PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20952540-0	2010	CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons.	Serotonin	20-29	cAMP responsive element binding protein 1	Mus musculus	0-4	
22945629-4	2012	We found that the transcription factor FOXO1 is a crucial determinant of the effects of duodenum-derived serotonin on bone formation We identified two key FOXO1 complexes in osteoblasts, one with the transcription factor cAMP-responsive element-binding protein 1 (CREB) and another with activating transcription factor 4 (ATF4).	Serotonin	105-114	cAMP responsive element binding protein 1	Mus musculus	221-262	
22945629-4	2012	We found that the transcription factor FOXO1 is a crucial determinant of the effects of duodenum-derived serotonin on bone formation We identified two key FOXO1 complexes in osteoblasts, one with the transcription factor cAMP-responsive element-binding protein 1 (CREB) and another with activating transcription factor 4 (ATF4).	Serotonin	105-114	cAMP responsive element binding protein 1	Mus musculus	264-268	
22945629-5	2012	Under normal levels of circulating serotonin, the proliferative activity of FOXO1 was promoted by a balance between its interaction with CREB and ATF4.	Serotonin	35-44	cAMP responsive element binding protein 1	Mus musculus	137-141	
22945629-6	2012	However, high circulating serotonin levels prevented the association of FOXO1 with CREB, resulting in suppressed osteoblast proliferation.	Serotonin	26-35	cAMP responsive element binding protein 1	Mus musculus	83-87	
21187319-3	2011	Cell-specific gene deletion experiments and intracerebroventricular leptin infusions reveal that serotonin signals in arcuate nuclei of the hypothalamus through the Htr1a receptor to favor food intake and that this serotonin function requires the expression of Creb, which regulates the expression of several genes affecting appetite.	Serotonin	97-106	cAMP responsive element binding protein 1	Mus musculus	261-265	
20952540-3	2010	The signal transduction events elicited by gut-derived serotonin once it binds to the Htr1b receptor present on osteoblasts have been identified and culminate in cAMP response element-binding protein (CREB) regulation of osteoblast proliferation.	Serotonin	55-64	cAMP responsive element binding protein 1	Mus musculus	162-199	
20952540-3	2010	The signal transduction events elicited by gut-derived serotonin once it binds to the Htr1b receptor present on osteoblasts have been identified and culminate in cAMP response element-binding protein (CREB) regulation of osteoblast proliferation.	Serotonin	55-64	cAMP responsive element binding protein 1	Mus musculus	201-205	
20952540-6	2010	We further show that the transcriptional mediator of these events is CREB, whose phosphorylation on Ser 133 is increased by CaMKIV following serotonin treatment of hypothalamic explants.	Serotonin	141-150	cAMP responsive element binding protein 1	Mus musculus	69-73	
19041748-6	2008	Serotonin acts on osteoblasts through the Htr1b receptor and CREB to inhibit their proliferation.	Serotonin	0-9	cAMP responsive element binding protein 1	Mus musculus	61-65	
20122921-2	2010	Recently, chronic psychosocial stress as animal model of depression has been shown to stimulate CREB transcriptional activity in the brain; this stimulation was prevented by treatment with the antidepressant imipramine, which inhibits both noradrenaline and serotonin reuptake.	Serotonin	258-267	cAMP responsive element binding protein 1	Mus musculus	96-100	
20122921-3	2010	However, it was unknown whether the selective inhibition of serotonin reuptake is sufficient for inhibition of stress-induced CREB activation, as it is for the clinical antidepressant effect.	Serotonin	60-69	cAMP responsive element binding protein 1	Mus musculus	126-130	
17634380-5	2007	Serotonin depletion decreased neurogenesis in CREB(alpha delta) mutant mice to WT levels, which correlated with a reversal of the antidepressant phenotype in the TST.	Serotonin	0-9	cAMP responsive element binding protein 1	Mus musculus	46-50	
33162095-8	2021	The research revealed that the GABAB-cyclic AMP-protein kinase A-cAMP-response element binding protein (GABAB-cAMP-PKA-CREB) signaling pathway was related to the depression-like symptoms and that levels of 5-hydroxytryptamine, norepinephrine, and dopamine in the hippocampus of mice increased after treatment with the adzuki bean sprout fermented milk.	Serotonin	206-225	cAMP responsive element binding protein 1	Mus musculus	119-123	
34838579-0	2022	Role of the cAMP-PKA-CREB-BDNF pathway in abnormal behaviours of serotonin transporter knockout mice.	Serotonin	65-74	cAMP responsive element binding protein 1	Mus musculus	21-25	
29847220-8	2020	Furthermore, increase in the hippocampus protein expression of brain-derived neurotrophic factor (BDNF), cAMP response element binding protein (CREB), and phosphorylated CREB, with increased serotonin level were also observed in the treated animals.	Serotonin	191-200	cAMP responsive element binding protein 1	Mus musculus	144-148	
29847220-8	2020	Furthermore, increase in the hippocampus protein expression of brain-derived neurotrophic factor (BDNF), cAMP response element binding protein (CREB), and phosphorylated CREB, with increased serotonin level were also observed in the treated animals.	Serotonin	191-200	cAMP responsive element binding protein 1	Mus musculus	170-174