PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20799605-2 2010 The MAOs from both studied biological sources show catalytic properties resembling those of the classical MAO of terrestrial vertebrates: they deaminate tyramine, tryptamine, serotonin, benzylamine and do not deaminate histamine, have sensitivity to chlorgiline, the specific inhibitor of the MAO A form, and deprenyl, the specific inhibitor of the MAO B form, and are not inhibited with 10(-2) M semicarbazide. Serotonin 175-184 monoamine oxidase A Rattus norvegicus 4-7 20799605-2 2010 The MAOs from both studied biological sources show catalytic properties resembling those of the classical MAO of terrestrial vertebrates: they deaminate tyramine, tryptamine, serotonin, benzylamine and do not deaminate histamine, have sensitivity to chlorgiline, the specific inhibitor of the MAO A form, and deprenyl, the specific inhibitor of the MAO B form, and are not inhibited with 10(-2) M semicarbazide. Serotonin 175-184 monoamine oxidase A Rattus norvegicus 106-109 20799605-2 2010 The MAOs from both studied biological sources show catalytic properties resembling those of the classical MAO of terrestrial vertebrates: they deaminate tyramine, tryptamine, serotonin, benzylamine and do not deaminate histamine, have sensitivity to chlorgiline, the specific inhibitor of the MAO A form, and deprenyl, the specific inhibitor of the MAO B form, and are not inhibited with 10(-2) M semicarbazide. Serotonin 175-184 monoamine oxidase A Rattus norvegicus 106-109 20799605-5 2010 In the species Rana temporaria the MAO activity in reaction of deamination of serotonin and benzylamine were practically identical, whereas in the species Rana ridibunda these parameters for serotonin were almost one order of magnitude higher than for benzylamine. Serotonin 78-87 monoamine oxidase A Rattus norvegicus 35-38 19883764-8 2010 Compared with human MAO A, rat MAO A oxidizes serotonin or kynuramine with twofold higher k(cat)/K(m) values, oxidizes phenethylamine with a 6.7-fold higher catalytic efficiency and benzylamine with a approximately 40-fold higher catalytic efficiency. Serotonin 46-55 monoamine oxidase A Rattus norvegicus 31-36 19076925-6 2009 The obtained results demonstrated that the administration of a neurotoxic binge dose of MDMA to an adolescent rat model previously treated with the specific MAO-A inhibitor, clorgyline, resulted in synergistic effects on serotonin- (5-HT) mediated behaviour and body temperature, provoking high mortality. Serotonin 221-230 monoamine oxidase A Rattus norvegicus 157-162 17372973-5 2007 In vivo binding in both models was studied before and after presumably having increased interstitial 5HT concentrations using tranylcypromine (TCP), which inhibits the enzyme (monoamine oxidase, MAO), that degrades 5HT. Serotonin 215-218 monoamine oxidase A Rattus norvegicus 195-198 19198157-2 2008 It has been established that MAO of mink, like MAO of rat, has properties of classic mammalian MAO: it deaminates tyramine, tryptamine, serotonin, benzilamine, beta-phenylethylamine and does not deaminate histamine as well as does not have sensitivity to semicarbazide. Serotonin 136-145 monoamine oxidase A Rattus norvegicus 29-32 19198157-2 2008 It has been established that MAO of mink, like MAO of rat, has properties of classic mammalian MAO: it deaminates tyramine, tryptamine, serotonin, benzilamine, beta-phenylethylamine and does not deaminate histamine as well as does not have sensitivity to semicarbazide. Serotonin 136-145 monoamine oxidase A Rattus norvegicus 47-50 19198157-2 2008 It has been established that MAO of mink, like MAO of rat, has properties of classic mammalian MAO: it deaminates tyramine, tryptamine, serotonin, benzilamine, beta-phenylethylamine and does not deaminate histamine as well as does not have sensitivity to semicarbazide. Serotonin 136-145 monoamine oxidase A Rattus norvegicus 47-50 16487506-7 2006 These behavioral data indicate the functional significance of increased extracellular serotonin concentrations due to combined use of a MAO-A inhibitor with subchronic lithium. Serotonin 86-95 monoamine oxidase A Rattus norvegicus 136-141 16408260-8 2006 Colocalization between serotonin and SERT positive fibers was close to 100% in MAO inhibitor treated animals but only 30% in untreated rats. Serotonin 23-32 monoamine oxidase A Rattus norvegicus 79-82 16488409-1 2006 5-hydroxytryptamine (5-HT) syndrome is a dangerous condition of 5-HT excess that can occur in the case of co-administration of a monoamine oxidase (MAO) inhibitor and a serotonin reuptake inhibitor (SSRI). Serotonin 2-19 monoamine oxidase A Rattus norvegicus 129-146 16490344-1 2006 Monoamine oxidase (MAO) regulates levels of dopamine, serotonin, and noradrenaline in the nervous tissue and is required for proper neuronal development. Serotonin 54-63 monoamine oxidase A Rattus norvegicus 0-17 16490344-1 2006 Monoamine oxidase (MAO) regulates levels of dopamine, serotonin, and noradrenaline in the nervous tissue and is required for proper neuronal development. Serotonin 54-63 monoamine oxidase A Rattus norvegicus 19-22 16487506-9 2006 The present study suggests that lithium augmentation of the antidepressant effect of MAO inhibitors is mediated by additional increases in the extracellular serotonin concentrations induced by MAO-A inhibition and suggests that the anxiolytic action of MAO inhibitors may be enhanced by lithium. Serotonin 157-166 monoamine oxidase A Rattus norvegicus 85-88 16488409-1 2006 5-hydroxytryptamine (5-HT) syndrome is a dangerous condition of 5-HT excess that can occur in the case of co-administration of a monoamine oxidase (MAO) inhibitor and a serotonin reuptake inhibitor (SSRI). Serotonin 2-19 monoamine oxidase A Rattus norvegicus 148-151 16487506-9 2006 The present study suggests that lithium augmentation of the antidepressant effect of MAO inhibitors is mediated by additional increases in the extracellular serotonin concentrations induced by MAO-A inhibition and suggests that the anxiolytic action of MAO inhibitors may be enhanced by lithium. Serotonin 157-166 monoamine oxidase A Rattus norvegicus 193-198 16487506-9 2006 The present study suggests that lithium augmentation of the antidepressant effect of MAO inhibitors is mediated by additional increases in the extracellular serotonin concentrations induced by MAO-A inhibition and suggests that the anxiolytic action of MAO inhibitors may be enhanced by lithium. Serotonin 157-166 monoamine oxidase A Rattus norvegicus 193-196 12871570-8 2003 Inhibition of brain MAO-A and -B by TV3326 resulted in significant elevations of dopamine, noradrenaline and serotonin in the striatum and hippocampus. Serotonin 109-118 monoamine oxidase A Rattus norvegicus 20-25 16286591-1 2005 BACKGROUND: Serotonin (5-hydroxytryptamine [5-HT]), released by activated platelets during cardiac ischemia, is metabolized by the mitochondrial enzyme monoamine oxidase A (MAO-A). Serotonin 12-21 monoamine oxidase A Rattus norvegicus 152-171 16286591-1 2005 BACKGROUND: Serotonin (5-hydroxytryptamine [5-HT]), released by activated platelets during cardiac ischemia, is metabolized by the mitochondrial enzyme monoamine oxidase A (MAO-A). Serotonin 12-21 monoamine oxidase A Rattus norvegicus 173-178 16286591-1 2005 BACKGROUND: Serotonin (5-hydroxytryptamine [5-HT]), released by activated platelets during cardiac ischemia, is metabolized by the mitochondrial enzyme monoamine oxidase A (MAO-A). Serotonin 23-42 monoamine oxidase A Rattus norvegicus 152-171 16286591-1 2005 BACKGROUND: Serotonin (5-hydroxytryptamine [5-HT]), released by activated platelets during cardiac ischemia, is metabolized by the mitochondrial enzyme monoamine oxidase A (MAO-A). Serotonin 23-42 monoamine oxidase A Rattus norvegicus 173-178 15703274-2 2005 We have recently shown that the serotonin-degrading enzyme monoamine oxidase A (MAO A) is an important source of hydrogen peroxide in rat heart. Serotonin 32-41 monoamine oxidase A Rattus norvegicus 59-78 15703274-2 2005 We have recently shown that the serotonin-degrading enzyme monoamine oxidase A (MAO A) is an important source of hydrogen peroxide in rat heart. Serotonin 32-41 monoamine oxidase A Rattus norvegicus 80-85 15703274-3 2005 In the present study, we investigated the potential role of hydrogen peroxide generated by MAO A in cardiomyocyte hypertrophy by serotonin. Serotonin 129-138 monoamine oxidase A Rattus norvegicus 91-96 15703274-9 2005 These data suggest that part of cardiac hypertrophic effect of serotonin requires hydrogen peroxide production by MAO A and ERK1/2 activation. Serotonin 63-72 monoamine oxidase A Rattus norvegicus 114-119 15351283-1 2004 A simple and selective assay for the evaluation of in vivo inhibition of rat brain monoamine oxidases (MAO) A and B following a single dose of MAO inhibitors was developed through the simultaneous determination of endogenous 5-hydroxy tryptamine, 5-hydroxyindole-3-acetic acid (5-HIAA), tryptophane, and 2-phenethylamine (PEA) in rat brain using liquid chromatography-tandem mass spectrometry (LC/MS/MS). Serotonin 225-245 monoamine oxidase A Rattus norvegicus 83-115 15351283-1 2004 A simple and selective assay for the evaluation of in vivo inhibition of rat brain monoamine oxidases (MAO) A and B following a single dose of MAO inhibitors was developed through the simultaneous determination of endogenous 5-hydroxy tryptamine, 5-hydroxyindole-3-acetic acid (5-HIAA), tryptophane, and 2-phenethylamine (PEA) in rat brain using liquid chromatography-tandem mass spectrometry (LC/MS/MS). Serotonin 225-245 monoamine oxidase A Rattus norvegicus 103-106 14581168-1 2003 The contaminants in deionized and distilled water (DDI water) boiled with polystyrene resin inhibited A-type monoamine oxidase (MAO, MAO-A preferentially deaminates serotonin and norepinephrine and regulates these amines concentration) activity in monkey brain mitochondria. Serotonin 165-174 monoamine oxidase A Rattus norvegicus 133-138 14581168-7 2003 These results indicate that zinc benzoate, which inhibits MAO-A activity, is easily incorporated in DDI water by boiling polystyrene and also may be a contaminating environmental chemical compound that alters the levels of serotonin and norepinephrine in the central nervous system. Serotonin 223-232 monoamine oxidase A Rattus norvegicus 58-63 17447419-2 2006 ), an endogenous MAO inhibitor, significantly increased norepinephrine and 5-hydroxytryptamine concentrations in the rat brain and also significantly increased acetylcholine and dopamine (DA) levels in the rat striatum. Serotonin 75-94 monoamine oxidase A Rattus norvegicus 17-20 12972688-2 2003 MAO-A activity increased to about 40% with 0.1 microM calcium disodium edetate (CaNa2EDTA) using serotonin as a substrate, and this activation was proportional to the concentration of CaNa2EDTA. Serotonin 97-106 monoamine oxidase A Rattus norvegicus 0-5 12972688-9 2003 These results also indicate the possibility that Zn ions may regulate physiologically the level of serotonin and norepinephrine content in brain by inhibiting a MAO-A activity. Serotonin 99-108 monoamine oxidase A Rattus norvegicus 161-166 11454416-1 2001 Elevating cortical serotonin (5-HT) in rats from postnatal day (P-) 0 to P-6 by administering the monoamine oxidase (MAO(A)) inhibitor, clorgyline, produces a dose-dependent spectrum of effects on rat somatosensory organization, ranging from enlarged with indistinct septa to a complete lack of vibrissae-related patterns. Serotonin 19-28 monoamine oxidase A Rattus norvegicus 98-115 12686747-2 2003 After preincubation at 25 degrees C for 20 min with 1 microM ZnSO(4), MAO-A activity in monkey brain was about 50% using serotonin (5-HT) as a substrate, and the inhibition was proportional to the concentration of