs. 1.1 +/- 0.9 ng/ml x min, p < 0.05) in the second half of the night, whereas cortisol (8.3 +/- 2.4 pg/ml x min vs. 11.8 +/- 3.8 pg/ml x min, p < 0.01) decreased significantly and AVP by trend in the first part of the night. Aldosterone 110-121 renin Homo sapiens 0-5 11874420-7 2002 Perturbation of the renin-angiotensin-aldosterone system resulted in appropriately enhanced renin activity but with a subnormal aldosterone response, which appeared to be due to adrenal hyporesponsiveness. Aldosterone 38-49 renin Homo sapiens 92-97 11874420-7 2002 Perturbation of the renin-angiotensin-aldosterone system resulted in appropriately enhanced renin activity but with a subnormal aldosterone response, which appeared to be due to adrenal hyporesponsiveness. Aldosterone 128-139 renin Homo sapiens 20-25 11532707-8 2001 Sodium-retaining endocrine systems, such as renin-aldosterone and catecholamines, are much more activated during microG than on Earth. Aldosterone 50-61 renin Homo sapiens 44-49 11803527-3 2001 Epidemiological, clinical, and experimental data suggest that the renin-angiotensin-aldosterone system is a critical regulator of blood pressure. Aldosterone 84-95 renin Homo sapiens 66-71 11780688-2 2001 Excess secretion of aldosterone or other mineralocorticoids, or abnormal sensitivity to mineralocorticoids, may result in hypokalemia, suppressed plasma renin activity, and hypertension. Aldosterone 20-31 renin Homo sapiens 153-158 11566898-10 2001 Significant inverse correlations were obtained for all subjects between the fall in blood pressure from the high-salt to low-salt diet and the rise in plasma renin activity and aldosterone that occurred in addition to the absolute level on the low-salt diet. Aldosterone 177-188 renin Homo sapiens 158-163 11422109-14 2001 In the renin secretion stimulating test, the increase in CYP11B2 messenger RNA levels in MNLs was parallel with that of plasma aldosterone concentration. Aldosterone 127-138 renin Homo sapiens 7-12 10720581-10 2000 We detected an association between the CYP11B2 gene polymorphisms and low-renin hypertension with inappropriate elevation of aldosterone. Aldosterone 125-136 renin Homo sapiens 74-79 11174896-4 2000 A severe form of low-renin hypertension in which a molecular mutation in ENaC prevents removal of the channel from the cell surface, known as Liddle"s syndrome, results in increased net ENaC activity but, in this case, independently of an increase in aldosterone. Aldosterone 251-262 renin Homo sapiens 21-26 9928756-0 1999 High and non-suppressible plasma renin activity in a patient with aldosterone producing adenoma: pathophysiologic and diagnostic implications. Aldosterone 66-77 renin Homo sapiens 33-38 10363743-13 1999 CONCLUSION: In patients with dilated cardiomyopathy and only a partly activated renin-angiotensin system, both metoprolol and captopril reduced urinary excretion of aldosterone. Aldosterone 165-176 renin Homo sapiens 80-85 10726708-2 2000 Inhibition by xenobiotics such as liquorice or mutations in the HSD11 B2 gene, as occur in the rare monogenic hypertensive syndrome of apparent mineralocorticoid excess (AME), result in a compromised 11 betaHSD2 enzyme activity, which in turn leads to overstimulation of the MR by cortisol, sodium retention, hypokalaemia, low plasma renin and aldosterone concentrations, and hypertension. Aldosterone 344-355 renin Homo sapiens 334-339 10205242-1 1999 NCI-H295, a human adrenocarcinoma cell line, has been proposed as a model system to define the role of the renin-angiotensin system in the regulation of aldosterone production in humans. Aldosterone 153-164 renin Homo sapiens 107-112 9453523-9 1998 Patients with vasodepressor syncope had a significant rise in renin (9.03 +/- 4.56 pg/ml versus 52.53 +/- 41.63 pg/ml; p < 0.05) and aldosterone concentration (95.43 +/- 103.03 ng/ml versus 249.57 +/- 191.54 ng/ml; p < 0.05), whereas no change in level of epinephrine (0.12 +/- 0.12 ng/ml versus 0.28 +/- 0.33 ng/ml; p = NS) or norepinephrine (0.60 +/- 0.26 ng/ml versus 0.86 +/- 0.53 ng/ml; p = NS) was detected. Aldosterone 136-147 renin Homo sapiens 62-67 9175301-5 1997 A 33-year-old male Chinese patient presented with hypertension, hypokalemia, metabolic alkalosis, and the hypersecretion of aldosterone associated with suppressed plasma renin activity which is a typical hallmark of primary aldosteronism. Aldosterone 124-135 renin Homo sapiens 170-175 9274896-12 1997 There was also a correlation between the plasma renin activity measured in these patients and their concomitant plasma aldosterone level. Aldosterone 119-130 renin Homo sapiens 48-53 8952579-2 1996 Excess secretion of aldosterone or other mineralocorticoids or abnormal sensitivity to mineralocorticoids may result in hypertension, suppressed plasma renin activity, and hypokalemia. Aldosterone 20-31 renin Homo sapiens 152-157 9075066-4 1997 Thus, DBcAMP did not stimulate renin release in patients with PA, suggesting that the chronic excess production of aldosterone suppresses the release of renin from JG cells. Aldosterone 115-126 renin Homo sapiens 153-158 8979285-2 1997 Excess secretion of aldosterone or other mineralocorticoids, or abnormal sensitivity to mineralocorticoids, may results in hypokalemia, suppressed plasma renin activity, and hypertension. Aldosterone 20-31 renin Homo sapiens 154-159 8879602-7 1996 Nightly systolic blood pressure fall was inversely related to arterial (r = -0.75, p < 0.003) and venous (r = -0.65, p < 0.04) plasma renin activity and arterial aldosterone (r = -0.64, p < 0.05) in valvular aortic disease patients. Aldosterone 168-179 renin Homo sapiens 140-145 7883820-3 1995 If such a mutation were to occur in human patients the predicted phenotype would be low-renin hypertension with elevated ratios of plasma aldosterone to plasma renin activity. Aldosterone 138-149 renin Homo sapiens 88-93 8621214-3 1996 A decrease in plasma norepinephrine (from 208 +/- 74 to 142 +/- 52 pg/mL, P < .01) was associated with decreases in plasma renin activity (from 1.06 +/- 0.98 to 0.62 +/- 0.63 ng/mL per hour, P < .01) and serum aldosterone (from 70 +/- 28 to 57 +/- 24 pg/mL, P < .05). Aldosterone 216-227 renin Homo sapiens 126-131 8582111-2 1995 Angiotensin-responsive aldosterone-producing adenomas (AII-R-APA) have increased expression of renin mRNA compared with angiotensin-unresponsive aldosterone-producing adenomas (AII-U-APA) or normal adrenals. Aldosterone 23-34 renin Homo sapiens 95-100 7915644-6 1994 We compared the frequency of four renin gene polymorphisms in peripheral blood DNA from the two subgroups and found significant associations between BglI, TaqI and HinfI restriction fragment length polymorphisms (RFLP) and aldosterone responsiveness. Aldosterone 223-234 renin Homo sapiens 34-39 7700015-1 1994 Approximately one half of the aldosterone-producing adenomas (APA) removed from patients with primary aldosteronism in the Hypertension Unit at Greenslopes Hospital belong to a subgroup in which aldosterone levels are responsive to the renin-angiotensin system (angiotensin-responsive APA; AII-R-APA), unlike classical APAs in which aldosterone is unresponsive (AII-U-APA). Aldosterone 30-41 renin Homo sapiens 236-241 7700015-1 1994 Approximately one half of the aldosterone-producing adenomas (APA) removed from patients with primary aldosteronism in the Hypertension Unit at Greenslopes Hospital belong to a subgroup in which aldosterone levels are responsive to the renin-angiotensin system (angiotensin-responsive APA; AII-R-APA), unlike classical APAs in which aldosterone is unresponsive (AII-U-APA). Aldosterone 195-206 renin Homo sapiens 236-241 7826555-2 1994 To determine the interrelation between increased plasma renin activity in response to epinephrine and plasma aldosterone concentration and renal excretion of potassium and sodium, 26 normal subjects were subjected to 4 h of an intravenous infusion of low-dose epinephrine (12 ng/kg/min). Aldosterone 109-120 renin Homo sapiens 56-61 8205752-13 1994 The data suggest that in KD the increased activity of the renin-angiotensin system affected the renal function both through direct effects and through effects dependent on the angiotensin-supported secretions of aldosterone and probably of vasopressin. Aldosterone 212-223 renin Homo sapiens 58-63 8284908-3 1993 In the genesis of hypertension participates the dual regulation of blood pressure by the kidneys: a) the renin-angiotensin-aldosterone system in the renal cortex which is manifested by two mechanisms (high- and low-renin hypertension resp.) with a number of functional and metabolic effects of angiotensins and aldosterone, b) the medullipine system with the production of medullipine I by interstitial cells in the renal medulla and its transformation into effective medullipine in the liver. Aldosterone 123-134 renin Homo sapiens 105-110 7902711-3 1993 We compared the frequency of two renin gene polymorphisms in peripheral blood DNA from the two subgroups and found a significant association (allele frequency X2 = 7.67, p < 0.006) between BglI polymorphism and aldosterone responsiveness. Aldosterone 214-225 renin Homo sapiens 33-38 8324299-4 1993 There is a close temporal and directional relationship between the age-related decrease in plasma renin activity and the age-related decrease in plasma aldosterone. Aldosterone 152-163 renin Homo sapiens 98-103 1914200-2 1991 In the zona glomerulosa, aldosterone excess leads to hypertension, hypokalemia, and suppressed plasma renin activity, with increased concentrations of urinary aldosterone (either as the 18-glucuronide or free aldosterone) as an index of its production. Aldosterone 25-36 renin Homo sapiens 102-107 1592471-8 1992 Total amounts of active renin and angiotensin II/III released from normal adrenals during 270 minutes of superfusion were higher than the amounts released from aldosteronomas (312 +/- 35 versus 187 +/- 43 and 823 +/- 100 versus 436 +/- 55 pg/100 mg tissue, respectively; mean +/- SEM, p less than 0.05), whereas aldosterone release from the adenomatous tissue was approximately threefold higher (320 +/- 21 versus 115 +/- 18 ng/100 mg tissue; mean +/- SEM, p less than 0.01). Aldosterone 312-323 renin Homo sapiens 24-29 1583627-3 1992 Fasting insulin and the early insulin response at an intravenous glucose tolerance test were both correlated to plasma renin activity (r = 0.48, P less than 0.003 and r = 0.55, P less than 0.002, respectively) while HDL-cholesterol was found to be inversely related to the urinary excretion of aldosterone (r = 0.35, P less than 0.03). Aldosterone 294-305 renin Homo sapiens 119-124 1330385-1 1992 19-hydroxy-androstenedione (19-OH-A), a C19 steroid, is an amplifier of the sodium retaining action of aldosterone under the control of ACTH and renin-angiotensin system. Aldosterone 103-114 renin Homo sapiens 145-150 1829901-10 1991 We conclude that under various physiologic conditions ANH suppresses aldosterone predominantly through suppression of renin. Aldosterone 69-80 renin Homo sapiens 118-123 1853123-8 1991 Oedema can be due to RHF but in some cases they can also be explained by the stimulation of the renin-angiotensin system with increasing of the aldosterone level, due to the fall in renal blood flow. Aldosterone 144-155 renin Homo sapiens 96-101 33783448-10 2021 A part of the favorable mechanisms is mediated by the natriuretic effect that is associated with the glycosuric effect, which reduces the activation of the renin-angiotensin-aldosterone system together with glomerular hyperfiltration.The aim of this review is to expand the knowledge among general cardiologists on the role of SGLT2 and SGLT1 in renal glucose homeostasis in healthy and diabetic subjects in the light of a potent class of drugs counteracting heart failure. Aldosterone 174-185 renin Homo sapiens 156-161 1830843-4 1991 Plasma renin activity was inversely related to sodium excretion at both proximal (r = -0.145, P less than 0.05) and distal (r = -0.236, P less than 0.001) tubular site, whereas plasma aldosterone was significantly and inversely related to distal sodium excretion only (r = -0.305, P less than 0.001). Aldosterone 184-195 renin Homo sapiens 7-12 1840232-11 1991 Thus, the present results indicate that the renin-angiotensin-aldosterone system is an important mediator of Na+ retention in CHF, as evidenced by the reversal of the positive Na+ balance with a specific aldosterone antagonist. Aldosterone 62-73 renin Homo sapiens 44-49 1830607-13 1991 The antagonist effect of AFN on the renin--angiotensin-aldosterone system was corroborated: we found decreased aldosterone, PRA and creatinine clearance, and increased diuresis and natriuresis. Aldosterone 55-66 renin Homo sapiens 36-41 2229301-1 1990 Low renin essential hypertensives (LRH) have normal plasma aldosterone levels which are inappropriately high in relation to their PRA. Aldosterone 59-70 renin Homo sapiens 4-9 33942084-1 2021 PURPOSE: We aimed to evaluate the effect of mineralocorticoid receptor antagonists on aldosterone-to-renin ratio in patients with primary aldosteronism. Aldosterone 86-97 renin Homo sapiens 101-106 33942084-5 2021 RESULTS: Renin and potassium levels showed a significant increase, and aldosterone-to-renin ratio displayed a significant reduction compared with baseline after both a short and long-term treatment. Aldosterone 71-82 renin Homo sapiens 86-91 2184065-3 1990 During exercise, increments (increase from the resting value to the value at 80% of maximal working capacity) in renin (1.5 +/- 0.4 nmol.l-1.h-1 and 3.7 +/- 0.5 nmol.l-1.h-1; p less than 0.001), angiotensin II (28 +/- 8 nmol/l and 60 +/- 8 nmol/l; p less than 0.001), aldosterone (0.16 +/- 0.04 nmol/l and 0.25 +/- 0.05 nmol/l; p less than 0.05), adrenaline (1.96 +/- 0.49 nmol/l and 2.92 +/- 0.51 nmol/l; p less than 0.05), and noradrenaline (12.01 +/- 1.25 nmol/l and 18.74 +/- 1.45 nmol/l; p less than 0.01) were significantly lower in the patients than in control subjects. Aldosterone 268-279 renin Homo sapiens 113-118 33798678-1 2021 Renin, encoded by REN, is an essential enzyme in the renin-angiotensin aldosterone system (RAAS) which is responsible for the maintenance of blood pressure homeostasis. Aldosterone 71-82 renin Homo sapiens 0-5 33798678-1 2021 Renin, encoded by REN, is an essential enzyme in the renin-angiotensin aldosterone system (RAAS) which is responsible for the maintenance of blood pressure homeostasis. Aldosterone 71-82 renin Homo sapiens 18-21 33944843-1 2021 Background Fibromuscolar dysplasia (FMD) is an idiopathic, non-atherosclerotic and non-inflammatory stenotic lesion of renal arteries causing renovascular hypertension up-regulating renin-angiotensin-aldosterone system. Aldosterone 200-211 renin Homo sapiens 182-187 33944843-11 2021 Renal angioplasty turned off renin-angiotensin-aldosterone overactivity allowing the cure the hypertension and a surprisingly rapid reverse of myocardial hypertrophy and of excess of albumin urine excretion not only dependent on blood pressure normalization. Aldosterone 47-58 renin Homo sapiens 29-34 33779290-2 2021 Angiotensin II is a key biologically active hormone in the renin-angiotensin-aldosterone system. Aldosterone 77-88 renin Homo sapiens 59-64 33779290-3 2021 It has been suggested that measurement of equilibrium levels of this peptide, involving an in vitro incubation of serum prior to analysis, may provide a better marker of renin-angiotensin-aldosterone system activity than renin. Aldosterone 188-199 renin Homo sapiens 170-175 33779290-10 2021 EqAng II was significantly correlated with renin, and the aldosterone:eqAng II ratio had a strong positive correlation with the aldosterone:renin ratio. Aldosterone 58-69 renin Homo sapiens 140-145 33779290-10 2021 EqAng II was significantly correlated with renin, and the aldosterone:eqAng II ratio had a strong positive correlation with the aldosterone:renin ratio. Aldosterone 128-139 renin Homo sapiens 140-145 34547917-4 2022 Extrinsic components of the autonomic nervous system, such as carotid baroreceptors and renin-angiotensin-aldosterone system, modulate sympathetic input to the heart through the stellate ganglion and parasympathetic input via the vagus nerve. Aldosterone 106-117 renin Homo sapiens 88-93 34176836-3 2022 After minocycline treatment cessation and management of the