PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25497297-7 2015 RESULTS: Results suggest that MAOA promoter hypermethylation is associated with ASPD and may contribute to downregulation of MAOA gene expression, as indicated by functional assays in vitro, and regression analysis with whole-blood serotonin levels in offenders with ASPD. Serotonin 232-241 monoamine oxidase A Homo sapiens 30-34 1413647-2 1992 Activity of MAO-A with serotonin as a substrate was statistically distinctly lower (by 22%) in placenta within early periods of pregnancy as compared which the mature placenta during the delivery time. Serotonin 23-32 monoamine oxidase A Homo sapiens 12-17 1413625-4 1992 In the system containing membrane bound MAO from human placenta, where the MAO-A is predominating, the modulators studied mostly inhibited deamination of 14C-serotonin. Serotonin 158-167 monoamine oxidase A Homo sapiens 75-80 1741773-8 1991 The ratio, MAO A molecular activity:MAO B molecular activity decreased in the order: serotonin (35:1) greater than tryptamine (12:1) greater than tyramine (3.3:1) greater than dopamine (2.4:1) greater than benzylamine (1:23). Serotonin 85-94 monoamine oxidase A Homo sapiens 11-16 1759390-7 1991 In deprenyl pretreated mitochondria the potency of MAO-A-dependent effects of these amines was: serotonin greater than tyramine much greater than much greater than 2-phenylethylamine. Serotonin 96-105 monoamine oxidase A Homo sapiens 51-56 3340083-5 1988 FNPA acted as a competitive inhibitor for human placental MAO-A in the dark (Ki = 10 microM) when [14C]serotonin was used as the substrate. Serotonin 103-112 monoamine oxidase A Homo sapiens 58-63 34923109-2 2022 Among these, Monoamine oxidase A (MAOA) catalyzes the degradation of dopamine, norepinephrine, and serotonin into their inactive metabolites. Serotonin 99-108 monoamine oxidase A Homo sapiens 13-32 34923109-2 2022 Among these, Monoamine oxidase A (MAOA) catalyzes the degradation of dopamine, norepinephrine, and serotonin into their inactive metabolites. Serotonin 99-108 monoamine oxidase A Homo sapiens 34-38 34560070-9 2021 More importantly, by western blotting, we detected that the upregulation of Tph1, AADC and MAO-A expression induced by cisplatin both in vivo and in vitro could be obviously suppressed by SH to decrease 5-HT synthesis and mitochondrial 5-HT degradation. Serotonin 203-207 monoamine oxidase A Homo sapiens 91-96 34560070-9 2021 More importantly, by western blotting, we detected that the upregulation of Tph1, AADC and MAO-A expression induced by cisplatin both in vivo and in vitro could be obviously suppressed by SH to decrease 5-HT synthesis and mitochondrial 5-HT degradation. Serotonin 236-240 monoamine oxidase A Homo sapiens 91-96 2496202-5 1989 Similar to the endogenous enzymes, the expressed MAO A prefers serotonin as a substrate and is sensitive to the inhibitor clorgyline. Serotonin 63-72 monoamine oxidase A Homo sapiens 49-54 34795483-1 2021 Background: Monoamine oxidase-A (MAO-A) decomposes dopamine and serotonin, and decreased MAO-A expression increases monoamine levels and is related to the pathophysiology of schizophrenia. Serotonin 64-73 monoamine oxidase A Homo sapiens 12-31 34795483-1 2021 Background: Monoamine oxidase-A (MAO-A) decomposes dopamine and serotonin, and decreased MAO-A expression increases monoamine levels and is related to the pathophysiology of schizophrenia. Serotonin 64-73 monoamine oxidase A Homo sapiens 33-38 34280394-7 2021 5-HT2A receptors, 5-HT synthetase and MAO-A were expressed in hepatocytes; their gene and protein expression were upregulated by CCl4, which led to the degradation of mitochondrial 5-HT and overproduction of reactive oxygen species (ROS). Serotonin 181-185 monoamine oxidase A Homo sapiens 38-43 35202708-1 2022 Previously we found that acute liver injury (ALI) with inflammation caused by carbon tetrachloride (CCl4) was associated with the activation of the 5-HT degradation system (5DS), which includes monoamine oxidase A (MAO-A), the 5-HT2A receptor, and 5-HT synthases in hepatocytes. Serotonin 148-152 monoamine oxidase A Homo sapiens 194-213 35202708-1 2022 Previously we found that acute liver injury (ALI) with inflammation caused by carbon tetrachloride (CCl4) was associated with the activation of the 5-HT degradation system (5DS), which includes monoamine oxidase A (MAO-A), the 5-HT2A receptor, and 5-HT synthases in hepatocytes. Serotonin 148-152 monoamine oxidase A Homo sapiens 215-220 35202708-1 2022 Previously we found that acute liver injury (ALI) with inflammation caused by carbon tetrachloride (CCl4) was associated with the activation of the 5-HT degradation system (5DS), which includes monoamine oxidase A (MAO-A), the 5-HT2A receptor, and 5-HT synthases in hepatocytes. Serotonin 248-252 monoamine oxidase A Homo sapiens 215-220 2924086-4 1989 The results demonstrated the presence of MAO A and B in human thyroid cells which oxidized 5-hydroxytryptamine and 2-phenylethylamine, respectively, and were selectively inhibited by the MAO inhibitors clorgyline and (-)-deprenyl. Serotonin 91-110 monoamine oxidase A Homo sapiens 41-52 3340083-7 1988 The specificity of the photodependent incorporation of FNPA to MAO-A was shown by the protective effect of serotonin during the irradiation. Serotonin 107-116 monoamine oxidase A Homo sapiens 63-68 2420928-1 1986 Monoamine oxidase (MAO) type A and type B were measured using kynuramine, 3,4-dihydroxyphenylethylamine (dopamine, DA), and 5-hydroxytryptamine (5-HT, serotonin) in 20 brain areas. Serotonin 124-143 monoamine oxidase A Homo sapiens 0-41 2420928-1 1986 Monoamine oxidase (MAO) type A and type B were measured using kynuramine, 3,4-dihydroxyphenylethylamine (dopamine, DA), and 5-hydroxytryptamine (5-HT, serotonin) in 20 brain areas. Serotonin 145-149 monoamine oxidase A Homo sapiens 0-41 2420928-1 1986 Monoamine oxidase (MAO) type A and type B were measured using kynuramine, 3,4-dihydroxyphenylethylamine (dopamine, DA), and 5-hydroxytryptamine (5-HT, serotonin) in 20 brain areas. Serotonin 151-160 monoamine oxidase A Homo sapiens 0-41 20227955-2 1980 With 5-hydroxytryptamine (5-HT), beta-phenylethylamine (PEA) and benzylamine (Bz) as substrates and clorgyline and deprenyl, respectively, as selective MAO A and B inhibitors, their activity pattern has been defined and compared with that of human liver. Serotonin 26-30 monoamine oxidase A Homo sapiens 152-157 7130973-2 1982 Concentrations of 5-hydroxytryptamine and phenylethylamine, approximately at their Km values, were used as substrates for MAO A and B respectively. Serotonin 18-37 monoamine oxidase A Homo sapiens 122-127 7327272-1 1981 One--day cold exposure decreases the monoamine oxidase type A activity by 52--54% (serotonin and noradrenaline substrates); the monoamine oxidase type B activity by 14%. Serotonin 83-92 monoamine oxidase A Homo sapiens 37-61 3008207-7 1986 As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition. Serotonin 8-17 monoamine oxidase A Homo sapiens 71-76 3008207-7 1986 As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition. Serotonin 8-17 monoamine oxidase A Homo sapiens 254-259 3008207-7 1986 As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition. Serotonin 125-134 monoamine oxidase A Homo sapiens 71-76 3008207-7 1986 As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition. Serotonin 125-134 monoamine oxidase A Homo sapiens 254-259 3875898-2 1985 The reagents recognized different populations of neurons: those that recognized MAO A were located in cell groups containing catecholamines, including the substantia nigra, nucleus locus coeruleus, nucleus subcoeruleus, and the periventricular region of the hypothalamus, whereas those that recognized MAO B were observed in serotonin regions, including the nucleus raphe dorsalis and nucleus centralis superior. Serotonin 325-334 monoamine oxidase A Homo sapiens 80-85 7159481-0 1982 Monoamine oxidase type A: differences in selectivity towards l-norepinephrine compared to serotonin. Serotonin 90-99 monoamine oxidase A Homo sapiens 0-24 7159481-3 1982 Serotonin was a more selective substrate for MAO-A, being inhibited by low concentrations (less than 10(-7) M) of the irreversible MAO-A inhibitor, clorgyline, more consistently and to a greater extent (80-100%) than was l-norepinephrine (30-85%). Serotonin 0-9 monoamine oxidase A Homo sapiens 45-50 7159481-3 1982 Serotonin was a more selective substrate for MAO-A, being inhibited by low concentrations (less than 10(-7) M) of the irreversible MAO-A inhibitor, clorgyline, more consistently and to a greater extent (80-100%) than was l-norepinephrine (30-85%). Serotonin 0-9 monoamine oxidase A Homo sapiens 131-136 7159481-5 1982 Serotonin also had a 2- to 4-fold smaller apparent Km for MAO-A than l-norepinephrine and was deaminated 2- to 5-fold more readily by MAO in vitro in most tissues. Serotonin 0-9 monoamine oxidase A Homo sapiens 58-63 33990379-9 2021 We further demonstrated that MAO-A restrains antitumor T cell immunity through controlling intratumoral T cell autocrine serotonin signaling. Serotonin 121-130 monoamine oxidase A Homo sapiens 29-34 33262691-8 2020 Given the multifaceted other players than MAOA that are involved in the regulation of serotonin levels, potential compensatory effects are surveyed, which may underlie the autism heterogeneity. Serotonin 86-95 monoamine oxidase A Homo sapiens 42-46 32454163-8 2020 MAO-A inhibitors prevent neurotransmitter breakdown and increase dopamine and serotonin concentrations in the brain. Serotonin 78-87 monoamine oxidase A Homo sapiens 0-5 32942081-1 2020 Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine, serotonin, and some other amines. Serotonin 175-184 monoamine oxidase A Homo sapiens 20-25 32574581-2 2020 The best-documented gene implicated in aggression is MAOA (Monoamine oxidase A), which encodes the key enzyme for the degradation of serotonin and catecholamines. Serotonin 133-142 monoamine oxidase A Homo sapiens 53-57 32574581-2 2020 The best-documented gene implicated in aggression is MAOA (Monoamine oxidase A), which encodes the key enzyme for the degradation of serotonin and catecholamines. Serotonin 133-142 monoamine oxidase A Homo sapiens 59-78 32845149-0 2020 How Monoamine Oxidase A Decomposes