PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24903772-0 2014 Serotonin-related polymorphisms in TPH1 and HTR5A genes are not associated with escitalopram treatment response in Korean patients with major depression. Serotonin 0-9 tryptophan hydroxylase 1 Homo sapiens 35-39 22487062-10 2012 Gut-derived Lrp5 has been shown to regulate serotonin synthesis by controlling the production of serotonin rate-limiting enzyme, Tph1. Serotonin 44-53 tryptophan hydroxylase 1 Homo sapiens 129-133 24092348-7 2013 Serotonin is contained in platelets but is also synthesized by pulmonary endothelial cells which express tryptophan hydroxylase 1, the rate-limiting enzyme of 5-HT synthesis. Serotonin 0-9 tryptophan hydroxylase 1 Homo sapiens 105-129 23008335-2 2012 Here we report the novel finding that Tph-1 (tryptophan hydroxylase-1), a synthase which catalyses the conversion of tryptophan to serotonin and exhausts tryptophan, is a potent regulator of immunity. Serotonin 131-140 tryptophan hydroxylase 1 Homo sapiens 38-43 23008335-2 2012 Here we report the novel finding that Tph-1 (tryptophan hydroxylase-1), a synthase which catalyses the conversion of tryptophan to serotonin and exhausts tryptophan, is a potent regulator of immunity. Serotonin 131-140 tryptophan hydroxylase 1 Homo sapiens 45-69 22819790-1 2012 The aim of this study was to determine whether intrauterine malnutrition (IUM) produces a change in the expression of tryptophan-5-hydroxylase (TPH) 1 and/or 2 as the primary mechanism to explain the observed chronic cerebral acceleration of the synthesis of 5-hydroxytryptamine (5-HT). Serotonin 259-278 tryptophan hydroxylase 1 Homo sapiens 118-150 24265583-1 2013 In this study, we investigated the association between tryptophan hydroxylase-1 (TPH1 ) (218A>C), tryptophan hydroxylase-2 ( TPH2 ) (1463G>A) and serotonin carrier family 6, member 4 (SLC6A4) [long (L) vs. short (S)] gene polymorphisms with post-partum depression (PPD) in women from Jordan. Serotonin 152-161 tryptophan hydroxylase 1 Homo sapiens 55-79 23665899-2 2013 Tryptophan hydroxylase-1 (TPH1) is a key enzyme of serotonin synthesis. Serotonin 51-60 tryptophan hydroxylase 1 Homo sapiens 0-24 23665899-2 2013 Tryptophan hydroxylase-1 (TPH1) is a key enzyme of serotonin synthesis. Serotonin 51-60 tryptophan hydroxylase 1 Homo sapiens 26-30 22487062-10 2012 Gut-derived Lrp5 has been shown to regulate serotonin synthesis by controlling the production of serotonin rate-limiting enzyme, Tph1. Serotonin 97-106 tryptophan hydroxylase 1 Homo sapiens 129-133 22754301-1 2012 Tryptophan hydroxylase-1 (TPH1) is a key enzyme in the synthesis of serotonin. Serotonin 68-77 tryptophan hydroxylase 1 Homo sapiens 0-24 20818612-2 2011 Serotonin (5-HT) depletion has been obtained via targeting of genes involved in 5-HT synthesis (Tph1 and Tph2), specification and determination of the 5-HT phenotype during development (GATA3, Pet1, and Lmx1b), and 5-HT storage or clearance (Vmat2 and SERT). Serotonin 0-9 tryptophan hydroxylase 1 Homo sapiens 96-100 22754301-1 2012 Tryptophan hydroxylase-1 (TPH1) is a key enzyme in the synthesis of serotonin. Serotonin 68-77 tryptophan hydroxylase 1 Homo sapiens 26-30 22403677-8 2012 Expression of tryptophan hydroxylase 1 (TPH1), the rate-limiting enzyme in serotonin (5-HT) biosynthesis, and the 5-HT(7) receptor (HTR7), which regulates mammary gland involution, were significantly increased in mammary glands of HFD animals. Serotonin 75-84 tryptophan hydroxylase 1 Homo sapiens 14-38 22403677-8 2012 Expression of tryptophan hydroxylase 1 (TPH1), the rate-limiting enzyme in serotonin (5-HT) biosynthesis, and the 5-HT(7) receptor (HTR7), which regulates mammary gland involution, were significantly increased in mammary glands of HFD animals. Serotonin 75-84 tryptophan hydroxylase 1 Homo sapiens 40-44 21073637-2 2011 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin and has two isoforms: TPH1 and TPH2. Serotonin 80-89 tryptophan hydroxylase 1 Homo sapiens 112-116 20945066-1 2011 RATIONALE: Tryptophan hydroxylase 1 (TPH1), which encodes