PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21558403-4	2011	METHODS: We carried out serial Gd-bis-5-HT-DTPA (MPO-Gd) MRI before and after treating rodent gliomas with different doses of oncolytic virus (OV) and analyzed animal survival.	gd-bis-5-ht-dtpa	31-47	myeloperoxidase	Homo sapiens	49-52	
22073424-6	2004	For this, investigators developed gadolinium-bis-5-hydroxytriptamide-diethylenetriamine pentaacetic acid (Gd-bis-5-HT-DTPA; also known as MPO-Gd), a magnetic resonance imaging (MRI) agent, that acts as a substrate for the MPO and used it for the noninvasive visualization of MPO activity in normal and diseased tissues (3).	gd-bis-5-ht-dtpa	106-122	myeloperoxidase	Homo sapiens	138-141	
22073424-6	2004	For this, investigators developed gadolinium-bis-5-hydroxytriptamide-diethylenetriamine pentaacetic acid (Gd-bis-5-HT-DTPA; also known as MPO-Gd), a magnetic resonance imaging (MRI) agent, that acts as a substrate for the MPO and used it for the noninvasive visualization of MPO activity in normal and diseased tissues (3).	gd-bis-5-ht-dtpa	106-122	myeloperoxidase	Homo sapiens	222-225	
22073424-6	2004	For this, investigators developed gadolinium-bis-5-hydroxytriptamide-diethylenetriamine pentaacetic acid (Gd-bis-5-HT-DTPA; also known as MPO-Gd), a magnetic resonance imaging (MRI) agent, that acts as a substrate for the MPO and used it for the noninvasive visualization of MPO activity in normal and diseased tissues (3).	gd-bis-5-ht-dtpa	106-122	myeloperoxidase	Homo sapiens	222-225	
22073424-7	2004	Oxidative activation of the paramagnetic substrate (Gd-bis-5-HT-DTPA) by MPO leads to oligomerization and entrapment of the activated Gd-bis-5-HT-DTPA within the tissue by cross-linking the monomer or the oligomer with tyrosine-containing proteins, thereby increasing the localized concentration Gd at the site of MPO activity as explained in detail by Rodriguez et al.	gd-bis-5-ht-dtpa	52-68	myeloperoxidase	Homo sapiens	73-76	
22073424-7	2004	Oxidative activation of the paramagnetic substrate (Gd-bis-5-HT-DTPA) by MPO leads to oligomerization and entrapment of the activated Gd-bis-5-HT-DTPA within the tissue by cross-linking the monomer or the oligomer with tyrosine-containing proteins, thereby increasing the localized concentration Gd at the site of MPO activity as explained in detail by Rodriguez et al.	gd-bis-5-ht-dtpa	52-68	myeloperoxidase	Homo sapiens	314-317	
22073424-7	2004	Oxidative activation of the paramagnetic substrate (Gd-bis-5-HT-DTPA) by MPO leads to oligomerization and entrapment of the activated Gd-bis-5-HT-DTPA within the tissue by cross-linking the monomer or the oligomer with tyrosine-containing proteins, thereby increasing the localized concentration Gd at the site of MPO activity as explained in detail by Rodriguez et al.	gd-bis-5-ht-dtpa	134-150	myeloperoxidase	Homo sapiens	73-76	
22073424-7	2004	Oxidative activation of the paramagnetic substrate (Gd-bis-5-HT-DTPA) by MPO leads to oligomerization and entrapment of the activated Gd-bis-5-HT-DTPA within the tissue by cross-linking the monomer or the oligomer with tyrosine-containing proteins, thereby increasing the localized concentration Gd at the site of MPO activity as explained in detail by Rodriguez et al.	gd-bis-5-ht-dtpa	134-150	myeloperoxidase	Homo sapiens	314-317	
22073424-9	2004	In addition, the oligomeric and entrapped Gd-bis-5-HT-DTPA has a slow clearance rate from the tissue compared to the non-activated compound, and delayed clearance of the activated Gd-bis-5-HT-DTPA allows for the imaging of MPO in the inflamed tissue.	gd-bis-5-ht-dtpa	42-58	myeloperoxidase	Homo sapiens	223-226	
22073424-9	2004	In addition, the oligomeric and entrapped Gd-bis-5-HT-DTPA has a slow clearance rate from the tissue compared to the non-activated compound, and delayed clearance of the activated Gd-bis-5-HT-DTPA allows for the imaging of MPO in the inflamed tissue.	gd-bis-5-ht-dtpa	180-196	myeloperoxidase	Homo sapiens	223-226	
16864673-5	2006	Two paramagnetic myeloperoxidase substrates--that is, gadolinium-5-hydroxytryptamide-tetraazacyclododecane tetraacetic acid (Gd-5-HT-DOTA) and Gd-bis-5-HT-diethylenetriaminepentaacetic acid (Gd-bis-5-HT-DTPA)--were synthesized.	gd-bis-5-ht-dtpa	191-207	myeloperoxidase	Homo sapiens	17-32	
16864673-12	2006	RESULTS: After the administration of Gd-bis-5-HT-DTPA, strong MR signal enhancement (up to 2.5-fold increase in CNR, P < .001) was observed in vivo for implants that contained human myeloperoxidase.	gd-bis-5-ht-dtpa	37-53	myeloperoxidase	Homo sapiens	185-200	
16864673-14	2006	Prolonged contrast material enhancement was observed in the myeloperoxidase-containing areas that were injected with Gd-5-HT-DOTA or Gd-bis-5-HT-DTPA but was not observed in areas that were injected with Gd-DTPA or Gd-dopamine-DOTA (P < .05).	gd-bis-5-ht-dtpa	133-149	myeloperoxidase	Homo sapiens	60-75