hypertension, his blood pressure, renin-aldosterone levels, and urinary protein levels gradually improved. Aldosterone 100-111 renin Homo sapiens 94-99 34614533-4 2022 In the current review, research insights on the pathogenetic background and clinical significance of autonomous aldosterone secretion (AAS) are presented, which is defined as a constellation of either: 1) normotension, normokalemia, a positive PA screening (high aldosterone-to-renin ratio) and/or confirmation test, or 2) hypertension, normokalemia and a positive PA screening but negative confirmation test. Aldosterone 112-123 renin Homo sapiens 278-283 34954909-0 2022 Sex influences the effect of adiposity on arterial stiffness and renin-angiotensin aldosterone system activity in young adults. Aldosterone 83-94 renin Homo sapiens 65-70 34967935-0 2022 Understanding diabetes-induced cardiomyopathy from the perspective of renin angiotensin aldosterone system. Aldosterone 88-99 renin Homo sapiens 70-75 34889107-1 2021 Background While both renin-dependent and renin-independent aldosterone secretion contribute to aldosteronism, their relative associations with cardiovascular disease (CVD) risk has not been investigated. Aldosterone 60-71 renin Homo sapiens 42-47 34945112-0 2021 Effect of the Renin-Angiotensin-Aldosterone System Reactivity on Endothelial Function and Modulative Role of Valsartan in Male Subjects with Essential Hypertension. Aldosterone 32-43 renin Homo sapiens 14-19 34326480-2 2021 Although experimental studies have demonstrated that pendrin regulates blood pressure downstream of the renin-angiotensin-aldosterone system, its role in human hypertension remains unclear. Aldosterone 122-133 renin Homo sapiens 104-109 34101028-2 2021 This study aimed to investigate whether anti-atherosclerotic therapy (AT), defined as the simultaneous use of antiplatelet agents, statins, and renin aldosterone system inhibitors, had long-term clinical benefits for patients who underwent transcatheter aortic valve replacement (TAVR). Aldosterone 150-161 renin Homo sapiens 144-149 34326480-7 2021 Correlation analysis revealed that the magnitude of pendrin reduction after treatment significantly correlated with the baseline aldosterone-renin ratio (ARR). Aldosterone 129-140 renin Homo sapiens 141-146 34826118-2 2022 Abnormal aldosterone-renin metabolism is a risk factor for arterial hypertension and cardiovascular risk, but its association with pathological conditions in pregnancy remains unknown. Aldosterone 9-20 renin Homo sapiens 21-26 33941037-14 2021 Keyword analysis revealed transforming growth factor-beta, oxidative stress, proteinuria, and renin-angiotensin-aldosterone system interruption are classic research topics. Aldosterone 112-123 renin Homo sapiens 94-99 34944415-4 2021 In hypertension, microRNAs act on the renin-angiotensin-aldosterone system, sympathetic nervous system and left ventricular hypertrophy, however the signaling pathways that interact in these processes and are regulated by microRNAs inducing hypertension and the worsening of the disease still need to be elucidated. Aldosterone 56-67 renin Homo sapiens 38-43 34869917-0 2021 COVID-19 and renin angiotensin aldosterone system: Pathogenesis and therapy. Aldosterone 31-42 renin Homo sapiens 13-18 34926077-2 2021 The most sensitive screening test for primary aldosteronism is the measurement of the plasma aldosterone concentration and plasma renin activity to calculate the aldosterone/renin ratio. Aldosterone 162-173 renin Homo sapiens 130-135 34745006-0 2021 Effects of SGLT2 Inhibitors and GLP-1 Receptor Agonists on Renin-Angiotensin-Aldosterone System. Aldosterone 77-88 renin Homo sapiens 59-64 34514971-1 2021 The renin protein is an upstream enzymatic regulator of the renin-aldosterone-angiotensin system (RAAS) essential for the maintenance of blood pressure. Aldosterone 66-77 renin Homo sapiens 4-9 34645113-13 2021 In case of unawareness from NSIAD, plasma renin-aldosterone profile can be confused with HH, especially in the infants. Aldosterone 48-59 renin Homo sapiens 42-47 34363052-12 2021 Clinicians should pay attention to the ratio of visceral-to-subcutaneous fat tissue volume and encourage primary aldosteronism patients to improve their lifestyle in addition to treating renin-aldosterone activity. Aldosterone 193-204 renin Homo sapiens 187-192 34605197-10 2021 This indicates that high-flow AVF is associated with increased natriuretic peptides and hormones of the renin-angiotensin-aldosterone system, that may balance each other regarding fluid retention and hypertension and support remaining kidney function. Aldosterone 122-133 renin Homo sapiens 104-109 34574015-4 2021 Several mechanisms have been identified that explain the relationship between hyperuricemia and chronic kidney disease, including the crystal effect, renin-angiotensin-aldosterone system activation, nitric oxide synthesis inhibition, and intracellular oxidative stress stimulation, and urate-lowering therapy (ULT) has been proven to reduce renal disease progression in the past few years. Aldosterone 168-179 renin Homo sapiens 150-155 34645113-5 2021 First, a 2-month-old male presented with hyponatremia, low plasma osmolality, relatively high urine osmolality, and low plasma renin-aldosterone levels. Aldosterone 133-144 renin Homo sapiens 127-132 34514971-1 2021 The renin protein is an upstream enzymatic regulator of the renin-aldosterone-angiotensin system (RAAS) essential for the maintenance of blood pressure. Aldosterone 66-77 renin Homo sapiens 60-65 34414500-1 2021 Monogenic disorders of hypertension are a distinct group of diseases causing dysregulation of the renin-angiotensin-aldosterone system and are characterized by low plasma renin activity. Aldosterone 116-127 renin Homo sapiens 98-103 34348666-11 2021 All patients showed a substantial but transient reduction in renal function accompanied by activation of the renin-angiotensin-aldosterone system. Aldosterone 127-138 renin Homo sapiens 109-114 34320843-0 2021 Renin-Angiotensin Aldosterone System Inhibitors in Primary Prevention and COVID-19. Aldosterone 18-29 renin Homo sapiens 0-5 34294029-2 2021 The aldosterone-to-renin ratio (ARR) is recommended as the most reliable screening method for PA, but ARR screening is often influenced by many factors. Aldosterone 4-15 renin Homo sapiens 19-24 34171624-2 2021 Normal pregnancy is associated with a rise in aldosterone and renin levels early in pregnancy making the aldosterone:renin ratio which is normally used to screen for primary aldosteronism, difficult to interpret. Aldosterone 46-57 renin Homo sapiens 117-122 34286472-0 2022 Effects of high- vs low-dose native vitamin D on albuminuria and the renin-angiotensin-aldosterone system: a randomized pilot study. Aldosterone 87-98 renin Homo sapiens 69-74 34242264-8 2021 After log-log transformations, linear relations with high coefficients of determination were observed between Accuraseed immunoanalyzer-based and RIA-based data of renin and aldosterone. Aldosterone 175-186 renin Homo sapiens 165-170 34267727-5 2021 PA results from renin-independent adrenal expression of CYP11B2 and production of aldosterone. Aldosterone 82-93 renin Homo sapiens 16-21 34267727-8 2021 Whole-exome sequencing has led to the discovery of mutations in six genes that cause renin-independent aldosterone production and thus PA. To facilitate broad-based prospective and retrospective studies of APA, recent technologic advancements have allowed the determination of tumor mutation status using formalin-fixed paraffin-embedded (FFPE) tissue sections. Aldosterone 103-114 renin Homo sapiens 85-90 34201168-12 2021 Blockades of the renin-angiotensin-aldosterone system in 2006 and calcium channel blockers in 2011 and 2016 were the drugs with highest impact on lowering blood pressure. Aldosterone 35-46 renin Homo sapiens 17-22 34134181-2 2021 Hyponatremia in heart failure (HF) is mainly associated with hypervolemia resulting from activation of baroreceptor-mediated hormones, such as arginine vasopressin (AVP), renin-angiotensin-aldosterone system, and catecholamines. Aldosterone 189-200 renin Homo sapiens 171-176 34201168-14 2021 Blockade of renin-angiotensin-aldosterone system and calcium channel blockers decrease the blood pressure significantly. Aldosterone 30-41 renin Homo sapiens 12-17 34060646-0 2021 A systematic review of nonsynonymous single nucleotide polymorphisms in the renin-angiotensin-aldosterone system. Aldosterone 94-105 renin Homo sapiens 76-81 34060646-1 2021 In this recent publication review the authors aimed to collect evidence of impact of nonsynonymous single nucleotide polymorphisms (nsSNP) in the renin-angiotensin-aldosterone system on patients" phenotype not only regarding arterial hypertension and its complications, but also the impact on other diseases of interest outside the field of cardiovascular medicine. Aldosterone 164-175 renin Homo sapiens 146-151 34065198-0 2021 Gene Polymorphisms of the Renin-Angiotensin-Aldosterone System as Risk Factors for the Development of In-Stent Restenosis in Patients with Stable Coronary Artery Disease. Aldosterone 44-55 renin Homo sapiens 26-31 34154031-10 2021 We showed that acute administration of exenatide in a full therapeutic dose modestly stimulates the hypothalamic-pituitary-adrenal axis but inhibits the renin-aldosterone system. Aldosterone 159-170 renin Homo sapiens 153-158 34125950-0 2021 Gene variants of the renin angiotensin aldosterone system for risk stratification in heart disease. Aldosterone 39-50 renin Homo sapiens 21-26 34137684-7 2021 Aldosterone (serum, plasma) to plasmatic renin ratios for CLIA (rP=0.999, P=0.286) and for radioimmunoassay (rP=0.992, P=0.025). Aldosterone 0-11 renin Homo sapiens 41-46 35621175-1 2022 PURPOSE OF REVIEW: Renin-independent aldosterone production from one or both affected adrenal(s), a condition known as primary aldosteronism (PA), is a common cause of secondary hypertension. Aldosterone 37-48 renin Homo sapiens 19-24 35622189-1 2022 BACKGROUND: A large aneurysmal renal arteriovenous fistula (AVF) can cause hypokalaemic hypertension due to activation of renin-aldosterone system due to steal effect from renal parenchyma. Aldosterone 128-139 renin Homo sapiens 122-127 35627493-9 2022 Patients with isolated systolic hypertension may differ from patients with systolic-diastolic hypertension in less severe activation of the renin-angiotensin-aldosterone system. Aldosterone 158-169 renin Homo sapiens 140-145 35511367-1 2022 The protease renin, the key enzyme of the renin-angiotensin-aldosterone system, is mainly produced and secreted by juxtaglomerular cells in the kidney, which are located in the walls of the afferent arterioles at their entrance into the glomeruli. Aldosterone 60-71 renin Homo sapiens 13-18 35511367-1 2022 The protease renin, the key enzyme of the renin-angiotensin-aldosterone system, is mainly produced and secreted by juxtaglomerular cells in the kidney, which are located in the walls of the afferent arterioles at their entrance into the glomeruli. Aldosterone 60-71 renin Homo sapiens 42-47 35518929-8 2022 Another three patients were classified as confirmed/likely PA based on the markedly elevated aldosterone-renin ratio and clinical characteristics. Aldosterone 93-104 renin Homo sapiens 105-110 35509038-13 2022 Based on the results of normal Aldo concentration despite high renin level in our patient, we hypothesized that Aldo may be connecting with the level of urinary calcium excretion in patients with the GS. Aldosterone 112-116 renin Homo sapiens 63-68 35165831-5 2022 Cardiovascular and renal damage likely begins in early stages of renin-independent aldosterone excess. Aldosterone 83-94 renin Homo sapiens 65-70 35472685-0 2022 Association of statin and/or renin-angiotensin-aldosterone system modulating therapy with mortality in adults with diabetes admitted to hospital with COVID-19: A retrospective multicentre European study. Aldosterone 47-58 renin Homo sapiens 29-34 35472685-1 2022 BACKGROUND & AIMS: To assess the impact of pre-admission renin-angiotensin-aldosterone system inhibitor (RAASi) and statin use on mortality following COVID-19 hospitalization in adults with pre-existing diabetes. Aldosterone 75-86 renin Homo sapiens 57-62 35477724-0 2022 The use of renin angiotensin aldosterone system inhibitors may be associated with decreased mortality after cancer surgery. Aldosterone 29-40 renin Homo sapiens 11-16 35518929-6 2022 Results: Twenty-six of 192 (14%) patients had an elevated aldosterone-renin ratio. Aldosterone 58-69 renin Homo sapiens 70-75 35060833-7 2022 RESULTS: : Male sex, older age, hospital admissions in the previous year, flu vaccination in the previous season, a Charlson Comorbidities Index>3 and a prescription of renin-angiotensin aldosterone system inhibitors at baseline were the main risk factors for hospital admission. Aldosterone 187-198 renin Homo sapiens 169-174 35456336-4 2022 Current concerns may affect the practical approach to the traditional treatment, and in this setting, physicians are often reluctant to administer and titrate some agents acting on the renin angiotensin aldosterone system and the sympathetic activity. Aldosterone 203-214 renin Homo sapiens 185-190 35620081-0 2022 Renin-Angiotensin-Aldosterone System Activation and Diuretic Response in Ambulatory Patients With Heart Failure. Aldosterone 18-29 renin Homo sapiens 0-5 35278618-5 2022 We found 51 significant pleiotropic SNPs affecting the two traits, which could contribute to the Renin-Angiotensin-Aldosterone System (RAAS). Aldosterone 115-126 renin Homo sapiens 97-102 35413743-0 2022 Early Renin Recovery After Adrenalectomy in Aldosterone-Producing Adenomas: A Prospective Study. Aldosterone 44-55 renin Homo sapiens 6-11 35413743-1 2022 The aim of the study was to clarify the relationship and the time of aldosterone and renin recoveries at immediate and long-term follow-up in aldosterone-producing adenoma (APA) patients who underwent adrenalectomy. Aldosterone 142-153 renin Homo sapiens 85-90 35475027-8 2022 Following oral sodium suppression, the aldosterone-to-renin ratio was 4-fold higher using immunoassay (27.2 (19.7, 62.4) vs 6.4 (3.5, 19.1) ng/dL per ng/mL/hour; P < .001). Aldosterone 39-50 renin Homo sapiens 54-59 35471479-0 2022 Diagnostic value of aldosterone to renin ratio calculated by plasma renin activity or plasma renin concentration in primary aldosteronism: a meta-analysis. Aldosterone 20-31 renin Homo sapiens 68-73 35471479-0 2022 Diagnostic value of aldosterone to renin ratio calculated by plasma renin activity or plasma renin concentration in primary aldosteronism: a meta-analysis. Aldosterone 20-31 renin Homo sapiens 93-98 35471479-1 2022 BACKGROUND: Since the diagnostic value of aldosterone to renin ratio (ARR) calculated by plasma renin concentration (PRC) or plasma renin activity (PRA) is still inconclusive, we conducted a meta-analysis by systematically reviewing relevant literature to explore the difference in the diagnostic efficacy of ARR calculated by PRC or PRA, so as to provide guidance for clinical diagnosis. Aldosterone 42-53 renin Homo sapiens 96-101 35360231-5 2022 The potential mechanisms whereby prenatal stress negatively impacts vascular function in the offspring, including poor hypothalamic-pituitary-adrenal axis regulation of inflammatory response, activation of Th17 cells, renin-angiotensin-aldosterone system hyperactivation, reactive oxygen species imbalance, generation of neoantigens and TLR4 activation, are discussed. Aldosterone 236-247 renin Homo sapiens 218-223 34862332-3 2022 Although renin-angiotensin-aldosterone-system (RAAS) blockers have been suggested to upregulate ACE2, their use in COVID-19 patients is now considered well tolerated. Aldosterone 27-38 renin Homo sapiens 9-14 35143015-0 2022 Unraveling the Differentially Articulated Axes of the Century-Old Renin-Angiotensin-Aldosterone System: Potential Therapeutic Implications. Aldosterone 84-95 renin Homo sapiens 66-71 35148974-0 2022 Echocardiography and renin-aldosterone interplay as predictors of death in COVID-19. Aldosterone 27-38 renin Homo sapiens 21-26 35175847-2 2022 Some of these sex-specific considerations are driven by the cellular effects of sex hormones on the renin-angiotensin-aldosterone system, endothelial response to