ZnSO(4). Serotonin 121-130 monoamine oxidase A Rattus norvegicus 70-75 12566091-2 2003 Type A MAO activity in monkey brain decreased to about 50% with 1 microM ZnSO(4) using serotonin as a substrate, and this inhibition was proportional to the concentration of ZnSO(4). Serotonin 87-96 monoamine oxidase A Rattus norvegicus 7-10 11911838-1 2002 Recent studies with rat tissue preparations have suggested that the anorectic drug phentermine inhibits serotonin degradation by inhibition of monoamine oxidase (MAO) A with a K(I) value of 85-88 microM, a potency suggested to be similar to that of other reversible MAO inhibitors (Ulus et al., Biochem Pharmacol 2000;59:1611-21). Serotonin 104-113 monoamine oxidase A Rattus norvegicus 143-160 11911838-1 2002 Recent studies with rat tissue preparations have suggested that the anorectic drug phentermine inhibits serotonin degradation by inhibition of monoamine oxidase (MAO) A with a K(I) value of 85-88 microM, a potency suggested to be similar to that of other reversible MAO inhibitors (Ulus et al., Biochem Pharmacol 2000;59:1611-21). Serotonin 104-113 monoamine oxidase A Rattus norvegicus 162-165 12018584-0 2001 Serotonin and benzylamine oxidation by type A and type B MAO of rat brain in presence of organophosphate pesticides. Serotonin 0-9 monoamine oxidase A Rattus norvegicus 57-60 12480131-1 2002 Elevating cortical serotonin (5-HT) in rats with clorgyline, a monoamine oxidase A (MAO(A)) inhibitor, from postnatal day (P-0) to P-6 delays the organization of thalamocortical afferent fibers into a vibrissae-related pattern in the somatosensory cortex (S-I). Serotonin 19-28 monoamine oxidase A Rattus norvegicus 63-82 12480131-1 2002 Elevating cortical serotonin (5-HT) in rats with clorgyline, a monoamine oxidase A (MAO(A)) inhibitor, from postnatal day (P-0) to P-6 delays the organization of thalamocortical afferent fibers into a vibrissae-related pattern in the somatosensory cortex (S-I). Serotonin 19-28 monoamine oxidase A Rattus norvegicus 84-90 11454416-1 2001 Elevating cortical serotonin (5-HT) in rats from postnatal day (P-) 0 to P-6 by administering the monoamine oxidase (MAO(A)) inhibitor, clorgyline, produces a dose-dependent spectrum of effects on rat somatosensory organization, ranging from enlarged with indistinct septa to a complete lack of vibrissae-related patterns. Serotonin 19-28 monoamine oxidase A Rattus norvegicus 117-123 10927191-1 2000 Catecholamines and serotonin, which act as neurotransmitters and regulate blood circulation, are degraded by monoamine oxidase (MAO) [EC 1.4.3.4.] Serotonin 19-28 monoamine oxidase A Rattus norvegicus 109-126 11245847-3 2001 Immunoblots and enzyme assays, performed using [14C]5-hydroxytriptamine and [14C]beta-phenylethylamine as substrates for monoamine oxidases-A and -B, respectively, showed that monoamine oxidase-A is the isoenzyme largely predominant in 9-day-old rats renal cortex. Serotonin 52-71 monoamine oxidase A Rattus norvegicus 121-148 11245847-3 2001 Immunoblots and enzyme assays, performed using [14C]5-hydroxytriptamine and [14C]beta-phenylethylamine as substrates for monoamine oxidases-A and -B, respectively, showed that monoamine oxidase-A is the isoenzyme largely predominant in 9-day-old rats renal cortex. Serotonin 52-71 monoamine oxidase A Rattus norvegicus 176-195 10799660-1 2000 Phentermine was shown in the 1970s to inhibit the metabolism of serotonin by monoamine oxidase (MAO), but never was labeled as an MAO inhibitor; hence, it was widely used in combination with fenfluramine, and continues to be used, in violation of their labels, with other serotonin uptake blockers. Serotonin 64-73 monoamine oxidase A Rattus norvegicus 77-94 10799660-1 2000 Phentermine was shown in the 1970s to inhibit the metabolism of serotonin by monoamine oxidase (MAO), but never was labeled as an MAO inhibitor; hence, it was widely used in combination with fenfluramine, and continues to be used, in violation of their labels, with other serotonin uptake blockers. Serotonin 64-73 monoamine oxidase A Rattus norvegicus 96-99 10799660-4 2000 Phentermine inhibited serotonin-metabolizing (MAO-A) activity in all three tissues with K(i) values of 85-88 microM. Serotonin 22-31 monoamine oxidase A Rattus norvegicus 46-51 11501051-3 2000 MAO activity was determined radiochemically with [14C]5-hydroxytryptamine (5-HT) and [14C]beta-phenylethylamine (beta-PEA) used as MAO A or B specific radiolabled substrates, respectively. Serotonin 75-79 monoamine oxidase A Rattus norvegicus 0-3 10927191-1 2000 Catecholamines and serotonin, which act as neurotransmitters and regulate blood circulation, are degraded by monoamine oxidase (MAO) [EC 1.4.3.4.] Serotonin 19-28 monoamine oxidase A Rattus norvegicus 128-131 10548268-1 1999 Evidence for a role of dopamine and serotonin in the control of ethanol intake in animals suggests that monoamine oxidase (MAO) inhibitors, which increase the synaptic availability of serotonin and dopamine by blocking their metabolism, might have efficacy in the treatment of alcohol dependence. Serotonin 36-45 monoamine oxidase A Rattus norvegicus 104-121 10548268-7 1999 In conclusion, the present results showing that several MAO inhibitors decreased ethanol self-administration in rats are consistent with previous findings that synaptic levels of serotonin and dopamine play a critical role in the control of ethanol self-administration. Serotonin 179-188 monoamine oxidase A Rattus norvegicus 56-59 10548268-1 1999 Evidence for a role of dopamine and serotonin in the control of ethanol intake in animals suggests that monoamine oxidase (MAO) inhibitors, which increase the synaptic availability of serotonin and dopamine by blocking their metabolism, might have efficacy in the treatment of alcohol dependence. Serotonin 36-45 monoamine oxidase A Rattus norvegicus 123-126 10548268-1 1999 Evidence for a role of dopamine and serotonin in the control of ethanol intake in animals suggests that monoamine oxidase (MAO) inhibitors, which increase the synaptic availability of serotonin and dopamine by blocking their metabolism, might have efficacy in the treatment of alcohol dependence. Serotonin 184-193 monoamine oxidase A Rattus norvegicus 104-121 10548268-1 1999 Evidence for a role of dopamine and serotonin in the control of ethanol intake in animals suggests that monoamine oxidase (MAO) inhibitors, which increase the synaptic availability of serotonin and dopamine by blocking their metabolism, might have efficacy in the treatment of alcohol dependence. Serotonin 184-193 monoamine oxidase A Rattus norvegicus 123-126 10709190-3 1999 In all brain structures Ache and MAO (substrate 5-hydroxytryptamine) activities were not influenced by DSIP. Serotonin 48-67 monoamine oxidase A Rattus norvegicus 33-36 10504491-7 1999 The MAO substrate [14C]serotonin was transported into mesangial cells by a saturable uptake system (Vmax 310 +/- 36 pmol/30 min/mg protein; Km 5.9 +/- 1.4 microM) displaying the pharmacological properties of a serotonin transporter. Serotonin 23-32 monoamine oxidase A Rattus norvegicus 4-7 10504491-9 1999 MAO activity measured in intact cells showed that after accumulation into mesangial cells, [14C]serotonin was metabolized by MAO-A. Serotonin 96-105 monoamine oxidase A Rattus norvegicus 0-3 10504491-10 1999 Finally, serotonin-mediated mesangial cell proliferation was significantly increased after irreversible MAO inhibition. Serotonin 9-18 monoamine oxidase A Rattus norvegicus 104-107 10504491-11 1999 CONCLUSIONS: Our results suggest that serotonin concentration and function in glomeruli may be regulated in part by its transport into mesangial cells and degradation by MAO-A. Serotonin 38-47 monoamine oxidase A Rattus norvegicus 170-175 10208305-0 1999 Effects of local MAO inhibition in the locus coeruleus on extracellular serotonin and 5-HIAA during exposure to sensory and cardiovascular stimuli. Serotonin 72-81 monoamine oxidase A Rattus norvegicus 17-20 9838121-7 1998 Moreover, dopamine- and serotonin-degrading MAO activity has also been found in LC neurons. Serotonin 24-33 monoamine oxidase A Rattus norvegicus 44-47 10897801-4 1999 MAO-A and MAO-B activities were estimated with radioassays employing serotonin and beta-phenylethylamine, respectively and specific inhibitors, clorgyline and deprenyl. Serotonin 69-78 monoamine oxidase A Rattus norvegicus 0-5 9838121-8 1998 Therefore, our results indicate that MAO activity is localized within noradrenergic neurons in the LC and is likely involved in the degradation of dopamine that is endogenously synthesized, and also in the elimination of serotonin that is produced from exogenous precursors. Serotonin 221-230 monoamine oxidase A Rattus norvegicus 37-40 9037433-9 1997 When the sections without inhibitor pretreatment were incubated with the type A preferential substrate serotonin, the MAO activity was strongly stained in LC neurons but very weakly in DR neurons. Serotonin 103-112 monoamine oxidase A Rattus norvegicus 118-121 9570466-0 1998 Effect of the reversible monoamine oxidase-A inhibitor befloxatone on the rat 5-hydroxytryptamine neurotransmission. Serotonin 78-97 monoamine oxidase A Rattus norvegicus 25-44 9570466-1 1998 The aim of the present study was to assess, using in vivo electrophysiological paradigms, the effect of sustained administration of the selective and reversible monoamine oxidase-A inhibitor beflotaxone on serotonin (5-hydroxytryptamine, 5-HT) neurotransmission. Serotonin 206-215 monoamine oxidase A Rattus norvegicus 161-180 9813366-3 1998 We further examined MAO activity in these neurons using other substrates, including serotonin (an MAO type A preferential substrate), beta-phenylethylamine (an MAO type B preferential substrate), and tyramine (a substrate common to both MAO types A and B). Serotonin 84-93 monoamine oxidase A Rattus norvegicus 20-23 9813366-3 1998 We further examined MAO activity in these neurons using other substrates, including serotonin (an MAO type A preferential substrate), beta-phenylethylamine (an MAO type B preferential substrate), and tyramine (a substrate common to both MAO types A and B). Serotonin 84-93 monoamine oxidase A Rattus norvegicus 98-101 9813366-3 1998 We further examined MAO activity in these neurons using other substrates, including serotonin (an MAO type A preferential substrate), beta-phenylethylamine (an MAO type B preferential substrate), and tyramine (a substrate common to both MAO types A and B). Serotonin 84-93 monoamine oxidase A Rattus norvegicus 98-101 9813366-3 1998 We further examined MAO activity in these neurons using other substrates, including serotonin (an MAO type A preferential substrate), beta-phenylethylamine (an MAO type B preferential substrate), and tyramine (a substrate common to both MAO types A and B). Serotonin 84-93 monoamine oxidase A Rattus norvegicus 98-101 9813366-8 1998 Our results suggest that dopamine-degrading MAO activity and MAO types A and B activities in SNC dopamine neurons are very low compared to MAO activity in LC noradrenaline neurons and in DR serotonin neurons. Serotonin 190-199 monoamine oxidase A Rattus norvegicus 44-47 9698044-4 1998 Animals were sacrificed at 3 weeks and MAO-A and -B activity was assessed in homogenates of heart, liver, lung, uterus, kidney, adrenal and small intestine using 5-hydroxytryptamine and phenylethylamine as substrates. Serotonin 162-181 monoamine oxidase A Rattus norvegicus 39-51 9503569-1 1997 Vladimir Zinovievich Gorkin"s theory of the transformation of catalytic activity of amine oxidases and, therweby, selectivity of amine oxidases, carried over from my personal acquaintance with Vladimir Zinovievich, significantly influenced our studies into the mechanism of MAO-induced stimulation of pineal melatonin biosynthesis from serotonin. Serotonin 