Serotonin: An Empirical Valence Bond Simulation of the Reactive Step. Serotonin 35-44 monoamine oxidase A Homo sapiens 4-23 31706600-4 2020 Monoamine oxidase A (MAOA) aids in serotonin uptake and is often implicated in behavioral and emotional disorders, including ADHD. Serotonin 35-44 monoamine oxidase A Homo sapiens 21-25 32311818-11 2020 Together with 5-HT degrading enzyme, monoamine oxidase-A, this offers a protective mechanism against local vasoconstriction effects of 5-HT in the placenta. Serotonin 135-139 monoamine oxidase A Homo sapiens 37-56 32342809-3 2020 MAO-A is a flavoenzyme, which binds to the outer mitochondrial membrane and catalyzes the oxidative transformations of neurotransmitters like serotonin, norepinephrine, and dopamine. Serotonin 142-151 monoamine oxidase A Homo sapiens 0-5 32311818-0 2020 Serotonin homeostasis in the materno-fetal interface at term: role of transporters (SERT/SLC6A4 and OCT3/SLC22A3) and monoamine oxidase A (MAO-A) in uptake and degradation of serotonin by human and rat term placenta. Serotonin 0-9 monoamine oxidase A Homo sapiens 118-137 32244397-3 2020 Chemical stressors influence behavioral outcomes by affecting the monoamine oxidase A (MAOA) enzyme, which is involved in serotonin metabolism and the neuroendocrine response to stress. Serotonin 122-131 monoamine oxidase A Homo sapiens 66-85 32244397-3 2020 Chemical stressors influence behavioral outcomes by affecting the monoamine oxidase A (MAOA) enzyme, which is involved in serotonin metabolism and the neuroendocrine response to stress. Serotonin 122-131 monoamine oxidase A Homo sapiens 87-91 31706600-4 2020 Monoamine oxidase A (MAOA) aids in serotonin uptake and is often implicated in behavioral and emotional disorders, including ADHD. Serotonin 35-44 monoamine oxidase A Homo sapiens 0-19 31754354-5 2019 To better understand the relationship between serotonin and BTIC we expanded our analysis to include monoamine oxidase-A (MAO-A), an enzyme that metabolizes serotonin. Serotonin 157-166 monoamine oxidase A Homo sapiens 101-120 31725281-6 2019 When implementing the bioassay for the screening of plasma, a pronounced receptor activation was already observed in blank samples, which could be ascribed to endogenous serotonin, as suggested by annihilation of this activity by a 5-HT2AR antagonist or after incubation with MAO-A (monoamine oxidase-A). Serotonin 170-179 monoamine oxidase A Homo sapiens 276-281 31725281-6 2019 When implementing the bioassay for the screening of plasma, a pronounced receptor activation was already observed in blank samples, which could be ascribed to endogenous serotonin, as suggested by annihilation of this activity by a 5-HT2AR antagonist or after incubation with MAO-A (monoamine oxidase-A). Serotonin 170-179 monoamine oxidase A Homo sapiens 283-302 31725281-7 2019 The presence and degradability by MAO-A of serotonin in plasma extracts were confirmed by LC-HRMS. Serotonin 43-52 monoamine oxidase A Homo sapiens 34-39 30716416-2 2019 The best-characterized of these interplays occurs between: a) low-activity alleles of the gene encoding monoamine oxidase A (MAOA), the main serotonin-degrading enzyme; and b) child maltreatment. Serotonin 141-150 monoamine oxidase A Homo sapiens 104-123 30716416-2 2019 The best-characterized of these interplays occurs between: a) low-activity alleles of the gene encoding monoamine oxidase A (MAOA), the main serotonin-degrading enzyme; and b) child maltreatment. Serotonin 141-150 monoamine oxidase A Homo sapiens 125-129 31754354-5 2019 To better understand the relationship between serotonin and BTIC we expanded our analysis to include monoamine oxidase-A (MAO-A), an enzyme that metabolizes serotonin. Serotonin 157-166 monoamine oxidase A Homo sapiens 122-127 30043181-2 2018 After the demonstrations that both cardiac neuronal and extraneuronal MAO-A contribute to the degradation of norepinephrine and serotonin, several studies attempted to determine the impact of MAO-A activity in the control of local concentration of the two biogenic amines and in their receptor-mediated effects. Serotonin 128-137 monoamine oxidase A Homo sapiens 70-75 31556016-1 2019 BACKGROUND: The Mono-amine oxidase-A (MAO-A) enzyme is involved in the degradation and regulation of catecholamines such as serotonin, dopamine, epinephrine and nor-epinephrine. Serotonin 124-133 monoamine oxidase A Homo sapiens 16-36 31556016-1 2019 BACKGROUND: The Mono-amine oxidase-A (MAO-A) enzyme is involved in the degradation and regulation of catecholamines such as serotonin, dopamine, epinephrine and nor-epinephrine. Serotonin 124-133 monoamine oxidase A Homo sapiens 38-43 30456877-1 2019 The monoamine oxidase A (MAOA) enzyme metabolizes monoamine neurotransmitters such as dopamine, serotonin and norepinephrine, and its genetic polymorphism (rs1137070) influences its activity level and is associated with smoking behaviors. Serotonin 96-105 monoamine oxidase A Homo sapiens 4-23 30456877-1 2019 The monoamine oxidase A (MAOA) enzyme metabolizes monoamine neurotransmitters such as dopamine, serotonin and norepinephrine, and its genetic polymorphism (rs1137070) influences its activity level and is associated with smoking behaviors. Serotonin 96-105 monoamine oxidase A Homo sapiens 25-29 30852703-4 2019 Finally, the density of monoamine oxidase-A (MAO-A), a mitochondrial enzyme that degrades 5-HT, norepinephrine, and dopamine (DA), was reported as lower in the OFC and ventral striatum of ASPD. Serotonin 90-94 monoamine oxidase A Homo sapiens 24-43 30852703-4 2019 Finally, the density of monoamine oxidase-A (MAO-A), a mitochondrial enzyme that degrades 5-HT, norepinephrine, and dopamine (DA), was reported as lower in the OFC and ventral striatum of ASPD. Serotonin 90-94 monoamine oxidase A Homo sapiens 45-50 30003648-4 2018 The mitochondrial enzyme monoamine oxidase-A (MAO-A) is a relevant source of ROS in the heart through the formation of H2 O2 derived from the degradation of its main substrates, norepinephrine (NE) and serotonin. Serotonin 202-211 monoamine oxidase A Homo sapiens 25-44 30003648-4 2018 The mitochondrial enzyme monoamine oxidase-A (MAO-A) is a relevant source of ROS in the heart through the formation of H2 O2 derived from the degradation of its main substrates, norepinephrine (NE) and serotonin. Serotonin 202-211 monoamine oxidase A Homo sapiens 46-51 29478144-7 2018 The MAOA gene encodes an enzyme which is involved in the catabolism of dopamine, norepinephrine, serotonin, and other monoaminergic neurotransmitters. Serotonin 97-106 monoamine oxidase A Homo sapiens 4-8 30271325-1 2018 Monoamine oxidase A (MAO-A) is an enzyme that regulates the levels of monoamine neurotransmitters, such as serotonin, noradrenaline and dopamine and it has been used as a therapeutic target for depression. Serotonin 107-116 monoamine oxidase A Homo sapiens 0-19 30271325-1 2018 Monoamine oxidase A (MAO-A) is an enzyme that regulates the levels of monoamine neurotransmitters, such as serotonin, noradrenaline and dopamine and it has been used as a therapeutic target for depression. Serotonin 107-116 monoamine oxidase A Homo sapiens 21-26 28377303-2 2017 The central inhibition of MAO-A by MB has also been linked to serotonin toxicity (ST) which may arise when MB is used in combination with serotonergic drugs. Serotonin 62-71 monoamine oxidase A Homo sapiens 26-31 28293733-1 2018 Type A monoamine oxidase (MAOA) catabolizes monoamine transmitters, serotonin, norepinephrine and dopamine, and plays a major role in the onset, progression and therapy of neuropsychiatric disorders. Serotonin 68-77 monoamine oxidase A Homo sapiens 7-24 28293733-1 2018 Type A monoamine oxidase (MAOA) catabolizes monoamine transmitters, serotonin, norepinephrine and dopamine, and plays a major role in the onset, progression and therapy of neuropsychiatric disorders. Serotonin 68-77 monoamine oxidase A Homo sapiens 26-30 28293733-3 2018 The functional polymorphism of MAOA gene and genes in serotonin signal pathway are associated with depression. Serotonin 54-63 monoamine oxidase A Homo sapiens 31-35 28293733-5 2018 MAOA and serotonin regulate the prenatal development and postnatal maintenance of brain architecture and neurocircuit, as shown by MAOA-deficient humans and MAO knockout animal models. Serotonin 9-18 monoamine oxidase A Homo sapiens 131-135 29505805-3 2018 Monoamine oxidase A (MAO-A) is an outer mitochondrial membrane enzyme which is involved in the metabolic pathway of serotonin degradation. Serotonin 116-125 monoamine oxidase A Homo sapiens 0-19 29505805-3 2018 Monoamine oxidase A (MAO-A) is an outer mitochondrial membrane enzyme which is involved in the metabolic pathway of serotonin degradation. Serotonin 116-125 monoamine oxidase A Homo sapiens 21-26 29381782-12 2018 We conclude that serotonin is conveyed from the maternal blood stream through syncytiotrophoblasts, cytotrophoblasts and the villus core to the fetus through a physiological pathway that involves at least SERT, gap junctions, P-gp, OCT3, and MAOA. Serotonin 17-26 monoamine oxidase A Homo sapiens 242-246 28052533-3 2017 Inhibitors that act on MAO A are used to treat depression, due to their ability to raise serotonin concentrations, whereas MAO B inhibitors decrease dopamine degradation and improve motor control in patients with Parkinson disease. Serotonin 89-98 monoamine oxidase A Homo sapiens 23-28 28418735-8 2017 Patients with parkinsonism with MAO-A TT genotype have a significantly higher level of 5-HT [5-HT (II), p < 0.05] compared to controls. Serotonin 87-91 monoamine oxidase A Homo sapiens 32-37 28418735-8 2017 Patients with parkinsonism with MAO-A TT genotype have a significantly higher level of 5-HT [5-HT (II), p < 0.05] compared to controls. Serotonin 93-97 monoamine oxidase A Homo sapiens 32-37 28599322-4 2017 The MAO-A upregulation resulted in increased 5-hydroxyindoleacetic acid/serotonin ratio, oxidative stress, leading to NF-kappaB activation, inflammation and apoptosis. Serotonin 72-81 monoamine oxidase A Homo sapiens 4-9 28599322-9 2017 Collectively, the MAO-A upregulation induced by chronic intermittent hypoxia plays significant pathogenic role in oxidative stress, inflammation and IDO-1 activation resulting in serotonin depletion and neurodegeneration. Serotonin 