PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33255185-8	2020	Diazepam also promotes up-regulation of CYP2B6 in PHHs and in HepaRG cells.	Diazepam	0-8	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	40-46	
18983865-6	2009	The strong and overlapping inductive role of phenobarbital strengthens the participation of CYP2B6 and CYP3A in diazepam N-demethylation and CYP3A in temazepam formation.	Diazepam	112-120	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	92-98	
9633999-1	1998	The human cytochrome P450 2B6 metabolizes, among numerous other substrates, diazepam, 7-ethoxycoumarin, testosterone, and phenanthrene.	Diazepam	76-84	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	10-29	
8948091-2	1996	We have examined the metabolism of diazepam by ten human cytochrome P450 forms (CYP1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 3A4 and 3A5) expressed in HepG2 cells using a recombinant vaccinia virus system.	Diazepam	35-43	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	68-72	
8948091-4	1996	Among the P450 forms tested, diazepam was significantly demethylated by CYP2B6, 2C9, 2C19, 3A4 and 3A5, with 2C19 exhibiting the highest rate at concentrations < 0.1 mM, and hydroxylated only by the latter three enzymes, with 3A5 being the most active.	Diazepam	29-37	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	10-14	
8948091-4	1996	Among the P450 forms tested, diazepam was significantly demethylated by CYP2B6, 2C9, 2C19, 3A4 and 3A5, with 2C19 exhibiting the highest rate at concentrations < 0.1 mM, and hydroxylated only by the latter three enzymes, with 3A5 being the most active.	Diazepam	29-37	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	72-78	
8948091-13	1996	Our results suggest that in the human liver, the metabolism of diazepam to nordiazepam is mediated by CYP3A4, which has been reported as the most abundant P450 form in human liver as well as 2C19, which has been reported as a polymorphic enzyme.	Diazepam	63-71	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	155-159	
8819299-4	1996	Coumarin, 7-ethoxyresorufin, 7-benzyloxyresorufin, tolbutamide, aniline and diazepam were form-selective substrates towards CYP2A6, the CYP1A subfamily, CYP2B6, the CYP2C subfamily, CYP2E1 and the CYP3A subfamily respectively.	Diazepam	76-84	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	153-159