336-345 monoamine oxidase A Rattus norvegicus 274-277 7803985-5 1994 Since MAO-A is an isoform of MAO that preferentially uses norepinephrine and serotonin as substrates and MAO-B acts on phenylethylamine and benzylamine as substrates, our findings suggest that the restoration of sexual behavior after the treatment with estradiol benzoate followed by progesterone may be associated with the differential effect exerted by the hormones on MAO subtypes, rather than to the simple decrease in hypothalamic monoamine concentrations as reported in the literature. Serotonin 77-86 monoamine oxidase A Rattus norvegicus 6-11 8813364-1 1996 The aim of the present study is to examine by immunohistochemistry whether dopamine produced from L-DOPA in serotonin neurons of the rat brain is degraded by endogenous monoamine oxidase (MAO). Serotonin 108-117 monoamine oxidase A Rattus norvegicus 169-186 8813364-1 1996 The aim of the present study is to examine by immunohistochemistry whether dopamine produced from L-DOPA in serotonin neurons of the rat brain is degraded by endogenous monoamine oxidase (MAO). Serotonin 108-117 monoamine oxidase A Rattus norvegicus 188-191 8914926-1 1996 Monoamine oxidases A/B (EC 1.4.3.4, MAO), flavoenzymes located on the outer mitochondrial membrane, catalyze the oxidative deamination of biogenic amines, such as dopamine, serotonin, and norepinephrine. Serotonin 173-182 monoamine oxidase A Rattus norvegicus 0-22 8914926-1 1996 Monoamine oxidases A/B (EC 1.4.3.4, MAO), flavoenzymes located on the outer mitochondrial membrane, catalyze the oxidative deamination of biogenic amines, such as dopamine, serotonin, and norepinephrine. Serotonin 173-182 monoamine oxidase A Rattus norvegicus 36-39 8930312-2 1996 By means of 5-hydroxyin-doleacetic acid (5-HIAA) voltammetric measurements, this study investigated their influence on serotonin metabolism which depends mainly upon the activity of monoamine oxidase type A. Serotonin 119-128 monoamine oxidase A Rattus norvegicus 182-206 8813364-6 1996 These findings suggest that the newly produced dopamine from L-DOPA in serotonin neurons of the rat DR is degraded by endogenous MAO. Serotonin 71-80 monoamine oxidase A Rattus norvegicus 129-132 7478301-3 1995 In the present study, release of the false transmitter serotonin from the dopaminergic nerve terminals was studied by loading the neurons in vivo with serotonin precursor L-tryptophan and MAO inhibitor pargyline, which results in accumulation of false transmitter serotonin. Serotonin 55-64 monoamine oxidase A Rattus norvegicus 188-191 7803985-5 1994 Since MAO-A is an isoform of MAO that preferentially uses norepinephrine and serotonin as substrates and MAO-B acts on phenylethylamine and benzylamine as substrates, our findings suggest that the restoration of sexual behavior after the treatment with estradiol benzoate followed by progesterone may be associated with the differential effect exerted by the hormones on MAO subtypes, rather than to the simple decrease in hypothalamic monoamine concentrations as reported in the literature. Serotonin 77-86 monoamine oxidase A Rattus norvegicus 6-9 7803985-5 1994 Since MAO-A is an isoform of MAO that preferentially uses norepinephrine and serotonin as substrates and MAO-B acts on phenylethylamine and benzylamine as substrates, our findings suggest that the restoration of sexual behavior after the treatment with estradiol benzoate followed by progesterone may be associated with the differential effect exerted by the hormones on MAO subtypes, rather than to the simple decrease in hypothalamic monoamine concentrations as reported in the literature. Serotonin 77-86 monoamine oxidase A Rattus norvegicus 29-32 7504085-1 1993 We have examined the changes induced by the monoamine oxidase (MAO; EC 1.4.3.4) inhibitors tranylcypromine, clorgyline, and deprenyl on MAO activity and 5-hydroxytryptamine (serotonin, 5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) content in rat brain and blood (plasma and whole blood). Serotonin 185-189 monoamine oxidase A Rattus norvegicus 44-61 8058030-2 1994 The activities toward serotonin (MAO-A), benzylamine (MAO-B), and dopamine (MAO-DA) in SM2 from all three regions were different from the corresponding values in SM. Serotonin 22-31 monoamine oxidase A Rattus norvegicus 33-38 8058030-2 1994 The activities toward serotonin (MAO-A), benzylamine (MAO-B), and dopamine (MAO-DA) in SM2 from all three regions were different from the corresponding values in SM. Serotonin 22-31 monoamine oxidase A Rattus norvegicus 33-36 8117318-5 1994 The MAO activity was measured radiochemically using [14C]5-hydroxytryptamine (5-HT; 100 microM), [14C]phenethylamine (PEA; 20 microM) and [14C]DA (100 microM) as substrates. Serotonin 78-82 monoamine oxidase A Rattus norvegicus 4-7 7957717-9 1994 The findings of this study suggest that the pattern of MAO-A parallels both in neuroanatomical distribution and in density that of norepinephrine and serotonin innervation. Serotonin 150-159 monoamine oxidase A Rattus norvegicus 55-60 7931249-8 1994 Increases of tissue and extracellular concentrations of NA and 5HT were highest after Pargyline suggesting that both monoamines may be metabolized by MAO-A and MAO-B. Serotonin 63-66 monoamine oxidase A Rattus norvegicus 150-155 8138017-2 1993 Lipid peroxidation (LPO) in rat liver mitochondria decreased the activity of monoamine oxidase (MAO) with physiological substrates serotonin and 2-phenylethylamine (by 15-30%) and induced deamination of glucosamine, which was highly sensitive to selective MAO A inhibitor pirlindole. Serotonin 131-140 monoamine oxidase A Rattus norvegicus 77-94 8138017-2 1993 Lipid peroxidation (LPO) in rat liver mitochondria decreased the activity of monoamine oxidase (MAO) with physiological substrates serotonin and 2-phenylethylamine (by 15-30%) and induced deamination of glucosamine, which was highly sensitive to selective MAO A inhibitor pirlindole. Serotonin 131-140 monoamine oxidase A Rattus norvegicus 96-99 8330200-1 1993 Monoamine oxidase A and B (MAO A and B; EC 1.4.3.4) are integral proteins of the outer mitochondrial membrane that degrade monoamines including the neurotransmitters norepinephrine, dopamine, and serotonin. Serotonin 196-205 monoamine oxidase A Rattus norvegicus 0-25 8216383-3 1993 The procedure is suitable for use with a wide range of MAO substrates, although 5-hydroxytryptamine, adrenaline and noradrenaline are too readily oxidized by hydrogen peroxide to be used. Serotonin 80-99 monoamine oxidase A Rattus norvegicus 55-58 8333043-8 1993 The activity of MAO with 0.1 mM 5-hydroxytryptamine (5-HT) (substrate for MAO-A) and with 0.01 mM 2-phenylethylamine (substrate for MAO-B) were not affected by denervation. Serotonin 32-51 monoamine oxidase A Rattus norvegicus 16-19 8330200-1 1993 Monoamine oxidase A and B (MAO A and B; EC 1.4.3.4) are integral proteins of the outer mitochondrial membrane that degrade monoamines including the neurotransmitters norepinephrine, dopamine, and serotonin. Serotonin 196-205 monoamine oxidase A Rattus norvegicus 27-38 1897194-3 1991 2.5-fold decrease of Vmax of serotonin (MAO-A substrate) deamination has been found. Serotonin 29-38 monoamine oxidase A Rattus norvegicus 40-45 1397038-2 1992 CGP 11305-A, a monoamine oxidase-A inhibitor that also blocks serotonin reuptake, elicited an increase of latency in the tail-flick and the hot-plate test. Serotonin 62-71 monoamine oxidase A Rattus norvegicus 15-34 1397038-6 1992 The data suggest that the increase in serotonin availability induced by monoamine oxidase-A inhibition alone is not sufficient to affect nociceptive thresholds. Serotonin 38-47 monoamine oxidase A Rattus norvegicus 72-91 1413625-4 1992 In the system containing membrane bound MAO from human placenta, where the MAO-A is predominating, the modulators studied mostly inhibited deamination of 14C-serotonin. Serotonin 158-167 monoamine oxidase A Rattus norvegicus 40-43 1520403-2 1992 Incubation of rat brain synaptosomes and mitochondria with LPO inducers (Fe2+ and ascorbate) was accompanied by a decrease of deamination of serotonin (substrate of MAO-A) in mitochondria, but not in synaptosomes, with simultaneous stimulation of GABA and GLCA deamination, apparently owing to modification of catalytic properties of brain membrane-bound MAO. Serotonin 141-150 monoamine oxidase A Rattus norvegicus 165-170 1520403-2 1992 Incubation of rat brain synaptosomes and mitochondria with LPO inducers (Fe2+ and ascorbate) was accompanied by a decrease of deamination of serotonin (substrate of MAO-A) in mitochondria, but not in synaptosomes, with simultaneous stimulation of GABA and GLCA deamination, apparently owing to modification of catalytic properties of brain membrane-bound MAO. Serotonin 141-150 monoamine oxidase A Rattus norvegicus 165-168 1520403-4 1992 Reactions of deamination of serotonin, GABA, and GLCA (but not PEA), were highly sensitive to a selective inhibitor of MAO-A pyrazidol (pyrlindole). Serotonin 28-37 monoamine oxidase A Rattus norvegicus 119-124 1839019-3 1991 The results show that centrally administered serotonin, the serotonin precursor, 5-hydroxytryptophan administered with clorgyline, a selective MAO A inhibitor, quipazine, a serotonin receptor agonist, and fluoxetine, a selective inhibitor of neuronal re-uptake of serotonin, attenuated all paradigms of FIA and apomorphine induced potentiation of FIA. Serotonin 45-54 monoamine oxidase A Rattus norvegicus 143-148 22290665-0 1993 Effect of monoamine oxidase A and B inhibition on the uptake and metabolism of serotonin within serotonergic neurons of rat brain. Serotonin 79-88 monoamine oxidase A Rattus norvegicus 10-29 22290665-1 1993 The effects of inhibiting monoamine oxidase (MAO) A and B on metabolism and uptake of serotonin (5-HT) in serotonergic synaptosomes were studied. Serotonin 86-95 monoamine oxidase A Rattus norvegicus 26-51 1413623-2 1992 While the activity of MAO-A (serotonin as a substrate) was decreased in brain, functions of the enzyme were altered: the enzyme acquired the ability to deaminate glucosamine, which is not a substrate of MAO under normal conditions. Serotonin 29-38 monoamine oxidase A Rattus norvegicus 22-27 1413623-2 1992 While the activity of MAO-A (serotonin as a substrate) was decreased in brain, functions of the enzyme were altered: the enzyme acquired the ability to deaminate glucosamine, which is not a substrate of MAO under normal conditions. Serotonin 29-38 monoamine oxidase A Rattus norvegicus 22-25 1922690-4 1991 Modes of inhibition of MAO-A and MAO-B by ifenprodil were competitive towards oxidation of their respective substrates, 5-hydroxytryptamine and benzylamine, with Ki values of 75 microM for inhibition of MAO-A and 110 microM for inhibition of MAO-B. Serotonin 120-139 monoamine oxidase A Rattus norvegicus 23-28 1881457-2 1991 N2-Acetylphenelzine is a relatively potent inhibitor of monoamine oxidase-A and -B and causes increases in whole-brain levels of noradrenaline and 5-hydroxytryptamine, and decreases in homovanillic acid, 5-hydroxyindole-3-acetic acid, and 3,4-dihydroxyphenylacetic acetic after acute i.p. Serotonin 147-166 monoamine oxidase A Rattus norvegicus 56-82 1904113-12 1991 In conclusion, NE, DA, and 5HT are exclusively or preferentially deaminated by MAO-A in the cortex, hippocampus, and striatum of rats, and RS-8359 exhibits a reversible MAO-A inhibitory action in all three regions tested in vivo. Serotonin 27-30 monoamine oxidase A Rattus norvegicus 79-84 1700071-0 1990 Serotonin metabolism by monoamine oxidase in rat primary astrocyte cultures. Serotonin 0-9 monoamine oxidase A Rattus norvegicus 24-41 2087001-7 1990 These results suggest that deamination of NE, DA, and 5HT is activated by the increases in the substrates for MAO in all three