179-188 monoamine oxidase A Homo sapiens 18-23 26227907-1 2016 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the metabolism of several biological amines such as dopamine, norepinephrine, and serotonin, which are important neurochemicals in the pathogenesis of major psychiatric illnesses. Serotonin 147-156 monoamine oxidase A Homo sapiens 0-19 28294055-6 2017 Selective inhibition of MAO-A results in the elevated level of serotonin and noradrenaline. Serotonin 63-72 monoamine oxidase A Homo sapiens 24-29 27821364-1 2016 The monoamine oxidases (MAOA/B) and catechol-O-methyltransferase (COMT) enzymes break down regulatory components within serotonin and dopamine pathways, and polymorphisms within these genes are candidates for OCD susceptibility. Serotonin 120-129 monoamine oxidase A Homo sapiens 24-28 27734680-1 2016 Monoamine oxidases (MAOs) A and B are flavoenzymes responsible for the metabolism of biogenic amines, such as dopamine, serotonin, and noradrenaline (NA), which is why they have been extensively implicated in the etiology and course of various neurodegenerative disorders and, accordingly, used as primary pharmacological targets to treat these debilitating cognitive diseases. Serotonin 120-129 monoamine oxidase A Homo sapiens 0-33 26227907-1 2016 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the metabolism of several biological amines such as dopamine, norepinephrine, and serotonin, which are important neurochemicals in the pathogenesis of major psychiatric illnesses. Serotonin 147-156 monoamine oxidase A Homo sapiens 21-25 27112704-5 2016 Serotonin"s homeostasis involves serotoninergic autoreceptor such as 5-HT1A, 5-HT1B, 5-HT1D, the enzymatic degradation of serotonin by monoamine oxidase A (MAO-A), and a transporter (serotoninergic transporter [SERT]). Serotonin 0-9 monoamine oxidase A Homo sapiens 135-154 27471444-8 2016 Inhibitors that act mainly on MAO A are used in the treatment of depression, due to their ability to raise serotonin concentrations, while MAO B inhibitors decrease dopamine degradation and improve motor control in patients with Parkinson disease. Serotonin 107-116 monoamine oxidase A Homo sapiens 30-35 26776902-2 2016 In particular, converging lines of evidence have documented that these maladaptive manifestations of aggression are influenced by monoamine oxidase A (MAOA), the enzyme that catalyzes the degradation of brain serotonin, norepinephrine and dopamine. Serotonin 209-218 monoamine oxidase A Homo sapiens 130-149 26776902-2 2016 In particular, converging lines of evidence have documented that these maladaptive manifestations of aggression are influenced by monoamine oxidase A (MAOA), the enzyme that catalyzes the degradation of brain serotonin, norepinephrine and dopamine. Serotonin 209-218 monoamine oxidase A Homo sapiens 151-155 27112704-5 2016 Serotonin"s homeostasis involves serotoninergic autoreceptor such as 5-HT1A, 5-HT1B, 5-HT1D, the enzymatic degradation of serotonin by monoamine oxidase A (MAO-A), and a transporter (serotoninergic transporter [SERT]). Serotonin 0-9 monoamine oxidase A Homo sapiens 156-161 26721607-5 2016 Therefore the inhibition potential of MDMA and its metabolites on the deamination of the neurotransmitters DA and serotonin (5-HT) by MAO-A and B using recombinant human enzymes in vitro should be investigated. Serotonin 114-123 monoamine oxidase A Homo sapiens 134-139 26956991-7 2016 The fluoxetine effect on sleep fragmentation, but not on daytime rest, was modified by the monkey"s genotype for polymorphisms of monoamine oxidase A (MAOA), an enzyme that metabolizes serotonin. Serotonin 185-194 monoamine oxidase A Homo sapiens 130-149 26956991-7 2016 The fluoxetine effect on sleep fragmentation, but not on daytime rest, was modified by the monkey"s genotype for polymorphisms of monoamine oxidase A (MAOA), an enzyme that metabolizes serotonin. Serotonin 185-194 monoamine oxidase A Homo sapiens 151-155 25613051-9 2015 Methylene blue and its metabolite, azure B, are potent, reversible inhibitors of monoamine oxidase A which is responsible for serotonin metabolism. Serotonin 126-135 monoamine oxidase A Homo sapiens 81-100 26086546-0 2015 Androgen metabolites impact CSF amines and axonal serotonin via MAO-A and -B in male macaques. Serotonin 50-59 monoamine oxidase A Homo sapiens 64-69 26086546-1 2015 A number of studies have shown that mutations or deletions of the monoamine oxidase-A (MAO-A) gene cause elevated CNS serotonin and elevated impulsive aggression in humans and animal models. Serotonin 118-127 monoamine oxidase A Homo sapiens 66-85 26086546-1 2015 A number of studies have shown that mutations or deletions of the monoamine oxidase-A (MAO-A) gene cause elevated CNS serotonin and elevated impulsive aggression in humans and animal models. Serotonin 118-127 monoamine oxidase A Homo sapiens 87-92 26086546-3 2015 To reconcile these different analyses, we hypothesized that CSF 5HIAA reflected degradation of serotonin by the activity of MAO-A; and that low MAO-A activity would result in lower CSF 5HIAA, but overall higher serotonin in the CNS. Serotonin 211-220 monoamine oxidase A Homo sapiens 144-149 26086546-15 2015 Androgens lower MAO-A activity via metabolism to E, thus elevating CNS serotonin and decreasing CSF 5HIAA. Serotonin 71-80 monoamine oxidase A Homo sapiens 16-21 26086546-16 2015 Since androgens increase certain types of aggression, these data are consistent with studies demonstrating that lower MAO-A activity is associated with elevated serotonin and increased aggression. Serotonin 161-170 monoamine oxidase A Homo sapiens 118-123 26573170-2 2016 This study explores the potential of the monoamine oxidase A (MAO-A) enzyme-based assay with polymeric dendrimers as cofactors and serotonin as substrate, which generates H2O2, quantified by the conversion of the Carboxy-H2DCFDA dye to its fluorescent form. Serotonin 131-140 monoamine oxidase A Homo sapiens 62-67 24809685-10 2015 However, the presently observed trend towards CpG-specific MAO-A gene hypomethylation-possibly via increased gene expression and consecutively decreased serotonin and/or norepinephrine availability-to potentially drive impaired antidepressant treatment response in female patients might be worthwhile to be followed up in larger pharmacoepigenetic studies. Serotonin 153-162 monoamine oxidase A Homo sapiens 59-64 24356376-1 2014 Expression levels of monoamine oxidase A (MAOA), the enzyme that related to monoamine neurotransmitters metabolism such as serotonin, are related to schizophrenia and autism spectrum disorder. Serotonin 123-132 monoamine oxidase A Homo sapiens 21-40 24356376-1 2014 Expression levels of monoamine oxidase A (MAOA), the enzyme that related to monoamine neurotransmitters metabolism such as serotonin, are related to schizophrenia and autism spectrum disorder. Serotonin 123-132 monoamine oxidase A Homo sapiens 42-46 28962277-1 2014 Monoamine oxidase-A (MAO-A) is the main enzyme in the metabolism of the neurotransmitter serotonin (5-hydroxytryptamine). Serotonin 89-98 monoamine oxidase A Homo sapiens 0-19 25220264-1 2014 Monoamine oxidases (MAOs) A and B are flavoenzymes responsible for the metabolism of biogenic amines such as dopamine, serotonin and noradrenaline. Serotonin 119-128 monoamine oxidase A Homo sapiens 0-33 23761378-1 2014 OBJECTIVES: Monoamine oxidase A (MAOA) modulates metabolism of serotonin and dopamine metabolism, neurotransmitters involved in regulation of appetite and food intake. Serotonin 63-72 monoamine oxidase A Homo sapiens 12-31 23761378-1 2014 OBJECTIVES: Monoamine oxidase A (MAOA) modulates metabolism of serotonin and dopamine metabolism, neurotransmitters involved in regulation of appetite and food intake. Serotonin 63-72 monoamine oxidase A Homo sapiens 33-37 28962277-1 2014 Monoamine oxidase-A (MAO-A) is the main enzyme in the metabolism of the neurotransmitter serotonin (5-hydroxytryptamine). Serotonin 89-98 monoamine oxidase A Homo sapiens 21-26 28962277-1 2014 Monoamine oxidase-A (MAO-A) is the main enzyme in the metabolism of the neurotransmitter serotonin (5-hydroxytryptamine). Serotonin 100-119 monoamine oxidase A Homo sapiens 0-19 28962277-1 2014 Monoamine oxidase-A (MAO-A) is the main enzyme in the metabolism of the neurotransmitter serotonin (5-hydroxytryptamine). Serotonin 100-119 monoamine oxidase A Homo sapiens 21-26 25322896-3 2014 In this study, two genes, 5HTR2a and MAO-A playing important roles in serotonin function, were analyzed in peripheral blood mononuclear cells (PBMCs) of individuals who had been exposed to air pollution and allergic asthmatic patients as well. Serotonin 70-79 monoamine oxidase A Homo sapiens 37-42 24291416-3 2014 In the current study X-chromosomal gene, MAOA responsible for degradation of serotonin is investigated for possible association with ASD using population-based approach. Serotonin 77-86 monoamine oxidase A Homo sapiens 41-45 24510409-1 2014 Monoamine oxidase A (MAOA) catalyzes monoamine neurotransmitters including dopamine, 5-hydroxytryptamine (5-HT, serotonin), and norepinephrine. Serotonin 85-104 monoamine oxidase A Homo sapiens 0-19 24510409-1 2014 Monoamine oxidase A (MAOA) catalyzes monoamine neurotransmitters including dopamine, 5-hydroxytryptamine (5-HT, serotonin), and norepinephrine. Serotonin 85-104 monoamine oxidase A Homo sapiens 21-25 24510409-1 2014 Monoamine oxidase A (MAOA) catalyzes monoamine neurotransmitters including dopamine, 5-hydroxytryptamine (5-HT, serotonin), and norepinephrine. Serotonin 106-110 monoamine oxidase A Homo sapiens 0-19 24510409-1 2014 Monoamine oxidase A (MAOA) catalyzes monoamine neurotransmitters including dopamine, 5-hydroxytryptamine (5-HT, serotonin), and norepinephrine. Serotonin 106-110 monoamine oxidase A Homo sapiens 21-25 24510409-1 2014 Monoamine oxidase A (MAOA) catalyzes monoamine neurotransmitters including dopamine, 5-hydroxytryptamine (5-HT, serotonin), and norepinephrine. Serotonin 112-121 monoamine oxidase A Homo sapiens 0-19 24510409-1 2014 Monoamine oxidase A (MAOA) catalyzes monoamine neurotransmitters including dopamine, 5-hydroxytryptamine (5-HT, serotonin), and norepinephrine. Serotonin 112-121 monoamine oxidase A Homo sapiens 21-25 24443391-3 2014 Several genetic variations have been suggested to associate