injury, vascular aging, and left ventricular remodeling. Aldosterone 118-129 renin Homo sapiens 100-105 35187382-0 2022 Coexistence of Renin-independent Aldosterone Secretion and Multiple Endocrine Neoplasia Type 1 Within a Family. Aldosterone 33-44 renin Homo sapiens 15-20 35187382-1 2022 Primary aldosteronism (PA) is a state of renin-independent aldosterone secretion that can range from subclinical to overt. Aldosterone 59-70 renin Homo sapiens 41-46 35187382-3 2022 Cases of PA associated with MEN1 have been reported; however, there has been no previous report on renin-independent aldosterone secretion within a family with MEN1. Aldosterone 117-128 renin Homo sapiens 99-104 35187382-4 2022 Herein, we present the case of a normotensive family presenting with both MEN1 and renin-independent aldosterone secretion. Aldosterone 101-112 renin Homo sapiens 83-88 35187382-8 2022 The loading tests for PA confirmation, including saline infusion, and furosemide upright and captopril challenge tests, yielded positive findings, confirming a case of renin-independent aldosterone secretion. Aldosterone 186-197 renin Homo sapiens 168-173 35187382-10 2022 All of them were also normotensive and confirmed to have renin-independent aldosterone secretion. Aldosterone 75-86 renin Homo sapiens 57-62 35187382-11 2022 The coexistence of renin-independent aldosterone secretion and MEN1 within this family suggests a relationship between the 2 entities. Aldosterone 37-48 renin Homo sapiens 19-24 35095768-2 2021 The possible mechanism includes oxidative stress, endothelial injury, sympathetic excitement, renin-angiotensin-aldosterone system activation, etc. Aldosterone 112-123 renin Homo sapiens 94-99 34906037-2 2022 Recently, the renin-angiotensin-aldosterone system, one of the core stress hormone systems, has been demonstrated to be modified by childhood trauma. Aldosterone 32-43 renin Homo sapiens 14-19 35141300-15 2022 In summary, these data demonstrate an association between a high aldosterone-to-renin ratio and low T50-values in PA. Aldosterone 65-76 renin Homo sapiens 80-85 2666704-3 1989 There was a direct correlation between Na+-Li+ countertransport and renin-angiotensin-aldosterone components in group 2. Aldosterone 86-97 renin Homo sapiens 68-73 34611113-0 2022 Determinants and Mechanisms of the Renin Aldosterone Stress Response. Aldosterone 41-52 renin Homo sapiens 35-40 35086943-8 2022 The aldosterone-renin ratio was inversely associated with type 2 diabetes and several measures of glucose metabolism. Aldosterone 4-15 renin Homo sapiens 16-21 2702097-5 1989 Recent studies suggest that during oedema formation reduced effective circulatory volume triggers changes in various hormonal systems, such as renin-angiotensin-aldosterone, noradrenaline, dopamine, vasopressin, prostaglandins and natriuretic factors, which contribute to sodium and water retention. Aldosterone 161-172 renin Homo sapiens 143-148 2543544-2 1989 Hyporeninemic hypoaldosteronism was disclosed on the basis of a lack of response of plasma renin activity to furosemide administration or tilting with marked hypotension and a subnormal response of aldosterone to furosemide stimulation, tilting, angiotensin II infusion and ACTH administration, as well as increased vascular responsiveness to angiotensin II infusion. Aldosterone 198-209 renin Homo sapiens 4-9 2543546-1 1989 A 54-yr-old woman with the symptoms of primary reninism, i.e. hypertension, metabolic alkalosis and elevated levels of plasma renin activity (PRA) and aldosterone, is described. Aldosterone 151-162 renin Homo sapiens 47-52 2542013-0 1989 Chronobiological evidence for an uncoupling of the Na,K-ATPase to aldosterone in normal renin hypertension. Aldosterone 66-77 renin Homo sapiens 88-93 3154627-0 1988 Adrenal renin: a possible local hormonal regulator of aldosterone production. Aldosterone 54-65 renin Homo sapiens 8-13 3154627-3 1988 The renin-angiotensin system has the highest activity in the zona glomerulosa cells, the site of aldosterone formation. Aldosterone 97-108 renin Homo sapiens 4-9 3154627-6 1988 The adrenal renin angiotensin system may be a local regulator of aldosterone production. Aldosterone 65-76 renin Homo sapiens 12-17 2830077-11 1988 The renin-induced aldosterone response studied in six exchanged patients was consistent with a relative hyperreninemic hypoaldosteronism after repeated PE. Aldosterone 18-29 renin Homo sapiens 4-9 3037891-8 1987 Angiotensin II plays an important role in preserving systemic BP and in preserving the glomerular filtration rate as renal artery pressure and renal blood flow decline; in addition, by stimulating the synthesis of aldosterone, the renin-angiotensin system provides an important role for potassium disposal. Aldosterone 214-225 renin Homo sapiens 231-236 3326892-5 1987 Despite replacement therapy, during follow-up he had an increase in basal plasma renin activity with aldosterone concentration normal. Aldosterone 101-112 renin Homo sapiens 81-86 3104659-7 1987 There were correlations (P less than 0.05) of lethality with plasma renin activity and cortisol levels and correlations (P less than 0.01) of aldosterone concentrations with plasma renin activity and cortisol levels. Aldosterone 142-153 renin Homo sapiens 181-186 3445702-0 1987 [Role of the renin-angiotensin system and prolactin in dopamine-induced secretion of aldosterone]. Aldosterone 85-96 renin Homo sapiens 13-18 2879443-9 1986 The renin-angiotensin system seems to be activated to a somewhat lesser degree by calcium channel blocking agents than it is by nonspecific vasodilators; in addition, these agents interfere with the actions of angiotensin on aldosterone release. Aldosterone 225-236 renin Homo sapiens 4-9 3890783-3 1985 There was a marked increase of plasma renin activity in the patients with the cardiac form and a high circulating aldosterone concentration with the cerebral form of hypertension. Aldosterone 114-125 renin Homo sapiens 38-43 2422494-4 1986 Because of the activation of the renin-angiotensin system, angiotensin-mediated vasoconstriction and aldosterone-mediated sodium retention can be suppressed and, in some individuals, completely blocked by converting enzyme inhibitors. Aldosterone 101-112 renin Homo sapiens 33-38 3886427-5 1985 In this short paper we have analyzed the most probable integrated sequence of responses in neural activity, systemic pressure, and renal renin that lead to escape from high circulating levels of aldosterone. Aldosterone 195-206 renin Homo sapiens 137-142 6388911-1 1984 The interrelationships between the renin-aldosterone system and the sympathetic and dopaminergic activities were studied by measuring the plasma renin activity (PRA), plasma aldosterone concentration (PAC), serum prolactin (PRL) concentration, and 24 hr-urinary excretions of adrenaline (Ad), noradrenaline (NA) and dopamine (DA) in elderly normotensive subjects aged 60 to 90 yrs. Aldosterone 41-52 renin Homo sapiens 35-40 3156142-15 1985 The data suggest that the early aldosterone rise may be secondary to an increase in renin release, but renin cannot account for the sustained postinfusion elevations of aldosterone. Aldosterone 32-43 renin Homo sapiens 84-89 3902239-5 1985 The discrepancy between plasma renin activity and plasma aldosterone levels, which is also found with beta-blockers, could be explained by the following sequence: decreased renin----decreased aldosterone----increased serum potassium----recovery of aldosterone. Aldosterone 57-68 renin Homo sapiens 173-178 6203005-0 1984 Synergic effects of kallikrein-kinin and prostaglandins on renin release on infusion of isolated hog kidney with aldosterone. Aldosterone 113-124 renin Homo sapiens 59-64 6203005-1 1984 The effects of infusion of a large amount of aldosterone into the renal artery of isolated perfused hog kidney on the release of renin, prostaglandins (PG) and kinin and the excretion of urinary kallikrein were investigated. Aldosterone 45-56 renin Homo sapiens 129-134 6203005-3 1984 Infusion of aldosterone and an inhibitor of kallikrein, aprotinin, decreased the releases of renin, PG and kinin and infusion of aldosterone with indomethacin decreased the release of PG but increased that of kinin and urinary kallikrein without significant change in renin releases. Aldosterone 12-23 renin Homo sapiens 93-98 6203005-3 1984 Infusion of aldosterone and an inhibitor of kallikrein, aprotinin, decreased the releases of renin, PG and kinin and infusion of aldosterone with indomethacin decreased the release of PG but increased that of kinin and urinary kallikrein without significant change in renin releases. Aldosterone 12-23 renin Homo sapiens 268-273 2981464-1 1985 The renin-angiotension system is activated in many patients with congestive heart failure (CHF), resulting in angiotensin-mediated vasoconstriction and aldosterone-mediated sodium and water retention. Aldosterone 152-163 renin Homo sapiens 4-9 2984449-1 1985 The authors studied the effect of adrenocorticotropic hormone (ACTH), potassium and plasma renin activity on blood aldosterone in normal subjects as well as in patients with essential hypertension (of a labile and stable course) and hyperaldosteronism (primary and idiopathic). Aldosterone 115-126 renin Homo sapiens 91-96 6086794-3 1984 Treatment with spironolactone has been given before the removal of some of the adenomas studied in vitro, and it can blunt increases in plasma aldosterone concentrations that occur in response to increases in renin activity. Aldosterone 143-154 renin Homo sapiens 209-214 6139188-2 1983 Pharmacological interference with the renin-angiotensin axis in addition to reducing angiotensin-mediated vasoconstriction reduces angiotensin"s effect on aldosterone, alpha-adrenoceptor mediated vasoconstriction and central activation of sympathetic nerve activity. Aldosterone 155-166 renin Homo sapiens 38-43 6357558-3 1983 There is a positive correlation between adrenal renin and aldosterone concentration. Aldosterone 58-69 renin Homo sapiens 48-53 6357558-4 1983 The data suggest that adrenal renin may be a local hormone that plays a role in the regulation of aldosterone production. Aldosterone 98-109 renin Homo sapiens 30-35 6288988-0 1982 19-hydroxyandrostenedione, a new amplifier of the action of aldosterone, in low renin essential hypertension. Aldosterone 60-71 renin Homo sapiens 80-85 6290130-1 1982 Interruption of the renin-aldosterone system with angiotensin-converting enzyme inhibitors (CEI) should result in a low aldosterone secretion, but most investigators have measured aldosterone production only indirectly by plasma aldosterone (PA) levels or urinary metabolites. Aldosterone 26-37 renin Homo sapiens 20-25 6290130-1 1982 Interruption of the renin-aldosterone system with angiotensin-converting enzyme inhibitors (CEI) should result in a low aldosterone secretion, but most investigators have measured aldosterone production only indirectly by plasma aldosterone (PA) levels or urinary metabolites. Aldosterone 120-131 renin Homo sapiens 20-25 6291819-1 1982 To investigate whether changes in aldosterone during antihypertensive treatment would be related to alterations in the renin-angiotensin system or to changes in sodium-fluid balance, 54 essential hypertensives were hospitalized. Aldosterone 34-45 renin Homo sapiens 119-124 6756696-6 1982 Parenteral administration of aldosterone induced a striking fall in all renin components without changing the proportions of active and inactive renin whereas urinary kallikrein excretion increased. Aldosterone 29-40 renin Homo sapiens 72-77 6291819-6 1982 When the renin system is depressed, sodium loss may prevent a large drop in aldosterone levels. Aldosterone 76-87 renin Homo sapiens 9-14 7251214-1 1981 To evaluate the relative influence of changes in plasma renin activity, potassium, ACTH, and sodium concentrations on the secretion of aldosterone, a multifactorial analysis was performed on different sets of investigations in anephric as well as non-nephrectomized patients on regular hemodialysis. Aldosterone 135-146 renin Homo sapiens 56-61 7032916-4 1981 In further evaluation of the hypertension, high plasma renin activity (32.8 ug/l/h) with a high serum aldosterone concentration (13000 pmol/l) was measured. Aldosterone 102-113 renin Homo sapiens 55-60 6266691-7 1981 The plasma renin activity increased from 12.6 +/- 5.0 to 29.9 +/- 8.4 ng/ml/hr (p = 0.030) as plasma aldosterone concentration decreased from 30.5 +/- 6.5 to 11.3 4/- 1.2 ng/dl (p = 0.010) and norepinephrine concentrations decreased from 774 +/- 105 to 618 +/- 85 pg/ml (p = 0.020). Aldosterone 101-112 renin Homo sapiens 11-16 7336779-1 1981 An investigation into the renin-angiotensin-aldosterone system (RAAS) in patients of advanced age with ischaemic heart disease (IHD) and different degrees of atherosclerotic cardiosclerosis by means of radioimmunoassay, which was used to determine the renin activity and the aldosterone concentration in the plasma, showed that there is in IHD an activation of the above regulatory system even under the conditions of relative rest. Aldosterone 44-55 renin Homo sapiens 26-31 7035983-1 1981 The role of the renin-angiotensin system in the control of aldosterone and other mineralocorticoids was studied in 9 hyperkalemic patients with chronic renal failure showing mild azotemia (group I) and 6 normokalemic patients with chronic renal failure showing creatinine clearance similar to that in group I (group II). Aldosterone 59-70 renin Homo sapiens 16-21 7035983-6 1981 These results suggest that suppression of the renin-angiotensin system is probably related to functional disturbance in the conversion from B to 18-OH-B and/or 18-OH-B to aldosterone in most abnormally hyperkalemic patients with chronic renal failure. Aldosterone 171-182 renin Homo sapiens 46-51 6249611-7 1980 The plasma renin aldosterone profile is diagnostically useful in the investigation of salt-wasting disease and can easily distinguish between aldosterone biosynthetic defects and pseudohypoaldosteronism. Aldosterone 17-28 renin Homo sapiens 11-16 7440698-1 1980 The relative importance of ACTH and the renin angiotensin system for control of aldosterone was studied in eight patients with adenomatous primary (APA) and four with idiopathic aldosteronism (IHA). Aldosterone 80-91 renin Homo sapiens 40-45 7009025-12 1980 These results demonstrate a dissociation of renin--aldosterone and prostaglandin E during hypervolaemia and suggest that whereas prostaglandin E may constitute one of the major determinants of renin release clinically and experimentally, these two hormonal systems can be dissociated from each other in response to central volume expansion in man. Aldosterone 50-62 renin Homo sapiens 44-49 6248590-3 1980 The interrelationship between the rhythm components revealed that the circadian cyclicity of aldosterone in both mesor-normotensive and mesor-hypertensive subjects, with either normal or high renin patterns, has a similar timing in acrophase with renin periodicity, which leads the circadian cortisol rhythm. Aldosterone 93-104 renin Homo sapiens 192-197 6992087-4 1980 Furosemide administration also resulted in a significant increase from 4.41 +/- 2.00 to 9.70 +/- 2.32 ng/ml/hr (P less than 0.02) in plasma renin activity, from 1.17 +/- 0.22 to 1.68 +/- 0.36 ng/ml (P less than 0.025) in plasma aldosterone, from 0.93 +/- 0.16 to 1.53 +/- 0.35 microgram/12 hr (P less than 0.025) in urinary aldosterone, from 17.53 +/- 3.37 to 23.73 +/- 3.16 ng/12 hr (P less than 0.025) in prostaglandin E, and from 16.48 +/- 4.12 to 26.27 +/- 4.12 ng/12 hr (P less than 0.05) in prostaglandin F2 alpha. Aldosterone 228-239 renin Homo sapiens 140-145 6992087-4 1980 Furosemide administration also resulted in a significant increase from 4.41 +/- 2.00 to 9.70 +/- 2.32 ng/ml/hr (P less than 0.02) in plasma renin activity, from 1.17 +/- 0.22 to 1.68 +/- 0.36 ng/ml (P less than 0.025) in plasma aldosterone, from 0.93 +/- 0.16 to 1.53 +/- 0.35 microgram/12 hr (P less than 0.025) in urinary aldosterone, from 17.53 +/- 3.37 to 23.73 +/- 3.16 ng/12 hr (P less than 0.025) in prostaglandin E, and from 16.48 +/- 4.12 to 26.27 +/- 4.12 ng/12 hr (P less than 0.05) in prostaglandin F2 alpha. Aldosterone 324-335 renin Homo sapiens 140-145 6248590-3 1980 The interrelationship between the