regions, except the noradrenergic system in the striatum, and that MAO-A participates in the activated deamination after reperfusion. Serotonin 54-57 monoamine oxidase A Rattus norvegicus 110-113 2087001-7 1990 These results suggest that deamination of NE, DA, and 5HT is activated by the increases in the substrates for MAO in all three regions, except the noradrenergic system in the striatum, and that MAO-A participates in the activated deamination after reperfusion. Serotonin 54-57 monoamine oxidase A Rattus norvegicus 194-199 34599937-11 2021 H/R-induced production of mitochondrial ROS in HK-2 cells was due to MAO-A-catalyzed 5-HT degradation, and 5-HT2AR was involved by mediating the expression of 5-HT synthases and MAO-A. Serotonin 85-89 monoamine oxidase A Rattus norvegicus 69-74 34867385-9 2021 Meanwhile, Semen Strychni inhibited the mRNA expression of NMDAR1, NMDAR2A, NMDAR2B, GABRa1, GABRb2 and reduced the level of MAO, which disrupted the DA and 5-HT metabolic pathway. Serotonin 157-161 monoamine oxidase A Rattus norvegicus 125-128 2251787-2 1990 It was shown that in experimental catatonia (as compared with rats of the corresponding control group) there was a dramatic increase in the brain stem of the rate of oxidative deamination of beta-phenylethylamine catalyzed by MAO-III; there was also a statistically significant (albeit less expressed than in the experiments with beta-phenylethylamine) increase in the rate of deamination of tyramine and a decrease in the rate of deamination of serotonin. Serotonin 446-455 monoamine oxidase A Rattus norvegicus 226-229 2815668-1 1989 Dissimilar effect of emotional stress on activity of the A and B forms of brain monoamine oxidase (MAO) was found in motionless rats within 1 and 5 hrs: increase in the rate of serotonin deamination catalyzed by MAO A and decrease in the rate of catalyzed by MAO B benzylamine deamination. Serotonin 177-186 monoamine oxidase A Rattus norvegicus 80-97 34599937-1 2021 AIMS: To explore the relationship between renal ischemia/reperfusion injury (RIRI) and the activation of the renal 5-HT degradation system, including 5-HT2A receptor (5-HT2AR), 5-HT synthases and monoamine oxidase-A (MAO-A). Serotonin 115-119 monoamine oxidase A Rattus norvegicus 196-215 34599937-1 2021 AIMS: To explore the relationship between renal ischemia/reperfusion injury (RIRI) and the activation of the renal 5-HT degradation system, including 5-HT2A receptor (5-HT2AR), 5-HT synthases and monoamine oxidase-A (MAO-A). Serotonin 115-119 monoamine oxidase A Rattus norvegicus 217-222 2806381-0 1989 The reversible MAO inhibitor, brofaromine, inhibits serotonin uptake in vivo. Serotonin 52-61 monoamine oxidase A Rattus norvegicus 15-18 2815668-1 1989 Dissimilar effect of emotional stress on activity of the A and B forms of brain monoamine oxidase (MAO) was found in motionless rats within 1 and 5 hrs: increase in the rate of serotonin deamination catalyzed by MAO A and decrease in the rate of catalyzed by MAO B benzylamine deamination. Serotonin 177-186 monoamine oxidase A Rattus norvegicus 99-102 2815668-1 1989 Dissimilar effect of emotional stress on activity of the A and B forms of brain monoamine oxidase (MAO) was found in motionless rats within 1 and 5 hrs: increase in the rate of serotonin deamination catalyzed by MAO A and decrease in the rate of catalyzed by MAO B benzylamine deamination. Serotonin 177-186 monoamine oxidase A Rattus norvegicus 212-217 2815668-3 1989 Both low 10(-11) 10(-13) M and high 10(-5) 10(-6) M concentrations of corticosterone stimulated the MAO A deamination of serotonin, while the steroid high concentrations inhibited the MAO B deamination of benzylamine either in vitro and in vivo (after intraperitoneal administration of 5 mg/kg). Serotonin 121-130 monoamine oxidase A Rattus norvegicus 100-105 2730337-0 1989 Monoamine oxidase inhibition as a sequel of hydrogen sulfide intoxication: increases in brain catecholamine and 5-hydroxytryptamine levels. Serotonin 112-131 monoamine oxidase A Rattus norvegicus 0-17 2720154-2 1989 It was shown that in rat brain MAO"s affinity for serotonin reduced from the 5th minute of exposure to hyperbaric oxygen and went on reducing on the 15th minute. Serotonin 50-59 monoamine oxidase A Rattus norvegicus 31-34 2720154-3 1989 In rat heart the affinity of MAO for serotonin firstly decreased and then returned to normal meaning. Serotonin 37-46 monoamine oxidase A Rattus norvegicus 29-32 2510776-9 1989 A strong activity of monoamine oxidase (MAO) is found in intercellular spaces in the arcuate nucleus region of the hypothalamus, where a high 5HT immunoreactivity is seen in the young rat before MAO activity appears. Serotonin 142-145 monoamine oxidase A Rattus norvegicus 21-38 2510776-9 1989 A strong activity of monoamine oxidase (MAO) is found in intercellular spaces in the arcuate nucleus region of the hypothalamus, where a high 5HT immunoreactivity is seen in the young rat before MAO activity appears. Serotonin 142-145 monoamine oxidase A Rattus norvegicus 40-43 3401582-2 1988 HBO was shown to cause a substantial reduction in MAO affinity to serotonin in the brain, but not in the heart. Serotonin 66-75 monoamine oxidase A Rattus norvegicus 50-53 2478663-4 1989 It is suggested that blocking of the oxidation of both MAO-A substrates, noradrenaline and serotonin, upon clorgyline administration results in the observed increase in melatonin synthesis which is thought to contribute to the antidepressant effects of MAO inhibition. Serotonin 91-100 monoamine oxidase A Rattus norvegicus 55-58 2811598-6 1989 The highest activity of the monoamine oxidase-A in substantia nigra coincided with the highest 5-hydroxyindolacetic acid:serotonin ratio. Serotonin 121-130 monoamine oxidase A Rattus norvegicus 28-47 3346672-8 1988 Finally, dopamine and 5-hydroxytryptamine depleted from their striatal stores by tetrabenazine were able to displace SR 95191 from the active site of MAO-A. Serotonin 22-41 monoamine oxidase A Rattus norvegicus 150-155 2455784-3 1988 When the MAO inhibitor pargyline was injected and the animals killed at different times, there was an exponential decrease in the concentration of 5-hydroxyindole acetic acid (5-HIAA) with time, whereas the increase in 5-hydroxytryptamine was linear only during the first 30 min, thereafter reaching a plateau. Serotonin 219-238 monoamine oxidase A Rattus norvegicus 9-12 2965308-7 1987 The deamination of 14C-5-HT (0.1 mumol/l) in the presence of citalopram (0.25 mumol/l) was considered as that brought about outside the serotonergic synaptosomes, whereas the difference between the deamination in the absence and presence of citalopram was taken as the MAO activity inside the serotonergic synaptosomes. Serotonin 23-27 monoamine oxidase A Rattus norvegicus 269-272 3191966-5 1988 Antidepressants--MAO inhibitors--more actively reduce the rate of serotonin deamination, and tricyclic antidepressant desimipramine is similar to aminazine by its effect on MAO. Serotonin 66-75 monoamine oxidase A Rattus norvegicus 17-20 3822124-6 1986 The kinetics of the oxidase are similar to those of monoamine oxidase type A reported in other tissues including the adrenergic neuron, having apparent Km values of 400, 280, 170 and 227 microM for noradrenaline, dopamine, serotonin and tyramine. Serotonin 223-232 monoamine oxidase A Rattus norvegicus 52-76 3305788-4 1987 Clorgyline, a selective inhibitor of MAO-A, preferentially inhibited deamination of 5-hydroxytryptamine by all tissue homogenates, whereas deprenyl, a selective inhibitor of MAO-B, preferentially inhibited deamination of phenylethylamine. Serotonin 84-103 monoamine oxidase A Rattus norvegicus 37-42 3817298-1 1987 Two types of monoamine oxidase activity (MAO-A and MAO-B) help regulate the levels of biogenic amines such as catecholamines and serotonin. Serotonin 129-138 monoamine oxidase A Rattus norvegicus 41-46 2442302-4 1987 The MAO-A inhibitor amiflamine which is selective for serotonin neurons, was also more effective in reducing free 5-HTOL levels than of 5-HIAA levels, suggesting that the formation of 5-HTOL is closely associated with serotonin neurons. Serotonin 54-63 monoamine oxidase A Rattus norvegicus 4-9 2442302-4 1987 The MAO-A inhibitor amiflamine which is selective for serotonin neurons, was also more effective in reducing free 5-HTOL levels than of 5-HIAA levels, suggesting that the formation of 5-HTOL is closely associated with serotonin neurons. Serotonin 218-227 monoamine oxidase A Rattus norvegicus 4-9 3808082-1 1986 Amiflamine is a selective and reversible inhibitor of monoamine oxidase (MAO) type A which exerts a preferential effect on serotonin (5-HT) catabolism. Serotonin 123-132 monoamine oxidase A Rattus norvegicus 54-71 3808082-1 1986 Amiflamine is a selective and reversible inhibitor of monoamine oxidase (MAO) type A which exerts a preferential effect on serotonin (5-HT) catabolism. Serotonin 123-132 monoamine oxidase A Rattus norvegicus 73-76 3785579-7 1986 Oxidation of norepinephrine, serotonin, octopamine, tyramine and dopamine by monoamine oxidase (MAO), an enzyme marker of the outer mitochondrial membrane, was inhibited in the presence of 0.01 to 0.1 mM of chlorphentermine. Serotonin 29-38 monoamine oxidase A Rattus norvegicus 77-94 2430159-1 1986 Serotonin (5-HT) deamination by MAO-A is inhibited 35% at a dose of 100 mg/kg i.p. Serotonin 0-9 monoamine oxidase A Rattus norvegicus 32-37 3742029-3 1986 It was demonstrated that among all the compounds studied moclobamide appeared to be the most active and selective inhibitor of MAO-A: at a concentration of 100 microM it caused a 100% inhibition of serotonin and norepinephrine deamination, which might be explained by the presence of C1 atom in the para-position of benzene ring in moclobamide molecule. Serotonin 198-207 monoamine oxidase A Rattus norvegicus 127-132 2873848-1 1986 Dimebone was shown to inhibit monoamine oxidase (MAO) deaminating dopamine and serotonin, decrease dopamine metabolism in the basal ganglia of the rat brain, increase noradrenaline level and depress dopamine deamination in the hypothalamus. Serotonin 79-88 monoamine oxidase A Rattus norvegicus 30-47 2873848-1 1986 Dimebone was shown to inhibit monoamine oxidase (MAO) deaminating dopamine and serotonin, decrease dopamine metabolism in the basal ganglia of the rat brain, increase noradrenaline level and depress dopamine deamination in the hypothalamus. Serotonin 79-88 monoamine oxidase A Rattus norvegicus 49-52 2419508-0 1986 Brain dialysis: in vivo metabolism of dopamine and serotonin by monoamine oxidase A but not B in the striatum of unrestrained rats. Serotonin 51-60 monoamine oxidase A Rattus norvegicus 64-83 3785579-7 1986 Oxidation of norepinephrine, serotonin, octopamine, tyramine and dopamine by monoamine oxidase (MAO), an enzyme marker of the outer mitochondrial membrane, was inhibited in the presence of 0.01 to 0.1 mM of chlorphentermine. Serotonin 29-38 monoamine oxidase A Rattus norvegicus 96-99 3953019-1 1986 Activity of monoamine oxidases (MAO) of the types A and B (substrates: 5-hydroxytryptamine, 2-phenylethylamine, tyramine) has been studied in mitochondrial fractions from brain, heart, liver and kidney of 24-week-old rats of the normotonic strain Wistar Kyoto (WKY) and spontaneously hypertonic rats (SHR). Serotonin 71-90 monoamine oxidase A Rattus norvegicus 12-30 3961266-3 1986 PPA was found to inhibit both human brain and rat liver mitochondrial MAO activities in vitro, i.e. Ki"s were 150 microM and 800 microM with respect to serotonin (Type A substrate) and beta-phenylethylamine (Type B substrate). Serotonin 152-161 monoamine oxidase A Rattus norvegicus 70-73 3020531-3 1986 It was found, that daily administration of 0.25 mg/kg sc clorgyline, a specific MAO A inhibitor, reduced