with AD and DE, particularly in genes involved in the serotonergic system such as the serotonin transporter (SERT/SLC6A4), responsible for the removal from the synaptic cleft, and the monoamine-oxidase-A (MAOA), responsible for the presynaptic degradation of serotonin. Serotonin 146-155 monoamine oxidase A Homo sapiens 244-263 24443391-3 2014 Several genetic variations have been suggested to associate with AD and DE, particularly in genes involved in the serotonergic system such as the serotonin transporter (SERT/SLC6A4), responsible for the removal from the synaptic cleft, and the monoamine-oxidase-A (MAOA), responsible for the presynaptic degradation of serotonin. Serotonin 146-155 monoamine oxidase A Homo sapiens 265-269 23858446-2 2013 The combined deficiency of MAO A and B results in significantly elevated levels of serotonin (5-hydroxytryptamine), norepinephrine, dopamine, and beta-phenylethylamine; in humans and mice, these neurochemical changes are accompanied by neurodevelopmental perturbations as well as autistic-like responses. Serotonin 83-92 monoamine oxidase A Homo sapiens 27-38 23858446-2 2013 The combined deficiency of MAO A and B results in significantly elevated levels of serotonin (5-hydroxytryptamine), norepinephrine, dopamine, and beta-phenylethylamine; in humans and mice, these neurochemical changes are accompanied by neurodevelopmental perturbations as well as autistic-like responses. Serotonin 94-113 monoamine oxidase A Homo sapiens 27-38 22365943-4 2012 Patients who lack both MAOA and MAOB have the most extreme laboratory values (urine, blood, and CSF serotonin 4-6 times normal, with elevated O-methylated amine metabolites and reduced deaminated metabolites) in addition to severe intellectual deficiency and behavioral problems. Serotonin 100-109 monoamine oxidase A Homo sapiens 23-27 23018753-6 2013 These results argue for a mechanism of lowering extracellular serotonin in the prefrontal and anterior cingulate cortex, consequent to elevated MAO-A level. Serotonin 62-71 monoamine oxidase A Homo sapiens 144-149 26593027-1 2012 Monoamine oxidase (MAO), which exists in two isozymic forms, MAO A and MAO B, is an important flavoenzyme responsible for the metabolism of amine neurotransmitters such as dopamine, serotonin, and norepinephrine. Serotonin 182-191 monoamine oxidase A Homo sapiens 61-66 22906985-2 2012 Monoamine oxidase A (MAOA), the degradation enzyme of serotonin and dopamine, is suppressed in cholangiocarcinoma via an unknown mechanism. Serotonin 54-63 monoamine oxidase A Homo sapiens 0-19 22906985-2 2012 Monoamine oxidase A (MAOA), the degradation enzyme of serotonin and dopamine, is suppressed in cholangiocarcinoma via an unknown mechanism. Serotonin 54-63 monoamine oxidase A Homo sapiens 21-25 22890201-2 2012 Both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) regulate neurochemistry by degrading monoamine neurotransmitters (serotonin, dopamine, and norepinephrine). Serotonin 131-140 monoamine oxidase A Homo sapiens 5-24 22890201-2 2012 Both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) regulate neurochemistry by degrading monoamine neurotransmitters (serotonin, dopamine, and norepinephrine). Serotonin 131-140 monoamine oxidase A Homo sapiens 26-31 20641293-2 2004 MAO-A preferentially oxidizes serotonin and noradrenaline, whereas MAO-B preferentially oxidizes phenethylamine. Serotonin 30-39 monoamine oxidase A Homo sapiens 0-5 21570786-2 2012 We report four cases of fatal serotonin toxicity caused by the combination of MDMA and moclobemide, a reversible MAO-A inhibitor with potent serotonergic activity. Serotonin 30-39 monoamine oxidase A Homo sapiens 113-118 21775495-5 2011 MAO A is a key enzyme that degrades a number of monoamine neurotransmitters, including serotonin. Serotonin 87-96 monoamine oxidase A Homo sapiens 0-5 22162429-1 2012 Monoamine oxidase A (MAOA) is the enzyme responsible for degradation of several monoamines, such as dopamine and serotonin that are considered as being two of the most important neurotransmitters involved in the pathophysiology of schizophrenia. Serotonin 113-122 monoamine oxidase A Homo sapiens 0-19 22162429-1 2012 Monoamine oxidase A (MAOA) is the enzyme responsible for degradation of several monoamines, such as dopamine and serotonin that are considered as being two of the most important neurotransmitters involved in the pathophysiology of schizophrenia. Serotonin 113-122 monoamine oxidase A Homo sapiens 21-25 21761555-1 2011 Monoamine oxidase A (MAOA) plays a critical role in the metabolism of monoamine neurotransmitters including serotonin (5-HT), norepinephrine (NE), and dopamine (DA). Serotonin 108-117 monoamine oxidase A Homo sapiens 0-19 21761555-1 2011 Monoamine oxidase A (MAOA) plays a critical role in the metabolism of monoamine neurotransmitters including serotonin (5-HT), norepinephrine (NE), and dopamine (DA). Serotonin 108-117 monoamine oxidase A Homo sapiens 21-25 20528162-6 2011 We identified a strong expression of the serotonin transporter and confirmed the high-affinity serotonin transporter-mediated uptake of serotonin (5-HT), along with uptake via the norepinephrine transporter, and an evidence of 5-HT breakdown due to the expression of the degradative enzymes monoamine oxidase A and B. Serotonin 41-50 monoamine oxidase A Homo sapiens 291-316 20810002-1 2011 BACKGROUND: Monoamine oxidase A (MAOA) is an important enzyme that metabolizes monoamines such as serotonin, norepinephrine and dopamine in the brain. Serotonin 98-107 monoamine oxidase A Homo sapiens 12-31 20810002-1 2011 BACKGROUND: Monoamine oxidase A (MAOA) is an important enzyme that metabolizes monoamines such as serotonin, norepinephrine and dopamine in the brain. Serotonin 98-107 monoamine oxidase A Homo sapiens 33-37 21302344-2 2011 Well-characterized common functional polymorphisms in the genes MAOA, COMT, and 5HTTLPR each have predictable effects on the availability of the monoamine neurotransmitters dopamine, noradrenaline, and serotonin. Serotonin 202-211 monoamine oxidase A Homo sapiens 64-68 20595415-1 2010 OBJECTIVE: To use measures of cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5HIAA) and genotype of a functional polymorphism of the monoamine oxidase A gene promoter (MAOA-uVNTR) to study the role of central nervous system (CNS) serotonin in clustering of hostility, other psychosocial, metabolic and cardiovascular endophenotypes. Serotonin 237-246 monoamine oxidase A Homo sapiens 140-159 20204405-1 2010 PURPOSE: Inhibitors of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades neurotransmitters including serotonin and norepinephrine, are commonly used to treat neurological conditions including depression. Serotonin 116-125 monoamine oxidase A Homo sapiens 23-42 20204405-1 2010 PURPOSE: Inhibitors of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades neurotransmitters including serotonin and norepinephrine, are commonly used to treat neurological conditions including depression. Serotonin 116-125 monoamine oxidase A Homo sapiens 44-48 20679667-5 2010 Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine. Serotonin 265-274 monoamine oxidase A Homo sapiens 157-176 20679667-5 2010 Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine. Serotonin 265-274 monoamine oxidase A Homo sapiens 178-183 20485326-1 2010 Monoamine oxidases (MAO-A and MAO-B) have a key role in the degradation of amine neurotransmitters, such as dopamine, norepinephrine and serotonin. Serotonin 137-146 monoamine oxidase A Homo sapiens 20-25 20073575-3 2010 We have recently shown that the serotonin-degrading enzyme monoamine oxidase A (MAO-A) generates large amount of hydrogen peroxide (H2O2) responsible for cell apoptosis. Serotonin 32-41 monoamine oxidase A Homo sapiens 59-78 20073575-3 2010 We have recently shown that the serotonin-degrading enzyme monoamine oxidase A (MAO-A) generates large amount of hydrogen peroxide (H2O2) responsible for cell apoptosis. Serotonin 32-41 monoamine oxidase A Homo sapiens 80-85 20073575-5 2010 In the present study, we investigated whether MAO-A is expressed in MSCs and we defined its role in serotonin-dependent MSCs apoptosis. Serotonin 100-109 monoamine oxidase A Homo sapiens 46-51 20073575-7 2010 As shown by enzyme assays using [14C]serotonin or [14C]beta-phenylethylamine as selective MAO-A or MAO-B substrates, MAO-A is largely predominant in MSCs. Serotonin 37-46 monoamine oxidase A Homo sapiens 117-122 20642018-2 2004 MAO-A preferentially oxidizes serotonin and noradrenaline, whereas MAO-B preferentially oxidizes phenethylamine. Serotonin 30-39 monoamine oxidase A Homo sapiens 0-5 19890267-1 2010 Reversible inhibitors of monoamine oxidase-A (RIMA) inhibit the breakdown of three major neurotransmitters, serotonin, norepinephrine and dopamine, offering a multi-neurotransmitter strategy for the treatment of depression. Serotonin 108-117 monoamine oxidase A Homo sapiens 25-44 20332182-1 2010 Monoamine oxidase A (MAOA) and the transporters for serotonin (5-HTT) and norepinephrine (NET) may play important roles in regulating maternal monoamine neurotransmitters transferred across the placenta to the fetus. Serotonin 52-61 monoamine oxidase A Homo sapiens 0-19 20332182-1 2010 Monoamine oxidase A (MAOA) and the transporters for serotonin (5-HTT) and norepinephrine (NET) may play important roles in regulating maternal monoamine neurotransmitters transferred across the placenta to the fetus. Serotonin 52-61 monoamine oxidase A Homo sapiens 21-25 20592043-3 2010 Genetic association studies suggest that variation within the genes of central neurotransmitter systems, particularly the serotonin (5-HTTLPR, MAOA-uVNTR) and opioid (OPRM1 A118G), are associated with individual differences in social sensitivity, which reflects the degree of emotional responsivity to social events and experiences. Serotonin 122-131 monoamine oxidase A Homo sapiens 143-147 20477771-3 2010 ANX/DEP ALC may be related to dopamine and serotonin, which are catalyzed by monoamine oxidase A (MAOA) and acetaldehyde dehydrogenase 2 (ALDH2). Serotonin 43-52 monoamine oxidase A Homo sapiens 77-96 20477771-3 2010 ANX/DEP ALC may be related to dopamine and serotonin, which are catalyzed by monoamine oxidase A (MAOA) and acetaldehyde dehydrogenase 2 (ALDH2). Serotonin 43-52 monoamine oxidase A Homo sapiens 98-102 19619137-7 2009 Further, inhibition of monoamine oxidase A prevents the degradation of serotonin in bipolar neurons, suggesting that monoamine oxidase A is present in these neurons. Serotonin 71-80 monoamine oxidase A Homo sapiens 23-42 19661285-1 2009 Monoamine oxidase A (MAO A), encoded by the X chromosome, catalyzes the oxidative deamination of monoamine neurotransmitters, such as serotonin, and plays a critically important role in brain development and functions. Serotonin 134-143 monoamine oxidase A Homo sapiens 0-19 19661285-1 2009 Monoamine oxidase A (MAO A), encoded by the X chromosome, catalyzes the oxidative deamination of monoamine neurotransmitters, such as serotonin, and plays a critically important role in brain development and functions. Serotonin 134-143 monoamine oxidase A Homo sapiens 21-26 19666839-10 2009 Addition of serotonin to recombinant human MAO-A generated (O2*.