the rate-limiting enzyme tryptophan hydroxylase in the biosynthesis of serotonin, is a candidate gene in the development and treatment response of major depressive disorder (MDD); however, its actual role is uncertain. Serotonin 129-138 tryptophan hydroxylase 1 Homo sapiens 11-35 20945066-1 2011 RATIONALE: Tryptophan hydroxylase 1 (TPH1), which encodes the rate-limiting enzyme tryptophan hydroxylase in the biosynthesis of serotonin, is a candidate gene in the development and treatment response of major depressive disorder (MDD); however, its actual role is uncertain. Serotonin 129-138 tryptophan hydroxylase 1 Homo sapiens 37-41 20580984-7 2010 The results suggest that TPH1 gene variation participates in the regulation of serotonin and dopamine turnover rates in the central nervous system of healthy human subjects. Serotonin 79-88 tryptophan hydroxylase 1 Homo sapiens 25-29 21508359-3 2011 MATERIALS AND METHODS: PTEN was inhibited by pharmacological and molecular approaches, and the resultant secretion of serotonin and expression of tryptophan hydroxylase 1 (TPH1), the rate-limiting enzyme in serotonin synthesis, was assessed. Serotonin 207-216 tryptophan hydroxylase 1 Homo sapiens 146-170 21508359-3 2011 MATERIALS AND METHODS: PTEN was inhibited by pharmacological and molecular approaches, and the resultant secretion of serotonin and expression of tryptophan hydroxylase 1 (TPH1), the rate-limiting enzyme in serotonin synthesis, was assessed. Serotonin 207-216 tryptophan hydroxylase 1 Homo sapiens 172-176 20213726-1 2010 The tryptophan hydroxylase 1 and 2 (TPH1 and TPH2) genes encode the rate-limiting enzymes in the serotonin biosynthesis. Serotonin 97-106 tryptophan hydroxylase 1 Homo sapiens 4-34 20213726-1 2010 The tryptophan hydroxylase 1 and 2 (TPH1 and TPH2) genes encode the rate-limiting enzymes in the serotonin biosynthesis. Serotonin 97-106 tryptophan hydroxylase 1 Homo sapiens 36-40 20144688-2 2010 Although a genetic association of tryptophan hydroxylase isoform 1 (TPH1), the rate-limiting enzyme in serotonin synthesis, with schizophrenia has been suggested by recent systematic meta-analyses, the newly identified neuronal isoform TPH2 is more relevant to the central nervous system and the association of TPH2 gene with schizophrenia has been much less explored. Serotonin 103-112 tryptophan hydroxylase 1 Homo sapiens 34-66 20556201-1 2010 Trytophan Hydroxylase Type I (TPH1), most abundantly expressed in the gastrointestinal tract, initiates the synthesis of serotonin by catalyzing hydroxylation of tryptophan in the presence of biopterin and oxygen. Serotonin 121-130 tryptophan hydroxylase 1 Homo sapiens 30-34 20556201-2 2010 We have previously described three series of novel, periphery-specific TPH1 inhibitors that selectively deplete serotonin in the gastrointestinal tract. Serotonin 112-121 tryptophan hydroxylase 1 Homo sapiens 71-75 20043001-2 2010 We tested the hypothesis that variations in serotonergic genes (TPH2, TPH1, SLC6A4, HTR1A), which influence serotonin availability, affect choice behavior in a probabilistic gambling task. Serotonin 108-117 tryptophan hydroxylase 1 Homo sapiens 70-74 20144688-2 2010 Although a genetic association of tryptophan hydroxylase isoform 1 (TPH1), the rate-limiting enzyme in serotonin synthesis, with schizophrenia has been suggested by recent systematic meta-analyses, the newly identified neuronal isoform TPH2 is more relevant to the central nervous system and the association of TPH2 gene with schizophrenia has been much less explored. Serotonin 103-112 tryptophan hydroxylase 1 Homo sapiens 68-72 20329492-2 2010 Tryptophan hydroxylase 1 (TPH1) is the limiting enzyme for peripheral serotonin synthesis, and its expression by valve interstitial cells (IC) could implicate an autocrine serotonin signaling mechanism in primary degenerative myxomatous mitral valve disease. Serotonin 70-79 tryptophan hydroxylase 1 Homo sapiens 0-24 20396435-0 2010 Association between Serotonin-Related Polymorphisms in 5HT2A, TPH1, TPH2 Genes and Bipolar Disorder in Korean