PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12804891-1 2003 Human serum albumin (HSA) was immobilized on the surface of colloidal Au and exposed to diazepam. Diazepam 88-96 albumin Homo sapiens 6-25 12804891-6 2003 Cyclic voltammetry and electrochemical impedance techniques were used to investigate the immobilization of HSA and the interaction between HSA and diazepam. Diazepam 147-155 albumin Homo sapiens 139-142 11893390-1 2002 In our earlier communication on urea denaturation of bovine serum albumin (BSA), we showed significant unfolding of domain III along with domain I prior to intermediate formation around 4.6-5.2 M urea based on the binding results of domain specific ligands:chloroform, bilirubin and diazepam for domains I, II and III, respectively. Diazepam 283-291 albumin Homo sapiens 60-73 11575786-0 2001 Application of solid-phase microextraction in the determination of diazepam binding to human serum albumin. Diazepam 67-75 albumin Homo sapiens 93-106 11575786-1 2001 In this paper, protein-drug interactions were studied by solid-phase microextraction (SPME) using diazepam binding to human serum albumin as a model system. Diazepam 98-106 albumin Homo sapiens 124-137 11340971-1 2001 Human serum albumin (HSA) was immobilised on the gold surface of a quartz crystal resonance sensor (QCRS) and exposed to warfarin and diazepam. Diazepam 134-142 albumin Homo sapiens 6-25 16414799-0 1997 Effect of dextran 70 blood substitute on diazepam binding by human serum albumin. Diazepam 41-49 albumin Homo sapiens 67-80 10462056-3 1999 Attempts were made to characterize its binding site using as competitors warfarin, phenylbutazone and diazepam, which bind in a specific site or region on the HSA. Diazepam 102-110 albumin Homo sapiens 159-162 10462056-4 1999 Fluorescence polarization measurements and spectrofluorimetric results suggest that diazepam and Promen bind at different but interacting binding sites on the HSA. Diazepam 84-92 albumin Homo sapiens 159-162 10418961-3 1999 When human serum albumin (HSA) was incubated with 0.5 M glucose for 5 days, the unbound fractions of diazepam and warfarin were increased by 41 and 35%, respectively, less than that caused by glucuronic acid which increased the unbound fractions by 90% for diazepam and 420% for warfarin. Diazepam 257-265 albumin Homo sapiens 11-24 10418961-3 1999 When human serum albumin (HSA) was incubated with 0.5 M glucose for 5 days, the unbound fractions of diazepam and warfarin were increased by 41 and 35%, respectively, less than that caused by glucuronic acid which increased the unbound fractions by 90% for diazepam and 420% for warfarin. Diazepam 101-109 albumin Homo sapiens 11-24 16414799-1 1997 Diazepam binding studies with dextran 70 and human serum albumin (HSA) were carried out using centrifugation and a membrane ultrafiltration technique to separate the drug protein complex and the free microsolute. Diazepam 0-8 albumin Homo sapiens 51-64 1725995-8 1991 The cefotiam binding site seems to be close to the warfarin site (site I) whereas cyclohexanol probably shares the diazepam site (site II) on HSA. Diazepam 115-123 albumin Homo sapiens 142-145 7908973-0 1993 Human serum albumin conformational changes as induced by tenoxicam and modified by simultaneous diazepam binding. Diazepam 96-104 albumin Homo sapiens 6-19 2304452-0 1990 Binding of warfarin, salicylate, and diazepam to genetic variants of human serum albumin with known mutations. Diazepam 37-45 albumin Homo sapiens 81-88 1996962-1 1991 Binding of L-tryptophan, diazepam and octanoate to defatted human serum albumin was studied at pH 7.0 by equilibrium dialysis at low ligand/protein molar ratios. Diazepam 25-33 albumin Homo sapiens 66-79 2403378-5 1990 DIAZ and PROB displaced one another, confirming their common binding site (Site II, the benzodiazepine site) on serum albumin. Diazepam 0-4 albumin Homo sapiens 112-125 2304452-1 1990 Possible effects of single point mutations on the ligand-binding capabilities of human serum albumin (Alb) were investigated by studying the interactions between the strongly bound drugs warfarin, salicylate, and diazepam and five structurally characterized genetic variants of the protein. Diazepam 213-221 albumin Homo sapiens 102-105 2304452-1 1990 Possible effects of single point mutations on the ligand-binding capabilities of human serum albumin (Alb) were investigated by studying the interactions between the strongly bound drugs warfarin, salicylate, and diazepam and five structurally characterized genetic variants of the protein. Diazepam 213-221 albumin Homo sapiens 93-100 3124878-1 1988 The diazepam-binding behaviour of a large tryptic and a large peptic fragment of human serum albumin has been studied by circular dichroism and equilibrium dialysis in order to locate the primary diazepam-binding site on the albumin molecule. Diazepam 4-12 albumin Homo sapiens 87-100 2252845-1 1990 The stereochemistry of an achiral (Diazepam) and two chiral (3-methyl and 3-succinyloxy substituted) 1,4-benzodiazepin-2-ones interacting with human serum albumin (HSA) has been investigated by making use of difference absorption (UV) and circular dichroism (CD) spectroscopies. Diazepam 35-43 albumin Homo sapiens 149-162 3124878-1 1988 The diazepam-binding behaviour of a large tryptic and a large peptic fragment of human serum albumin has been studied by circular dichroism and equilibrium dialysis in order to locate the primary diazepam-binding site on the albumin molecule. Diazepam 196-204 albumin Homo sapiens 