-), and this effect was prevented by an MAO inhibitor. Serotonin 12-21 monoamine oxidase A Homo sapiens 43-48 19666839-11 2009 In conclusion, we have identified a novel mechanism whereby MAO-A can contribute to increased oxidative stress in human heart valves and pulmonary artery exposed to serotonin and dopamine. Serotonin 165-174 monoamine oxidase A Homo sapiens 60-65 19619137-7 2009 Further, inhibition of monoamine oxidase A prevents the degradation of serotonin in bipolar neurons, suggesting that monoamine oxidase A is present in these neurons. Serotonin 71-80 monoamine oxidase A Homo sapiens 117-136 19302089-1 2009 BACKGROUND: Antisocial alcoholism is related to dopamine and serotonin which are catalyzed by monoamine oxidase A (MAOA) and acetaldehyde dehydrogenase 2 (ALDH2). Serotonin 61-70 monoamine oxidase A Homo sapiens 94-113 19506905-5 2009 Indeed, a series of recent studies, particularly concentrating on the serotonin and norepinephrine metabolising enzyme, monoamine oxidase A, has emphasised the necessity of examining gene by environmental interactions if the contributions of individual loci are to be understood. Serotonin 70-79 monoamine oxidase A Homo sapiens 120-139 19772578-1 2009 BACKGROUND: We previously reported risk haplotypes for two genes related with serotonin and dopamine metabolism: MAOA in migraine without aura and DDC in migraine with aura. Serotonin 78-87 monoamine oxidase A Homo sapiens 113-117 19302089-1 2009 BACKGROUND: Antisocial alcoholism is related to dopamine and serotonin which are catalyzed by monoamine oxidase A (MAOA) and acetaldehyde dehydrogenase 2 (ALDH2). Serotonin 61-70 monoamine oxidase A Homo sapiens 115-119 19194374-10 2009 Monoamines such as noradrenalin and serotonin may modulate these relationships, given that their metabolism varies according to MAOA variants, and that they modulate both emotional brain systems and antisocial aggression. Serotonin 36-45 monoamine oxidase A Homo sapiens 128-132 19214141-1 2009 OBJECTIVE: Monoamine oxidase-A (MAO-A) is a key mitochondrial enzyme that metabolizes biogenic amine neurotransmitters such as dopamine and serotonin. Serotonin 140-149 monoamine oxidase A Homo sapiens 11-30 19214141-1 2009 OBJECTIVE: Monoamine oxidase-A (MAO-A) is a key mitochondrial enzyme that metabolizes biogenic amine neurotransmitters such as dopamine and serotonin. Serotonin 140-149 monoamine oxidase A Homo sapiens 32-37 19010890-5 2008 Specifically, there was an increased expression of tryptophan hydroxylase 1 and a suppression of monoamine oxidase A expression (enzymes responsible for the synthesis and degradation of serotonin, respectively) in cholangiocarcinoma. Serotonin 186-195 monoamine oxidase A Homo sapiens 97-116 18810510-7 2009 Findings are discussed considering the metabolic association among DAT, 5-HTT and MAOA with special emphasis on the linked action of 5-HTT/MAOA in regulating serotonin metabolism of SIDS and SIUD infants. Serotonin 158-167 monoamine oxidase A Homo sapiens 139-143 18361446-1 2008 Monoamine oxidase A (MAOA) is an enzyme expressed in the brain that metabolizes dopamine, norepinephrine, epinephrine, and serotonin. Serotonin 123-132 monoamine oxidase A Homo sapiens 0-19 18971477-3 2008 Monoamine oxidase A (MAO-A) is a key regulator of serotonin metabolism, and polymorphic variation in the X-linked MAO-A gene influences its expression. Serotonin 50-59 monoamine oxidase A Homo sapiens 0-19 18971477-3 2008 Monoamine oxidase A (MAO-A) is a key regulator of serotonin metabolism, and polymorphic variation in the X-linked MAO-A gene influences its expression. Serotonin 50-59 monoamine oxidase A Homo sapiens 21-26 18971477-3 2008 Monoamine oxidase A (MAO-A) is a key regulator of serotonin metabolism, and polymorphic variation in the X-linked MAO-A gene influences its expression. Serotonin 50-59 monoamine oxidase A Homo sapiens 114-119 18361446-1 2008 Monoamine oxidase A (MAOA) is an enzyme expressed in the brain that metabolizes dopamine, norepinephrine, epinephrine, and serotonin. Serotonin 123-132 monoamine oxidase A Homo sapiens 21-25 18437281-1 2008 Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepinephrine. Serotonin 185-194 monoamine oxidase A Homo sapiens 0-19 18437281-1 2008 Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepinephrine. Serotonin 185-194 monoamine oxidase A Homo sapiens 21-25 18437281-1 2008 Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepinephrine. Serotonin 185-194 monoamine oxidase A Homo sapiens 124-128 18366702-7 2008 RESULTS: Our analysis found that significant downregulation of MAO-A, the enzyme that metabolizes serotonin, occurred in multiple tissues from humans, rodents, and fish. Serotonin 98-107 monoamine oxidase A Homo sapiens 63-68 18501009-1 2008 BACKGROUND: Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in degrading several different biological amines, including serotonin. Serotonin 134-143 monoamine oxidase A Homo sapiens 12-31 18501009-1 2008 BACKGROUND: Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in degrading several different biological amines, including serotonin. Serotonin 134-143 monoamine oxidase A Homo sapiens 33-37 18463263-1 2008 The genetic deletion of monoamine oxidase A (MAO A), an enzyme that breaks down the monoamine neurotransmitters norepinephrine, serotonin, and dopamine, produces aggressive phenotypes across species. Serotonin 128-137 monoamine oxidase A Homo sapiens 24-43 18463263-1 2008 The genetic deletion of monoamine oxidase A (MAO A), an enzyme that breaks down the monoamine neurotransmitters norepinephrine, serotonin, and dopamine, produces aggressive phenotypes across species. Serotonin 128-137 monoamine oxidase A Homo sapiens 45-50 18388730-1 2008 Monoamine oxidase A (MAOA) enzymatically degrades biogenic amines such as norepinephrine, dopamine, and serotonin, and plays a key role in the regulation of their neurotransmission. Serotonin 104-113 monoamine oxidase A Homo sapiens 0-19 18388730-1 2008 Monoamine oxidase A (MAOA) enzymatically degrades biogenic amines such as norepinephrine, dopamine, and serotonin, and plays a key role in the regulation of their neurotransmission. Serotonin 104-113 monoamine oxidase A Homo sapiens 21-25 18596609-1 2008 The X-linked monoamine oxidase A (MAO A) gene, coding for an enzyme especially involved in the serotonin catabolism, presents a well-characterized functional polymorphism (long and short variants) in the promoter region that alters the transcriptional activity of the gene and hence the function of the corresponding proteins. Serotonin 95-104 monoamine oxidase A Homo sapiens 34-39 20641420-2 2004 MAO-A preferentially oxidizes serotonin and noradrenaline, whereas MAO-B preferentially oxidizes phenethylamine. Serotonin 30-39 monoamine oxidase A Homo sapiens 0-5 18227761-1 2008 BACKGROUND: The monoamine oxidase-A (MAOA) gene plays a vital role in the metabolism of neurotransmitters, e.g, serotonin, norepinephrine, and dopamine. Serotonin 112-121 monoamine oxidase A Homo sapiens 16-35 18294618-2 2008 The X-linked Mono-Amine Oxidase A (MAO A) gene, coding for an enzyme especially involved in the serotonin (5-HT) catabolism, presents a well-characterized functional polymorphism consisting in a variable number of tandem repeats (VNTR) in the promoter region with high activity and low activity variants. Serotonin 96-105 monoamine oxidase A Homo sapiens 35-40 18258310-5 2008 We propose that the MAOA-L, by causing an ontogenic excess of 5-hydroxytryptamine, labilizes critical neural circuitry for social evaluation and emotion regulation (the "socioaffective scaffold"), thereby amplifying the effects of adverse early-life experience and creating deleterious sociocognitive biases. Serotonin 62-81 monoamine oxidase A Homo sapiens 20-24 18227761-1 2008 BACKGROUND: The monoamine oxidase-A (MAOA) gene plays a vital role in the metabolism of neurotransmitters, e.g, serotonin, norepinephrine, and dopamine. Serotonin 112-121 monoamine oxidase A Homo sapiens 37-41 17561096-2 2007 This study aimed to investigate the role of ROS in the mitogenic signaling activated during tyramine and serotonin oxidation by MAO-A in smooth muscle cells (SMC). Serotonin 105-114 monoamine oxidase A Homo sapiens 128-133 18405062-6 2008 In addition, when TPH-cc and MAOA-4 were combined as "high 5HT" genotypes, a correlative increase in PSL was observed with the increase in the number of "high 5HT" genotypes. Serotonin 59-62 monoamine oxidase A Homo sapiens 29-33 18405062-6 2008 In addition, when TPH-cc and MAOA-4 were combined as "high 5HT" genotypes, a correlative increase in PSL was observed with the increase in the number of "high 5HT" genotypes. Serotonin 159-162 monoamine oxidase A Homo sapiens 29-33 17884271-5 2008 The present results suggest that high-activity MAO-A genotypes possibly by consecutively decreased serotonin and/or norepinephrine availability negatively influence antidepressant treatment response during the first six weeks of pharmacological treatment in female patients with Major Depression. Serotonin 99-108 monoamine oxidase A Homo sapiens 47-52 17721552-0 2007 Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction. Serotonin 19-28 monoamine oxidase A Homo sapiens 53-72 17721552-0 2007 Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction. Serotonin 19-28 monoamine oxidase A Homo sapiens 