Population. Serotonin 20-29 tryptophan hydroxylase 1 Homo sapiens 62-66 20329492-2 2010 Tryptophan hydroxylase 1 (TPH1) is the limiting enzyme for peripheral serotonin synthesis, and its expression by valve interstitial cells (IC) could implicate an autocrine serotonin signaling mechanism in primary degenerative myxomatous mitral valve disease. Serotonin 70-79 tryptophan hydroxylase 1 Homo sapiens 26-30 20329492-2 2010 Tryptophan hydroxylase 1 (TPH1) is the limiting enzyme for peripheral serotonin synthesis, and its expression by valve interstitial cells (IC) could implicate an autocrine serotonin signaling mechanism in primary degenerative myxomatous mitral valve disease. Serotonin 172-181 tryptophan hydroxylase 1 Homo sapiens 0-24 20329492-2 2010 Tryptophan hydroxylase 1 (TPH1) is the limiting enzyme for peripheral serotonin synthesis, and its expression by valve interstitial cells (IC) could implicate an autocrine serotonin signaling mechanism in primary degenerative myxomatous mitral valve disease. Serotonin 172-181 tryptophan hydroxylase 1 Homo sapiens 26-30 18536742-7 2008 Serotonin is synthesized, through Tph1, in the endothelial cells of the pulmonary artery and can then act on underlying pulmonary arterial smooth muscle cells and pulmonary arterial fibroblasts in a paracrine fashion causing constriction and remodelling. Serotonin 0-9 tryptophan hydroxylase 1 Homo sapiens 34-38 19744316-3 2009 Notch signalling regulates expression of TPH1, the rate limiting enzyme in the biosynthesis of serotonin. Serotonin 95-104 tryptophan hydroxylase 1 Homo sapiens 41-45 19286424-3 2009 The rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (SERT) and serotonin can induce pulmonary vasoconstriction via the 5-HT1B receptor in man. Serotonin 56-65 tryptophan hydroxylase 1 Homo sapiens 69-93 19286424-3 2009 The rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (SERT) and serotonin can induce pulmonary vasoconstriction via the 5-HT1B receptor in man. Serotonin 56-65 tryptophan hydroxylase 1 Homo sapiens 95-99 19286424-3 2009 The rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (SERT) and serotonin can induce pulmonary vasoconstriction via the 5-HT1B receptor in man. Serotonin 102-111 tryptophan hydroxylase 1 Homo sapiens 69-93 19286424-3 2009 The rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (SERT) and serotonin can induce pulmonary vasoconstriction via the 5-HT1B receptor in man. Serotonin 102-111 tryptophan hydroxylase 1 Homo sapiens 95-99 19286424-3 2009 The rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (SERT) and serotonin can induce pulmonary vasoconstriction via the 5-HT1B receptor in man. Serotonin 102-111 tryptophan hydroxylase 1 Homo sapiens 69-93 19286424-3 2009 The rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (SERT) and serotonin can induce pulmonary vasoconstriction via the 5-HT1B receptor in man. Serotonin 102-111 tryptophan hydroxylase 1 Homo sapiens 95-99 18826425-1 2009 The Iowa Gambling Task (IGT) was used to examine (i) social decision-making in women with borderline personality disorder (BPD), and (ii) the relationship between impaired decision-making and the tryptophan hydroxylase-1 (TPH-1) gene, involved in serotonin synthesis. Serotonin 247-256 tryptophan hydroxylase 1 Homo sapiens 196-220 18826425-1 2009 The Iowa Gambling Task (IGT) was used to examine (i) social decision-making in women with borderline personality disorder (BPD), and (ii) the relationship between impaired decision-making and the tryptophan hydroxylase-1 (TPH-1) gene, involved in serotonin synthesis. Serotonin 247-256 tryptophan hydroxylase 1 Homo sapiens 222-227 19903352-5 2009 METHODS: Serotonin biosynthetic capacity was analyzed in human breast tumor tissue microarrays using immunohistochemistry for tryptophan hydroxylase 1 (TPH1). Serotonin 9-18 tryptophan hydroxylase 1 Homo sapiens 126-150 19903352-5 2009 METHODS: Serotonin biosynthetic capacity was analyzed in human breast tumor tissue microarrays using immunohistochemistry for tryptophan hydroxylase 1 (TPH1). Serotonin 9-18 tryptophan