rhythm components revealed that the circadian cyclicity of aldosterone in both mesor-normotensive and mesor-hypertensive subjects, with either normal or high renin patterns, has a similar timing in acrophase with renin periodicity, which leads the circadian cortisol rhythm. Aldosterone 93-104 renin Homo sapiens 247-252 6248590-4 1980 In low-renin mesorhypertensive subjects a circadian rhythm of aldosterone and cortisol, but not of renin, remains demonstrable. Aldosterone 62-73 renin Homo sapiens 7-12 511974-3 1979 The aldosterone MCRs in these patients increased by 41% in response to minoxidil, from 1110 +/- 91 to 1570 +/- 180 (SEM) liters/day; this appeared to explain why plasma aldosterone levels did not increase in parallel with renin activity. Aldosterone 4-15 renin Homo sapiens 222-227 443256-4 1979 Plasma ALDO concentration was positively correlated with plasma renin (p less than 0.001) but not with serum sodium, potassium or albumin concentration, inferior vena cava pressure, corrected hepatic venous wedge pressure, plasma volume or sulfobromophthalein storage or transport. Aldosterone 7-11 renin Homo sapiens 64-69 400731-2 1978 Both saralasin, an angiotensin II antagonist, and SQ 20881, a converting enzyme inhibitor, induced a dose-related decrease in plasma aldosterone levels when the renin-angiotensin system was activated by restriction of sodium intake. Aldosterone 133-144 renin Homo sapiens 161-166 378492-5 1979 Renin studies performed in 34 hypertensive patients and in a control group of 11 recipients showed that elevation of plasma renin activity and of plasma aldosterone level is frequent but difficult to interpret, particularly when a renal artery stenosis is observed. Aldosterone 153-164 renin Homo sapiens 0-5 517244-1 1979 The present study was done to investigate the interrelationships between renal kallikrein-kinin, renal prostaglandin E and renin-angiotensin-aldosterone systems in normal subjects and in essential hypertension by means of measuring urinary excretion of kallikrein and prostaglandin E, plasma renin activity and plasma aldosterone concentration before and after stimulation or inhibition of the renin-angiotensin-aldosterone system and inhibition of renal prostaglandin E generation. Aldosterone 141-152 renin Homo sapiens 123-128 517244-2 1979 Urinary kallikrein excretion was increased after the stimulation of the renin-angiotensin-aldosterone system by low Na diet or the administration of furosemide and upright posture, while it decreased after the inhibition of the action of aldosterone by spironolactone. Aldosterone 90-101 renin Homo sapiens 72-77 638442-1 1978 The renin-angiotensin system, ACTH and hyperkalaemia are known to induce increased plasma levels of aldosterone. Aldosterone 100-111 renin Homo sapiens 4-9 688983-1 1978 In a hyperkalemic patient with stable chronic renal failure and suppression of the renin-angiotensin-aldosterone system intravenous infusion of hypertonic glucose induced a paradoxical transitory rise in serum potassium accompanied by a similar change in plasma aldosterone. Aldosterone 101-112 renin Homo sapiens 83-88 639332-7 1978 Many factors may be involved in the increased activation of the renin-angiotensin-aldosterone system: low blood pressure, hypersensitivity of the macula densa to catecholamines, relative insensitivity of the immature kidney to aldosterone, hyperkalaemia and other control mechanisms for aldosterone secretion all of which probably operate simultaneously during the first days of life. Aldosterone 82-93 renin Homo sapiens 64-69 750607-1 1978 Previous studies from this laboratory have demonstrated that the redistribution of blood volume and concomitant central hypervolemia induced by water immersion to the neck (NI), produces a prompt and profound suppression of plasma renin activity (PRA) and plasma aldosterone concentration (PA) without concomitant alterations in serum sodium and potassium concentrations. Aldosterone 263-274 renin Homo sapiens 231-236 366278-2 1978 "The present results indicate that there is a close relationship between the incretory function of the kidney, which is shown by the discharge of renin and similar materials, and the function of the adrenal cortex, especially the zona glomerulosa, which is the place of production of the sodium-retaining hormone aldosterone . Aldosterone 313-324 renin Homo sapiens 146-151 366278-5 1978 ... "Under these conditions the development of experimental renal hypertension could be explained as follows: the narrowing of the renal artery stimulates the secretion of renin which itself increases the formation or discharge of mineralocorticoid hormones (aldosterone or similarly acting corticoids). Aldosterone 259-270 renin Homo sapiens 172-177 1014711-11 1976 In 3 out of 7 patients with low-renin hypertension and high rectal P.D., plasma and urinary aldosterone were consistently suppressed. Aldosterone 92-103 renin Homo sapiens 32-37 874059-6 1977 These data support the concept that in the salt depleted state the renin-angiotensin system and potassium are equally important in the acute regulation of plasma levels of aldosterone. Aldosterone 172-183 renin Homo sapiens 67-72 998518-11 1976 Thus, the antirenin effect of clonidine enhances its antihypertensive action not only by acutely ablating renin-angiotensin pressor mechanisms, but also by inhibiting aldosterone production and thereby minimizing longer-term reactive volume retention during treatment. Aldosterone 167-178 renin Homo sapiens 14-19 773568-6 1976 Despite the disparity in the magnitude of these increases, significant correlations were identified between all four of the measured parameters, indicating a major role of the renin-angiotensin system in regulating aldosterone output in response to volume and posture-related stimuli. Aldosterone 215-226 renin Homo sapiens 176-181 943925-5 1976 Hypertensive children with low and high plasma renin activity were found to have an inappropriately high level of urinary aldosterone excretion in relation to urinary sodium excretion. Aldosterone 122-133 renin Homo sapiens 47-52 1262441-9 1976 We have concluded that the maintenance of plasma aldosterone in low-renin essential hypertension reflects sustained aldosterone secretion despite suppression of plasma renin activity, rather than reduced aldosterone metabolism. Aldosterone 49-60 renin Homo sapiens 68-73 1019166-3 1976 They also emphasize the importance of the renin-angiotensin system in the control of aldosterone in sodium depletion and in renal hypertension. Aldosterone 85-96 renin Homo sapiens 42-47 4362565-0 1974 Plasma renin concentration: comparison of angiotensinase inhibitors and correlation with plasma renin activity and aldosterone. Aldosterone 115-126 renin Homo sapiens 7-12 1192688-11 1975 In the tetraplegic patients, there was a late rise in plasma aldosterone which was probably due to the elevation in plasma renin activity. Aldosterone 61-72 renin Homo sapiens 123-128 166231-6 1975 These results demonstrate the complementary roles of circulating renin and potassium in the control of aldosterone release under basal and stimulatory conditions in patients with terminal renal failure. Aldosterone 103-114 renin Homo sapiens 65-70 211313-3 1975 Following a 9-month therapy with spironolactone episodic secretion of aldosterone and the significant correlation between aldosterone and cortisol persisted (r=0.819, p less than 0.001) in the presence of an abnormally high plasma renin activity. Aldosterone 70-81 renin Homo sapiens 231-236 211313-3 1975 Following a 9-month therapy with spironolactone episodic secretion of aldosterone and the significant correlation between aldosterone and cortisol persisted (r=0.819, p less than 0.001) in the presence of an abnormally high plasma renin activity. Aldosterone 122-133 renin Homo sapiens 231-236 211313-4 1975 First when the secretion of ACTH was suppressed by dexamethasone a weak correlation was found between renin activity and aldosterone (r=0.517, p is less than 0.05). Aldosterone 121-132 renin Homo sapiens 102-107 4312097-0 1969 The role of the renin-angiotensin system in the control of aldosterone in man. Aldosterone 59-70 renin Homo sapiens 16-21 4366233-0 1972 The role of the renin-angiotensin system in the aldosterone response to acute hemorrhage. Aldosterone 48-59 renin Homo sapiens 16-21 4330533-0 1971 Role of the renin angiotensin system on the biosynthesis of aldosterone. Aldosterone 60-71 renin Homo sapiens 12-17 33280043-0 2021 Title: Effect of increased potassium intake on the renin-angiotensin-aldosterone system and subcutaneous resistance arteries: a randomized crossover study. Aldosterone 69-80 renin Homo sapiens 51-56 5787986-0 1969 Renin-aldosterone system in Parkinson"s disease. Aldosterone 6-17 renin Homo sapiens 0-5 14453776-0 1962 The effect of ACTH, renin, angiotensin II, and various precursors on biosynthesis of aldosterone by adrenal slices. Aldosterone 85-96 renin Homo sapiens 20-25 33757646-0 2021 Use of renin-angiotensin-aldosterone system blockade in controversial chronic kidney disease populations. Aldosterone 25-36 renin Homo sapiens 7-12 33757646-1 2021 Renin-angiotensin-aldosterone system blockers have shown to be effective in controlling blood pressure and proteinuria, slowing the progression to end stage renal disease and reducing cardiovascular risk, so they are the mainstream treatment of hypertension in chronic kidney disease. Aldosterone 18-29 renin Homo sapiens 0-5 33757646-4 2021 The aim of the present review is to collect available published data on the effect of renin-angiotensin-aldosterone system blockers in some controversial populations and provide perspective on future research areas in this field. Aldosterone 104-115 renin Homo sapiens 86-91 33982185-5 2021 OCPIH and HDP share common risk factors such as age, BMI, past personal and family history of hypertension, as well as pathogenic mechanisms, including alterations in hormonal metabolism and the renin angiotensin aldosterone system; imbalance of vasodilator-vasoconstrictor compounds; and changes in the cardiovascular system. Aldosterone 213-224 renin Homo sapiens 195-200 34013966-7 2021 In MCI compared to controls, a greater increase in the TIS of renin angiotensin-aldosterone system blockers (0.05; 95% CI (0.02, 0.07); P<0.001) and calcium channel blockers (0.03; 95% CI (0.00, 0.05);p=0.031) , and in the number of antihypertensive medications (0.11, 95% CI (0.02, 0.19);P=0.016) was observed. Aldosterone 80-91 renin Homo sapiens 62-67 34008000-1 2021 CONTEXT: The aldosterone-to-renin ratio (ARR) is the guideline-recommended screening test for primary aldosteronism. Aldosterone 13-24 renin Homo sapiens 28-33 34054559-1 2021 Primary aldosteronism (PA) is a potentially curable form of secondary hypertension caused by excessive renin-independent aldosterone secretion, leading to increased target organ damage and cardiovascular morbidity and mortality. Aldosterone 121-132 renin Homo sapiens 103-108 34054559-3 2021 Various antihypertensive drug classes interfere with the renin-angiotensin-aldosterone axis and hence evaluation for PA should ideally be performed off-drugs. Aldosterone 75-86 renin Homo sapiens 57-62 34040531-0 2021 Assessment of Anti-Hypertensive Drug Adherence by Serial Aldosterone-To-Renin Ratio Measurement. Aldosterone 57-68 renin Homo sapiens 72-77 33497697-9 2021 CONCLUSIONS: Renin-angiotensin-aldosterone blockade therapy prescription and dose varied by comorbidity status, but betaB therapy did not. Aldosterone 31-42 renin Homo sapiens 13-18 33320784-1 2021 RATIONALE: The Renin-Angiotensin-Aldosterone-System is a major pathway in regulating blood pressure, glomerular filtration, and fluid homeostasis. Aldosterone 33-44 renin Homo sapiens 15-20 33831673-5 2021 Patients with a high pre-treatment aldosterone-to-renin ratio of more than 603 and a large post-treatment pulse pressure of more than 49 mmHg showed approximately three-fold higher hazard ratios for cardiovascular events risk compared to those with a lower aldosterone-to-renin ratio and smaller pulse pressure. Aldosterone 35-46 renin Homo sapiens 50-55 33416889-5 2021 Paricalcitol treatment reduced renal collagen I and renal interstitial fibrosis by decreasing the activation of the renin-angiotensin-aldosterone system through renal changes in renin, ATR1 and ATR2 mRNAs levels and renal inflammation by decreasing renal inflammatory leukocytes (CD45), ADAM17 mRNA, TGF-beta mRNA and protein and maintaining E-cadherin mRNA levels. Aldosterone 134-145 renin Homo sapiens 116-121 33853742-2 2021 RESULTS: Of the 7594 participants, 8.12% (n = 617) with plasma aldosterone-renin ratio >=3.7 were possible PA cases. Aldosterone 63-74 renin Homo sapiens 75-80 33853742-3 2021 Three hundred sixty-seven cases with plasma aldosterone-renin ratio >=3.7 and plasma aldosterone concentration >=10 ng/dL were confirmed using the recumbent saline infusion test (69.20%, 182 of 263) or the captopril challenge test (66.5%, 69 of 104, P > .05). Aldosterone 44-55 renin Homo sapiens 56-61 34018367-5 2021 In patients with suspected PA, the correlation coefficients of renin, aldosterone and aldosterone-to-renin ratio (ARR) assessed by CLIA and RIA were 0.901, 0.861 and 0.847 respectively (all P<0.001). Aldosterone 86-97 renin Homo sapiens 101-106 33416889-1 2021 BACKGROUND: In chronic kidney Disease (CKD) the activation of the renin-angiotensin-aldosterone system and renal inflammation stimulate renal fibrosis and the progression to end-stage renal disease. Aldosterone 84-95 renin Homo sapiens 66-71 33416889-4 2021 RESULTS: CRF increased the activation of the renin-angiotensin-aldosterone system, renal inflammation and interstitial fibrosis. Aldosterone 63-74 renin Homo sapiens 45-50 33957242-1 2021 BACKGROUND: The renin-angiotensin-aldosterone system plays a key role in blood pressure (BP) regulation and is the target of several anti-hypertensive medications. Aldosterone 34-45 renin Homo sapiens 16-21 33053160-4 2021 The systematic screening protocol included 24h urine collection on usual diet and avoidance of renin-angiotensin-aldosterone system-confounding medications. Aldosterone 113-124 renin Homo sapiens 95-100 33350096-0 2021 SARS-CoV-2 effects on the renin-angiotensin-aldosterone system, therapeutic implications. Aldosterone 44-55 renin Homo sapiens 26-31 33847830-6 2021 In patients with cardiovascular indications of renin-angiotensin-aldosterone system inhibition, given the well-described benefits in diabetic and proteinuric patients, it is reasonable to consider the use of renin-angiotensin-aldosterone system inhibitors. Aldosterone 65-76 renin Homo sapiens 47-52 33785905-0 2022 Aldosterone-producing adenoma associated with non-suppressed renin: a case series. Aldosterone 0-11 renin Homo sapiens 61-66 33539316-0 2021 Renin-Angiotensin-Aldosterone System peptide profiles in patients with COVID-19. Aldosterone 18-29 renin Homo sapiens 0-5 33544567-0 2021 Epicardial, pericardial fat and glucagon-like peptide-1 and 2 receptors expression in stable patients with multivessel coronary artery disease: an association with renin-angiotensin-aldosterone. Aldosterone 182-193 renin Homo sapiens 164-169 33742751-0 2021 Dipeptidyl peptidase-3, a marker of the antagonist pathway of the renin-angiotensin-aldosterone system in patients with heart failure. Aldosterone 84-95 renin Homo sapiens 66-71 32734004-4 2019 These peptides act on kidney tubules via the renin angiotensin aldosterone system. Aldosterone 63-74 renin Homo sapiens 45-50 33724426-5 2021 Additionally, the effect of COVID-19 on the renin-angiotensin-aldosterone system is reviewed with a focus on hypokalemic presentations. Aldosterone 62-73 renin Homo sapiens 44-49 33544293-0 2021 Clinical outcome of renin-angiotensin-aldosterone system blockers in treatment of hypertensive patients with COVID-19: a systematic review and meta-analysis. Aldosterone 38-49 renin Homo sapiens 20-25 32787515-0 2021 Treatment of Renin-Angiotensin-Aldosterone System Dysfunction With Angiotensin II in High-Renin Septic Shock. Aldosterone 31-42 renin Homo sapiens 13-18 32787515-0 2021 Treatment of Renin-Angiotensin-Aldosterone System Dysfunction With Angiotensin II in High-Renin Septic Shock. Aldosterone 31-42 renin Homo sapiens 90-95 33686368-3 2021 Case presentation: Two young female with