PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3871227-8 1985 These data support the hypothesis that in platelets, [3H]imipramine, tricyclic, and nontricyclic serotonin uptake inhibitors bind to a common recognition site that is associated with the serotonin transporter but that differs from the substrate recognition site of the carrier through which serotonin and tryptamine exert a heterotropic allosteric modulation on [3H]imipramine binding. Serotonin 97-106 solute carrier family 6 member 4 Homo sapiens 187-208 33785354-1 2021 The early characterization of ligands at the dopamine and serotonin transporters, DAT and SERT, respectively, is important for drug discovery, forensic sciences, and drug abuse research. Serotonin 58-67 solute carrier family 6 member 4 Homo sapiens 90-94 33744253-5 2021 hSERT plays a pivotal role in neurotransmitter regulation being responsible for the transport of the neurotransmitter 5-hydroxytryptamine (5-HT or serotonin). Serotonin 118-137 solute carrier family 6 member 4 Homo sapiens 0-5 33744253-5 2021 hSERT plays a pivotal role in neurotransmitter regulation being responsible for the transport of the neurotransmitter 5-hydroxytryptamine (5-HT or serotonin). Serotonin 139-143 solute carrier family 6 member 4 Homo sapiens 0-5 33744253-5 2021 hSERT plays a pivotal role in neurotransmitter regulation being responsible for the transport of the neurotransmitter 5-hydroxytryptamine (5-HT or serotonin). Serotonin 147-156 solute carrier family 6 member 4 Homo sapiens 0-5 34032190-0 2022 Changes in platelet serotonin concentration after four weeks of alcohol abstinence depending on the genotype of the serotonin transporter. Serotonin 20-29 solute carrier family 6 member 4 Homo sapiens 116-137 34032190-3 2022 OBJECTIVES: Objective of this study is to investigate changes in platelet serotonin concentration after four weeks of alcohol abstinence in regards to the genotype of the serotonin transporter. Serotonin 74-83 solute carrier family 6 member 4 Homo sapiens 171-192 33945927-2 2021 The serotonin system is mainly modulated by the serotonin transporter (SERT) which regulates serotonin uptake and the metabolism of its precursor, tryptophan and following kynurenine pathway. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 48-69 33945927-2 2021 The serotonin system is mainly modulated by the serotonin transporter (SERT) which regulates serotonin uptake and the metabolism of its precursor, tryptophan and following kynurenine pathway. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 71-75 33945927-2 2021 The serotonin system is mainly modulated by the serotonin transporter (SERT) which regulates serotonin uptake and the metabolism of its precursor, tryptophan and following kynurenine pathway. Serotonin 48-57 solute carrier family 6 member 4 Homo sapiens 71-75 33667309-2 2021 These antidepressants exert their effects by blocking the serotonin transporter (SERT) leading to increased levels of serotonin in the synaptic cleft and subsequently to an attenuation of depressive symptoms and elevation in mood. Serotonin 58-67 solute carrier family 6 member 4 Homo sapiens 81-85 34040506-1 2021 The serotonin transporter (SERT) terminates neurotransmission by transporting serotonin from the synapse into the pre-synaptic nerve terminal. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 34040506-4 2021 Transport of serotonin by SERT is energized by the transmembrane electrochemical gradient of sodium. Serotonin 13-22 solute carrier family 6 member 4 Homo sapiens 26-30 34040506-5 2021 We used extensive molecular dynamics simulations to investigate the process of sodium binding to SERT, which is the first step in the transport cycle that leads to serotonin uptake. Serotonin 164-173 solute carrier family 6 member 4 Homo sapiens 97-101 33315681-2 2021 We identified 2 cases with remarkably changed pulmonary uptake between 2 metaiodobenzylguanidine scintigraphies; pulmonary uptake was reduced when patients were taking selective serotonin reuptake inhibitor/serotonin noradrenaline reuptake inhibitor and preserved during the medication-naive or withdrawal state, suggesting that pulmonary uptake involves not only the noradrenaline