hydroxylase 1 Homo sapiens 152-156 20204739-4 2010 Synthesis of serotonin can occur in pulmonary artery endothelial cells by the enzyme tryptophan hydroxylase 1 (TPH1). Serotonin 13-22 tryptophan hydroxylase 1 Homo sapiens 85-109 20204739-4 2010 Synthesis of serotonin can occur in pulmonary artery endothelial cells by the enzyme tryptophan hydroxylase 1 (TPH1). Serotonin 13-22 tryptophan hydroxylase 1 Homo sapiens 111-115 19500158-1 2009 Tryptophan hydroxylase-1 (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, and allelic variations at the TPH1 locus have been implicated in the pathophysiology of depression. Serotonin 63-72 tryptophan hydroxylase 1 Homo sapiens 0-24 19500158-1 2009 Tryptophan hydroxylase-1 (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, and allelic variations at the TPH1 locus have been implicated in the pathophysiology of depression. Serotonin 63-72 tryptophan hydroxylase 1 Homo sapiens 26-30 19500158-1 2009 Tryptophan hydroxylase-1 (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, and allelic variations at the TPH1 locus have been implicated in the pathophysiology of depression. Serotonin 63-72 tryptophan hydroxylase 1 Homo sapiens 117-121 17203304-8 2007 The most significant models contributing to serotonin distribution were found for interactions between TPH1 rs4537731 and SLC6A4 haplotypes (P = 0.002) and between HTR1D rs6300 and SLC6A4 haplotypes (P = 0.013). Serotonin 44-53 tryptophan hydroxylase 1 Homo sapiens 103-107 17663674-2 2007 Serotonin can be synthesised in the pulmonary endothelium with the rate-limiting step being the activity of tryptophan hydroxylase1 (Tph1). Serotonin 0-9 tryptophan hydroxylase 1 Homo sapiens 108-131 17663674-2 2007 Serotonin can be synthesised in the pulmonary endothelium with the rate-limiting step being the activity of tryptophan hydroxylase1 (Tph1). Serotonin 0-9 tryptophan hydroxylase 1 Homo sapiens 133-137 17481962-9 2007 CONCLUSIONS: CD patients in remission who experience IBS-like symptoms have increased mucosal TpH-1 levels in the colon, suggesting that increased serotonin biosynthesis in the colon plays a role in the generation of the symptoms. Serotonin 147-156 tryptophan hydroxylase 1 Homo sapiens 94-99 18234316-6 2008 The amounts of histamine/serotonin stored were reflected by the expression levels of histidine decarboxylase and tryptophan hydroxylase 1, respectively. Serotonin 25-34 tryptophan hydroxylase 1 Homo sapiens 113-137 17973628-1 2008 TPH (tryptophan hydroxylase) catalyses the rate-limiting step in the synthesis of serotonin, and exists in two isoforms: TPH1, mainly found in peripheral tissues and the pineal body, and TPH2, a neuronal form. Serotonin 82-91 tryptophan hydroxylase 1 Homo sapiens 121-125 16979275-1 2007 Tryptophan hydroxylase-1 (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, and selective serotonin reuptake inhibitors (SSRIs) exert their activity enhancing the general serotonergic tone. Serotonin 63-72 tryptophan hydroxylase 1 Homo sapiens 0-24 16979275-1 2007 Tryptophan hydroxylase-1 (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, and selective serotonin reuptake inhibitors (SSRIs) exert their activity enhancing the general serotonergic tone. Serotonin 63-72 tryptophan hydroxylase 1 Homo sapiens 26-30 17241888-5 2007 Serotonin is synthesized through the actions of 2 different tryptophan hydroxylases, TpH1 and TpH2, which are found, respectively, in EC cells and neurons. Serotonin 0-9 tryptophan hydroxylase 1 Homo sapiens 85-89 16958027-1 2006 The TPH1 and TPH2 genes encode the rate-limiting enzymes that control serotonin biosynthesis, and serotonin is clearly altered in autism. Serotonin 70-79 tryptophan hydroxylase 1 Homo sapiens 4-8 16958027-1 2006 The TPH1 and TPH2 genes encode the rate-limiting enzymes that control serotonin biosynthesis, and serotonin is clearly altered in autism. Serotonin 98-107 tryptophan hydroxylase 1 Homo sapiens 4-8 34772352-0 2021 TPH1 gene polymorphism rs211105 is associated with serotonin and tryptophan hydroxylase 1 concentrations in acute