typical manifestations of reninoma, including hypertension, hypokalemia, high renin, high aldosterone and normal ARR, were treated successfully with real-time contrast-enhanced ultrasound guided radiofrequency ablation, and contrast-enhanced ultrasound was also performed before and after treatment for diagnosis and postoperative assessment. Aldosterone 131-142 renin Homo sapiens 67-72 33605160-11 2021 Conclusions: Suppressed renin activity and higher aldosterone:renin ratios were associated with both higher SBP and DBP in the office and during the awake and asleep periods as evidenced by ABPM. Aldosterone 50-61 renin Homo sapiens 62-67 33568342-14 2021 The heterogeneity between studies assessing acute kidney injury and hyperkalaemia events was reduced when focusing on drugs that affect the renin angiotensin-aldosterone system. Aldosterone 158-169 renin Homo sapiens 140-145 33544293-4 2021 MAIN BODY: Aiming to show clinical outcome of renin-angiotensin-aldosterone system blockers in hospital treatment of hypertensive patients with coronavirus disease 2019, systematically searched literatures through five databases were intensively appraised using The Grading of Recommendations Assessment, Development and Evaluation checklists for cohort studies. Aldosterone 64-75 renin Homo sapiens 46-51 33460525-2 2021 The aldosterone-to-renin ratio (ARR) is a common screening test for primary aldosteronism in hypertensives. Aldosterone 4-15 renin Homo sapiens 19-24 33525896-6 2021 Further workup showed a high aldosterone level and aldosterone-to-renin ratio. Aldosterone 51-62 renin Homo sapiens 66-71 32868642-10 2021 A negative correlation was observed between MEEi and aldosterone levels (r = -0.203, P < 0.05) and aldosterone : renin ratio (P = -0.172, P < 0.05); the correlation remained significant after adjustment for possible confounders. Aldosterone 99-110 renin Homo sapiens 113-118 33546058-8 2021 LESSONS: We presumed that MSK may be associated with secondary hypertension, and the mechanism may be the activation of the renin-angiotensin-aldosterone system. Aldosterone 142-153 renin Homo sapiens 124-129 33495193-5 2021 Further evaluation revealed an elevated aldosterone renin ratio suggestive of primary hyperaldosteronism which was localised to left adrenal adenoma on contrast-enhanced CT. Aldosterone 40-51 renin Homo sapiens 52-57 33401654-5 2021 Others, such as retinoic acid, renin-angiotensin-aldosterone system, TLR2 (Toll-like receptor 2) and leptin, are also important in this process. Aldosterone 49-60 renin Homo sapiens 31-36 32635757-4 2021 PA with RAS patients had lower mean orthostatic aldosterone-to-renin ratios (38.4 +- 41.4 ng dL-1/ng mL-1 h-1 vs. 87.4.4 +- 38.4 ng dL-1/ng mL-1 h-1, respectively; p < .01) and a higher false-negative rate (50% vs. 15%, respectively; p < .05) compared with controls. Aldosterone 48-59 renin Homo sapiens 63-68 33171402-0 2021 Interrelationship between renin-angiotensin-aldosterone system and oxidative stress in chronic heart failure patients with or without renal impairment. Aldosterone 44-55 renin Homo sapiens 26-31 33095646-0 2021 Increased Pulse Wave Velocity in Persons with Spinal Cord Injury: The Effect of the Renin-Angiotensin-Aldosterone System. Aldosterone 102-113 renin Homo sapiens 84-89 33268573-6 2021 The APA group showed significantly higher plasma aldosterone concentration (PAC) and aldosterone to renin rate (ARR) than the BHA group. Aldosterone 85-96 renin Homo sapiens 100-105 33000146-7 2021 RESULTS: Renin-independent aldosterone secretion increased in response to several aberrant stimuli (upright posture, GnRH) in up to 83% of patients with APA or BAH in whom ACTH 1-24 and HT4R agonists also produced aldosterone over-secretion in all patients. Aldosterone 27-38 renin Homo sapiens 9-14 33000146-7 2021 RESULTS: Renin-independent aldosterone secretion increased in response to several aberrant stimuli (upright posture, GnRH) in up to 83% of patients with APA or BAH in whom ACTH 1-24 and HT4R agonists also produced aldosterone over-secretion in all patients. Aldosterone 214-225 renin Homo sapiens 9-14 33329934-2 2020 Direct viral toxicity, pro-inflammatory and pro-thrombotic induction, endothelial damage, immune imbalance, and dysregulation of the renin-angiotensin-aldosterone system are the mechanisms underlying the viral potential of multiple organ damage. Aldosterone 151-162 renin Homo sapiens 133-138 32801297-3 2021 Hypoxemia and hypercapnia, induced by repeated collapses of upper airways, have been suggested to trigger a cascade of events such as activation of the sympathetic tone, renin-angiotensin-aldosterone system leading to endothelial dysfunction, vasoconstriction, myocardial and vascular remodeling, and hypertension. Aldosterone 188-199 renin Homo sapiens 170-175 33749373-6 2021 In both patients, a typical biological profile of PA was demonstrated that included hypokalemia with kaliuresis, elevated plasma aldosterone concentration (PAC), suppressed plasma renin concentration, and a high aldosterone-to-renin ratio. Aldosterone 212-223 renin Homo sapiens 227-232 33615069-8 2021 Prescription of renin-angiotensin aldosterone system inhibitors ranged from 52% in the United States to 81% in Germany. Aldosterone 34-45 renin Homo sapiens 16-21 32738257-1 2020 A role for the renin-angiotensin-aldosterone-system in Severe Acute Respiratory Syndrome-Coronavirus-2 infection and in the development of COronaVIrus Disease-19 disease has generated remarkable concerns among physicians and patients. Aldosterone 33-44 renin Homo sapiens 15-20 32738257-2 2020 Even though a suggestive pathophysiological link between renin-angiotensin-aldosterone-system and the virus has been proposed, its pathogenic role remains very difficult to be defined. Aldosterone 75-86 renin Homo sapiens 57-62 32738257-3 2020 Although COronaVIrus Disease-19 targets preferentially older people with high prevalence of hypertension and extensive use of renin-angiotensin-aldosterone-system inhibitors, an independent role for hypertension and its therapies is not defined. Aldosterone 144-155 renin Homo sapiens 126-131 32738257-6 2020 Consequently, we conclude that treatment with renin-angiotensin-aldosterone-system inhibitors should not be discontinued and, therefore, these therapies should not be interrupted. Aldosterone 64-75 renin Homo sapiens 46-51 31997551-14 2020 Conversely, older age and the use of renin-angiotensin aldosterone system blockades were associated with decreased risks for rapid CKD progression and incidence CKD stage 5 or dialysis. Aldosterone 43-66 renin Homo sapiens 37-42 33471733-2 2020 Screening for PA should ideally be conducted after stopping medications that might interfere with the renin-angiotensin-aldosterone system, but this is challenging in patients with recalcitrant hypertension or hypokalemia. Aldosterone 120-131 renin Homo sapiens 102-107 32865201-5 2020 INTERPRETATION OF EVIDENCE: Renin-independent aldosterone production is a prevalent phenotype that is diagnosed as primary aldosteronism when severe in magnitude, but is largely unrecognized when milder in severity. Aldosterone 46-57 renin Homo sapiens 28-33 32865201-6 2020 Renin-independent aldosterone production can be detected in normotensive and hypertensive individuals, and the magnitude of this biochemical phenotype parallels the magnitude of blood pressure elevation, the risk for incident hypertension and cardiovascular disease, and the likelihood and magnitude of blood pressure reduction with mineralocorticoid receptor antagonist therapy. Aldosterone 18-29 renin Homo sapiens 0-5 32865201-8 2020 CONCLUSIONS: The landscape of primary aldosteronism has evolved to recognize that it is a prevalent syndrome of renin-independent aldosterone production that contributes to the pathogenesis of hypertension and cardiovascular disease. Aldosterone 130-141 renin Homo sapiens 112-117 33256676-1 2020 BACKGROUND: Plasma aldosterone-to-renin ratio (ARR) is popularly used for screening primary aldosteronism (PA). Aldosterone 19-30 renin Homo sapiens 34-39 33381672-7 2021 This may have stimulated the renin-angiotensin-aldosterone system. Aldosterone 47-58 renin Homo sapiens 29-34 32612066-0 2020 Effects of dapagliflozin on renin-angiotensin-aldosterone system under renin-angiotensin system inhibitor administration. Aldosterone 46-57 renin Homo sapiens 28-33 32612066-0 2020 Effects of dapagliflozin on renin-angiotensin-aldosterone system under renin-angiotensin system inhibitor administration. Aldosterone 46-57 renin Homo sapiens 71-76 33346481-0 2020 [Dynamic changes of renin-angiotensin-aldosterone system parameters after surgery of primary hyperparathyroidism]. Aldosterone 38-49 renin Homo sapiens 20-25 33256138-1 2020 The purpose of this study was to investigate the function of the renin-angiotensin-aldosterone system (RAAS) in normal tension glaucoma (NTG) patients by measuring the level of renin and angiotensin II (AngII) in the plasma. Aldosterone 83-94 renin Homo sapiens 65-70 33188272-0 2020 Aldosterone-to-renin ratio is related to arterial stiffness when the screening criteria of primary aldosteronism are not met. Aldosterone 0-11 renin Homo sapiens 15-20 32818224-5 2020 After adrenalectomy, the increase in FMD and NID were significantly correlated with the decrease in PAC and the decrease in aldosterone-renin ratio. Aldosterone 124-135 renin Homo sapiens 136-141 32846037-3 2020 In conditions where the renin-angiotensin aldosterone system (RAAS) is chronically challenged, the renin-producing cells increase significantly in number and their localization expands from a juxtaglomerular position to a widespread distribution upstream the afferent glomerular arterioles and to extraglomerular mesangial cells. Aldosterone 42-53 renin Homo sapiens 24-29 33328060-4 2020 Vasodilation also results in activation of the renin-angiotensin-aldosterone axis, which combined with changing tubular handling causes alterations in total body stores of electrolytes and total body water, resulting in a lower serum sodium concentration. Aldosterone 65-76 renin Homo sapiens 47-52 32985236-5 2020 Aldosterone secretion further contributes to distal Na+ reabsorption in CKD and is not only mediated by renin and potassium, but also by metabolic acidosis, endothelin-1, and vasopressin. Aldosterone 0-11 renin Homo sapiens 104-109 32458054-10 2020 The composite endpoint group was elderly and had higher ejection fraction, lower hemoglobin, and less used beta blockers, and renin angiotensin aldosterone system inhibitors. Aldosterone 144-155 renin Homo sapiens 126-131 32744913-5 2020 ABBREVIATIONS: ACE: angiotensin-converting enzyme; ESKD: end-stage kidney disease; FSGS: focal segmental glomerulosclerosis; RAAS: renin aldosterone angiotensin system. Aldosterone 137-148 renin Homo sapiens 131-136 32853347-0 2020 Determinants of Maternal Renin-Angiotensin-Aldosterone-System Activation in Early Pregnancy: Insights From Two Cohorts. Aldosterone 43-54 renin Homo sapiens 25-30 32853347-2 2020 It may thus contribute to the renin-angiotensin-aldosterone-system (RAAS) activation that is required for maternal adaptation in pregnancy. Aldosterone 48-59 renin Homo sapiens 30-35 32951351-0 2020 COVID-19, hypertension, and renin-angiotensin-aldosterone system inhibitors: Much ado about nothing or real problem to be solved? Aldosterone 46-57 renin Homo sapiens 28-33 33017655-0 2020 Renin-aldosterone system evaluation over four decades in an extended family with autosomal dominant pseudohypoaldosteronism due to a deletion in the NR3C2 gene. Aldosterone 6-17 renin Homo sapiens 0-5 33350197-11 2020 We obtained 21 key targets, 154 signal pathways, and 382 biological processes in topological, GO, and KEGG enrichment analysis of the protein interaction network, and in the comprehensive analysis, it was found that Zuomua Decoction could reduce blood pressure by regulating renin angiotension aldosterone system, balancing the concentration of intracellular calcium and sodium ions and regulating vasoconstriction and relaxation. Aldosterone 294-305 renin Homo sapiens 275-280 33254538-8 2020 We hypothesize that overreaction of the renin-angiotensin-aldosterone may account for the myriad of unusual biochemical and clinical abnormalities noted in patients infected with SARS-CoV-2. Aldosterone 58-69 renin Homo sapiens 40-45 32717198-0 2020 An Overview of the Classical and Tissue-derived Renin-Angiotensin-Aldosterone System and its Genetic Polymorphisms in Essential Hypertension. Aldosterone 66-77 renin Homo sapiens 48-53 33130795-13 2020 In the treatment, according to the literature, a drug blocking the renin-angiotensin-aldosterone-enalapril system was used, which normalized blood pressure. Aldosterone 85-96 renin Homo sapiens 67-72 32928982-0 2020 Heartbeat: interaction of renin-angiotensin-aldosterone blocking drugs with COVID-19 disease susceptibility and severity. Aldosterone 44-55 renin Homo sapiens 26-31 32931196-12 2020 Prospective research is warranted to determine the utility of angiotensin II and to better understand it effects on the dysfunctional renin-angiotensin-aldosterone system during vasoplegic shock. Aldosterone 152-163 renin Homo sapiens 134-139 32558211-5 2020 We explore potential interactions between antidiabetic medications and renin-angiotensin-aldosterone system inhibitors with COVID-19. Aldosterone 89-100 renin Homo sapiens 71-76 33434178-13 2020 WS is a disease with a high frequency of hypertension but the renin-aldosterone system in WS cases has not been studied at all. Aldosterone 68-79 renin Homo sapiens 62-67 32926258-6 2020 Chronic kidney disease may predispose to the development of preeclampsia due to comorbid conditions, such as hypertension, but is also associated with impaired glycocalyx integrity and alterations in the complement and renin-angiotensin-aldosterone systems. Aldosterone 237-248 renin Homo sapiens 219-224 33082849-4 2020 Angiotensin converting enzyme-2 (ACE-2) mediated cellular entry of SARS-Cov2 leads to receptor shedding of ACE-2 and disrupts the renin angiotensin aldosterone axis (RAAS). Aldosterone 148-159 renin Homo sapiens 130-135 32893333-0 2020 The Role of the Renin-Angiotensin-Aldosterone System in Preeclampsia: a Review. Aldosterone 34-45 renin Homo sapiens 16-21 32306417-0 2020 Age and sex-specific reference ranges are needed for the Aldosterone/Renin Ratio. Aldosterone 57-68 renin Homo sapiens 69-74 33471699-6 2020 Aldosterone-renin ratio was significantly higher in the MRA group (median, 375.0; interquartile range [IQR], 224.8 to 544.3 vs. 148.7, 118.4 to 192.1; P = .034). Aldosterone 0-11 renin Homo sapiens 12-17 32671399-0 2020 Outcomes of renin-angiotensin-aldosterone system blockers in patients with COVID-19: a systematic review and meta-analysis. Aldosterone 30-41 renin Homo sapiens 12-17 32908690-0 2020 High Efficiency and Problems of Chemiluminescence Assay-Detected Aldosterone-To-Renin Ratio in Practical Primary Aldosteronism Screening. Aldosterone 65-76 renin Homo sapiens 80-85 32908690-3 2020 In the previous retrospective study, we obtained the optimal cutoff value of aldosterone-to-renin ratio detected by chemiluminescence assay, a newly developing method, and prompted its high efficiency in primary aldosteronism screening in upright position. Aldosterone 77-88 renin Homo sapiens 92-97 32908690-9 2020 False negative rate can be improved by combining the aldosterone-to-renin ratio with aldosterone concentration. Aldosterone 53-64 renin Homo sapiens 68-73 32908690-12 2020 Although it has some shortcomings, chemiluminescence assay-detected aldosterone-to-renin ratio is a highly effective index for screening primary aldosteronism in practice. Aldosterone 68-79 renin Homo sapiens 83-88 32813674-1 2020 As part of the extended renin-angiotensin-aldosterone system, active renin and its precursor prorenin have been an area of research interest for decades. Aldosterone 42-53 renin Homo sapiens 24-29 32973674-1 2020 The renin-angiotensin-aldosterone system (RAAS) is the regulatory system by which renin induces aldosterone production. Aldosterone 22-33 renin Homo sapiens 4-9 32973674-1 2020 The renin-angiotensin-aldosterone system (RAAS) is the regulatory system by which renin induces aldosterone production. Aldosterone 96-107 renin Homo sapiens 4-9 33194862-11 2020 LEARNING POINTS: Polycythemia can