the turnover rate of both dopamine and serotonin after two weeks of injections. Serotonin 144-153 monoamine oxidase A Rattus norvegicus 80-85 4030926-1 1985 The major catabolic enzyme for serotonin, monoamine oxidase (MAO), is present in the endothelium of cerebral vessels. Serotonin 31-40 monoamine oxidase A Rattus norvegicus 42-59 4030926-1 1985 The major catabolic enzyme for serotonin, monoamine oxidase (MAO), is present in the endothelium of cerebral vessels. Serotonin 31-40 monoamine oxidase A Rattus norvegicus 61-64 4030926-2 1985 We report the effects of the intracarotid administration of serotonin on local cerebral glucose utilisation in rats following MAO inhibition with the drug clorgyline. Serotonin 60-69 monoamine oxidase A Rattus norvegicus 126-129 3953019-1 1986 Activity of monoamine oxidases (MAO) of the types A and B (substrates: 5-hydroxytryptamine, 2-phenylethylamine, tyramine) has been studied in mitochondrial fractions from brain, heart, liver and kidney of 24-week-old rats of the normotonic strain Wistar Kyoto (WKY) and spontaneously hypertonic rats (SHR). Serotonin 71-90 monoamine oxidase A Rattus norvegicus 32-35 3953019-3 1986 In brain mitochondria there was noted only slight tendency towards an increase in MAO-A (substrate: 5-hydroxytryptamine) and MAO-B (substrate: 2-phenylethylamine) activities in the SHR strain as compared with the normotonic animals of the same age. Serotonin 100-119 monoamine oxidase A Rattus norvegicus 82-87 3953019-5 1986 In kidney mitochondria of SHR the activity of MAO (substrates: 5-hydroxytryptamine, 2-phenylethylamine, tyramine) did not exhibit any alterations as compared with the control WKY rats. Serotonin 63-82 monoamine oxidase A Rattus norvegicus 46-49 3999927-6 1985 Although a high microvessel MAO activity (2.2 +/- 0.3 nmol min-1 mg prot.-1) was found using noradrenaline as substrate, significantly higher rates were found with tyramine, serotonin and beta-phenyl-ethylamine. Serotonin 174-183 monoamine oxidase A Rattus norvegicus 28-31 3861206-2 1985 This was recorded as the protection against the irreversible inhibition of MAO produced by phenelzine by determining the remaining deaminating activity in the absence and presence of citalopram using a low (0.1 microM) concentration of [14C]-5-hydroxytryptamine (5-HT) as substrate. Serotonin 242-261 monoamine oxidase A Rattus norvegicus 75-78 3861206-2 1985 This was recorded as the protection against the irreversible inhibition of MAO produced by phenelzine by determining the remaining deaminating activity in the absence and presence of citalopram using a low (0.1 microM) concentration of [14C]-5-hydroxytryptamine (5-HT) as substrate. Serotonin 263-267 monoamine oxidase A Rattus norvegicus 75-78 4016257-1 1985 An over two-fold decrease in the affinity of mitochondrial MAO to serotonin was found under hyperoxia, hypoxia and cold stress. Serotonin 66-75 monoamine oxidase A Rattus norvegicus 59-62 4002366-3 1985 The lowering of the mitochondrial monoamine oxidase A activity is accompanied by the appearance of serotonin and the glucosamine deaminating activity in supernatant. Serotonin 99-108 monoamine oxidase A Rattus norvegicus 34-53 4073474-2 1985 Results indicated an underestimation of MAO activity when liquid ion exchange chromatography (LIEC) was used instead of an ion exchange chromatographic method (IEC) to separate the different products of the deaminated tyramine, phenylethylamine, or serotonin. Serotonin 249-258 monoamine oxidase A Rattus norvegicus 40-43 2580723-1 1985 The question of whether serotonin is deaminated by MAO before it can be released or after release has occurred was investigated by studying the 5-HT behavioral syndrome in acutely reserpinized rats. Serotonin 24-33 monoamine oxidase A Rattus norvegicus 51-54 3935779-0 1985 Interactions between relatively selective monoamine oxidase inhibitors and an inhibitor of 5-hydroxytryptamine re-uptake, clomipramine. Serotonin 91-110 monoamine oxidase A Rattus norvegicus 42-59 4036650-3 1985 Monoamine oxidase A (substrate serotonin) and the total monoamine oxidase activity (substrate tyramine) are found to manifest identical development, their activity increasing quickly after birth, to reach constant values after the 10th day. Serotonin 31-40 monoamine oxidase A Rattus norvegicus 0-19 6443138-4 1984 The method makes possible the complete separation and detection of the deaminated products of monoamine oxidase A and B substrates benzylamine and 5-hydroxytryptamine, respectively. Serotonin 147-166 monoamine oxidase A Rattus norvegicus 94-113 3984267-2 1985 A decrease of the MAO activity at low concentrations of serotonin was found. Serotonin 56-65 monoamine oxidase A Rattus norvegicus 18-21 3835805-1 1985 In experiments on male Wistar albino rats was studied the effect of Co, Cd, Ni, Zn, Hg and Pb on the activity of rat liver and brain monoamine oxidase (MAO) using tyramine, serotonin and beta-phenylethylamine as substrates. Serotonin 173-182 monoamine oxidase A Rattus norvegicus 152-155 3835805-2 1985 It was established that ZnSO4 significantly increased the activity of liver MAO with all substrates studied, Co(NO3)2 increased it when tyramine and serotonin were used while NiSO4 increased MAO activity when serotonin was used as a substrate. Serotonin 149-158 monoamine oxidase A Rattus norvegicus 76-79 3835805-2 1985 It was established that ZnSO4 significantly increased the activity of liver MAO with all substrates studied, Co(NO3)2 increased it when tyramine and serotonin were used while NiSO4 increased MAO activity when serotonin was used as a substrate. Serotonin 209-218 monoamine oxidase A Rattus norvegicus 76-79 6518192-1 1984 The values of Km and V for serotonin, tyramine and beta-phenylethylamine deamination by solubilized and partially purified preparations of monoamine oxidase (MAO) from rat liver were determined. Serotonin 27-36 monoamine oxidase A Rattus norvegicus 139-156 6518192-1 1984 The values of Km and V for serotonin, tyramine and beta-phenylethylamine deamination by solubilized and partially purified preparations of monoamine oxidase (MAO) from rat liver were determined. Serotonin 27-36 monoamine oxidase A Rattus norvegicus 158-161 6206407-2 1984 The influence of DU 24565 and quipazine on the activity of MAO was studied in rat brain homogenates, using labelled serotonin as a substrate. Serotonin 116-125 monoamine oxidase A Rattus norvegicus 59-62 6736960-4 1984 Selective protection against inactivation of the two forms of MAO by MDL 72145 was obtained by preincubating the enzyme with suitable concentrations of the selective A and B substrates, 5-hydroxytryptamine and benzylamine. Serotonin 186-205 monoamine oxidase A Rattus norvegicus 62-65 6747915-0 1984 Interactions of a non-selective monoamine oxidase inhibitor, phenelzine, with inhibitors of 5-hydroxytryptamine, dopamine or noradrenaline re-uptake. Serotonin 92-111 monoamine oxidase A Rattus norvegicus 32-49 6748816-3 1984 produces a slight but appreciable inhibition of MAO activity with tyramine or serotonin but not with benzylamine as substrate in both rat brain and liver mitochondria. Serotonin 78-87 monoamine oxidase A Rattus norvegicus 48-51 6748816-4 1984 Lignocaine (2-20 mM) inhibits (in vitro) both brain and liver mitochondrial MAO activity, using tyramine, serotonin and benzylamine as substrates, in a concentration-dependent manner. Serotonin 106-115 monoamine oxidase A Rattus norvegicus 76-79 6748816-5 1984 Furthermore, lignocaine produces a marked in vitro inhibition of serotonin and tyramine oxidation in MAO-A and not in MAO-B preparation of rat brain. Serotonin 65-74 monoamine oxidase A Rattus norvegicus 101-106 6748816-7 1984 Lineweaver-Burk plots show that lignocaine (2-10 mM) produces a significant increase in Km and decrease in Vmax of MAO for tyramine and serotonin in both brain and liver. Serotonin 136-145 monoamine oxidase A Rattus norvegicus 115-118 6235366-0 1984 Interactions of non-selective monoamine oxidase inhibitors, tranylcypromine and nialamide, with inhibitors of 5-hydroxytryptamine, dopamine or noradrenaline re-uptake. Serotonin 110-129 monoamine oxidase A Rattus norvegicus 30-47 6441605-1 1984 Monoamine oxidase type A activity with substrate serotonine and type B with substrate p-nitrophenylethylamine decreases is rats" brain, liver, heart and blood during oxygen convulsions. Serotonin 49-59 monoamine oxidase A Rattus norvegicus 0-24 6531436-0 1984 Rat brain concentrations of 5-hydroxytryptamine following acute and chronic administration of MAO-inhibiting antidepressants. Serotonin 28-47 monoamine oxidase A Rattus norvegicus 94-97 6419132-3 1983 Phenylethylamine was preferentially deaminated by pancreatic islet MAO while 5-hydroxytryptamine was preferentially deaminated by MAO from exocrine pancreas, and tyramine was a good substrate for both tissues. Serotonin 77-96 monoamine oxidase A Rattus norvegicus 130-133 6419132-5 1983 Clorgyline, a selective inhibitor of MAO-A, preferentially inhibited deamination of 5-hydroxytryptamine by all three tissue homogenates, while deprenyl, a selective inhibitor of MAO-B, preferentially inhibited deamination of phenylethylamine. Serotonin 84-103 monoamine oxidase A Rattus norvegicus 37-42 6193823-3 1983 The level of serotonin and the rate of its catalytic deamination by MAO were found to be decreased in cold-adapted rats. Serotonin 13-22 monoamine oxidase A Rattus norvegicus 68-71 6649522-3 1983 In human placenta and rat heart containing only the type A MAO, which catalyzes deamination of 2-phenylethylamine, pyrazidol also inhibited the deamination of serotonin, tyramine and 2-phenylethylamine at comparatively low concentrations and in equal degree. Serotonin 159-168 monoamine oxidase A Rattus norvegicus 59-62 6877035-4 1983 The patterns of the MAO activities towards DA and 5HT were clearly dissimilar, despite considerable overlap, to the patterns of tyrosine hydroxylase (TH) and DOPA decarboxylase (DD) activity, both marking the presence of striatal dopaminergic synaptosomes. Serotonin 50-53 monoamine oxidase A Rattus norvegicus 20-23 6877035-6 1983 This indicates that rat striatal MAO activity towards DA and 5HT is not specifically or for the greater part localized in dopaminergic terminals. Serotonin 61-64 monoamine oxidase A Rattus norvegicus 33-36 6877035-9 1983 It is concluded that the amount of MAO activity towards DA and 5HT (probably MAO-A activity) present in dopaminergic terminals is very low compared with the total activity of this enzyme in rat striatal tissue. Serotonin 63-66 monoamine oxidase A Rattus norvegicus 35-38 6877035-9 1983 It is concluded that the amount of MAO activity towards DA and 5HT (probably MAO-A activity) present in dopaminergic terminals is very low compared with the total activity of this enzyme in rat striatal tissue. Serotonin 63-66 monoamine oxidase A Rattus norvegicus 77-82 6652339-1 1983 In vivo clorgyline (5 mg/kg) and (-)-deprenyl (5 mg/kg) selectively inhibit monoamine oxidase (MAO) type A and B activities in rat brain hypothalamus and caudate nucleus using 5-hydroxytryptamine (5-HT), noradrenaline (NA), and beta-phenylethylamine (PEA) as substrates. Serotonin 176-195 monoamine oxidase A Rattus norvegicus 76-112 6652339-1 1983 In vivo clorgyline (5 mg/kg) and (-)-deprenyl (5 mg/kg) selectively inhibit monoamine oxidase (MAO) type A and B activities in rat brain hypothalamus and caudate nucleus using 5-hydroxytryptamine (5-HT), noradrenaline (NA), and beta-phenylethylamine (PEA) as substrates. Serotonin 197-201 monoamine oxidase A Rattus norvegicus 76-112 6304562-5 1983 Considering that MAO A for most part is intraneuronal and its substrates noradrenaline (NA) and serotonin (5-HT) have been implicated in the pathogenesis of depressive illness, it would appear that