PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6604123-1 1983 C3a liberated from C3 by treatment with C3 convertase (or by trypsin) induced aggregation of gel-filtered human platelets and stimulated serotonin release. Serotonin 137-146 complement C3 Homo sapiens 0-3 3283237-10 1988 Human C3a, but not C3a des Arg induces serotonin release and aggregation of the guinea pig platelets. Serotonin 39-48 complement C3 Homo sapiens 6-9 3498585-11 1987 It markedly inhibits C3a-induced 3H-serotonin release from platelets in vitro and similarly inhibits the C3a-induced extravasation of Evans blue into the skin in vivo. Serotonin 36-45 complement C3 Homo sapiens 21-24 6604123-5 1983 C3a and C3a des-arg were equally reactive in mediating platelet aggregation and release of serotonin. Serotonin 91-100 complement C3 Homo sapiens 0-3 6604123-5 1983 C3a and C3a des-arg were equally reactive in mediating platelet aggregation and release of serotonin. Serotonin 91-100 complement C3 Homo sapiens 8-11 6604123-3 1983 However, at lower concentrations (2 X 10(-12) M) C3a did not aggregate platelets directly but exhibited highly significant synergism (two-way analysis of variance P less than 0.0001) with ADP in mediating platelet aggregation and release of serotonin. Serotonin 241-250 complement C3 Homo sapiens 49-52 25528336-2 2015 Concomitant insertion of a hydroxymethyl in the beta-acetamide position and aliphatic groups in C-3 position produced a positive effect on both melatonin (MT1, MT2) and serotonin (5-HT2C) binding affinities. Serotonin 169-178 complement C3 Homo sapiens 96-99 734357-1 1978 3H-serotonin release from guinea-pig platelets was demonstrated to be the consequence of C3a binding to these cells. Serotonin 3-12 complement C3 Homo sapiens 89-92 734357-5 1978 The release of serotonin may be induced by a combined reaction of C3a with HA receptors and LA receptors on the platelet membrane. Serotonin 15-24 complement C3 Homo sapiens 66-69