PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26148936-6	2015	Silencing TRAF3IP2 blunted Aldo-induced IKKbeta, p65, JNK, and c-Jun activation, IL-18, IL-6 and CT-1 upregulation, and cardiomyocyte hypertrophy.	Aldosterone	27-31	interleukin 18	Mus musculus	81-86	
27413021-0	2016	Interleukin-18 deficiency protects against renal interstitial fibrosis in aldosterone/salt-treated mice.	Aldosterone	74-85	interleukin 18	Mus musculus	0-14	
27413021-3	2016	Aldosterone has been reported to induce IL-18, resulting in cardiac fibrosis with induced IL-18-mediated osteopontin (OPN).	Aldosterone	0-11	interleukin 18	Mus musculus	40-45	
27413021-3	2016	Aldosterone has been reported to induce IL-18, resulting in cardiac fibrosis with induced IL-18-mediated osteopontin (OPN).	Aldosterone	0-11	interleukin 18	Mus musculus	90-95	
27413021-8	2016	This renal damage caused by aldosterone was attenuated significantly by IL-18 knockout with down-regulation of OPN expression.	Aldosterone	28-39	interleukin 18	Mus musculus	72-77	
27413021-9	2016	In the present in vitro study, aldosterone directly induced IL-18 gene expression in renal tubular epithelial cells in a concentration- and time-dependent manner.	Aldosterone	31-42	interleukin 18	Mus musculus	60-65	
27413021-11	2016	IL-18 may be a key mediator of aldosterone-induced renal fibrosis by inducing OPN, thereby exacerbating renal interstitial fibrosis.	Aldosterone	31-42	interleukin 18	Mus musculus	0-5	
27014913-4	2016	The NLRP3 inflammasome is induced by Aldo in a dose- and time-dependent manner, as evidenced by increased NLRP3, ASC, caspase-1, and downstream cytokines, such as interleukin (IL)-1beta and IL-18.	Aldosterone	37-41	interleukin 18	Mus musculus	190-195	
26148936-7	2015	In isolated adult mouse cardiac fibroblasts (CF), Aldo stimulated TRAF3IP2-dependent IL-18 and IL-6 production, CTGF, collagen I and III expression, MMP2 activation, and proliferation and migration.	Aldosterone	50-54	interleukin 18	Mus musculus	85-90	
26054366-5	2015	Infusing wild-type mice with aldosterone (0.25 mg/kg/d) caused tubulointerstitial damage, increased expression of inflammasome components, caspase 1 activation, and overproduction of IL-1beta and IL-18.	Aldosterone	29-40	interleukin 18	Mus musculus	196-201	
26054366-9	2015	IL-18 was detected in culture supernatants of macrophages treated with aldosterone, and mitochondria-derived reactive oxygen species activated the inflammasome in these macrophages.	Aldosterone	71-82	interleukin 18	Mus musculus	0-5