pancreatitis patients. Serotonin 51-60 tryptophan hydroxylase 1 Homo sapiens 0-4 16408289-5 2006 RT-PCR on the human osteoclasts demonstrated several serotonin receptors, the serotonin transporter, and the rate-limiting enzyme in serotonin synthesis, tryptophan hydroxylase 1 (Tph1). Serotonin 53-62 tryptophan hydroxylase 1 Homo sapiens 180-184 15544576-3 2004 Since tryptophan hydroxylase (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, its role in the pathophysiology of these psychiatric diseases has been intensively studied. Serotonin 67-76 tryptophan hydroxylase 1 Homo sapiens 30-34 16165107-1 2006 BACKGROUND: Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin (5-HT) and might be related to the pathogenesis of major depression (MD). Serotonin 92-101 tryptophan hydroxylase 1 Homo sapiens 12-35 15663479-7 2005 The differences between TPH1 and TPH2 have important implications for the regulation of serotonin production in the brain and the periphery and may provide an explanation for some of the diverging results reported for TPH from different sources in the past. Serotonin 88-97 tryptophan hydroxylase 1 Homo sapiens 24-28 34882257-1 2022 OBJECTIVES: This exploratory research aimed to evaluate the levels of tryptophan hydroxylase 1 (TPH1) and aromatic l-amino acid decarboxylase (DDC), which play an important role in the serotonin synthesis pathway, in individuals with sleep bruxism (SB) diagnosed using audio-video polysomnography (vPSG) and compare them with that of individuals not presenting with SB. Serotonin 185-194 tryptophan hydroxylase 1 Homo sapiens 70-94 34882257-1 2022 OBJECTIVES: This exploratory research aimed to evaluate the levels of tryptophan hydroxylase 1 (TPH1) and aromatic l-amino acid decarboxylase (DDC), which play an important role in the serotonin synthesis pathway, in individuals with sleep bruxism (SB) diagnosed using audio-video polysomnography (vPSG) and compare them with that of individuals not presenting with SB. Serotonin 185-194 tryptophan hydroxylase 1 Homo sapiens 96-100 35391733-10 2022 HSV infection induced expression of the critical serotonin synthesis enzymes TPH-1, TPH-2, and DOPA decarboxylase (DDC), as well as the serotonin transporter, SERT. Serotonin 49-58 tryptophan hydroxylase 1 Homo sapiens 77-82 34771469-2 2021 In aggressive PANC-1 and MIA PaCa-2 cells, knock-down (KD) of EZH2, TPH1, or HTR7 induced a decrease in CSCs and recovery from gemcitabine resistance, while preconditioning of less aggressive Capan-1 cells with 5-HT induced gemcitabine resistance with increased expression of EZH2, TPH1, and 5-HT7. Serotonin 211-215 tryptophan hydroxylase 1 Homo sapiens 282-286 34065903-4 2021 The SIBO-D patients showed an increased serum concentration of 5-HT and small intestinal mucosa mRNA expression of tryptophan hydroxylase 1 (TPH-1), a rate-limiting enzyme in 5-HT biosynthesis. Serotonin 175-179 tryptophan hydroxylase 1 Homo sapiens 115-139 34065903-4 2021 The SIBO-D patients showed an increased serum concentration of 5-HT and small intestinal mucosa mRNA expression of tryptophan hydroxylase 1 (TPH-1), a rate-limiting enzyme in 5-HT biosynthesis. Serotonin 175-179 tryptophan hydroxylase 1 Homo sapiens 141-146 34285037-4 2021 In this study, we found that 5-HT levels, as well as the expression of tryptophan hydroxylase 1 (TPH1), the 5-HT biosynthesis rate-limiting enzyme, were significantly upregulated in colorectal tumor tissues from CRC patients, CRC mouse models, and CRC cell lines, when compared with normal colorectal tissues or epithelial cell lines. Serotonin 108-112 tryptophan hydroxylase 1 Homo sapiens 71-95 34285037-4 2021 In this study, we found that 5-HT levels, as well as the expression of tryptophan hydroxylase 1 (TPH1), the 5-HT biosynthesis rate-limiting enzyme, were significantly upregulated in colorectal tumor tissues from CRC patients, CRC mouse models, and CRC cell lines, when compared with normal colorectal tissues or epithelial cell lines. Serotonin 108-112 tryptophan hydroxylase 1 Homo sapiens 97-101 34368536-6 2021 To evaluate