PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16864673-5 2006 Two paramagnetic myeloperoxidase substrates--that is, gadolinium-5-hydroxytryptamide-tetraazacyclododecane tetraacetic acid (Gd-5-HT-DOTA) and Gd-bis-5-HT-diethylenetriaminepentaacetic acid (Gd-bis-5-HT-DTPA)--were synthesized. gd-bis-5-ht-dtpa 191-207 myeloperoxidase Homo sapiens 17-32 16864673-12 2006 RESULTS: After the administration of Gd-bis-5-HT-DTPA, strong MR signal enhancement (up to 2.5-fold increase in CNR, P < .001) was observed in vivo for implants that contained human myeloperoxidase. gd-bis-5-ht-dtpa 37-53 myeloperoxidase Homo sapiens 185-200 16864673-14 2006 Prolonged contrast material enhancement was observed in the myeloperoxidase-containing areas that were injected with Gd-5-HT-DOTA or Gd-bis-5-HT-DTPA but was not observed in areas that were injected with Gd-DTPA or Gd-dopamine-DOTA (P < .05). gd-bis-5-ht-dtpa 133-149 myeloperoxidase Homo sapiens 60-75 22073424-6 2004 For this, investigators developed gadolinium-bis-5-hydroxytriptamide-diethylenetriamine pentaacetic acid (Gd-bis-5-HT-DTPA; also known as MPO-Gd), a magnetic resonance imaging (MRI) agent, that acts as a substrate for the MPO and used it for the noninvasive visualization of MPO activity in normal and diseased tissues (3). gd-bis-5-ht-dtpa 106-122 myeloperoxidase Homo sapiens 138-141 22073424-6 2004 For this, investigators developed gadolinium-bis-5-hydroxytriptamide-diethylenetriamine pentaacetic acid (Gd-bis-5-HT-DTPA; also known as MPO-Gd), a magnetic resonance imaging (MRI) agent, that acts as a substrate for the MPO and used it for the noninvasive visualization of MPO activity in normal and diseased tissues (3). gd-bis-5-ht-dtpa 106-122 myeloperoxidase Homo sapiens 222-225 22073424-6 2004 For this, investigators developed gadolinium-bis-5-hydroxytriptamide-diethylenetriamine pentaacetic acid (Gd-bis-5-HT-DTPA; also known as MPO-Gd), a magnetic resonance imaging (MRI) agent, that acts as a substrate for the MPO and used it for the noninvasive visualization of MPO activity in normal and diseased tissues (3). gd-bis-5-ht-dtpa 106-122 myeloperoxidase Homo sapiens 222-225 22073424-7 2004 Oxidative activation of the paramagnetic substrate (Gd-bis-5-HT-DTPA) by MPO leads to oligomerization and entrapment of the activated Gd-bis-5-HT-DTPA within the tissue by cross-linking the monomer or the oligomer with tyrosine-containing proteins, thereby increasing the localized concentration Gd at the site of MPO activity as explained in detail by Rodriguez et al. gd-bis-5-ht-dtpa 52-68 myeloperoxidase Homo sapiens 73-76 22073424-7 2004 Oxidative activation of the paramagnetic substrate (Gd-bis-5-HT-DTPA) by MPO leads to oligomerization and entrapment of the activated Gd-bis-5-HT-DTPA within the tissue by cross-linking the monomer or the oligomer with tyrosine-containing proteins, thereby increasing the localized concentration Gd at the site of MPO activity as explained in detail by Rodriguez et al. gd-bis-5-ht-dtpa 52-68 myeloperoxidase Homo sapiens 314-317 22073424-7 2004 Oxidative activation of the paramagnetic substrate (Gd-bis-5-HT-DTPA) by MPO leads to oligomerization and entrapment of the activated Gd-bis-5-HT-DTPA within the tissue by cross-linking the monomer or the oligomer with tyrosine-containing proteins, thereby increasing the localized concentration Gd at the site of MPO activity as explained in detail by Rodriguez et al. gd-bis-5-ht-dtpa 134-150 myeloperoxidase Homo sapiens 73-76 22073424-7 2004 Oxidative activation of the paramagnetic substrate (Gd-bis-5-HT-DTPA) by MPO leads to oligomerization and entrapment of the activated Gd-bis-5-HT-DTPA within the tissue by cross-linking the monomer or the oligomer with tyrosine-containing proteins, thereby increasing the localized concentration Gd at the site of MPO activity as explained in detail by Rodriguez et al. gd-bis-5-ht-dtpa 134-150 myeloperoxidase Homo sapiens 314-317 22073424-9 2004 In addition, the oligomeric and entrapped Gd-bis-5-HT-DTPA has a slow clearance rate from the tissue compared to the non-activated compound, and delayed clearance of the activated Gd-bis-5-HT-DTPA allows for the imaging of MPO in the inflamed tissue. gd-bis-5-ht-dtpa 42-58 myeloperoxidase Homo sapiens 223-226 22073424-9 2004 In addition, the oligomeric and entrapped Gd-bis-5-HT-DTPA has a slow clearance rate from the tissue compared to the non-activated compound, and delayed clearance of the activated Gd-bis-5-HT-DTPA allows for the imaging of MPO in the inflamed tissue. gd-bis-5-ht-dtpa 180-196 myeloperoxidase Homo sapiens 223-226 21558403-4 2011 METHODS: We carried out serial Gd-bis-5-HT-DTPA (MPO-Gd) MRI before and after treating rodent gliomas with different doses of oncolytic virus (OV) and analyzed animal survival. gd-bis-5-ht-dtpa 31-47 myeloperoxidase Homo sapiens 49-52