selective A inhibitors would be more effective as antidepressants. Serotonin 96-105 monoamine oxidase A Rattus norvegicus 17-22 6096645-2 1984 After the treatment cycles with Triton X-100 about 23 and 36% of the original mitochondrial MAO-A and MAO-B activity, respectively, towards 0.1 mM serotonin and benzylamine remained in the residue. Serotonin 147-156 monoamine oxidase A Rattus norvegicus 92-97 6197309-4 1983 Using a different approach, it was found that dopamine and serotonin released from their stores in rat striatum by tetrabenazine could displace CGP 11305 A from the MAO A active site in vivo, in contrast to clorgyline. Serotonin 59-68 monoamine oxidase A Rattus norvegicus 165-170 6418254-5 1983 Higher concentrations of (-)-deprenyl (20 and 50 microM) also inhibited 5-hydroxytryptamine oxidation by monoamine oxidase A. Serotonin 72-91 monoamine oxidase A Rattus norvegicus 105-124 6195533-1 1983 CGP 11305 A [4-(5-methoxy-7-bromo-benzofuranyl-2)piperidine HCl), a reversible, selective inhibitor of MAO A, increased the levels of rat brain noradrenaline, dopamine, and serotonin dose-dependently and to approximately the same extent. Serotonin 173-182 monoamine oxidase A Rattus norvegicus 103-108 6877035-0 1983 Localization of rat striatal monoamine oxidase activities towards dopamine, serotonin and kynuramine by gradient centrifugation and nigro-striatal lesions. Serotonin 76-85 monoamine oxidase A Rattus norvegicus 29-46 6877035-2 1983 The distribution pattern of monoamine oxidase (MAO) activity towards dopamine (DA) was very similar to the pattern of MAO activity towards serotonin (5HT), but differed from the pattern of MAO activity towards kynuramine (KYN). Serotonin 139-148 monoamine oxidase A Rattus norvegicus 47-50 6877035-2 1983 The distribution pattern of monoamine oxidase (MAO) activity towards dopamine (DA) was very similar to the pattern of MAO activity towards serotonin (5HT), but differed from the pattern of MAO activity towards kynuramine (KYN). Serotonin 139-148 monoamine oxidase A Rattus norvegicus 118-121 6877035-2 1983 The distribution pattern of monoamine oxidase (MAO) activity towards dopamine (DA) was very similar to the pattern of MAO activity towards serotonin (5HT), but differed from the pattern of MAO activity towards kynuramine (KYN). Serotonin 139-148 monoamine oxidase A Rattus norvegicus 118-121 6877035-2 1983 The distribution pattern of monoamine oxidase (MAO) activity towards dopamine (DA) was very similar to the pattern of MAO activity towards serotonin (5HT), but differed from the pattern of MAO activity towards kynuramine (KYN). Serotonin 150-153 monoamine oxidase A Rattus norvegicus 28-45 6877035-2 1983 The distribution pattern of monoamine oxidase (MAO) activity towards dopamine (DA) was very similar to the pattern of MAO activity towards serotonin (5HT), but differed from the pattern of MAO activity towards kynuramine (KYN). Serotonin 150-153 monoamine oxidase A Rattus norvegicus 118-121 6877035-2 1983 The distribution pattern of monoamine oxidase (MAO) activity towards dopamine (DA) was very similar to the pattern of MAO activity towards serotonin (5HT), but differed from the pattern of MAO activity towards kynuramine (KYN). Serotonin 150-153 monoamine oxidase A Rattus norvegicus 118-121 6877035-3 1983 As 5HT is specifically deaminated by MAO-A while KYN is a common MAO substrate, this supports earlier suggestions that in rat striatal preparations DA is deaminated preferentially by MAO-A. Serotonin 3-6 monoamine oxidase A Rattus norvegicus 37-42 6877035-3 1983 As 5HT is specifically deaminated by MAO-A while KYN is a common MAO substrate, this supports earlier suggestions that in rat striatal preparations DA is deaminated preferentially by MAO-A. Serotonin 3-6 monoamine oxidase A Rattus norvegicus 37-40 6877035-3 1983 As 5HT is specifically deaminated by MAO-A while KYN is a common MAO substrate, this supports earlier suggestions that in rat striatal preparations DA is deaminated preferentially by MAO-A. Serotonin 3-6 monoamine oxidase A Rattus norvegicus 183-188 6633672-1 1983 In both rat brain and heart, noradrenaline and 5-hydroxytryptamine are metabolised predominantly by monoamine oxidase-A. Serotonin 47-66 monoamine oxidase A Rattus norvegicus 100-119 6650186-3 1983 Serotonin turnover, measured by serotonin accumulation induced by the MAO inhibitor pargyline, decreased in the mesencephalon. Serotonin 0-9 monoamine oxidase A Rattus norvegicus 70-73 6650186-3 1983 Serotonin turnover, measured by serotonin accumulation induced by the MAO inhibitor pargyline, decreased in the mesencephalon. Serotonin 32-41 monoamine oxidase A Rattus norvegicus 70-73 6816972-0 1982 5-hydroxytryptamine: a substrate for rat liver mitochondrial monoamine oxidase-A and -B. Serotonin 0-19 monoamine oxidase A Rattus norvegicus 61-87 6196020-2 1983 Monoamine-oxidase (MAO) activity was detected in rat pineal gland with dopamine, 5-hydroxytryptamine (5-HT), norepinephrine and tryptamine as substrates, and nitroblue tetrazolium salt as electron acceptor. Serotonin 81-100 monoamine oxidase A Rattus norvegicus 0-17 6196020-2 1983 Monoamine-oxidase (MAO) activity was detected in rat pineal gland with dopamine, 5-hydroxytryptamine (5-HT), norepinephrine and tryptamine as substrates, and nitroblue tetrazolium salt as electron acceptor. Serotonin 81-100 monoamine oxidase A Rattus norvegicus 19-22 6884911-1 1983 The inhibiting effect of monoamine oxidase (MAO) activities towards 5-hydroxytryptamine, dopamine and beta-phenylethylamine by an acute and chronic administration of clorgyline was investigated in five locations of the rat brain. Serotonin 68-87 monoamine oxidase A Rattus norvegicus 25-42 6884911-1 1983 The inhibiting effect of monoamine oxidase (MAO) activities towards 5-hydroxytryptamine, dopamine and beta-phenylethylamine by an acute and chronic administration of clorgyline was investigated in five locations of the rat brain. Serotonin 68-87 monoamine oxidase A Rattus norvegicus 44-47 6184883-2 1982 At the same time, no distinct alterations could be found in the activity and kinetic parameters of the brain monoamine oxidase enzymatic system (MAO) catalyzing oxidative deamination of serotonin. Serotonin 186-195 monoamine oxidase A Rattus norvegicus 145-148 7127078-3 1982 Des-Tyr1-a-endorphin (beta-endorphin2-16; DTaE), on the other hand, inhibits the accumulation of serotonin following MAO-inhibition by pargyline in all 3 brain regions, while, in addition to causing a transient reduction in the serotonin concentration of the raphe area, it decreases the serotonin concentration of the mediobasal hypothalamus. Serotonin 97-106 monoamine oxidase A Rattus norvegicus 117-120 6406646-3 1983 The activity of MAO-A was lower in old rats than in young rats, and the same degree of decrease was found for 5-hydroxytryptamine as for dopamine as substrates for this enzyme form. Serotonin 110-129 monoamine oxidase A Rattus norvegicus 16-21 6184883-3 1982 Reduction of body temperature was accompanied by an increase in the MAO activity with serotonin as a substrate due to elevation in the enzyme-substrate affinity. Serotonin 86-95 monoamine oxidase A Rattus norvegicus 68-71 7092930-7 1982 After benserazide administration to rats, MAO-A activity towards 5-hydroxytryptamine was generally not inhibited, and in fact was significantly increased in some cases. Serotonin 65-84 monoamine oxidase A Rattus norvegicus 42-47 6126334-1 1982 Monoamine oxidase (MAO) is responsible for the pulmonary metabolism of 5-hydroxytryptamine (5-HT) and phenylethylamine (PEA). Serotonin 71-90 monoamine oxidase A Rattus norvegicus 0-17 6126334-1 1982 Monoamine oxidase (MAO) is responsible for the pulmonary metabolism of 5-hydroxytryptamine (5-HT) and phenylethylamine (PEA). Serotonin 71-90 monoamine oxidase A Rattus norvegicus 19-22 6126334-1 1982 Monoamine oxidase (MAO) is responsible for the pulmonary metabolism of 5-hydroxytryptamine (5-HT) and phenylethylamine (PEA). Serotonin 92-96 monoamine oxidase A Rattus norvegicus 0-17 6126334-1 1982 Monoamine oxidase (MAO) is responsible for the pulmonary metabolism of 5-hydroxytryptamine (5-HT) and phenylethylamine (PEA). Serotonin 92-96 monoamine oxidase A Rattus norvegicus 19-22 7070594-7 1982 In general, these results support the hypothesis that 5HT may exert inhibitory control over hormone dependent female sexual behavior and suggest that previously reported changes in MAO activity and 5HT levels following gonadal steroid treatment could pay a role in hormonal facilitation of female sexual behavior. Serotonin 54-57 monoamine oxidase A Rattus norvegicus 181-184 6807318-2 1982 A-form MAO activity was similar to the control value throughout the feeding periods with serotonin as substrate. Serotonin 89-98 monoamine oxidase A Rattus norvegicus 7-10 7057191-4 1982 min-1 towards 5-hydroxytryptamine were found for MAO-A and -B, respectively. Serotonin 14-33 monoamine oxidase A Rattus norvegicus 49-61 6285048-2 1982 All local anesthetics tested at 1 x 10(-7) M to 1 x 10(-3) M inhibited MAO activity in rat liver mitochondria with 5-hydroxytryptamine (5-HT) as substrate. Serotonin 115-134 monoamine oxidase A Rattus norvegicus 71-74 7088264-4 1982 The compounds increased the monoamine concentrations in whole rat brain, particularly that of 5-hydroxytryptamine, in the same dose range which produced MAO inhibition. Serotonin 94-113 monoamine oxidase A Rattus norvegicus 153-156 7225552-2 1981 Pyrazidol selectively blocks type A MAO (the substrates serotonin and noradrenaline) and does not virtually affect or has a far less action on type B MAO (the substrate 2-phenylethylamine). Serotonin 56-65 monoamine oxidase A Rattus norvegicus 36-39 6797482-3 1981 After solubilization of MAO by methylethylketone 7% of mitochondrial activity passes into solution and the rate of deamination of serotonin, tyramine and beta-phenylethylamine by soluble MAO preparation is selectively decreased. Serotonin 130-139 monoamine oxidase A Rattus norvegicus 24-27 6797482-3 1981 After solubilization of MAO by methylethylketone 7% of mitochondrial activity passes into solution and the rate of deamination of serotonin, tyramine and beta-phenylethylamine by soluble MAO preparation is selectively decreased. Serotonin 130-139 monoamine oxidase A Rattus norvegicus 187-190 7264651-1 1981 The inhibiton of type A and B MAO in rat forebrain crude membrane preparation by MD780515, (3-(4-[(3-cyanophenyl)methoxy]phenyl)-5-(methoxymethyl)-2-oxazolidinone-Centre de Recherche Delalande, France) has been investigated in vitro with 5-hydroxytryptamine and beta-phenylethylamine as substrates. Serotonin 238-257 monoamine oxidase A Rattus norvegicus 30-33 6108349-2 1980 Monoamine oxidase (MAO) activity towards dopamine, tryptamine, 5-hydroxytryptamine and phenylethylamine in whole brain homogenates was, at day 30 of gestation, already similar to that found in the adult animal. Serotonin 63-82 monoamine oxidase A Rattus norvegicus 19-22 7341636-6 1980 The activity of MAO in homogenates of heart, kidney, liver and brain was measured with 5-hydroxytryptamine (5-HT) and benzylamine (BZ). Serotonin 87-106 monoamine oxidase A Rattus norvegicus 16-19 6156366-2 1980 This method utilizes high pressure liquid chromatography with fluorescence excitation at 280 nm and detection of 330 nm at pH 5.0 of indoleacetic acid and 5-hydroxyindoleacetic acid, the deaminated products of two substrates for MAO, tryptamine, and serotonin, respectively. Serotonin 250-259 monoamine oxidase A Rattus norvegicus 229-232 6156366-4 1980 The method has been used to determine MAO activity in the frontal cortex and caudate nucleus of rat brain using tryptamine and serotonin as substrates. Serotonin 127-136 monoamine oxidase A Rattus norvegicus 38-41 451349-3 1979 We now present evidence