PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15638997-0 2005 Microarray analysis of bicalutamide action on telomerase activity, p53 pathway and viability of prostate carcinoma cell lines. bicalutamide 23-35 tumor protein p53 Homo sapiens 67-70 15638997-4 2005 Response to bicalutamide in LNCaP cells was represented by downregulation of androgen-regulated genes, activation of the p53 pathway and inhibition of telomerase, which was associated with downregulation of v-myc avian myelocytomatosis viral oncogene homologue (MYC) and telomerase reverse transcriptase subunit. bicalutamide 12-24 tumor protein p53 Homo sapiens 121-124 15638997-6 2005 In conclusion, we provide an explanation for telomerase inhibition after androgen receptor blockade in LNCaP cells and we also report activation of the p53 pathway in LNCaP cells and in-vitro sensitivity to bicalutamide of low confluent androgen-insensitive DU145 cells. bicalutamide 207-219 tumor protein p53 Homo sapiens 152-155 15638997-8 2005 In particular, activation of the p53 pathway after treatment with 80 microM bicalutamide could justify usage of bicalutamide dosages higher than 150 mg daily in androgen-sensitive carcinoma therapy. bicalutamide 76-88 tumor protein p53 Homo sapiens 33-36 15638997-8 2005 In particular, activation of the p53 pathway after treatment with 80 microM bicalutamide could justify usage of bicalutamide dosages higher than 150 mg daily in androgen-sensitive carcinoma therapy. bicalutamide 112-124 tumor protein p53 Homo sapiens 33-36