calcification progress, calcium and collagen deposits along with the expression of protein markers, including the rate-limiting enzyme of serotonin synthesis (tryptophan hydroxylase 1 (TPH1)), were assessed. Serotonin 150-159 tryptophan hydroxylase 1 Homo sapiens 197-201 35473609-0 2022 Tryptophan hydroxylase 1 drives glioma progression by modulating the serotonin/L1CAM/NF-kappaB signaling pathway. Serotonin 69-78 tryptophan hydroxylase 1 Homo sapiens 0-24 35473609-9 2022 Mechanistically, TPH-1 increased the production of serotonin in glioma cells. Serotonin 51-60 tryptophan hydroxylase 1 Homo sapiens 17-22 35473609-12 2022 CONCLUSION: Taken together, these data suggested that TPH-1 facilitated cellular proliferation, migration, and chemoresistance in glioma through the serotonin/L1CAM/NF-kappaB pathway. Serotonin 149-158 tryptophan hydroxylase 1 Homo sapiens 54-59 33517848-4 2021 Fluoxetine treatment increased lipid accumulation in association with increased mRNA expression of tryptophan hydroxylase 1 (Tph1, serotonin biosynthetic enzyme) and intracellular serotonin content. Serotonin 134-143 tryptophan hydroxylase 1 Homo sapiens 99-123 32967429-6 2020 The mRNA of the rate-limiting enzyme in serotonin synthesis, tryptophan hydroxylase 1 was unregulated. Serotonin 40-49 tryptophan hydroxylase 1 Homo sapiens 61-85 33466782-3 2021 In the present work, the level of 5-HT in serum and the number of enteroendocrine cells (EECs) as well as the expression of the 5-HT rate-limiting enzyme tryptophan hydroxylase 1 (TPH1) in colonic biopsies and urine 5-hydroxyindoeoacetic acid (5-HIAA) were determined in 36 LC patients that were treated with budesonide and 32 healthy controls. Serotonin 128-132 tryptophan hydroxylase 1 Homo sapiens 154-178 33466782-3 2021 In the present work, the level of 5-HT in serum and the number of enteroendocrine cells (EECs) as well as the expression of the 5-HT rate-limiting enzyme tryptophan hydroxylase 1 (TPH1) in colonic biopsies and urine 5-hydroxyindoeoacetic acid (5-HIAA) were determined in 36 LC patients that were treated with budesonide and 32 healthy controls. Serotonin 128-132 tryptophan hydroxylase 1 Homo sapiens 180-184 33466782-5 2021 The levels of 5-HT and 5-HIAA and the number of EECs were higher in LC patients than in the controls, and positive correlations were observed between the 5-HT and 5-HIAA levels, 5-HT and EEC number, TPH1 mRNA and EEC number, as well as the severity of disease symptoms and 5-HIAA. Serotonin 154-158 tryptophan hydroxylase 1 Homo sapiens 199-203 33466782-5 2021 The levels of 5-HT and 5-HIAA and the number of EECs were higher in LC patients than in the controls, and positive correlations were observed between the 5-HT and 5-HIAA levels, 5-HT and EEC number, TPH1 mRNA and EEC number, as well as the severity of disease symptoms and 5-HIAA. Serotonin 154-158 tryptophan hydroxylase 1 Homo sapiens 199-203 33215629-8 2020 The level of serotonin synthesis enzyme TPH-1 was higher in early gestation female placentas and at term serotonin concentration was 3-fold higher in the umbilical vein than in the umbilical artery. Serotonin 13-22 tryptophan hydroxylase 1 Homo sapiens 40-45 32801896-1 2020 Purpose: Neuroendocrine tumors (NETs) associated with carcinoid syndrome (CS) overproduce serotonin, mediated by tryptophan hydroxylase-1 (TPH1). Serotonin 90-99 tryptophan hydroxylase 1 Homo sapiens 113-137 32752885-1 2020 Aim: Tryptophan hydroxylase 1 (TPH1) catalyzes serotonin synthesis in peripheral tissues. Serotonin 47-56 tryptophan hydroxylase 1 Homo sapiens 5-29 32752885-1 2020 Aim: Tryptophan hydroxylase 1 (TPH1) catalyzes serotonin synthesis in peripheral tissues. Serotonin 47-56 tryptophan hydroxylase 1 Homo sapiens 31-35 32752885-2 2020 Selective TPH1 inhibitors may be useful for treating disorders related to serotonin dysregulation. Serotonin 74-83 tryptophan hydroxylase 1 Homo sapiens 10-14 32752885-7 2020 Conclusion: This TPH1 inhibitor scaffold may be useful for developing new therapeutics for treating elevated peripheral serotonin. Serotonin 120-129 