to show that the endogenous amines present in platelets (serotonin) react non-enzymatically with the highly reactive aldehyde produced by MAO and thereby reduce the extractable radioactivity in the radiometric assays for MAO. Serotonin 81-90 monoamine oxidase A Rattus norvegicus 162-165 451349-3 1979 We now present evidence to show that the endogenous amines present in platelets (serotonin) react non-enzymatically with the highly reactive aldehyde produced by MAO and thereby reduce the extractable radioactivity in the radiometric assays for MAO. Serotonin 81-90 monoamine oxidase A Rattus norvegicus 245-248 435561-5 1979 In analogous experiments with deprenyl (the specific inhibitor of MAO type B) 4-ethylpyridine (5.10(-3) M) decreased the inhibitory effect of deprenyl not only on the deamination of serotonin (substrate of MAO A), but also on the oxidation of beta-phenylethylamine (the main substrate of MAO type B). Serotonin 182-191 monoamine oxidase A Rattus norvegicus 66-69 435561-5 1979 In analogous experiments with deprenyl (the specific inhibitor of MAO type B) 4-ethylpyridine (5.10(-3) M) decreased the inhibitory effect of deprenyl not only on the deamination of serotonin (substrate of MAO A), but also on the oxidation of beta-phenylethylamine (the main substrate of MAO type B). Serotonin 182-191 monoamine oxidase A Rattus norvegicus 206-211 435561-1 1979 The inhibition of the deamination of serotonin (the main substrate of monoamine oxidase (MAO) type A) by chlorgiline and deprenyl and of beta-phenylethylamine (the main substrate of the B type MAO) by fragments of rat liver mitochondrial membrane as well as the influence of 4-ethylpyridine on this process were studied. Serotonin 37-46 monoamine oxidase A Rattus norvegicus 70-100 435561-5 1979 In analogous experiments with deprenyl (the specific inhibitor of MAO type B) 4-ethylpyridine (5.10(-3) M) decreased the inhibitory effect of deprenyl not only on the deamination of serotonin (substrate of MAO A), but also on the oxidation of beta-phenylethylamine (the main substrate of MAO type B). Serotonin 182-191 monoamine oxidase A Rattus norvegicus 206-209 435561-1 1979 The inhibition of the deamination of serotonin (the main substrate of monoamine oxidase (MAO) type A) by chlorgiline and deprenyl and of beta-phenylethylamine (the main substrate of the B type MAO) by fragments of rat liver mitochondrial membrane as well as the influence of 4-ethylpyridine on this process were studied. Serotonin 37-46 monoamine oxidase A Rattus norvegicus 89-92 490150-8 1979 Only FSH modified MAO activity in the ganglia by increasing significantly type A enzyme (assaying by using serotonin as substrate). Serotonin 107-116 monoamine oxidase A Rattus norvegicus 18-21 435561-2 1979 It was shown that the MAO activity of the mitochondrial membrane fragments was highly sensitive to chlorgiline, when serotonin was used as substrate, whereas a high sensitivity toward deprenyl was observed with beta-phenylethylamine as substrate. Serotonin 117-126 monoamine oxidase A Rattus norvegicus 22-25 435561-3 1979 4-Ethylpyridine (5.10(-3) M), a competitive and reversible inhibitor of the MAO activity, inhibited deamination of serotonin and beta-phenylethylamine by 34 and 30%, respectively. Serotonin 115-124 monoamine oxidase A Rattus norvegicus 76-79 446597-0 1979 Effects of thyroidectomy on monoamine oxidase activities toward tyramine and serotonin in the circumventricular nuclei of the rat. Serotonin 77-86 monoamine oxidase A Rattus norvegicus 28-45 446597-1 1979 Following thyroidectomy, monoamine oxidase (MAO) activities toward tyramine decreased significantly by 20% in the nucleus periventricularis and the nucleus arcuatus among the 3 hypothalamic nuclei of the rat, while MAO activity toward serotonin decreased significantly by 10% only in the nucleus periventricularis. Serotonin 235-244 monoamine oxidase A Rattus norvegicus 25-42 446597-1 1979 Following thyroidectomy, monoamine oxidase (MAO) activities toward tyramine decreased significantly by 20% in the nucleus periventricularis and the nucleus arcuatus among the 3 hypothalamic nuclei of the rat, while MAO activity toward serotonin decreased significantly by 10% only in the nucleus periventricularis. Serotonin 235-244 monoamine oxidase A Rattus norvegicus 44-47 32944-1 1979 1 Metabolism of 5-hydroxytryptamine (5-HT) and beta-phenylethylamine (PHE) by monoamine oxidase (MAO) was investigated in rat isolated lungs and in mitochondrial preparations from rat lung. Serotonin 16-35 monoamine oxidase A Rattus norvegicus 78-95 32944-1 1979 1 Metabolism of 5-hydroxytryptamine (5-HT) and beta-phenylethylamine (PHE) by monoamine oxidase (MAO) was investigated in rat isolated lungs and in mitochondrial preparations from rat lung. Serotonin 16-35 monoamine oxidase A Rattus norvegicus 97-100 32944-1 1979 1 Metabolism of 5-hydroxytryptamine (5-HT) and beta-phenylethylamine (PHE) by monoamine oxidase (MAO) was investigated in rat isolated lungs and in mitochondrial preparations from rat lung. Serotonin 37-41 monoamine oxidase A Rattus norvegicus 78-95 32944-1 1979 1 Metabolism of 5-hydroxytryptamine (5-HT) and beta-phenylethylamine (PHE) by monoamine oxidase (MAO) was investigated in rat isolated lungs and in mitochondrial preparations from rat lung. Serotonin 37-41 monoamine oxidase A Rattus norvegicus 97-100 663404-1 1978 The (+) isomer of 2,3-dichloro-alpha-methylbenzylamine inhibited the oxidation of serotonin (a substrate of type A MAO) by rat brain mitochondrial monoamine oxidase (MAO) more effectively than it inhibited the oxidation of phenylethylamine (a substrate for type B MAO). Serotonin 82-91 monoamine oxidase A Rattus norvegicus 115-118 748921-1 1978 The effect of serotonin and malate benzyl hydrazine (inhibitor MAO) on the activity of glutathione peroxidase and intensity of ascorbate-dependent peroxidation of lipids in mitochondria was investigated. Serotonin 14-23 monoamine oxidase A Rattus norvegicus 63-66 711033-2 1978 The rates of serotonin, beta-phenylethylamine and benzylamine oxidations by placental MAO were approximately 191, 12 and 48% to those of rat liver MAO, respectively. Serotonin 13-22 monoamine oxidase A Rattus norvegicus 86-89 663404-1 1978 The (+) isomer of 2,3-dichloro-alpha-methylbenzylamine inhibited the oxidation of serotonin (a substrate of type A MAO) by rat brain mitochondrial monoamine oxidase (MAO) more effectively than it inhibited the oxidation of phenylethylamine (a substrate for type B MAO). Serotonin 82-91 monoamine oxidase A Rattus norvegicus 147-164 663404-1 1978 The (+) isomer of 2,3-dichloro-alpha-methylbenzylamine inhibited the oxidation of serotonin (a substrate of type A MAO) by rat brain mitochondrial monoamine oxidase (MAO) more effectively than it inhibited the oxidation of phenylethylamine (a substrate for type B MAO). Serotonin 82-91 monoamine oxidase A Rattus norvegicus 166-169 663404-1 1978 The (+) isomer of 2,3-dichloro-alpha-methylbenzylamine inhibited the oxidation of serotonin (a substrate of type A MAO) by rat brain mitochondrial monoamine oxidase (MAO) more effectively than it inhibited the oxidation of phenylethylamine (a substrate for type B MAO). Serotonin 82-91 monoamine oxidase A Rattus norvegicus 166-169 272480-0 1978 Deamination of 5-methoxytryptamine, serotonin and phenylethylamine by rat MAO in vitro and in vivo. Serotonin 36-45 monoamine oxidase A Rattus norvegicus 74-77 429200-1 1979 Monoamine oxidase (MAO) activity has been demonstrated histochemically in rat hypothalamic ependyma using the sulphate-tetrazolium and coupled peroxidatic techniques with tryptamine, tyramine, 5-hydroxytryptamine and benzylamine as substrates. Serotonin 193-212 monoamine oxidase A Rattus norvegicus 0-17 429200-1 1979 Monoamine oxidase (MAO) activity has been demonstrated histochemically in rat hypothalamic ependyma using the sulphate-tetrazolium and coupled peroxidatic techniques with tryptamine, tyramine, 5-hydroxytryptamine and benzylamine as substrates. Serotonin 193-212 monoamine oxidase A Rattus norvegicus 19-22 21126-6 1977 At 100% oxygen concentration, harmaline showed the most potent inhibition of MAO activity in the liver when serotonin served as substrate, while inhibitions of the MAO activity by pargyline and pheniprazine were weak. Serotonin 108-117 monoamine oxidase A Rattus norvegicus 77-80 595495-3 1977 Interaction of N-(8-quinolylmethyl)-N-methyl-2-propinyl amine with MAO of the A type (serotonin as a substrate) and of the B type (beta-phenylethylamine as a substrate) was studied by the kinetic method, which enabled to determine and quantitatively estimate the steps of enzyme-inhibitor complexes formation. Serotonin 86-95 monoamine oxidase A Rattus norvegicus 67-70 595495-5 1977 The data on K1 values, estimated in experiments with serotonin and beta-phenylethylamine as substrates, show that the affinity of N-(8-quinolyl methyl)-N-methyl-2-propinyl amine towards MAO of the A type was 10-fold higher than the affinity towards MAO of the B type. Serotonin 53-62 monoamine oxidase A Rattus norvegicus 186-189 595495-5 1977 The data on K1 values, estimated in experiments with serotonin and beta-phenylethylamine as substrates, show that the affinity of N-(8-quinolyl methyl)-N-methyl-2-propinyl amine towards MAO of the A type was 10-fold higher than the affinity towards MAO of the B type. Serotonin 53-62 monoamine oxidase A Rattus norvegicus 249-252 590332-3 1977 The response to 5HT was also enhanced by the monoamine oxidase (MAO) inhibitor, tranylcypromine (0.05 mg/ml), suggesting that MAO located in the vascular wall is involved in the termination of the response to 5HT in the peripheral circulation. Serotonin 16-19 monoamine oxidase A Rattus norvegicus 45-62 590332-3 1977 The response to 5HT was also enhanced by the monoamine oxidase (MAO) inhibitor, tranylcypromine (0.05 mg/ml), suggesting that MAO located in the vascular wall is involved in the termination of the response to 5HT in the peripheral circulation. Serotonin 16-19 monoamine oxidase A Rattus norvegicus 64-67 590332-3 1977 The response to 5HT was also enhanced by the monoamine oxidase (MAO) inhibitor, tranylcypromine (0.05 mg/ml), suggesting that MAO located in the vascular wall is involved in the termination of the response to 5HT in the peripheral circulation. Serotonin 16-19 monoamine oxidase A Rattus norvegicus 126-129 590332-3 1977 The response to 5HT was also enhanced by the monoamine oxidase (MAO) inhibitor, tranylcypromine (0.05 mg/ml), suggesting that MAO located in the vascular wall is involved in the termination of the response to 5HT in the peripheral circulation. Serotonin 209-212 monoamine oxidase A Rattus norvegicus 45-62 590332-3 1977 The response to 5HT was also enhanced by the monoamine oxidase (MAO) inhibitor, tranylcypromine (0.05 mg/ml), suggesting that MAO located in the vascular wall is involved in the termination of the response to 5HT in the peripheral circulation. Serotonin 209-212 monoamine oxidase A Rattus norvegicus 64-67 590332-3 1977 The response to 5HT was also enhanced by the monoamine oxidase (MAO) inhibitor, tranylcypromine (0.05 mg/ml), suggesting that MAO located in the vascular wall is involved in the termination of the response to 5HT in the peripheral circulation. Serotonin 209-212 monoamine oxidase A Rattus norvegicus 126-129 590332-4 1977 MAO inhibition abolishes the potentiation of 5HT by NA, indicating that this potentiation results from competition for MAO by both amines, leaving more amine intact to activate membrane receptors. Serotonin 45-48 monoamine oxidase A Rattus norvegicus 0-3 590332-4 1977 MAO inhibition abolishes the potentiation of 5HT by NA, indicating that this potentiation results from competition for MAO by both amines, leaving more amine intact to activate membrane