cause erythromelalgia, which should be treated with aspirin.Primary aldosteronism causes secondary erythropoiesis through activation of the renin-aldosterone system, but the mechanism is not clear.Erythropoiesis may be promoted by concurrent primary aldosteronism and polycythemia vera, resulting in secondary erythromelalgia. Aldosterone 180-191 renin Homo sapiens 174-179 32786343-1 2020 Immune system and renin-angiotensin-aldosterone system dysregulation with associated cytokine release syndrome may be a key feature of early stage of SARS-CoV-2 organotropism and infection. Aldosterone 36-47 renin Homo sapiens 18-23 32874109-3 2020 Moreover, the renin angiotensin-aldosterone system is activated in the luteal phase in rest. Aldosterone 32-43 renin Homo sapiens 14-19 32874109-12 2020 The results of our study suggested that increased activity of the renin-angiotensin-aldosterone system in the luteal phase of the menstrual cycle might be further activated during exercise. Aldosterone 84-95 renin Homo sapiens 66-71 32923203-6 2020 The patient was found to have an aldosterone-producing adenoma based on an elevated aldosterone-to-renin ratio and was started on a mineralocorticoid antagonist. Aldosterone 33-44 renin Homo sapiens 99-104 32923203-6 2020 The patient was found to have an aldosterone-producing adenoma based on an elevated aldosterone-to-renin ratio and was started on a mineralocorticoid antagonist. Aldosterone 84-95 renin Homo sapiens 99-104 32564695-3 2020 Strong independent positive relations between age and stroke volume or peak aortic Q were noted (P<0.0001), effects associated with ventricular end diastolic volume and aldosterone-to-renin ratios. Aldosterone 169-180 renin Homo sapiens 184-189 32348783-0 2020 Hyperinflammation and derangement of renin-angiotensin-aldosterone system in COVID-19: A novel hypothesis for clinically suspected hypercoagulopathy and microvascular immunothrombosis. Aldosterone 55-66 renin Homo sapiens 37-42 32736558-13 2020 The plasma aldosterone/renin ratio was elevated because of suppressed plasma renin and elevated serum aldosterone levels. Aldosterone 11-22 renin Homo sapiens 77-82 32736558-13 2020 The plasma aldosterone/renin ratio was elevated because of suppressed plasma renin and elevated serum aldosterone levels. Aldosterone 102-113 renin Homo sapiens 23-28 32635768-12 2020 CONCLUSIONS: Higher diuretic efficiency in black patients with acute heart failure may be related to racial differences in activity of the renin-angiotensin-aldosterone system. Aldosterone 157-168 renin Homo sapiens 139-144 32449886-2 2020 BACKGROUND: Primary aldosteronism is a nonsuppressible renin-independent aldosterone production that causes hypertension and cardiovascular disease. Aldosterone 73-84 renin Homo sapiens 55-60 32449886-3 2020 OBJECTIVE: To characterize the prevalence of nonsuppressible renin-independent aldosterone production, as well as biochemically overt primary aldosteronism, in relation to blood pressure. Aldosterone 79-90 renin Homo sapiens 61-66 32449886-7 2020 MEASUREMENTS: Participants completed an oral sodium suppression test, regardless of aldosterone or renin levels, as a confirmatory diagnostic for primary aldosteronism and to quantify the magnitude of renin-independent aldosterone production. Aldosterone 219-230 renin Homo sapiens 201-206 32449886-8 2020 Urinary aldosterone was measured in participants in high sodium balance with suppressed renin activity. Aldosterone 8-19 renin Homo sapiens 88-93 32449886-9 2020 Biochemically overt primary aldosteronism was diagnosed when urinary aldosterone levels were higher than 12 microg/24 h. RESULTS: Every blood pressure category had a continuum of renin-independent aldosterone production, where greater severity of production was associated with higher blood pressure, kaliuresis, and lower serum potassium levels. Aldosterone 197-208 renin Homo sapiens 179-184 32449886-11 2020 The aldosterone-renin ratio had poor sensitivity and negative predictive value for detecting biochemically overt primary aldosteronism. Aldosterone 4-15 renin Homo sapiens 16-21 32449886-14 2020 Beyond this categorical definition of primary aldosteronism, there is a prevalent continuum of renin-independent aldosterone production that parallels the severity of hypertension. Aldosterone 113-124 renin Homo sapiens 95-100 32567439-7 2020 The acute decrease in proximal sodium reabsorption, as determined by endogenous fractional excretion of lithium (-34.6% versus placebo), was compensated at 1 month by a rise in plasma renin activity (+28.6%) and aldosterone (+55.7%). Aldosterone 212-223 renin Homo sapiens 184-189 32714441-9 2020 Pregnancy has significant effects on the renin-angiotensin-aldosterone pathway leading to physiologic elevations in both aldosterone and renin. Aldosterone 59-70 renin Homo sapiens 41-46 32418495-7 2020 Among 700 subjects who had follow-up coronary artery calcium score (median follow-up of 6.4 years), higher aldosterone levels (per 100 pg/mL) were associated with higher coronary artery calcium (relative ratio, 1.17 [95% CI, 1.04-1.32]), with the association being most prominent in males with suppressed plasma renin activity (<=0.5 mug/L/hr). Aldosterone 107-118 renin Homo sapiens 312-317 32418495-9 2020 Over a median follow-up of 12.5 years (120 deaths identified among 948 subjects), aldosterone was associated with the increased risk of all-cause mortality when plasma renin activity was suppressed; hazard ratio per 100 pg/mL, 1.70 (95% CI, 1.10-2.63). Aldosterone 82-93 renin Homo sapiens 168-173 32418495-10 2020 In this study, we found that higher aldosterone levels were associated with the increased risk of subclinical coronary atherosclerosis and all-cause mortality particularly when renin was suppressed. Aldosterone 36-47 renin Homo sapiens 177-182 32307090-1 2020 Experimental studies support a link between activation of the renin-angiotensin-aldosterone system and cardiovascular disease (CVD). Aldosterone 80-91 renin Homo sapiens 62-67 32498812-7 2020 Hyperkalemia (>5.5 mmol/l) has also been associated with increased risk of adverse events; however, this association is prone to reverse-causation bias as stopping renin angiotensin aldosterone system inhibitor therapy in the advent of hyperkalemia likely contributes the observed risk. Aldosterone 182-193 renin Homo sapiens 164-169 32275191-3 2020 Based on experimental data, we hypothesized an effect of IL-1 antagonism via modulation of the renin-angiotensin-aldosterone system. Aldosterone 113-124 renin Homo sapiens 95-100 32301766-4 2020 In addition, renin-angiotensin aldosterone system inhibitors reduce adverse atherosclerotic cardiovascular disease, heart failure, and chronic kidney disease outcomes, but may increase ACE2 levels. Aldosterone 31-42 renin Homo sapiens 13-18 32714441-9 2020 Pregnancy has significant effects on the renin-angiotensin-aldosterone pathway leading to physiologic elevations in both aldosterone and renin. Aldosterone 59-70 renin Homo sapiens 137-142 32714441-9 2020 Pregnancy has significant effects on the renin-angiotensin-aldosterone pathway leading to physiologic elevations in both aldosterone and renin. Aldosterone 121-132 renin Homo sapiens 41-46 32444441-8 2020 We conclude that symptomatic MAS, caused by unilateral renal artery stenosis, resulting in increased renin-angiotensin-aldosterone system activity and subsequent polyuria of the non-stenotic kidney, lead to clinically significant polyhydramnios. Aldosterone 119-130 renin Homo sapiens 101-106 32443509-4 2020 For diagnose of PA were performed: screening test-aldosterone-renin ratio (ARR) and saline suppression test (SIT) as a confirmatory test. Aldosterone 50-61 renin Homo sapiens 62-67 32543130-4 2020 Results: The area under the ROC curve ( AUC) of the plasma aldosterone concentration (PAC) to plasma renin activity (PRA) ratio (ARR) was greater than that of the ratio of the upright PAC to the angiotensin II (AT-II) (AA2R), upright PRA, upright PAC, supine ARR, and lowest blood potassium ( P<0.05). Aldosterone 59-70 renin Homo sapiens 101-106 32407660-6 2020 Aldosterone-renin ratio was significantly higher in the MRA group (median 375.0, IQR 224.8-544.3 vs 148.7, 118.4-192.1; p 0.034). Aldosterone 0-11 renin Homo sapiens 12-17 32384065-1 2020 In women and females of different species of laboratory animals, oestrogens stimulate the renin-angiotensin-aldosterone system (RAAS) by increasing tissue and circulating levels of angiotensinogen and renin during the preovulatory period. Aldosterone 108-119 renin Homo sapiens 90-95 32061664-2 2020 Fibrosis is a direct and indirect target of established HF therapies, namely inhibitors of the renin-angiotensin-aldosterone system, but its resilience to therapy warrants a search for novel, more targeted approaches to myocardial fibrosis. Aldosterone 101-124 renin Homo sapiens 95-100 32373414-7 2020 In light of this, plasma aldosterone and renin levels were sent and were found to be elevated: aldosterone: 50.4 ng/dL, renin: 0.4 ng/dL, aldosterone-renin Ratio (ARR): 126. Aldosterone 25-36 renin Homo sapiens 120-125 32327102-3 2020 METHODS: In a large community health center, consecutive hypertensive patients with an aldosterone-renin ratio >20 ng/mIU and plasma aldosterone concentration >10 ng/dl underwent captopril challenge test and/or saline infusion test for confirmation of PA. Adrenal computed tomography scan and adrenal vein sampling were used for subtyping. Aldosterone 87-98 renin Homo sapiens 99-104 32252748-1 2020 BACKGROUND: Overactivation of renin-aldosterone-angiotensin system (RAS) is part of the pathogenesis of obesity-associated hypertension. Aldosterone 36-47 renin Homo sapiens 30-35 32373414-7 2020 In light of this, plasma aldosterone and renin levels were sent and were found to be elevated: aldosterone: 50.4 ng/dL, renin: 0.4 ng/dL, aldosterone-renin Ratio (ARR): 126. Aldosterone 25-36 renin Homo sapiens 120-125 32373414-7 2020 In light of this, plasma aldosterone and renin levels were sent and were found to be elevated: aldosterone: 50.4 ng/dL, renin: 0.4 ng/dL, aldosterone-renin Ratio (ARR): 126. Aldosterone 95-106 renin Homo sapiens 41-46 32373414-7 2020 In light of this, plasma aldosterone and renin levels were sent and were found to be elevated: aldosterone: 50.4 ng/dL, renin: 0.4 ng/dL, aldosterone-renin Ratio (ARR): 126. Aldosterone 95-106 renin Homo sapiens 41-46 31881099-1 2020 Pulmonary vascular disease, including pulmonary arterial hypertension (PAH), is increasingly recognized to be affected by systemic alterations including up-regulation of the renin-angiotensin-aldosterone system and perturbations to metabolic pathways, particularly glucose and fat metabolism. Aldosterone 180-203 renin Homo sapiens 174-179 32067644-1 2020 The left atrial appendage (LAA) affects body homeostasis via atrial natriuretic peptide and the renin-angiotensin-aldosterone system and plays an important role in atrial compliance. Aldosterone 102-125 renin Homo sapiens 96-101 31909799-2 2020 Subtypes of essential hypertension characterized by low renin levels allowed the identification of 2 different clinical entities: aldosterone-mediated mineralocorticoid receptor (MR) activation and cortisol-mediated MR activation. Aldosterone 130-141 renin Homo sapiens 56-61 31790052-4 2020 A mathematical function was defined with these three variables, and a nomogram was built that would return the expected aldosterone concentration from the obtained plasma renin and urinary Na/K ratio values. Aldosterone 120-131 renin Homo sapiens 171-176 31790052-8 2020 CONCLUSION: The strong correlation between the urinary Na/K ratio, from urine samples taken at the same as the blood samples, and plasma renin and aldosterone concentrations allowed us to build a nomogram to predict aldosterone levels. Aldosterone 216-227 renin Homo sapiens 137-142 31790052-9 2020 This approach may be useful for evaluating the renin-angiotensin-aldosterone system (RAAS) in pediatric patients with hypertension and RAAS dysfunction. Aldosterone 53-76 renin Homo sapiens 47-52 32296206-1 2020 OBJECTIVE: To investigate the association of genetic variants of renin angiotensin aldosterone system, endothelial nitric oxide synthase and 11-beta-hydroxylase genes, and the drug efficacy of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker. Aldosterone 83-94 renin Homo sapiens 65-70 32370649-5 2020 The plasma aldosterone concentration and aldosterone-renin ratio were significantly higher and serum potassium concentration and plasma renin activity were significantly lower in patients with unilateral hypersecretion. Aldosterone 41-52 renin Homo sapiens 53-58 32370685-0 2020 Meta-analysis of effect of renin-angiotensin-aldosterone system blockers on contrast-induced nephropathy. Aldosterone 45-56 renin Homo sapiens 27-32 32370685-3 2020 A total of 12 studies with 14 trials that performed studies on a total of 4864 patients (2484 treated with renin-angiotensin-aldosterone system blockers and 2380 in the control group) were included. Aldosterone 125-136 renin Homo sapiens 107-112 32370685-6 2020 RESULTS: The overall contrast-induced nephropathy incidence in renin-angiotensin-aldosterone system blocker and control groups was 10.43% and 6.81%, respectively. Aldosterone 81-92 renin Homo sapiens 63-68 32370685-7 2020 The pooled relative risk of contrast-induced nephropathy incidence was 1.22 (95% confidence interval: 0.81-1.84) in the renin-angiotensin-aldosterone system blocker group. Aldosterone 138-149 renin Homo sapiens 120-125 32370685-9 2020 CONCLUSIONS: Intervention with renin-angiotensin-aldosterone system blockers was associated with an increased risk of contrast-induced nephropathy among non-Asians, chronic users, older people, and studies with larger sample size. Aldosterone 49-60 renin Homo sapiens 31-36 32324352-4 2020 Inhibitors of the renin-angiotensin aldosterone system should be continued when there is a solid indication, and stopped in case of hemodynamic problems. Aldosterone 36-47 renin Homo sapiens 18-23 32309249-2 2020 This is characterized by hypokalaemia, hypertension, metabolic alkalosis and suppression of the renin-aldosterone system. Aldosterone 102-113 renin Homo sapiens 96-101 32062648-1 2020 BACKGROUND: The renin-angiotensin-aldosterone axis plays a pivotal role in the pathophysiology of acute and chronic heart failure (HF) and represents an important target for guideline-directed medical therapy. Aldosterone 22-45 renin Homo sapiens 16-21 31652100-2 2020 We reported that hyperkalemia was observed mainly in elderly patients treated with renin-angiotensin-aldosterone system (RAS) inhibitors when levothyroxine treatment was withdrawn for the thyroidectomized patients with thyroid carcinoma to undergo radioactive iodine treatment. Aldosterone 89-112 renin Homo sapiens 83-88 31793908-1 2020 Albuminuria acts as a marker of progressive chronic kidney disease and as an indicator for initiation of hypertension treatment via modulation of the renin-angiotensin-aldosterone system with angiotensin receptor blockers or angiotensin-converting enzyme inhibitors. Aldosterone 156-179 renin Homo sapiens 150-155 32523145-4 2020 The drugs that act on the renin-angiotensin-aldosterone system are in many cases the backbone for the management of these diseases, it has been known for a long time that these drugs significantly increase the expression of receptors for angiotensin conversion enzyme type 2 in the lung tissue. Aldosterone 44-55 renin Homo sapiens 26-31 32062648-2 2020 SUMMARY: The use of appropriate directed medical therapies for inhibition of the renin-angiotensin-aldosterone axis in chronic HF has been the subject of several landmark clinical trials, with high levels of adherence exhibited in the outpatient setting. Aldosterone 87-110 renin Homo sapiens 81-86 31688312-9 2020 The random effect model analysis revealed a mean reduction of 2.63 ng/ml/h (95% CI: -4.46 to -0.8; P = 0.005) in plasma renin activity (PRA), mean reduction of 255.37 pg/ml (95% CI: -441.23 to -69.5; P = 0.007) in plasma aldosterone levels, and a mean increase of 0.14 mg/dl (95% CI: -0.13 to 0.41; P = 0.32) in serum creatinine levels favouring add-on alpha agonist group. Aldosterone 221-232 renin Homo sapiens 120-125 31711229-0 2020 Kinetics and Interrelations of the Renin Aldosterone Response to