tryptophan hydroxylase 1 Homo sapiens 17-21 32801896-1 2020 Purpose: Neuroendocrine tumors (NETs) associated with carcinoid syndrome (CS) overproduce serotonin, mediated by tryptophan hydroxylase-1 (TPH1). Serotonin 90-99 tryptophan hydroxylase 1 Homo sapiens 139-143 30468670-5 2019 Peripheral serotonin is synthesized by the enzyme tryptophan hydroxylase (Tph), which exists in two different isoforms: Tph2 being responsible for serotonin synthesis in neurons and Tph1 for generation of serotonin in peripheral organs. Serotonin 11-20 tryptophan hydroxylase 1 Homo sapiens 182-186 31294376-1 2019 Background: Tryptophan hydroxylase (TPH)1 catalyzes the biosynthesis of serotonin (5-hydroxytrptamine; 5-HT) in enterochromaffin (EC) cells, the predominant source of gut 5-HT. Serotonin 72-81 tryptophan hydroxylase 1 Homo sapiens 36-41 30351987-3 2018 We hypothesized that inhibiting nonneuronal serotonin activity by feeding a small-molecule inhibitor of the rate-limiting enzyme in serotonin synthesis [tryptophan hydroxylase 1 (TPH1)] would preserve maternal bone postweaning without affecting neonatal bone. Serotonin 44-53 tryptophan hydroxylase 1 Homo sapiens 153-177 30351987-3 2018 We hypothesized that inhibiting nonneuronal serotonin activity by feeding a small-molecule inhibitor of the rate-limiting enzyme in serotonin synthesis [tryptophan hydroxylase 1 (TPH1)] would preserve maternal bone postweaning without affecting neonatal bone. Serotonin 44-53 tryptophan hydroxylase 1 Homo sapiens 179-183 30351987-3 2018 We hypothesized that inhibiting nonneuronal serotonin activity by feeding a small-molecule inhibitor of the rate-limiting enzyme in serotonin synthesis [tryptophan hydroxylase 1 (TPH1)] would preserve maternal bone postweaning without affecting neonatal bone. Serotonin 132-141 tryptophan hydroxylase 1 Homo sapiens 153-177 30351987-3 2018 We hypothesized that inhibiting nonneuronal serotonin activity by feeding a small-molecule inhibitor of the rate-limiting enzyme in serotonin synthesis [tryptophan hydroxylase 1 (TPH1)] would preserve maternal bone postweaning without affecting neonatal bone. Serotonin 132-141 tryptophan hydroxylase 1 Homo sapiens 179-183 29035515-3 2017 TPH1 catalyzes the initial step in the synthesis of serotonin in the peripheral tissues, while TPH2 catalyzes this step in the brain. Serotonin 52-61 tryptophan hydroxylase 1 Homo sapiens 0-4 29468941-4 2018 Pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (TPH1) is increased in patients with PAH and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (PASMCs), In humans, serotonin can enter PASMCs via the serotonin transporter (SERT) or activate the 5-HT1B receptor; 5-HT1B activation and SERT activity cooperate to induce PASMC contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. Serotonin 22-31 tryptophan hydroxylase 1 Homo sapiens 71-75 29468941-4 2018 Pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (TPH1) is increased in patients with PAH and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (PASMCs), In humans, serotonin can enter PASMCs via the serotonin transporter (SERT) or activate the 5-HT1B receptor; 5-HT1B activation and SERT activity cooperate to induce PASMC contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. Serotonin 115-124 tryptophan hydroxylase 1 Homo sapiens 71-75 29468941-4 2018 Pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (TPH1) is increased in patients with PAH and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (PASMCs), In humans, serotonin can enter PASMCs via the serotonin transporter (SERT) or activate the 5-HT1B receptor; 5-HT1B activation and SERT activity cooperate to induce PASMC contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. Serotonin 115-124 tryptophan hydroxylase 1 Homo sapiens 71-75 29291611-12 2018 Further analysis via real-time polymerase chain reaction suggested that IBS patient-derived RNA exhibited lower levels of tryptophan hydroxylase-1 expression, the enzyme that catalyzes the rate-limiting step in serotonin biosynthesis. Serotonin 211-220 tryptophan