74-79 17721552-10 2007 This inhibition of MAO A would be expected to lead to perturbations of 5-hydroxytryptamine metabolism and hence account for ST occurring when administered to patients on SSRI treatment. Serotonin 71-90 monoamine oxidase A Homo sapiens 19-24 17561096-1 2007 The degradation of biogenic amines by monoamine oxidase A (MAO-A) generates reactive oxygen species (ROS) which participate in serotonin and tyramine signaling. Serotonin 127-136 monoamine oxidase A Homo sapiens 38-57 17561096-1 2007 The degradation of biogenic amines by monoamine oxidase A (MAO-A) generates reactive oxygen species (ROS) which participate in serotonin and tyramine signaling. Serotonin 127-136 monoamine oxidase A Homo sapiens 59-64 17585061-2 2007 The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency. Serotonin 106-115 monoamine oxidase A Homo sapiens 4-23 17944104-3 2007 5-HT2A and MAOA genes, regulating activity of serotonin, influence on subjective time flow. Serotonin 46-55 monoamine oxidase A Homo sapiens 11-15 17417058-1 2007 OBJECTIVE: Monoamine oxidase A is a mitochondrial enzyme involved in the degradation of certain neurotransmitter amines: serotonin and norepinephrine. Serotonin 121-130 monoamine oxidase A Homo sapiens 11-30 17585061-2 2007 The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency. Serotonin 106-115 monoamine oxidase A Homo sapiens 25-29 17585061-2 2007 The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency. Serotonin 106-115 monoamine oxidase A Homo sapiens 195-199 17295220-4 2007 Common alleles of some serotonin pathway genes, including those involved in its degradation (monoamine oxidase A, MAOA), or its re-uptake into pre-synaptic neurones (serotonin transporter, SERT) have been shown to confer functional variation. Serotonin 23-32 monoamine oxidase A Homo sapiens 93-112 17295220-4 2007 Common alleles of some serotonin pathway genes, including those involved in its degradation (monoamine oxidase A, MAOA), or its re-uptake into pre-synaptic neurones (serotonin transporter, SERT) have been shown to confer functional variation. Serotonin 23-32 monoamine oxidase A Homo sapiens 114-118 16806099-5 2007 RESULTS: A suggestive association of sequence variations in genes responsible for the synthesis (TPH), recognition (5-HTR2A), and degradation (MAOA) of serotonin with depression symptomatology was found, although the effect was generally restricted to men. Serotonin 152-161 monoamine oxidase A Homo sapiens 143-147 17328795-3 2007 Monoamine oxidase A (MAO-A) encodes an enzyme that degrades biogenic amines, including neurotransmitters such as norepinephrine, dopamine and serotonin. Serotonin 142-151 monoamine oxidase A Homo sapiens 0-19 17328795-3 2007 Monoamine oxidase A (MAO-A) encodes an enzyme that degrades biogenic amines, including neurotransmitters such as norepinephrine, dopamine and serotonin. Serotonin 142-151 monoamine oxidase A Homo sapiens 21-26 17088501-2 2006 Monoamine oxidase A (MAO-A) is an enzyme that metabolizes monoamines, such as serotonin, norepinephrine, and dopamine. Serotonin 78-87 monoamine oxidase A Homo sapiens 0-19 17088501-2 2006 Monoamine oxidase A (MAO-A) is an enzyme that metabolizes monoamines, such as serotonin, norepinephrine, and dopamine. Serotonin 78-87 monoamine oxidase A Homo sapiens 21-26 16770335-2 2006 Monoamine oxidase A deaminates the monoamine neurotransmitters serotonin, dopamine (DA), and noradrenaline. Serotonin 63-72 monoamine oxidase A Homo sapiens 0-19 16896926-1 2006 Monoamine oxidase A (MAOA) catalyses the oxidative deamination of biogenic amines including neurotransmitters, mainly norepinephrine and serotonin in the brain and peripheral tissues. Serotonin 137-146 monoamine oxidase A Homo sapiens 0-19 16896926-1 2006 Monoamine oxidase A (MAOA) catalyses the oxidative deamination of biogenic amines including neurotransmitters, mainly norepinephrine and serotonin in the brain and peripheral tissues. Serotonin 137-146 monoamine oxidase A Homo sapiens 21-25 16944667-5 2006 We hypothesized that the risk of sleep disturbance is, at least in part, influenced by the availability of serotonin used for melatonin synthesis secondary to polymorphic variation at the enzyme monoamine oxidase A (MAO-A). Serotonin 107-116 monoamine oxidase A Homo sapiens 195-214 16944667-5 2006 We hypothesized that the risk of sleep disturbance is, at least in part, influenced by the availability of serotonin used for melatonin synthesis secondary to polymorphic variation at the enzyme monoamine oxidase A (MAO-A). Serotonin 107-116 monoamine oxidase A Homo sapiens 216-221 16728402-1 2006 Monoamine oxidase (MAO) A is a key enzyme for the degradation of neurotransmitters serotonin, norepinephrine, and dopamine. Serotonin 83-92 monoamine oxidase A Homo sapiens 0-25 16829576-1 2006 Monoamine oxidase A (MAO A) degrades serotonin, norepinephrine, and dopamine and produces reactive oxygen that may cause neuronal cell death. Serotonin 37-46 monoamine oxidase A Homo sapiens 0-19 16829576-1 2006 Monoamine oxidase A (MAO A) degrades serotonin, norepinephrine, and dopamine and produces reactive oxygen that may cause neuronal cell death. Serotonin 37-46 monoamine oxidase A Homo sapiens 21-26 16723097-5 2006 The K(m) value of serotonin to MAO-A was 1.66 micromol/L, while that of benzylamine to MAO-B was 0.80 micromol/L. Serotonin 18-27 monoamine oxidase A Homo sapiens 31-36 16652315-3 2006 The concomitant administration of nonselective MAO inhibitors or MAO-A inhibitors with drugs that increase serotonin concentrations is associated with serotonin toxicity. Serotonin 107-116 monoamine oxidase A Homo sapiens 65-70 16652315-3 2006 The concomitant administration of nonselective MAO inhibitors or MAO-A inhibitors with drugs that increase serotonin concentrations is associated with serotonin toxicity. Serotonin 151-160 monoamine oxidase A Homo sapiens 65-70 16202396-2 2006 The monoamine oxidase-A (MAO-A) gene, coding for an enzyme primarily involved in serotonin and noradrenaline catabolism, presents a well-characterized functional polymorphism consisting of a variable number of tandem repeats in the promoter region, with high-activity and low-activity variants. Serotonin 81-90 monoamine oxidase A Homo sapiens 4-23 16202396-2 2006 The monoamine oxidase-A (MAO-A) gene, coding for an enzyme primarily involved in serotonin and noradrenaline catabolism, presents a well-characterized functional polymorphism consisting of a variable number of tandem repeats in the promoter region, with high-activity and low-activity variants. Serotonin 81-90 monoamine oxidase A Homo sapiens 25-30 17447416-1 2006 Monoamine oxidases A and B (MAO A and MAO B) are the major enzymes that catalyze the oxidative deamination of monoamine neurotaransmitters such as dopamine (DA), noradrenaline, and serotonin in the central and peripheral nervous systems. Serotonin 181-190 monoamine oxidase A Homo sapiens 0-26 16336631-3 2006 An endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol, an MAO-A inhibitor, reduced membrane potential, DeltaPsim, in isolated mitochondria, and induced apoptosis in the cells, which 5-hydroxytryptamine, an MAO-A substrate, prevented. Serotonin 189-208 monoamine oxidase A Homo sapiens 65-70 17447416-1 2006 Monoamine oxidases A and B (MAO A and MAO B) are the major enzymes that catalyze the oxidative deamination of monoamine neurotaransmitters such as dopamine (DA), noradrenaline, and serotonin in the central and peripheral nervous systems. Serotonin 181-190 monoamine oxidase A Homo sapiens 28-43 16139427-1 2005 Monoamine oxidase A (MAO-A) is an enzyme involved in the metabolism of monoamine neurotransmitters such as dopamine, serotonin, and noradrenaline in the brain. Serotonin 117-126 monoamine oxidase A Homo sapiens 0-19 16139427-1 2005 Monoamine oxidase A (MAO-A) is an enzyme involved in the metabolism of monoamine neurotransmitters such as dopamine, serotonin, and noradrenaline in the brain. Serotonin 117-126 monoamine oxidase A Homo sapiens 21-26 15717295-2 2005 Monoamine oxidases A and B (MAO-A and MAO-B) degrade biogenic amines such as dopamine and serotonin and thereby control the levels of these neurotransmitters in the central nervous system. Serotonin 90-99 monoamine oxidase A Homo sapiens 0-26 15908219-2 2005 Molecular dynamics simulations allowed a comparison between the most active MAO-A inhibitor of the series, the 1-(2-benzofuryl)-2-aminopropane, and the specific, analogous MAO-A substrate serotonin. Serotonin 188-197 monoamine oxidase A Homo sapiens 172-177 15717295-2 2005 Monoamine oxidases A and B (MAO-A and MAO-B) degrade biogenic amines such as dopamine and serotonin and thereby control the levels of these neurotransmitters in the central nervous system. Serotonin 90-99 monoamine oxidase A Homo sapiens 28-33 15990460-1 2005 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine and these neurotransmitters are hypothesized to be involved in the cognitive function of humans. Serotonin 94-103 monoamine oxidase A Homo sapiens 0-19 15990460-1 2005 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine and these neurotransmitters are hypothesized to be involved in the cognitive function of humans. Serotonin 94-103 monoamine oxidase A Homo sapiens 21-25 15088153-3 2004 One of the key enzymes in the degradation of serotonin and to a lesser extent of dopamine is monoamine oxidase A (MAO-A). Serotonin 45-54 monoamine oxidase A Homo sapiens 114-119 16110245-1 2005 Monoamine oxidase A (MAOA), a mitochondrial outer membrane enzyme, degrades biogenic amines including norepinephrine, dopamine and serotonin, which have been implicated in the expression of personality traits. Serotonin 131-140 monoamine oxidase A Homo sapiens 0-19 16110245-1 2005 Monoamine oxidase A (MAOA), a mitochondrial outer membrane enzyme, degrades biogenic amines including norepinephrine, dopamine and serotonin, which have been implicated in the expression of personality traits. Serotonin 131-140 monoamine oxidase A Homo sapiens 21-25 15564894-1 2004 Monoamine oxidase A (MAOA) has been suggested to be involved in human behaviour and physiology due to its key role in the metabolism of several different biological amines including the neurotransmitters serotonin, norepinephrin and dopamine.Recently, a 30 bp repeat