Acute Psychosocial Stress: A Neglected Stress System. Aldosterone 41-52 renin Homo sapiens 35-40 31711229-10 2020 Renin completed recovery at 10 minutes, cortisol at 60 minutes, salivary aldosterone at 90 minutes, and plasma aldosterone at 180 minutes after stress. Aldosterone 73-84 renin Homo sapiens 0-5 32076019-0 2020 Pool walking may improve renal function by suppressing the renin-angiotensin-aldosterone system in healthy pregnant women. Aldosterone 65-88 renin Homo sapiens 59-64 32076019-4 2020 The renin-angiotensin-aldosterone level was suppressed during pool walking: the mean starting and ending values of plasma renin activity and serum aldosterone were 6.8 vs. 5.5 ng/mL/h (p = 0.002) and 654 vs. 473 pg/mL (p = 0.01), respectively. Aldosterone 10-33 renin Homo sapiens 4-9 32076019-4 2020 The renin-angiotensin-aldosterone level was suppressed during pool walking: the mean starting and ending values of plasma renin activity and serum aldosterone were 6.8 vs. 5.5 ng/mL/h (p = 0.002) and 654 vs. 473 pg/mL (p = 0.01), respectively. Aldosterone 10-33 renin Homo sapiens 122-127 32076019-4 2020 The renin-angiotensin-aldosterone level was suppressed during pool walking: the mean starting and ending values of plasma renin activity and serum aldosterone were 6.8 vs. 5.5 ng/mL/h (p = 0.002) and 654 vs. 473 pg/mL (p = 0.01), respectively. Aldosterone 22-33 renin Homo sapiens 4-9 32076019-6 2020 Pool walking may improve renal function in pregnant women partly through the suppressed renin-angiotensin-aldosterone system. Aldosterone 94-117 renin Homo sapiens 88-93 31560448-1 2020 This prospective cohort study evaluated the association between renin-angiotensin-aldosterone-system genotypes and response to spironolactone in 155 Egyptian patients with heart failure with reduced ejection fraction (HFrEF). Aldosterone 82-93 renin Homo sapiens 64-69 31714287-5 2020 Inhibitors of the renin--angiotensin--aldosterone system (RAASi) are effective in reducing cardiovascular events and slowing the progression of CKD, yet hyperkalemia is a risk factor. Aldosterone 38-49 renin Homo sapiens 18-23 31760886-0 2020 Renin-Angiotensin-Aldosterone System Triple-A Analysis for the Screening of Primary Aldosteronism. Aldosterone 18-29 renin Homo sapiens 0-5 32688242-11 2020 CONCLUSION: The study highlights the role of AngII/Ang1-7 balance in alteration of endothelial function and central arterial stiffness in humans in addition to identifying the interrelationship between the renin-angiotensin-aldosterone-system components and clinically ascertainable parameters. Aldosterone 224-235 renin Homo sapiens 206-211 31760886-8 2020 This study shows for the first time the accuracy and reliability of renin-angiotensin-aldosterone system triple-A analysis for the screening of primary aldosteronism that can be applied in clinical routine. Aldosterone 86-97 renin Homo sapiens 68-73 31760886-2 2020 The interference of antihypertensive therapies with the aldosterone-to-renin ratio during screening process is a major confounder. Aldosterone 56-67 renin Homo sapiens 71-76 31760886-3 2020 Renin-angiotensin-aldosterone system Triple-A analysis is a novel liquid chromatography/tandem mass spectrometry diagnostic assay that allows simultaneous quantification of aldosterone, equilibrium Ang I (angiotensin I), and Equilibrium Ang II in a single sample of serum. Aldosterone 18-29 renin Homo sapiens 0-5 31760886-3 2020 Renin-angiotensin-aldosterone system Triple-A analysis is a novel liquid chromatography/tandem mass spectrometry diagnostic assay that allows simultaneous quantification of aldosterone, equilibrium Ang I (angiotensin I), and Equilibrium Ang II in a single sample of serum. Aldosterone 173-184 renin Homo sapiens 0-5 31760886-7 2020 The Youden index optimal cutoff value for the aldosterone-to-Ang II ratio was 6.6 ([pmol/L]/[pmol/L]) with a sensitivity of 90% and a specificity of 93%, proving noninferiority compared with the aldosterone-to-renin ratio while pointing to the potential for an interference-free application in patients under ACE (angiotensin-converting enzyme) inhibitor therapy. Aldosterone 46-57 renin Homo sapiens 210-215 33211434-0 2020 [Renin-angiotensin-aldosterone system : brief history and questions related to the COVID-19 pandemic]. Aldosterone 19-30 renin Homo sapiens 1-6 31770190-0 2020 Impact of renin-angiotensin-aldosterone system activation and body weight change on N-terminal pro-B-type natriuretic peptide variation in 100-km ultramarathon runners. Aldosterone 16-39 renin Homo sapiens 10-15 31770190-3 2020 This study investigated whether the BW change and renin-angiotensin-aldosterone system activation contribute to exercise-induced NT-proBNP release. Aldosterone 56-79 renin Homo sapiens 50-55 32089050-2 2020 Reduced angiotensin converting enzyme 2 activity from the counter angiotensin converting enzyme 2 /angiotensin-(1-7)/Mas receptor axis of the renin angiotensin aldosterone system has been reported in people with pre-hypertension, type 2 diabetes mellitus and chronic renal disease. Aldosterone 160-171 renin Homo sapiens 142-147 32089050-3 2020 This study investigates whether an imbalance in the regulatory mechanisms between the pressor arm of the renin angiotensin aldosterone system (angiotensin converting enzyme/angiotensin II/AT1 receptor) and the depressor axis (angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor) predisposes persons of African descent to hypertension. Aldosterone 123-134 renin Homo sapiens 105-110 32089050-8 2020 Our findings will characterize any imbalance in the counter axes of the renin angiotensin aldosterone system in hypertensive Afro-Caribbeans with a potential view of identifying novel approaches with the use of renin angiotensin aldosterone system and mineralocorticoid blockers to manage the condition. Aldosterone 90-101 renin Homo sapiens 72-77 32089050-8 2020 Our findings will characterize any imbalance in the counter axes of the renin angiotensin aldosterone system in hypertensive Afro-Caribbeans with a potential view of identifying novel approaches with the use of renin angiotensin aldosterone system and mineralocorticoid blockers to manage the condition. Aldosterone 229-240 renin Homo sapiens 72-77 32129199-0 2020 Aldosterone renin ratio and chronic kidney disease. Aldosterone 0-11 renin Homo sapiens 12-17 32129199-3 2020 We aimed to evaluate the relationship between aldosterone renin ratio (ARR) and chronic kidney disease (CKD). Aldosterone 46-57 renin Homo sapiens 58-63 32129199-11 2020 In view of high prevalence of noncommunicable disease and high early CKD population, there is an important need to consider comprehensive management strategies that involve the blockage of high renin-angiotensin-aldosterone and the use of mineralocorticosteroid receptor blockers. Aldosterone 212-223 renin Homo sapiens 194-199 31912710-0 2019 Continuation of renin-angiotensin-aldosterone system blockade therapy in acute decompensated heart failure. Aldosterone 22-45 renin Homo sapiens 16-21 31786420-1 2019 Renin is the rate-limiting step within the renin-angiotensin-aldosterone system, but the reliable quantification of human endogenous renin levels by liquid chromatography coupled with mass spectrometry remains challenging. Aldosterone 49-72 renin Homo sapiens 0-5 31786420-1 2019 Renin is the rate-limiting step within the renin-angiotensin-aldosterone system, but the reliable quantification of human endogenous renin levels by liquid chromatography coupled with mass spectrometry remains challenging. Aldosterone 49-72 renin Homo sapiens 43-48 31358344-6 2019 Renin angiotensin-aldosterone system inhibitors were the most common antihypertensive drugs, prescribed for 54% to 91% of cohort participants. Aldosterone 18-29 renin Homo sapiens 0-5 31791077-3 2019 On the other hand, inhibition of the renin angiotensin aldosterone system can lead to worsening of renal function and hyperkalemia potentially causing harm. Aldosterone 55-66 renin Homo sapiens 37-42 31549285-1 2019 The kidney plays a crucial role in controlling the blood volume and pressure, electrolyte and acid-base balance, erythropoietin secretion, as well as renin-angiotensin-aldosterone system activity. Aldosterone 168-179 renin Homo sapiens 150-155 31804307-0 2019 Lab monitoring and acute care utilization during initiation of renin angiotensin aldosterone inhibitors or diuretics in chronic kidney disease. Aldosterone 81-92 renin Homo sapiens 63-68 31804307-1 2019 Renin angiotensin aldosterone system inhibitors (RAASi) and diuretics are among the most frequently prescribed anti-hypertensives. Aldosterone 18-29 renin Homo sapiens 0-5 32832727-4 2019 Emerging data support the concept that primary aldosteronism may be better characterized as a continuum of renin-independent aldosterone production, whose severity influences the clinical presentation and risk for incident cardiovascular disease. Aldosterone 125-136 renin Homo sapiens 107-112 31345952-0 2019 Do beta-blockers and inhibitors of the renin-angiotensin aldosterone system improve outcomes in patients with heart failure and left ventricular ejection fraction >40%? Aldosterone 57-68 renin Homo sapiens 39-44 31476909-8 2019 In patients with APA, BAH, and primary hypertension combined, higher aldosterone-to-renin ratios and lower plasma renin concentrations were associated with higher compared with lower agonistic AT1R-Ab levels. Aldosterone 69-80 renin Homo sapiens 84-89 31719011-3 2019 It has been established that this vitamin is extensively involved in the regulation of both the renin angiotensin aldosterone system and the immune system. Aldosterone 114-125 renin Homo sapiens 96-101 31655771-3 2019 Low-renin, low-aldosterone hypertension represents a wide spectrum of disorders that includes essential low-renin hypertension, hereditary forms of hypertension, and hypertension secondary to endogenous or exogenous factors. Aldosterone 15-26 renin Homo sapiens 108-113 31655777-4 2019 This article describes rare monogenic forms of hypertension, characterized by electrolyte disorders and suppressed renin-aldosterone axis. Aldosterone 121-132 renin Homo sapiens 115-120 31655781-3 2019 The elevation of blood pressure in drug-induced hypertension occurs through a variety of mechanisms, most notably, sodium and fluid retention, activation of the renin-angiotensin-aldosterone system, alteration of vascular tone, or a combination of these pathways. Aldosterone 167-190 renin Homo sapiens 161-166 31443984-0 2019 Sympathetic and renin-angiotensin-aldosterone system activation in heart failure with preserved, mid-range and reduced ejection fraction. Aldosterone 34-45 renin Homo sapiens 16-21 31443984-1 2019 BACKGROUND: Evidence of sympathetic and renin-angiotensin-aldosterone system activation provided a rationale for neurohormonal antagonism in heart failure with reduced ejection fraction (HFrEF), while no data are available in patients with milder degree of systolic dysfunction. Aldosterone 58-69 renin Homo sapiens 40-45 31800078-1 2019 Hyperkalemia represents a common and potentially life-threating electrolyte abnormality, a complication frequently observed in patients with heart failure, kidney disease, diabetes or in those receiving drug therapies influencing the renin-angiotensin-aldosterone system. Aldosterone 240-263 renin Homo sapiens 234-239 31760936-6 2019 Estimated GFR trajectory was reported using linear mixed models adjusted for demographic characteristics, comorbidities and use of renin-angiotensin-aldosterone blockade. Aldosterone 137-160 renin Homo sapiens 131-136 31648696-2 2019 However, there are no guidelines to manage decline in kidney function that occurs with initiation and titration of renin-angiotensin-aldosterone system agents during management of heart failure. Aldosterone 121-144 renin Homo sapiens 115-120 31648696-3 2019 We discuss the complex interplay of kidney function and heart failure in the presence of renin-angiotensin-aldosterone system agents and suggest a clinical algorithm for management of acute decline in kidney function. Aldosterone 95-118 renin Homo sapiens 89-94 31884944-8 2019 The frequency of use of renin-angiotensin-aldosterone system blockers in the group of ET patients was 85.0%, which was significantly lower than 91.6% in the group of IT patients, r&lt;0.0001. Aldosterone 30-53 renin Homo sapiens 24-29 31754544-3 2019 Subsequent activation of the renin-angiotensin-aldosterone system results in an increase in systemic blood pressure. Aldosterone 35-58 renin Homo sapiens 29-34 31551925-1 2019 A healthy pregnancy outcome depends on the activation of the renin-angiotensin-aldosterone system (RAAS) as a regulated, integrated response to the growing demands of the conceptus. Aldosterone 67-90 renin Homo sapiens 61-66 31551803-10 2019 These factors include: (1) activation of the renin-angiotensin-aldosterone system, (2) anemia, (3) hypercalcemia, hyperphosphatemia and increased levels of FGF-23, and (4) uremic toxins. Aldosterone 51-74 renin Homo sapiens 45-50 31860842-2 2019 Data from other populations and animal experiments suggests that angiotensin-neprilysin inhibition may be superior to renin-angiotensin-aldosterone system inhibition in reducing the risk of cardiovascular mortality and retarding the progression of CKD. Aldosterone 124-147 renin Homo sapiens 118-123 31565833-0 2019 Erratum for The renin-angiotensin-aldosterone system and its suppression. Aldosterone 22-45 renin Homo sapiens 16-21 31177907-1 2019 The mineralocorticoid aldosterone increases in plasma in healthy pregnancy along with renin and angiotensin II and plays a key role in the physiological plasma volume expansion. Aldosterone 22-33 renin Homo sapiens 86-91 30707244-2 2019 The clinical presentation is heterogeneous, but a suppressed or low normal renin (especially with ACE inhibitors or sartans) should raise suspicion for primary aldosteronism, even when aldosterone levels are in the normal range. Aldosterone 185-196 renin Homo sapiens 75-80 31807298-0 2019 Responses of the renin-angiotensin-aldosterone system in pregnant chronic kidney disease patients with and without superimposed pre-eclampsia. Aldosterone 23-46 renin Homo sapiens 17-22 31807298-3 2019 We hypothesized that specific components of the renin-angiotensin-aldosterone system (RAAS) would discriminate between CKD and SPE. Aldosterone 54-77 renin Homo sapiens 48-53 30518805-0 2019 Effects of mineralocorticoid and AT-1 receptor antagonism on the aldosterone-renin ratio (ARR) in primary aldosteronism patients (EMIRA Study): rationale and design. Aldosterone 65-76 renin Homo sapiens 77-82 30256890-0 2019 Fibroblast Growth Factor-23, Heart Failure Risk, and Renin-Angiotensin-Aldosterone-System Blockade in Hypertension: The MESA Study. Aldosterone 71-82 renin Homo sapiens 53-58 30256890-3 2019 FGF23 may also enhance renin-angiotensin-aldosterone system activity. Aldosterone 41-52 renin Homo sapiens 23-28 32207720-4 2019 Genetic factors, modulating inflammation process, coagulation, lipid metabolism, NO formation, renin-angiotensin-aldosterone system and homeostasis play a significant role in stroke development. Aldosterone 113-124 renin Homo sapiens 95-100 31033727-1 2019 OBJECTIVES: Because of the influence on the renin-angiotensin-aldosterone system, it is recommended to avoid, if possible, the use of angiotensin-converting-enzyme inhibitors, angiotensin II type 1 receptor blockers, diuretics, beta-blockers, and mineralocorticoid receptor antagonists during the diagnostic period of primary aldosteronism. Aldosterone 62-73 renin Homo sapiens 44-49 30591990-2 2019 Drugs acting on the renin-angiotensin-aldosterone system, such as angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), showed similar benefit on major CV events to other antihypertensive medications. Aldosterone 38-49 renin Homo sapiens 20-25 28992758-1 2017 INTRODUCTION: Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are widely used in congestive heart failure and chronic kidney disease, but up to 40% of patients will experience aldosterone breakthrough, with aldosterone levels rising above pre-treatment levels after 6-12 months of renin-angiotensin-aldosterone system blockade. Aldosterone 203-214 renin Homo sapiens 308-313 29618841-10 2018 In the aliskiren group, there was a significant negative correlation between the basal level