hydroxylase 1 Homo sapiens 122-146 29696773-8 2018 A homozygous, missense variant in tryptophan hydroxylase 1 may be clinically important as this gene encodes the rate limiting step in serotonin biosynthesis, a biologic pathway connected with mood disorders. Serotonin 134-143 tryptophan hydroxylase 1 Homo sapiens 34-58 29194046-7 2018 SUMMARY: The gastrointestinal tract is the largest storage organ for serotonin where its biosynthesis is regulated by TPH1. Serotonin 69-78 tryptophan hydroxylase 1 Homo sapiens 118-122 25912293-9 2015 These genes encode for elements involved in circadian rhythm regulation (RBM3 and NR1D1) and in serotonin synthesis (TPH1), processes previously involved in both disorders, and in the mechanism of action of lithium. Serotonin 96-105 tryptophan hydroxylase 1 Homo sapiens 117-121 28443016-5 2017 Interestingly, (i) the expression of three of these six genes (COMT, DBH, NOS1) are highly variable; (ii) three of these six genes (COMT, DBH, TPH1) are involved in DA or serotonin metabolism, biosynthesis and/or neurotransmission; and (iii) five of these six genes (AR, BDNF, COMT, DBH, NOS1) have been implicated in the development, onset and/or propagation of schizophrenia. Serotonin 171-180 tryptophan hydroxylase 1 Homo sapiens 143-147 26238767-1 2015 Decoy receptor 3 (DcR3) is expressed in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) and downregulates the expression of tryptophan hydroxylase 1 (TPH1), which is the rate-limiting enzyme in serotonin synthesis. Serotonin 205-214 tryptophan hydroxylase 1 Homo sapiens 135-159 26238767-1 2015 Decoy receptor 3 (DcR3) is expressed in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) and downregulates the expression of tryptophan hydroxylase 1 (TPH1), which is the rate-limiting enzyme in serotonin synthesis. Serotonin 205-214 tryptophan hydroxylase 1 Homo sapiens 161-165 28751217-3 2017 Moreover, it is not known if the two tryptophan hydroxylase isoforms (TPH1 and TPH2), the rate-limiting enzymes in serotonin biosynthesis, are expressed in placenta. Serotonin 115-124 tryptophan hydroxylase 1 Homo sapiens 70-74 28751217-10 2017 This study demonstrates that both TPH1 and TPH2 are expressed in human and mouse placenta throughout pregnancy and helps to better understand the placental serotonin system, which is crucial for healthy pregnancy and fetal development. Serotonin 156-165 tryptophan hydroxylase 1 Homo sapiens 34-38 27866207-5 2017 The genomic DNA collected and stored in a -70 C freezer was genotyped for 6 polymorphisms in genes associated with serotonin synthesis (tryptophan hydroxylase 1 (TPH1) A218C, TPH2 rs10879355, and TPH2 rs4641528), transport (the promoter region of the serotonin transporter protein), and catabolism (the 30-bp functional variable number tandem repeat) polymorphism in the promoter region of monoamine oxidase A (MAO-A). Serotonin 115-124 tryptophan hydroxylase 1 Homo sapiens 136-160 27497328-2 2016 The first and rate-limiting step in the synthesis of serotonin is catalyzed by tryptophan hydroxylase (TPH) which is encoded by TPH1 and THP2 genes. Serotonin 53-62 tryptophan hydroxylase 1 Homo sapiens 128-132 27144435-5 2016 Tryptophan hydroxylase 1 (TPH1), the rate limit enzyme in serotonin synthesis, was one of the genes which expression was reduced in DHT-treated SE cells. Serotonin 58-67 tryptophan hydroxylase 1 Homo sapiens 0-24 27144435-5 2016 Tryptophan hydroxylase 1 (TPH1), the rate limit enzyme in serotonin synthesis, was one of the genes which expression was reduced in DHT-treated SE cells. Serotonin 58-67 tryptophan hydroxylase 1 Homo sapiens 26-30 26710093-1 2016 OBJECTIVE: The tryptophan hydroxylase 1 gene (TPH1) catalyzes the formation of 5-hydroxytryptophan, a precursor to the neurotransmitter serotonin. Serotonin 136-145 tryptophan hydroxylase 1 Homo sapiens 15-39 26710093-1 2016 OBJECTIVE: The tryptophan hydroxylase 1 gene (TPH1) catalyzes the formation of 5-hydroxytryptophan, a precursor to the neurotransmitter serotonin. Serotonin 136-145 tryptophan hydroxylase 1 Homo sapiens 46-50