in the MAOA gene promoter (uMAOA) has been demonstrated to be polymorphic and to affect transcriptional activity. Serotonin 204-213 monoamine oxidase A Homo sapiens 0-19 15564894-1 2004 Monoamine oxidase A (MAOA) has been suggested to be involved in human behaviour and physiology due to its key role in the metabolism of several different biological amines including the neurotransmitters serotonin, norepinephrin and dopamine.Recently, a 30 bp repeat in the MAOA gene promoter (uMAOA) has been demonstrated to be polymorphic and to affect transcriptional activity. Serotonin 204-213 monoamine oxidase A Homo sapiens 21-25 15251892-5 2004 Sequence variation within serotonin system genes, for example, a repeat polymorphism in the transcriptional control region of the monoamine oxidase gene (MAOA-LPR), increases the propensity for adolescent males to consume alcohol. Serotonin 26-35 monoamine oxidase A Homo sapiens 154-158 15088153-3 2004 One of the key enzymes in the degradation of serotonin and to a lesser extent of dopamine is monoamine oxidase A (MAO-A). Serotonin 45-54 monoamine oxidase A Homo sapiens 93-112 14697876-10 2004 MAO-A oxidizes noradrenaline and serotonin; and MAO-B, mainly beta-phenylethylamine. Serotonin 33-42 monoamine oxidase A Homo sapiens 0-5 14755456-1 2004 Monoamine oxidase A (MAOA) locus is an attractive candidate for exploring genetic contribution to the variation in the risk for substance use disorders (SUD) because of its important role in the metabolism of neurotransmitters, including dopamine and serotonin. Serotonin 251-260 monoamine oxidase A Homo sapiens 0-19 14755456-1 2004 Monoamine oxidase A (MAOA) locus is an attractive candidate for exploring genetic contribution to the variation in the risk for substance use disorders (SUD) because of its important role in the metabolism of neurotransmitters, including dopamine and serotonin. Serotonin 251-260 monoamine oxidase A Homo sapiens 21-25 14962671-3 2004 The monoamine oxidases A and B (MAO-A and -B) genes, which are involved in serotonin and dopamine metabolism, are possible candidate genes for susceptibility to PD. Serotonin 75-84 monoamine oxidase A Homo sapiens 32-44 14697878-6 2004 The presence of repeat units within the 2 kb human MAO A promoter which is associated with promoter activity and enzymatic activity in human fibroblast culture provided a tool to study human population with abnormal behaviors related to serotonin and other neurotransmitters. Serotonin 237-246 monoamine oxidase A Homo sapiens 51-56 14697899-5 2004 The cheese reaction is a consequence of inhibition of MAO-A, the enzyme responsible for metabolism of noradrenaline and serotonin, located in peripheral adrenergic neurons. Serotonin 120-129 monoamine oxidase A Homo sapiens 54-59 12629534-2 2003 Our objective in this study was to determine whether functional polymorphisms of the genes that encode for the serotonin transporter promoter (5HTTLPR) and monoamine oxidase A (MAOA-uVNTR) are associated with CNS serotonin turnover-indexed by cerebrospinal fluid levels of 5-hydroxyindoleacetic acid (5-HIAA)-in a community sample of healthy adults. Serotonin 111-120 monoamine oxidase A Homo sapiens 177-181 15539858-2 2004 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine. Serotonin 94-103 monoamine oxidase A Homo sapiens 0-19 15539858-2 2004 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine. Serotonin 94-103 monoamine oxidase A Homo sapiens 21-25 14671188-7 2003 The precursor of melatonin, serotonin was stepwise depleted during the course of AD, as indicated by the up-regulated monoamine oxidase A mRNA and activity (5-hydroxyindoleacetic acid:serotonin ratio). Serotonin 28-37 monoamine oxidase A Homo sapiens 118-137 14671188-7 2003 The precursor of melatonin, serotonin was stepwise depleted during the course of AD, as indicated by the up-regulated monoamine oxidase A mRNA and activity (5-hydroxyindoleacetic acid:serotonin ratio). Serotonin 184-193 monoamine oxidase A Homo sapiens 118-137 14671188-8 2003 We conclude that a dysfunction of noradrenergic regulation and the depletion of serotonin by increased monoamine oxidase A result in the loss of melatonin rhythm already in preclinical AD. Serotonin 80-89 monoamine oxidase A Homo sapiens 103-122 12958079-14 2003 This 4.96 Mb region contains, among others, the genes for monoamine oxidase A (MAOA) and B (MAOB), which are involved in the oxidative deamination of several neurotransmitters, including dopamine and serotonin. Serotonin 200-209 monoamine oxidase A Homo sapiens 58-77 12958079-14 2003 This 4.96 Mb region contains, among others, the genes for monoamine oxidase A (MAOA) and B (MAOB), which are involved in the oxidative deamination of several neurotransmitters, including dopamine and serotonin. Serotonin 200-209 monoamine oxidase A Homo sapiens 79-83 14651728-3 2003 We aimed to assess the MAO type A (MAO-A) involvement in the metabolic pathway of rizatriptan (RIZ), an antimigraine 5-hydroxytryptamine (5-HT)1B/1D agonist, and the interethnic difference in MAO activities between Caucasians and Japanese using RIZ as a model drug in in vitro experiments. Serotonin 117-136 monoamine oxidase A Homo sapiens 23-33 14651728-3 2003 We aimed to assess the MAO type A (MAO-A) involvement in the metabolic pathway of rizatriptan (RIZ), an antimigraine 5-hydroxytryptamine (5-HT)1B/1D agonist, and the interethnic difference in MAO activities between Caucasians and Japanese using RIZ as a model drug in in vitro experiments. Serotonin 117-136 monoamine oxidase A Homo sapiens 35-40 12855685-1 2003 Monoamine oxidase (MAO) A and B catalyze the oxidative deamination of neuroactive and dietary monoamines such as serotonin, tyramine, and phenylethylamine. Serotonin 113-122 monoamine oxidase A Homo sapiens 0-25 11945082-1 2002 A feature of pre-eclampsia is that circulating levels of maternal serotonin (5-hydroxytryptamine) are elevated and placental monoamine oxidase-A (MAO-A) activity, the major factor in the regulation of serotonin levels in pregnancy, is reduced. Serotonin 201-210 monoamine oxidase A Homo sapiens 125-144 12502014-1 2002 Monoamine oxidase A (MAOA) and tryptophan hydroxylase (TPH) are the staple enzymes in the metabolism of serotonin (5-HT). Serotonin 104-113 monoamine oxidase A Homo sapiens 0-19 12502014-1 2002 Monoamine oxidase A (MAOA) and tryptophan hydroxylase (TPH) are the staple enzymes in the metabolism of serotonin (5-HT). Serotonin 104-113 monoamine oxidase A Homo sapiens 21-25 11812236-7 2002 The steady-state kinetic properties of P. pastoris-expressed MAO-A are similar to those of S. cerevisiae-expressed MAO-A using the following substrates: phenethylamine, p-CF(3)-benzylamine, dopamine, serotonin, and kynuramine. Serotonin 200-209 monoamine oxidase A Homo sapiens 61-66 11812236-7 2002 The steady-state kinetic properties of P. pastoris-expressed MAO-A are similar to those of S. cerevisiae-expressed MAO-A using the following substrates: phenethylamine, p-CF(3)-benzylamine, dopamine, serotonin, and kynuramine. Serotonin 200-209 monoamine oxidase A Homo sapiens 115-120 11945082-1 2002 A feature of pre-eclampsia is that circulating levels of maternal serotonin (5-hydroxytryptamine) are elevated and placental monoamine oxidase-A (MAO-A) activity, the major factor in the regulation of serotonin levels in pregnancy, is reduced. Serotonin 201-210 monoamine oxidase A Homo sapiens 146-151 11945082-2 2002 It is not known whether this is due to a reduced MAO-A protein content or a reduced catalytic turnover of the serotonin by MAO-A; this question has been addressed in the present work. Serotonin 110-119 monoamine oxidase A Homo sapiens 123-128 11081224-2 2000 Results of the biochemical analysis of the MAO A activity with serotonin or noradrenaline as substrates revealed a seasonal dependence of the substrate specific changes of this enzyme activity in hibernating animals. Serotonin 63-72 monoamine oxidase A Homo sapiens 43-48 12140786-1 2002 Monoamine oxidase A (MAO A) is located on the X chromosome and metabolizes biogenic amines including dopamine, norepinephrine and serotonin. Serotonin 130-139 monoamine oxidase A Homo sapiens 0-19 12140786-1 2002 Monoamine oxidase A (MAO A) is located on the X chromosome and metabolizes biogenic amines including dopamine, norepinephrine and serotonin. Serotonin 130-139 monoamine oxidase A Homo sapiens 21-26 11732903-0 2001 Loss of serotonin oxidation as a component of the altered substrate specificity in the Y444F mutant of recombinant human liver MAO A. Serotonin 8-17 monoamine oxidase A Homo sapiens 127-132 11732903-6 2001 Y444F MAO A oxidizes kynuramine with a k(cat) <2% of WT enzyme and is greater than 100-fold slower in catalyzing the oxidation of phenylethylamine or of serotonin. Serotonin 156-165 monoamine oxidase A Homo sapiens 6-11 11732903-10 2001 These data show that mutation of Y444F in MAO A results in a mutant that has lost its ability to efficiently oxidize serotonin (its physiological substrate) but, however, exhibits unaltered quantitative structure-activity parameters in the binding and rate of benzylamine analogues. Serotonin 117-126 monoamine oxidase A Homo sapiens 42-47 11134050-5 2001 Mutant MAO A-I335Y became like MAO B, which exhibits a higher preference for beta-phenylethylamine than for the MAO A preferred substrate serotonin (5-hydroxytryptamine), and became more sensitive to deprenyl (MAO B-specific inhibitor) than to clorgyline (MAO A-specific inhibitor). Serotonin 138-147 monoamine oxidase A Homo sapiens 7-12 11134050-5 2001 Mutant MAO A-I335Y became like MAO B, which exhibits a higher preference for beta-phenylethylamine than for the MAO A preferred substrate serotonin (5-hydroxytryptamine), and became more sensitive to deprenyl (MAO B-specific inhibitor) than to clorgyline (MAO A-specific inhibitor). Serotonin 138-147 monoamine oxidase A Homo sapiens 112-117 11134050-5 2001 Mutant MAO A-I335Y became like MAO B, which exhibits a higher preference for beta-phenylethylamine than for the MAO A preferred substrate serotonin (5-hydroxytryptamine), and became more sensitive to deprenyl (MAO B-specific inhibitor) than to clorgyline (MAO A-specific inhibitor). Serotonin 138-147 monoamine oxidase A Homo sapiens 112-117 11134050-5 2001 Mutant MAO A-I335Y became like