of the soluble (pro)renin receptor and the change in plasma aldosterone concentration. Aldosterone 153-164 renin Homo sapiens 113-118 29580580-6 2018 Furthermore, strategies targeting renin-angiotensin-aldosterone system interruption have shown to improve DKD outcomes to a greater extent than other classes of antihypertensive regimens. Aldosterone 52-63 renin Homo sapiens 34-39 33488850-7 2021 Conclusions: Assessment of the influence of the renin-angiotensin-aldosterone system (RAAS) on AOD should include the relationship between renin and aldosterone. Aldosterone 66-77 renin Homo sapiens 48-53 33488850-7 2021 Conclusions: Assessment of the influence of the renin-angiotensin-aldosterone system (RAAS) on AOD should include the relationship between renin and aldosterone. Aldosterone 149-160 renin Homo sapiens 48-53 28957531-5 2017 Mechanosensitive transduction of adrenergic signalling and stimulation of the renin-angiotensin-aldosterone cascade trigger the activation of right ventricular fibroblasts. Aldosterone 96-107 renin Homo sapiens 78-83 27350174-2 2016 Renin-angiotensin system inhibitors reduce serum aldosterone levels and/or block its effects but can cause hyperkalemia. Aldosterone 49-60 renin Homo sapiens 0-5 25555247-3 2015 In the most common sporadic cases the mechanisms by which the excess aldosterone production persists in spite of high blood pressure, sodium retention, suppression of the renin angiotensin system and low potassium levels, all factors that by themselves would be expected to shut off aldosterone production, were a puzzle for decades. Aldosterone 69-80 renin Homo sapiens 171-176 27177790-4 2016 RESULTS: Aldosterone/renin ratio was elevated in 99 patients of whom 31 exhibited elevated supine aldosterone, as well. Aldosterone 98-109 renin Homo sapiens 21-26 26867057-3 2016 beta-blocker therapy suppresses renin production by inhibiting beta-adrenergic receptors in the juxtaglomerular apparatus of the kidney and consequently aldosterone secretion (to a lesser extent). Aldosterone 153-164 renin Homo sapiens 32-37 26536091-1 2015 BACKGROUND: A high aldosterone-renin ratio (ARR) is commonly used to identify primary aldosteronism, but the ARR is high when renin is low, even if plasma aldosterone concentration values are normal, suggesting the existence of "normoaldosteronemic" primary aldosteronism. Aldosterone 19-30 renin Homo sapiens 31-36 27424689-8 2016 The renin-angiotensin-aldosterone system of VLBW infants seems to be able, even immediately after birth, to respond to variations of plasma sodium concentrations; measurement of UAE constitutes an interesting method to determine aldosterone production in VLBW infants. Aldosterone 22-33 renin Homo sapiens 4-9 27317302-9 2016 CONCLUSIONS: Upon acute high-altitude exposure, budesonide, but not dexamethasone, blunted the response of aldosterone to renin elevation by suppressing angiotensin converting enzyme. Aldosterone 107-118 renin Homo sapiens 122-127 26113616-0 2016 Activation of the Endogenous Renin-Angiotensin-Aldosterone System or Aldosterone Administration Increases Urinary Exosomal Sodium Channel Excretion. Aldosterone 47-58 renin Homo sapiens 29-34 25542624-10 2015 CONCLUSIONS: Arterial stiffness indices are higher among essential hypertensive patients with high normal serum and urine ALDO levels, pointing to a causal relationship between renin-angiotensin-aldosterone system activation and large artery properties. Aldosterone 122-126 renin Homo sapiens 177-182 26042086-2 2015 The finding that intracellular renin and angiotensin II (Ang II) disrupts chemical communication and impairs metabolic cooperation between cardiomyocytes induced by aldosterone, hyperglycemia, and pathological conditions like myocardial ischemia is discussed. Aldosterone 165-176 renin Homo sapiens 31-36 22476023-2 2012 The aldosterone-to-renin ratio (ARR) is more reproducible than aldosterone levels alone and could be an index for inappropriate aldosterone secretion or activity. Aldosterone 4-15 renin Homo sapiens 19-24 25289084-4 2014 The plasma renin activity (PRA) level was identified to be markedly elevated (normal range in standing and supine positions, 1.3-4.0 ng/ml/h and 0.15-2.33 ng/ml/h, respectively) and the plasma aldosterone level was also increased (normal range in standing and supine positions, 4.0-31.0 ng/dl and 1.0-1.6 ng/dl, respectively). Aldosterone 193-204 renin Homo sapiens 11-16 23800077-0 2013 Current status of renin-aldosterone angiotensin system-targeting anti-hypertensive drugs as therapeutic options for Alzheimer"s disease. Aldosterone 24-35 renin Homo sapiens 18-23 25029426-2 2014 OBJECTIVE: To test the hypothesis that activation of the endogenous renin-angiotensin-aldosterone system or exogenous aldosterone impairs insulin secretion in humans. Aldosterone 86-97 renin Homo sapiens 68-73 23864056-3 2013 We therefore conducted a study in essential hypertensive patients to determine whether aldosterone breakthrough occurred during treatment with the direct renin inhibitor (DRI) aliskiren and to ascertain its clinical significance. Aldosterone 87-98 renin Homo sapiens 154-159 23757402-9 2013 CONCLUSIONS: In this community-based sample of white subjects, those with low-renin hypertension had a bimodal adjusted aldosterone distribution. Aldosterone 120-131 renin Homo sapiens 78-83 23509108-0 2013 Inhibition of the renin-angiotensin system reduces the rise in serum aldosterone in acute coronary syndrome patients with preserved left ventricular function: observations from the AVANT GARDE-TIMI 43 trial. Aldosterone 69-80 renin Homo sapiens 18-23 23509108-2 2013 We aimed to determine if early, more complete renin-angiotensin-aldosterone system inhibition (RAASI) in post-ACS patients without ventricular dysfunction or heart failure would result in a graded reduction in aldosterone concentrations. Aldosterone 64-75 renin Homo sapiens 46-51 23097668-3 2012 However, the efficacy of angiotensin II blockade by such drugs is sometimes diminished by the so-called "aldosterone breakthrough" effect, by which ACE-Is or ARBs (renin-angiotensin system (RAS) inhibitors) gradually lose their effectiveness against hypertension due to the overproduction of aldosterone, known as primary aldosteronism. Aldosterone 105-116 renin Homo sapiens 164-169 22493079-2 2012 They are suggested to be 2 states within a disease spectrum that progresses from LREH to IHA as the control of aldosterone production by the renin-angiotensin system is weakened. Aldosterone 111-122 renin Homo sapiens 141-146 22412047-1 2012 AIMS: Accurate serum aldosterone determination is critical to the screening and diagnosis of primary aldosteronism, the localisation of aldosterone producing tumours, and the investigation of other disorders of the renin-angiotensin system. Aldosterone 21-32 renin Homo sapiens 215-220 23097668-3 2012 However, the efficacy of angiotensin II blockade by such drugs is sometimes diminished by the so-called "aldosterone breakthrough" effect, by which ACE-Is or ARBs (renin-angiotensin system (RAS) inhibitors) gradually lose their effectiveness against hypertension due to the overproduction of aldosterone, known as primary aldosteronism. Aldosterone 292-303 renin Homo sapiens 164-169 20712135-8 2010 Since elevated levels of glucose and LDL, and increased action of the renin-angiotensin-aldosterone system is known to participate in the progression of diabetic nephropathy, it is speculated that the mesangial endocrine system that produces aldosterone locally is a promising therapeutic target for diabetic nephropathy where HMG-CoA reductase inhibitors provide a beneficial effect. Aldosterone 88-99 renin Homo sapiens 70-75 21810897-5 2011 RESULTS: After adjustment for multiple testing, we found that the G allele of rs6676670 (T/G) in intron 1 of REN was significantly associated with higher baseline aldosterone concentrations (p < 0.0001, explained variance (EV) = 2.3%). Aldosterone 163-174 renin Homo sapiens 109-112 21466768-0 2011 The renin-angiotensin-aldosterone system and its blockade in diabetic nephropathy: main focus on the role of aldosterone. Aldosterone 22-33 renin Homo sapiens 4-9 20881255-1 2010 The IGF-I pathway and renin-angiotensin-aldosterone axis are both involved in the pathogenesis of hypertension and atherosclerosis, but no information is available about IGF-I and aldosterone interaction or their potential synergistic effects in vascular smooth muscle cells (VSMCs). Aldosterone 40-51 renin Homo sapiens 22-27 20027193-3 2010 Furthermore, the aldosterone-to-renin ratio, an indicator of aldosterone excess, is associated with hypertension, even in patients without excessive absolute aldosterone levels. Aldosterone 17-28 renin Homo sapiens 32-37 21678653-3 2011 In this study, the angiotensin receptor blocker valsartan, ACE inhibitor enalapril, and direct renin inhibitor aliskiren were used for the correction of blood pressure and aldosterone levels in patients with hypertension and chronic kidney diseases. Aldosterone 172-183 renin Homo sapiens 95-100 19593208-10 2009 CONCLUSION: The CYP2C9*3 allele was associated with lower activity of the renin-angiotensin-aldosterone system in hypertensive men, which may reflect a more efficient sodium reabsorption capacity. Aldosterone 92-103 renin Homo sapiens 74-79 19593208-0 2009 CYP2C9 genotype modifies activity of the renin-angiotensin-aldosterone system in hypertensive men. Aldosterone 59-70 renin Homo sapiens 41-46 19593208-3 2009 METHODS: We studied the impact of these variants on BP response to losartan and three other antihypertensive drugs and on baseline indicators of the activity of the renin-angiotensin-aldosterone system. Aldosterone 183-194 renin Homo sapiens 165-170 19034869-8 2008 Plasma renin activity was significantly increased (2.0 [IQR 1.0-2.8] to 2.3 ng AngI/mL per hour [IQR 1.7-4.0], p=0.045), whereas aldosterone, erythropoietin and B-type natriuretic peptide levels did not change. Aldosterone 129-140 renin Homo sapiens 7-12 19542911-7 2009 This hyperactivation of the renin-angiotensin-aldosterone system was associated with hyponatremia and hyperkalemia in the newborn infants, and high urinary sodium loss, consistent with a partial aldosterone resistance at birth. Aldosterone 46-57 renin Homo sapiens 28-33 18710464-2 2009 Around 15% of patients with essential hypertension have a raised aldosterone to renin ratio (ARR) suggesting that aldosterone production is inappropriately high in relation to its principal agonist angiotensin II. Aldosterone 65-76 renin Homo sapiens 80-85 18710464-2 2009 Around 15% of patients with essential hypertension have a raised aldosterone to renin ratio (ARR) suggesting that aldosterone production is inappropriately high in relation to its principal agonist angiotensin II. Aldosterone 114-125 renin Homo sapiens 80-85 19829865-7 2009 Plasma renin activity was in the lower normal range with a three-fold increase of plasma aldosterone concentration. Aldosterone 89-100 renin Homo sapiens 7-12 19151144-0 2009 High aldosterone-to-renin variants of CYP11B2 and pregnancy outcome. Aldosterone 5-16 renin Homo sapiens 20-25 18622023-3 2008 In small series of patients previously reported, the molecular and phenotypic findings in FRG families, including first hints of extracellular volume depletion and activation of the renin-angiotensin-aldosterone system induced by natriuresis, have been described. Aldosterone 200-211 renin Homo sapiens 182-187 18856058-4 2008 We examined polymorphism of genes that code the renin-angiotensin-aldosterone system components in the groups of low-renin forms of AH, namely, primary HA, idiopathic HA and AH with normal level of aldosterone. Aldosterone 66-77 renin Homo sapiens 48-53 18505761-1 2008 CONTEXT: Primary aldosteronism is a leading cause of secondary hypertension (HTN), but the mechanisms underlying the characteristic renin-independent secretion of aldosterone remain unknown in most patients. Aldosterone 163-174 renin Homo sapiens 132-137 18856058-4 2008 We examined polymorphism of genes that code the renin-angiotensin-aldosterone system components in the groups of low-renin forms of AH, namely, primary HA, idiopathic HA and AH with normal level of aldosterone. Aldosterone 66-77 renin Homo sapiens 117-122 18212262-0 2008 New twist to the role of the renin-angiotensin system in heart failure: aldosterone upregulates renin-angiotensin system components in the brain. Aldosterone 72-83 renin Homo sapiens 29-34 24459520-4 2008 PGI2 (and possibly PGE2) increases potassium secretion mainly by stimulating secretion of renin and activating the renin-angiotensin system, which leads to increased secretion of aldosterone. Aldosterone 179-190 renin Homo sapiens 115-120 18268147-8 2008 Individuals with hypertension displayed significant associations of LTL with renin (beta=-0.060; P=0.005), aldosterone (beta=0.134; P=0.002), and renin-to-aldosterone ratio (beta=-0.072; P<0.001). Aldosterone 155-166 renin Homo sapiens 146-151 18212262-0 2008 New twist to the role of the renin-angiotensin system in heart failure: aldosterone upregulates renin-angiotensin system components in the brain. Aldosterone 72-83 renin Homo sapiens 96-101 17575088-9 2007 Blood pressure and plasma potassium, plasma cortisol, and renin levels, but not BMI, were also directly correlated with plasma aldosterone. Aldosterone 127-138 renin Homo sapiens 58-63 17909121-4 2007 This is a model of hypertension and atherosclerosis because of high angiotensin II and aldosterone levels as a result of the transgenic expression of the entire human renin-angiotensin system. Aldosterone 87-98 renin Homo sapiens 167-172 17575088-10 2007 Multiple regression analysis showed that HOMA, together with plasma potassium, cortisol, and renin levels, was independently correlated with plasma aldosterone. Aldosterone 148-159 renin Homo sapiens 93-98 16169319-1 2005 BACKGROUND: Sodium retention and volume expansion, mediated in part by aldosterone, are prominent features in low-renin hypertension. Aldosterone 71-82 renin Homo sapiens 114-119 17296872-9 2007 A significant interaction was observed between the T(-344)C polymorphism and renin activity in determining aldosterone levels. Aldosterone 107-118 renin Homo sapiens 77-82 17136130-2 2006 Inhibition of the renin-angiotensin system by angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers is beneficial in reducing proteinuria but incomplete in suppressing aldosterone production and its renal effects. Aldosterone 192-203 renin Homo sapiens 18-23 17147925-4 2006 Recent studies also suggest that elevated aldosterone biosynthesis, as defined by an increased aldosterone-to-renin ratio, is present in up to 15% of essential hypertensives and that aldosterone levels predict the development of hypertension in normotensive individuals. Aldosterone 42-53 renin Homo sapiens 110-115 16157075-6 2005 In subjects with resistant hypertension, suppressed renin levels are common, exceeding 75% in our studies, suggesting aldosterone excess effects beyond cases of true primary hyperaldosteronism. Aldosterone 118-129 renin Homo sapiens 52-57 16715648-2 2006 The intraadrenal renin-angiotensin system (RAS) has been suggested to possess the functional role of the synthesizing aldosterone and regulating blood pressure. Aldosterone 118-129 renin Homo sapiens 17-22 16613821-8 2005 An elevated plasma aldosterone concentration to plasma renin activity ratio was suggestive of hyperaldosteronism, which was confirmed by failure of aldosterone to suppress to a formal saline infusion test. Aldosterone 19-30 renin Homo sapiens 55-60 15851599-10 2005 The results suggest that spironolactone could be potentially effective in patients with MI, when used in combination with renin-angiotensin system blockade, by blocking the actions of aldosterone produced by Ang II-independent mechanisms. Aldosterone 184-195 renin Homo sapiens 122-127 15507509-11 2005 In vivo 11 beta-hydroxylase activity, estimated from urinary steroid profiling, was lower in subjects with an increased aldosterone to renin ratio or with the TconvGTA haplotype. Aldosterone 120-131 renin Homo sapiens 135-140 15745200-13 2005 Only patients with both hypokalaemia and low plasma renin, measured while the patient is off beta blockade, require measurement of aldosterone. Aldosterone 131-142 renin Homo sapiens 52-57