receptors. Serotonin 45-48 monoamine oxidase A Rattus norvegicus 119-122 21126-7 1977 At 20% oxygen concentration, harmaline showed the most potent inhibition of MAO activity in the brain when serotonin was used as substrate. Serotonin 107-116 monoamine oxidase A Rattus norvegicus 76-79 960237-1 1976 The monoamine oxidase (MAO) activity with tryptamine, 5-hydroxytryptamine and noreponephrine as substrates was studied as affected by different conditions of hyperbaric oxygenation. Serotonin 54-73 monoamine oxidase A Rattus norvegicus 4-21 12389-3 1976 Enzymic properties of partially purified monoamine oxidase (MAO) from human placenta were studied with tyramine, serotonin and benzylamine as substrates. Serotonin 113-122 monoamine oxidase A Rattus norvegicus 60-63 960237-1 1976 The monoamine oxidase (MAO) activity with tryptamine, 5-hydroxytryptamine and noreponephrine as substrates was studied as affected by different conditions of hyperbaric oxygenation. Serotonin 54-73 monoamine oxidase A Rattus norvegicus 23-26 1248576-1 1976 The distribution of type A and B monamine oxidase (MAO) activities in the central nervous system (CNS) of rat and chick was investigated using 5-hydroxytryptamine and beta-phenylethylamine as specific substrates. Serotonin 143-162 monoamine oxidase A Rattus norvegicus 51-54 1261496-0 1976 Differential effects of L-thyroxine on cardiac and hepatic monoamine oxidase activity toward benzylamine and serotonin. Serotonin 109-118 monoamine oxidase A Rattus norvegicus 59-76 1261496-2 1976 The activity of monoamine oxidase (MAO) in normal and thyrotoxic rats was studied with two substrates: benzylamine and serotonin. Serotonin 119-128 monoamine oxidase A Rattus norvegicus 16-33 1261496-2 1976 The activity of monoamine oxidase (MAO) in normal and thyrotoxic rats was studied with two substrates: benzylamine and serotonin. Serotonin 119-128 monoamine oxidase A Rattus norvegicus 35-38 1261496-4 1976 Kinetic studies of cardiac and liver MAO after thyroxine-treatment showed an unaltered Km for benzylamine but a change in Km for serotonin. Serotonin 129-138 monoamine oxidase A Rattus norvegicus 37-40 1151811-0 1975 Proceedings: Inactivation of phenylethylamine and 5-hydroxytryptamine in rat isolated lungs: evidence for monoamine oxidase A and B in lung. Serotonin 50-69 monoamine oxidase A Rattus norvegicus 106-125 809102-1 1975 MAO activities in mouse brain responsible for deamination of serotonin (5-HT) and p-dimethylaminobenzylamine (DAB) were found to follow different postnatal developmental patterns. Serotonin 61-70 monoamine oxidase A Rattus norvegicus 0-3 934359-1 1976 The effect of graded doses of clorgyline, a preferential inhibitor of MAO A, and of deprenil, a preferential inhibitor of MAO B, on the activities of serotonin-deaminating MAO (MAO A) of dopamine-deaminating MAO, and of phenethylamine-deaminating MAO, (MAO B), in rat corpus striatum were compared with the effects of the drugs on striatal levels of homovanillic acid(HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC). Serotonin 150-159 monoamine oxidase A Rattus norvegicus 177-182 1244091-2 1975 MAO reaction inhibited by quinoline compound and the inhibition of kynurenine aminotransferase activity through the injection of epinephrine or serotonin were observed. Serotonin 144-153 monoamine oxidase A Rattus norvegicus 0-3 32730891-15 2020 Furthermore, the alteration of 5-HT levels was mainly attributed to the downregulated expression of monoamine oxidase A (MAO-A). Serotonin 31-35 monoamine oxidase A Rattus norvegicus 100-119 1203627-1 1975 1 The effect of various doses of tranylcypromine on the degree of inhibition of rat brain monoamine oxidase (MAO) using 5-hydroxytryptamine (5-HT), dopamine and phenylethylamine as substrates has been examined 120 min after injection of the inhibitor. Serotonin 120-139 monoamine oxidase A Rattus norvegicus 90-107 32730891-15 2020 Furthermore, the alteration of 5-HT levels was mainly attributed to the downregulated expression of monoamine oxidase A (MAO-A). Serotonin 31-35 monoamine oxidase A Rattus norvegicus 121-126 32437889-9 2020 Bilateral VH infusion of Ang (1-7) recovered NMDAR-nNOS-NO signaling and MAO-mediated serotonin metabolism, as well as reducing anxiety-like behaviors in stressed rats. Serotonin 86-95 monoamine oxidase A Rattus norvegicus 73-76 31869485-4 2020 The enzyme monoamine oxidase A (MAOA) is important in the metabolism of serotonin and play an important role in behavious. Serotonin 72-81 monoamine oxidase A Rattus norvegicus 11-30 31869485-4 2020 The enzyme monoamine oxidase A (MAOA) is important in the metabolism of serotonin and play an important role in behavious. Serotonin 72-81 monoamine oxidase A Rattus norvegicus 32-36 31911191-9 2020 In summary, NP or/and OP exposure might cause anxiety-related behaviors in rats through regulating neurotransmitter 5-HT levels by altering the expression of 5-HT decomposition enzyme MAOA, transporters SERT and VMAT2, and 5-HT receptors 5-HT1A, 5-HT2A, and 5-HT2C. Serotonin 116-120 monoamine oxidase A Rattus norvegicus 184-188 31911191-9 2020 In summary, NP or/and OP exposure might cause anxiety-related behaviors in rats through regulating neurotransmitter 5-HT levels by altering the expression of 5-HT decomposition enzyme MAOA, transporters SERT and VMAT2, and 5-HT receptors 5-HT1A, 5-HT2A, and 5-HT2C. Serotonin 158-162 monoamine oxidase A Rattus norvegicus 184-188 31911191-9 2020 In summary, NP or/and OP exposure might cause anxiety-related behaviors in rats through regulating neurotransmitter 5-HT levels by altering the expression of 5-HT decomposition enzyme MAOA, transporters SERT and VMAT2, and 5-HT receptors 5-HT1A, 5-HT2A, and 5-HT2C. Serotonin 158-162 monoamine oxidase A Rattus norvegicus 184-188 28916252-3 2017 However, little is known about the role of MAO-A, an enzyme oxidizing 5-hydroxytryptamine and noradrenalin, in the pathogenesis. Serotonin 70-89 monoamine oxidase A Rattus norvegicus 43-48 30008960-0 2018 Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport (SERT) and degradation (MAO-A) gene expression in cultured rat serotonergic neuronal cell lines. Serotonin 24-33 monoamine oxidase A Rattus norvegicus 122-127 30008960-0 2018 Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport (SERT) and degradation (MAO-A) gene expression in cultured rat serotonergic neuronal cell lines. Serotonin 69-78 monoamine oxidase A Rattus norvegicus 122-127 25637699-7 2015 Dopamine and serotonin incubated with MAO-A both strongly oligomerized alpha-synuclein (more than 10 times control); pargyline blocked the oligomerization. Serotonin 13-22 monoamine oxidase A Rattus norvegicus 38-43 27181454-4 2016 We hypothesized that the resulting, excessive GC would stimulate brain monoamine oxidase A (MAO-A), which would reduce brain serotonin, and thereby increase anxiety. Serotonin 125-134 monoamine oxidase A Rattus norvegicus 71-90 27181454-4 2016 We hypothesized that the resulting, excessive GC would stimulate brain monoamine oxidase A (MAO-A), which would reduce brain serotonin, and thereby increase anxiety. Serotonin 125-134 monoamine oxidase A Rattus norvegicus 92-97 26393369-1 2015 The isozymes of monoamine oxidase (MAO-A and MAO-B) are important enzymes involved in the metabolism of numerous biogenic amines, including the neurotransmitters serotonin, dopamine, and norepinephrine. Serotonin 162-171 monoamine oxidase A Rattus norvegicus 35-40 27503749-3 2016 Benzylamine and serotonin oxidation were catalyzed by MAO-B and MAO-A, respectively, to aldehydes. Serotonin 16-25 monoamine oxidase A Rattus norvegicus 64-69 25533012-8 2014 However, the concentrations of the metabolites of dopamine and serotonin were increased and the drug use also resulted in a significant rise of monoamine oxidase A (MAOA) expression, which might be responsible to maintain the homeostasis of dopaminergic and serotonergic neurotransmission. Serotonin 63-72 monoamine oxidase A Rattus norvegicus 165-169 25542888-6 2015 Tryptophan hydroxylase 1 (TPH1) and monoamine oxidase (MAO), two important rate-limiting enzymes in serotonin synthesis and metabolic process respectively, were detected. Serotonin 100-109 monoamine oxidase A Rattus norvegicus 36-53 25542888-6 2015 Tryptophan hydroxylase 1 (TPH1) and monoamine oxidase (MAO), two important rate-limiting enzymes in serotonin synthesis and metabolic process respectively, were detected. Serotonin 100-109 monoamine oxidase A Rattus norvegicus 55-58 21819071-1 2011 Monoamine oxidase A (MAO A) is a mitochondrial outer membrane-bound flavoenzyme important in the regulation of serotonin and dopamine levels. Serotonin 111-120 monoamine oxidase A Rattus norvegicus 0-19 24065621-6 2014 However, the mechanism of action of 1MeTIQ is broader than the actions of desipramine, and 1MeTIQ inhibits the MAO-dependent oxidation of dopamine and serotonin in all investigated structures. Serotonin 151-160 monoamine oxidase A Rattus norvegicus 111-114 24116298-2 2012 In our previous research, the ethyl acetate fraction of G. jasminosides fruits inhibited the activities of both monoamine oxidase-A (MAO-A) and monoamine oxidase-B (MAO-B), and oral administration of the ethanolic extract slightly increased serotonin concentrations in the brain tissues of rats and decreased MAO-B activity. Serotonin 241-250 monoamine oxidase A Rattus norvegicus 133-138 24937371-8 2014 Serotonin level showed a decrease associated with enhanced monoamine oxidase (MAO) activity and increased 5-hydroxyindolacetic acid (5-HIAA) level. Serotonin 0-9 monoamine oxidase A Rattus norvegicus 59-76 24937371-8 2014 Serotonin level showed a decrease associated with enhanced monoamine oxidase (MAO) activity and increased 5-hydroxyindolacetic acid (5-HIAA) level. Serotonin 0-9 monoamine oxidase A Rattus norvegicus 78-81 25277944-1 2014 AIMS: The aim of this study was to elucidate myocardial interstitial serotonin (5-HT) kinetics in the heart, including 5-HT reuptake and enzymatic degradation to 5-hydroxyindole acetic acid (5-HIAA) via monoamine oxidase (MAO). Serotonin 69-78 monoamine oxidase A Rattus norvegicus 203-220 25277944-1 2014 AIMS: The aim of this study was to elucidate myocardial interstitial serotonin (5-HT) kinetics in the heart, including 5-HT reuptake and enzymatic degradation to 5-hydroxyindole acetic acid (5-HIAA) via monoamine oxidase (MAO). Serotonin 69-78 monoamine oxidase A Rattus norvegicus 222-225 25205989-12 2012 Since TPH and MAO levels regulate circulating and physiologically available serotonin content, the regulation of serotonin metabolizing enzymes suggest a plausible mechanism by which estrogen alleviates migraine in women. Serotonin 76-85 monoamine oxidase A Rattus norvegicus 14-17 21819071-1 2011 Monoamine oxidase A (MAO A) is a mitochondrial outer membrane-bound flavoenzyme important in the regulation of serotonin and dopamine levels. Serotonin 111-120 monoamine oxidase A Rattus norvegicus 21-26 20977458-0 2010 Mitochondrial monoamine oxidase-A-mediated hydrogen peroxide generation enhances 5-hydroxytryptamine-induced contraction of rat basilar artery. Serotonin 81-100 monoamine oxidase A Rattus norvegicus 14-31 20977458-1 2010 BACKGROUND AND PURPOSE: We evaluated the role(s) of monoamine oxidase (MAO)-mediated H2O2 generation on 5-hydroxytryptamine (5-HT)-induced tension development of isolated basilar artery of spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. Serotonin 104-123 monoamine oxidase A Rattus norvegicus 52-69 20977458-1 2010 BACKGROUND AND PURPOSE: We evaluated the role(s) of monoamine oxidase (MAO)-mediated H2O2 generation on 5-hydroxytryptamine (5-HT)-induced tension development of isolated basilar artery of spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. Serotonin 104-123 monoamine oxidase A Rattus norvegicus 71-74