MAO B, which exhibits a higher preference for beta-phenylethylamine than for the MAO A preferred substrate serotonin (5-hydroxytryptamine), and became more sensitive to deprenyl (MAO B-specific inhibitor) than to clorgyline (MAO A-specific inhibitor). Serotonin 149-168 monoamine oxidase A Homo sapiens 7-12 10936214-3 2000 When compared with MAO A, MAO A-F208I showed a sixfold decrease in the specificity constant k(cat)/K(m) for both the MAO A- and the MAO B-preferring substrates 5-hydroxytryptamine and beta-phenylethylamine, respectively. Serotonin 160-179 monoamine oxidase A Homo sapiens 19-24 10936214-3 2000 When compared with MAO A, MAO A-F208I showed a sixfold decrease in the specificity constant k(cat)/K(m) for both the MAO A- and the MAO B-preferring substrates 5-hydroxytryptamine and beta-phenylethylamine, respectively. Serotonin 160-179 monoamine oxidase A Homo sapiens 26-31 10936214-3 2000 When compared with MAO A, MAO A-F208I showed a sixfold decrease in the specificity constant k(cat)/K(m) for both the MAO A- and the MAO B-preferring substrates 5-hydroxytryptamine and beta-phenylethylamine, respectively. Serotonin 160-179 monoamine oxidase A Homo sapiens 26-31 10729753-5 2000 These findings suggest that the higher plasma-free serotonin levels observed in severe pre-eclampsia are mainly due to a reduction in MAO-A activity and not limited by the rate of serotonin uptake into the cells. Serotonin 51-60 monoamine oxidase A Homo sapiens 134-139 10867119-5 2000 The results suggest that MAOA genotypes may participate differentially in the regulation of dopamine and serotonin turnover rates under presumed steady state in the central nervous system. Serotonin 105-114 monoamine oxidase A Homo sapiens 25-29 10831475-2 2000 Given the link between abnormalities in serotonergic neurotransmission and bipolar disorder, a candidate gene association approach was applied to study the involvement of the monoamine oxidase A (MAOA) gene, which codes for a catabolic enzyme of serotonin, in the susceptibility to bipolar disorder. Serotonin 246-255 monoamine oxidase A Homo sapiens 175-194 10831475-2 2000 Given the link between abnormalities in serotonergic neurotransmission and bipolar disorder, a candidate gene association approach was applied to study the involvement of the monoamine oxidase A (MAOA) gene, which codes for a catabolic enzyme of serotonin, in the susceptibility to bipolar disorder. Serotonin 246-255 monoamine oxidase A Homo sapiens 196-200 10647887-7 1999 The uVNTR genotype may be a common genetic determinant of significant individual differences in oxidizing capacity for critical MAO-A substrates, which include serotonin, norepinephrine, and tyramine. Serotonin 160-169 monoamine oxidase A Homo sapiens 128-133 23531135-6 2000 Inhibitors of MAO A are clinically useful to treat anxiety and depression since they are expected to increase both noradrenalin and serotonin levels in the brain. Serotonin 132-141 monoamine oxidase A Homo sapiens 14-19 10504491-9 1999 MAO activity measured in intact cells showed that after accumulation into mesangial cells, [14C]serotonin was metabolized by MAO-A. Serotonin 96-105 monoamine oxidase A Homo sapiens 125-130 10063483-1 1999 The reversible inhibitors of monoamine oxidase type A (RIMAs) are a newer group of antidepressants that have had much less impact on clinical psychopharmacology than another contemporary class of medications, the selective serotonin reuptake-inhibitors (SSRIs). Serotonin 223-232 monoamine oxidase A Homo sapiens 29-53 9503561-4 1997 MAO-A preferentially deaminates serotonin (5HT) and is selectively inhibited by harmine and clorgyline, while MAO-B preferentially deaminates phenethylamine and benzylamine, and is selectively inhibited by (-)deprenyl as well as low concentrations of pargyline. Serotonin 32-41 monoamine oxidase A Homo sapiens 0-5 9682221-4 1998 The levels of MAo and B were assayed: MAO A showed a K(m) of 137.1 +/- 16.2 microM and a V(m) of 10.4 +/- 2.5 nmol mg-1 min-1 for serotonin; MAo B had a K(m) of 9.9 +/- 1.6 microM and V(m) of 4.3 +/- 1.1 nmol mg-1 min-1 for beta-phenylethylamine (mean +/- SE of seven hearts). Serotonin 130-139 monoamine oxidase A Homo sapiens 38-43 9703624-4 1998 The administration of MAO a inhibitor pyrazidol promoted the increase in brain serotonin content, normalized brain catecholamine contents and demonstrated positive effect on the animal state. Serotonin 79-88 monoamine oxidase A Homo sapiens 22-27 9794145-5 1998 The relative risk with different drug combinations is assessed from available evidence and argued to be strongly associated with the degree of elevation of 5-hydroxytryptamine, which is greatest following combinations of irreversible inhibitors of monoamine oxidase A and B with potent serotonin reuptake inhibitors. Serotonin 156-175 monoamine oxidase A Homo sapiens 248-267 9564621-1 1998 The deamination of 5-hydroxytryptamine, phenylethylamine and benzylamine by monoamine oxidases (MAO-A and B) and semicarbazide sensitive amine oxidase (SSAO) respectively has been studied in homogenates of human cystic and colonic arteries by radiochemical assays. Serotonin 19-38 monoamine oxidase A Homo sapiens 96-107 9503561-4 1997 MAO-A preferentially deaminates serotonin (5HT) and is selectively inhibited by harmine and clorgyline, while MAO-B preferentially deaminates phenethylamine and benzylamine, and is selectively inhibited by (-)deprenyl as well as low concentrations of pargyline. Serotonin 43-46 monoamine oxidase A Homo sapiens 0-5 8981559-1 1996 Pinoline (6-methoxy-1,2,3,4-tetrahydro-beta-carboline) is a naturally occurring compound in the mammalian body which inhibits serotonin (5-hydroxytryptamine) uptake and monoamine oxidase-A activity. Serotonin 126-135 monoamine oxidase A Homo sapiens 169-188 9112832-3 1997 Superimposition of norepinephrine and gauche forms of serotonin and mociobemide suggest that the phenyl ring, electronegative group attached to the aromatic ring and the amine terminal group may serve as the recognition elements for binding to monoamine oxidase-A (MAO-A). Serotonin 54-63 monoamine oxidase A Homo sapiens 244-263 9112832-3 1997 Superimposition of norepinephrine and gauche forms of serotonin and mociobemide suggest that the phenyl ring, electronegative group attached to the aromatic ring and the amine terminal group may serve as the recognition elements for binding to monoamine oxidase-A (MAO-A). Serotonin 54-63 monoamine oxidase A Homo sapiens 265-270 8987145-1 1997 Monoamine oxidases A and B (MAOA and MAOB) are the major catabolic isoenzymes of catecholamines and serotonin in the mammalian brain. Serotonin 100-109 monoamine oxidase A Homo sapiens 0-26 8987145-1 1997 Monoamine oxidases A and B (MAOA and MAOB) are the major catabolic isoenzymes of catecholamines and serotonin in the mammalian brain. Serotonin 100-109 monoamine oxidase A Homo sapiens 28-32 8889283-8 1996 The most reliable variables to assess inhibition of MAO-A and -B in humans proved to be DHPG in plasma and serotonin in platelets and MAO-B activity in platelets, respectively. Serotonin 107-116 monoamine oxidase A Homo sapiens 52-64 8965658-5 1996 They also suggest the coexistence of the isoenzymes in raphe neurons as well as the potential role of MAO-A in metabolizing serotonin in vivo. Serotonin 124-133 monoamine oxidase A Homo sapiens 102-107 9005353-4 1996 The development of new serotonin selective antidepressants and selective reversible inhibitors of monoamine oxidase A has led to the use of more and more substances that can cause these life-threatening complications if they are taken in too high doses or together with other drugs. Serotonin 23-32 monoamine oxidase A Homo sapiens 98-117 8632725-6 1996 Serotonin (5-HT), a preferred substrate for MAO-A, was not oxidized by AB(161-375)A or wild-type MAO-B. Serotonin 0-9 monoamine oxidase A Homo sapiens 44-49 8678123-1 1996 The monoamine oxidases (MAO-A and MAO-B) are the enzymes primarily responsible for the degradation of amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. Serotonin 165-174 monoamine oxidase A Homo sapiens 24-29 7792602-1 1995 Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. Serotonin 66-75 monoamine oxidase A Homo sapiens 14-33 8750929-5 1996 Both human keratinocytes and melanocytes expressed significant levels of monoamine oxidase A (MAO-A) activities as shown using 14C-labelled 5-hydroxytryptamine as substrate and immunohistochemical staining with mouse monoclonal antibody. Serotonin 140-159 monoamine oxidase A Homo sapiens 73-92 8750929-5 1996 Both human keratinocytes and melanocytes expressed significant levels of monoamine oxidase A (MAO-A) activities as shown using 14C-labelled 5-hydroxytryptamine as substrate and immunohistochemical staining with mouse monoclonal antibody. Serotonin 140-159 monoamine oxidase A Homo sapiens 94-99 7792602-1 1995 Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. Serotonin 66-75 monoamine oxidase A Homo sapiens 35-39 7891891-5 1994 Previous reports have described the accumulation of the 5HT metabolite 5-hydroxyindoleacetic acid and increased activities of the 5HT-metabolizing enzyme MAOA in this same material from patients with hepatic encephalopathy. Serotonin 130-133 monoamine oxidase A Homo sapiens 154-158 8584674-1 1995 Monoamine oxidase (MAO) A (EC 1.4.3.4) oxidizes norepinephrine and serotonin and is expressed in a cell type-specific manner. Serotonin 67-76 monoamine oxidase A Homo sapiens 0-25 7519662-1 1994 Monoamine oxidase (MAO) A (EC 1.4.3.4) oxidizes norepinephrine and serotonin and is expressed in a cell type-specific manner. Serotonin 67-76 monoamine oxidase A Homo sapiens 0-25 8122400-1 1994 Increase of serotonin content and decrease in 5-hydroxyindolyl acetic acid (5-HIAA) were observed under hypoxic conditions (9,000 m, 3 hrs) which correlated with inhibition of monoamine oxidase A. Serotonin 12-21 monoamine oxidase A Homo sapiens 176-195 8242348-2 1993 Activities of both MAOA and MAOB were significantly increased in frontal cortex and caudate nucleus, two brain regions shown previously to be the site of functional and morphological alterations of astrocytes and increased concentrations of the acid metabolites of dopamine and serotonin. Serotonin 278-287 monoamine oxidase A Homo sapiens 19-23