87-100 3429058-11 1987 For practical purposes, the change in the free fractions of phenytoin and diazepam can be adequately predicted by the serum creatinine or urea and serum albumin levels. Diazepam 74-82 albumin Homo sapiens 153-160 2833243-1 1988 The binding of oleic acid to human serum albumin causes progressive changes in (a) the pK of some amino acid residues, as detected by pH-stat titration and (b) the induced molar ellipticities of albumin-bound drugs (diazepam and oxyphenbutazone), as measured by c.d. Diazepam 216-224 albumin Homo sapiens 41-48 2833243-1 1988 The binding of oleic acid to human serum albumin causes progressive changes in (a) the pK of some amino acid residues, as detected by pH-stat titration and (b) the induced molar ellipticities of albumin-bound drugs (diazepam and oxyphenbutazone), as measured by c.d. Diazepam 216-224 albumin Homo sapiens 195-202 3950058-3 1986 For the drugs that bind predominantly to albumin, the serum free fractions were greater in patients one week after the burn incident than in control subjects (diazepam, 0.055 vs. 0.017; phenytoin, 0.24 vs. 0.16; and salicylic acid, 0.69 vs. 0.32). Diazepam 159-167 albumin Homo sapiens 41-48 2883283-4 1987 The displacement study showed that tolmetin caused a significant increase in the affinity of diazepam to HSA whereas it decreased the binding of warfarin to HSA. Diazepam 93-101 albumin Homo sapiens 105-108 6873136-6 1983 The binding of diazepam to human serum albumin (HSA) was markedly perturbed by the presence of NEFA but not by bilirubin and there was no apparent cooperativity between bilirubin and NEFA on diazepam-HSA binding. Diazepam 15-23 albumin Homo sapiens 33-46 6705453-1 1984 Plasma protein binding in seven severely burned (35% to 85% of body) patients 1 to 25 days after burn injury was examined for two drugs: diazepam (DZ), which binds mainly to serum albumin (ALB), and imipramine (IMI), which binds primarily to alpha 1-acid glycoprotein (AAG). Diazepam 147-149 albumin Homo sapiens 180-187 6847607-0 1983 Relations between high-affinity binding sites for L-tryptophan, diazepam, salicylate and Phenol Red on human serum albumin. Diazepam 64-72 albumin Homo sapiens 109-122 357700-0 1978 [Binding of prazepam, desalkylprazepam and diazepam to human serum albumin (author"s transl)]. Diazepam 43-51 albumin Homo sapiens 61-74 7237786-7 1981 Binding by the patient"s plasma of diazepam (1020 mg/L) and warfarin (1040 mg/L), which bind primarily to albumin, as well as of propranolol (1.05 g/L), which binds primarily to alpha 1-acid glycoprotein, was also studied. Diazepam 35-43 albumin Homo sapiens 106-113 393269-0 1979 Intravascular factors affecting diazepam binding to human serum albumin. Diazepam 32-40 albumin Homo sapiens 58-71 571707-0 1979 [Determination of the binding of chlorodiazepoxide, diazepam, nitrazepam and phenprocoumon to human and bovine serum albumin (author"s transl)]. Diazepam 52-60 albumin Homo sapiens 111-124 863908-5 1977 The binding properties of the HSA derivatives have been tested with bilirubin, diazepam (a benzodiazepine drug), phenylbutazone, and indomethacin by circular dichroism. Diazepam 79-87 albumin Homo sapiens 30-33 588298-0 1977 Circular dichroism studies on the inhibiting effect of oleic acid on the binding of diazepam to human serum albumin. Diazepam 84-92 albumin Homo sapiens 102-115 901814-5 1977 The fragment mainly retains the secondary and tertiary structure of intact human serum albumin as well as its capacity to bind bilirubin and diazepam. Diazepam 141-149 albumin Homo sapiens 87-94 863908-6 1977 The binding of diazepam to DHCH-HSA is almost completely inhibited and that of phenylbutazone and indomethacin decreased, while the binding of bilirubin is essentially unaffected. Diazepam 15-23 albumin Homo sapiens 32-35 29474768-1 2017 Binding of clopidogrel to serum albumin has been characterized in the presence and absence of linoleic acid by equilibrium dialysis method where ranitidine and diazepam were used as specific probes. Diazepam 160-168 albumin Homo sapiens 26-39 1148025-0 1975 The displacing effect of a fatty acid on the binding of diazepam to human serum albumin. Diazepam 56-64 albumin Homo sapiens 74-87 20641566-18 2004 The specific binding site II on HSA is located in a hydrophobic cavity of 8-10 A in diameter and has been a preferential binding site for many ligands, such as fenbufen, diazepam, and piroxicam, in drug designs (5). Diazepam 170-178 albumin Homo sapiens 32-35 25031079-6 2014 We report that curcumin has shown comparable binding affinity value vis-a-vis standard, the accessible surface area (ASA) of human serum albumin (uncomplexed) and its docked complex with curcumin at both binding sites was calculated and found to be close to that of warfarin and diazepam respectively. Diazepam 279-287 albumin Homo sapiens 131-144 25961707-0 2015 Stabilization of Human Serum Albumin against Urea Denaturation by Diazepam and Ketoprofen. Diazepam 66-74 albumin Homo sapiens 23-36 25961707-1 2015 Stabilizing effect of diazepam and ketoprofen, Sudlow"s site II markers on human serum albumin (HSA) against urea denaturation was studied using fluorescence spectroscopy. Diazepam 22-30 albumin Homo sapiens 81-94 21557446-0 2011 Binding of delta9-tetrahydrocannabinol and diazepam to human serum albumin. Diazepam 43-51 albumin Homo sapiens 61-74 21557446-3 2011 Here, Delta9-tetrahydrocannabinol (THC) and diazepam binding to human serum albumin (HSA) and HSA-heme is reported. Diazepam 44-52 albumin Homo sapiens 70-83