transporter, but also the serotonin transporter. Serotonin 178-187 solute carrier family 6 member 4 Homo sapiens 408-429 33315681-2 2021 We identified 2 cases with remarkably changed pulmonary uptake between 2 metaiodobenzylguanidine scintigraphies; pulmonary uptake was reduced when patients were taking selective serotonin reuptake inhibitor/serotonin noradrenaline reuptake inhibitor and preserved during the medication-naive or withdrawal state, suggesting that pulmonary uptake involves not only the noradrenaline transporter, but also the serotonin transporter. Serotonin 207-216 solute carrier family 6 member 4 Homo sapiens 408-429 33125470-10 2021 CONCLUSIONS: Impaired response to serotonergic antidepressants via SLC6A4 hypomethylation may be conveyed by increased gene expression and consequently decreased serotonin availability, which may counteract the effects of serotonergic antidepressants. Serotonin 162-171 solute carrier family 6 member 4 Homo sapiens 67-73 33480616-3 2021 Solute carrier family 6 member 4 (SLC6A4) has been reported to promote the reuptake of serotonin and to be closely correlated to depression. Serotonin 87-96 solute carrier family 6 member 4 Homo sapiens 0-32 33480616-3 2021 Solute carrier family 6 member 4 (SLC6A4) has been reported to promote the reuptake of serotonin and to be closely correlated to depression. Serotonin 87-96 solute carrier family 6 member 4 Homo sapiens 34-40 34049262-1 2021 The selective serotonin reuptake inhibitors (SSRIs), acting at the serotonin transporter (SERT), are one of the most widely prescribed antidepressant medications. Serotonin 14-23 solute carrier family 6 member 4 Homo sapiens 67-88 34049262-1 2021 The selective serotonin reuptake inhibitors (SSRIs), acting at the serotonin transporter (SERT), are one of the most widely prescribed antidepressant medications. Serotonin 14-23 solute carrier family 6 member 4 Homo sapiens 90-94 32848204-3 2021 Reuptake through the 5-HT transporter (5-HTT) is the main pathway decreasing extracellular 5-HT in the brain and a marker for the 5-HT system, but in vivo investigations of the 5-HTT and the 5-HT system in ASD are scarce and so far inconclusive. Serotonin 21-25 solute carrier family 6 member 4 Homo sapiens 39-44 33712280-9 2021 STX3 knockdown marginally but significantly decreased the serotonin uptake activity of Caco-2 cells, suggesting that STX3 positively regulates SERT function in Caco-2 cells, as opposed to SERT regulation by STX3 in overexpressing cells. Serotonin 58-67 solute carrier family 6 member 4 Homo sapiens 143-147 33587394-2 2021 Vortioxetine, a recently developed antidepressant, acts as a serotonin modulator through inhibition of the serotonin transporter and actions at multiple types of serotonin receptors. Serotonin 61-70 solute carrier family 6 member 4 Homo sapiens 107-128 33526821-2 2021 Methylation of the serotonin transporter gene (SLC6A4) is associated with 5-HT expression. Serotonin 74-78 solute carrier family 6 member 4 Homo sapiens 19-40 33531674-5 2021 RESULTS: Over 100 genes were differentially expressed at the >=4-fold level, including genes related to the serotonin signaling pathway: >60-fold downregulation of serotonin transporter SLC6A4 and >3-fold upregulation of serotonin receptor HTR2A. Serotonin 108-117 solute carrier family 6 member 4 Homo sapiens 186-192 31441508-2 2021 We conducted a longitudinal study to examine the effect of 5-hydroxyl tryptamine transporter gene-linked polymorphic region (5-HTTLPR) genotype on child and adolescent PTSD symptom course after the 2008 Wenchuan Earthquake. Serotonin 59-80 solute carrier family 6 member 4 Homo sapiens 125-133 33526821-2 2021 Methylation of the serotonin transporter gene (SLC6A4) is associated with 5-HT expression. Serotonin 74-78 solute carrier family 6 member 4 Homo sapiens 47-53 33462318-1 2021 The serotonin transporter (SLC6A4), 5-HT2A (HTR2A) and 5-HT2B (HTR2B) recepter genes, express proteins that are important regulators of serotonin reuptake and signaling, and thereby may contribute to the pathogenesis of aggressive criminal behavior. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-33 33584798-5 2020 This review has a particular emphasis on the interaction between early-life social stress and genetic variation of serotonin associate genes including the serotonin transporter gene (5-HTT; also known as SLC6A4), which are key molecules involved in depression. Serotonin 115-124 solute carrier family 6 member 4 Homo sapiens 155-176 33584798-5 2020 This review has a particular emphasis on the interaction between early-life social stress and genetic variation of serotonin associate genes including the serotonin transporter gene (5-HTT; also known as SLC6A4), which are key molecules involved in depression. Serotonin 115-124 solute carrier family 6 member 4 Homo sapiens 183-188 33584798-5 2020 This review has a particular emphasis on the interaction between early-life social stress and genetic variation of serotonin associate genes including the serotonin transporter gene (5-HTT; also known as SLC6A4), which are key molecules involved in depression. Serotonin 115-124 solute carrier family 6 member 4 Homo sapiens 204-210 32840058-2 2021 The serotonin transporter (SERT) is a key regulator of synaptic serotonin (5-HT) and its inhibition is an important pharmacological target for treating MDD. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 32840058-2 2021 The serotonin transporter (SERT) is a key regulator of synaptic serotonin (5-HT) and its inhibition is an important pharmacological target for treating MDD. Serotonin 75-79 solute carrier family 6 member 4 Homo sapiens 4-25 32840058-2 2021 The serotonin transporter (SERT) is a key regulator of synaptic serotonin (5-HT) and its inhibition is an important pharmacological target for treating MDD. Serotonin 75-79 solute carrier family 6 member 4 Homo sapiens 27-31 31897966-1 2021 OBJECTIVES: Selective serotonin reuptake inhibitors (SSRI) are a group of drugs that selectively and strongly block the serotonin transporter. Serotonin 22-31 solute carrier family 6 member 4 Homo sapiens 120-141 33245902-1 2021 Serotonin neurotransmission is largely governed by the regulation of the serotonin transporter (SERT). Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 73-94 33245902-1 2021 Serotonin neurotransmission is largely governed by the regulation of the serotonin transporter (SERT). Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 96-100 32866787-7 2020 We therefore examined the serotonergic-related machinery in Teff and Treg and found differential expression of the serotonin transporter SERT and 5-HT1a and 5-HT2 receptors. Serotonin 115-124 solute carrier family 6 member 4 Homo sapiens 137-141 33333511-3 2021 Recently, a tri-allelic serotonin transporter (5-HTTLPR/rs25531) polymorphism was reported to be more sensitive to personality traits compared to the bi-allelic 5-HTTLPR polymorphism. Serotonin 24-33 solute carrier family 6 member 4 Homo sapiens 47-55 33785133-3 2021 The facets of this control are multiple if we consider the molecular actors playing a role in the autoregulation of 5-HT neuron activity including the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2B, 5-HT7 receptors as well as the serotonin transporter. Serotonin 116-120 solute carrier family 6 member 4 Homo sapiens 214-235 32556264-1 2020 Associations between altered DNA methylation of the serotonin transporter (5-HTT)-encoding gene SLC6A4 and early life adversity, mood and anxiety disorders, and amygdala reactivity have been reported. Serotonin 52-61 solute carrier family 6 member 4 Homo sapiens 96-102 33294225-5 2020 Genetic analysis included the SLC6A4 and SLC29A4 genes encoding synaptic serotonin reuptake proteins. Serotonin 73-82 solute carrier family 6 member 4 Homo sapiens 30-36 33164949-4 2021 These experiences have been associated with methylation of SLC6A4, a gene which codes for serotonin transport proteins, and is associated with anxiety, depression, and increased incidence of autism spectrum disorders.The purpose of this study was to examine the effects of altered serotonin levels on behavioral and neuroanatomical outcomes in a neonatal rodent model with or without exposure to hypoxic-ischemic (HI) injury. Serotonin 90-99 solute carrier family 6 member 4 Homo sapiens 59-65 33164949-4 2021 These experiences have been associated with methylation of SLC6A4, a gene which codes for serotonin transport proteins, and is associated with anxiety, depression, and increased incidence of autism spectrum disorders.The purpose of this study was to examine the effects of altered serotonin levels on behavioral and neuroanatomical outcomes in a neonatal rodent model with or without exposure to hypoxic-ischemic (HI) injury. Serotonin 281-290 solute carrier family 6 member 4 Homo sapiens 59-65 32348179-1 2020 The serotonin transporter (SERT) functions to regulate the availability of serotonin (5-HT) in the brain and intestine. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 33061998-0 2020 Upregulation of miR-361-3p suppresses serotonin-induced proliferation in human pulmonary artery smooth muscle cells by targeting SERT. Serotonin 38-47 solute carrier family 6 member 4 Homo sapiens 129-133 33061998-18 2020 Upregulation of miR-361-3p suppresses serotonin-induced proliferation of hPASMCs by targeting SERT. Serotonin 38-47 solute carrier family 6 member 4 Homo sapiens 94-98 32494974-1 2020 RATIONALE: The long-held speculation that the brain serotonin system mediates some behavioral effects of the psychostimulant cocaine is supported in part by the high affinity of cocaine for the serotonin transporter (SERT) and by reports that the serotonin transporter (SERT), estimated by SERT binding, is increased in brain of human chronic cocaine users. Serotonin 52-61 solute carrier family 6 member 4 Homo sapiens 194-215 32494974-1 2020 RATIONALE: The long-held speculation that the brain serotonin system mediates some behavioral effects of the psychostimulant cocaine is supported in part by the high affinity of cocaine for the serotonin transporter (SERT) and by reports that the serotonin transporter (SERT), estimated by SERT binding, is increased in brain of human chronic cocaine users. Serotonin 52-61 solute carrier family 6 member 4 Homo sapiens 217-221 32494974-1 2020 RATIONALE: The long-held speculation that the brain serotonin system mediates some behavioral effects of the psychostimulant cocaine is supported in part by the high affinity of cocaine for the serotonin transporter (SERT) and by reports that the serotonin transporter (SERT), estimated by SERT binding, is increased in brain of human chronic cocaine users. Serotonin 52-61 solute carrier family 6 member 4 Homo sapiens 247-268 32494974-1 2020 RATIONALE: The long-held speculation that the brain serotonin system mediates some behavioral effects of the psychostimulant cocaine is supported in part by the high affinity of cocaine for the serotonin transporter (SERT) and by reports that the serotonin transporter (SERT), estimated by SERT binding, is increased in brain of human chronic cocaine users. Serotonin 52-61 solute carrier family 6 member 4 Homo sapiens 270-274 32494974-1 2020 RATIONALE: The long-held speculation that the brain serotonin system mediates some behavioral effects of the psychostimulant cocaine is supported in part by the high affinity of cocaine for the serotonin transporter (SERT) and by reports that the serotonin transporter (SERT), estimated by SERT binding, is increased in brain of human chronic cocaine users. Serotonin 52-61 solute carrier family 6 member 4 Homo sapiens 270-274 32968548-4 2020 The serotonin reuptake transporter (SERT) maintains serotonin levels by regulating its reuptake. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 36-40 32968548-5 2020 An increase in SERT expression causes a decrease in serotonin, which leads to IBS-C (irritable bowel syndrome, constipation-predominant), whereas a decrease in SERT transcription causes an increase in serotonin, which leads to IBS-D (irritable bowel syndrome, diarrhea-predominant). Serotonin 52-61 solute carrier family 6 member 4 Homo sapiens 15-19 32968548-5 2020 An increase in SERT expression causes a decrease in serotonin, which leads to IBS-C (irritable bowel syndrome, constipation-predominant), whereas a decrease in SERT transcription causes an increase in serotonin, which leads to IBS-D (irritable bowel syndrome, diarrhea-predominant). Serotonin 201-210 solute carrier family 6 member 4 Homo sapiens 160-164 32543106-1 2020 BACKGROUND: The short (s) allele of the 5-HTTLPR polymorphism in the promoter region of the human serotonin transporter (5-HTT) gene SLC6A4 has previously been associated with anxiety-related personality dimensions. Serotonin 98-107 solute carrier family 6 member 4 Homo sapiens 40-48 32543106-1 2020 BACKGROUND: The short (s) allele of the 5-HTTLPR polymorphism in the promoter region of the human serotonin transporter (5-HTT) gene SLC6A4 has previously been associated with anxiety-related personality dimensions. Serotonin 98-107 solute carrier family 6 member 4 Homo sapiens 133-139 32614901-2 2020 The short (S)/long (L) 5-HTTLPR polymorphism has a functional role in the regulation of extracellular serotonin levels and both alleles have been associated to ASD. Serotonin 102-111 solute carrier family 6 member 4 Homo sapiens 23-31 32522387-1 2020 A polymorphism in the gene encoding the serotonin (5-HT) transporter (5-HTT) has been shown to moderate the response to CO2 inhalation, an experimental model for panic attacks (PAs). Serotonin 40-49 solute carrier family 6 member 4 Homo sapiens 70-75 32522387-1 2020 A polymorphism in the gene encoding the serotonin (5-HT) transporter (5-HTT) has been shown to moderate the response to CO2 inhalation, an experimental model for panic attacks (PAs). Serotonin 51-55 solute carrier family 6 member 4 Homo sapiens 70-75 32479312-1 2020 BACKGROUND: Studies in adult depressed patients have indicated that altered DNA methylation patterns at genes related to serotonin and HPA axis functioning (e.g., SLC6A4, FKBP5) are associated with changes in frontolimbic functional connectivity and structure. Serotonin 121-130 solute carrier family 6 member 4 Homo sapiens 163-169 33108341-2 2021 In the present study we focus on three genetic variants important for modulating experimental pain related to serotonin (SLC6A4 5-HTTLPR/rs25531 A>G), catecholamine (COMT rs4680 Val158Met) and opioid (OPRM1 rs1799971 A118G) signaling. Serotonin 110-119 solute carrier family 6 member 4 Homo sapiens 121-127 33114535-3 2020 The SCL6A4 protein (5HTTLPR) functions transporting serotonin, a neurotransmitter linked to mood and emotion, to the synaptic cleft. Serotonin 52-61 solute carrier family 6 member 4 Homo sapiens 20-27 33122957-3 2020 Dopamine transporter (DAT) and serotonin transporter play a key role in the reuptake of DA and 5-HT from the synaptic cleft into presynaptic neurons. Serotonin 95-99 solute carrier family 6 member 4 Homo sapiens 31-52 32750222-1 2020 Vortioxetine is a potent antagonist of the 5-hydroxytryptamine (5-HT) receptor and serotonin transporter (SERT), and has been reported to function as an antidepressant for treatment of major depressive disorder (MDD). Serotonin 43-62 solute carrier family 6 member 4 Homo sapiens 106-110 32629297-1 2020 Previous studies have reported associations between the serotonin transporter 5-HTTLPR genotype and antisocial and aggressive traits and between child maltreatment and antisocial traits. Serotonin 56-65 solute carrier family 6 member 4 Homo sapiens 78-86 32618269-1 2020 Antidepressants target the serotonin transporter (SERT) by inhibiting serotonin reuptake. Serotonin 27-36 solute carrier family 6 member 4 Homo sapiens 50-54 32618269-6 2020 These studies provide mutually consistent insights into how paroxetine and its analogues bind to the central substrate-binding site of SERT, stabilize the outward-open conformation, and inhibit serotonin transport. Serotonin 194-203 solute carrier family 6 member 4 Homo sapiens 135-139 32492052-11 2020 Unexpectedly we saw an increased fetal exposure to serotonin when inhibiting the serotonin transporter, which may be related to the increased serotonin concentration on the maternal side of the placenta. Serotonin 51-60 solute carrier family 6 member 4 Homo sapiens 81-102 32348179-1 2020 The serotonin transporter (SERT) functions to regulate the availability of serotonin (5-HT) in the brain and intestine. Serotonin 86-90 solute carrier family 6 member 4 Homo sapiens 4-25 32348179-1 2020 The serotonin transporter (SERT) functions to regulate the availability of serotonin (5-HT) in the brain and intestine. Serotonin 86-90 solute carrier family 6 member 4 Homo sapiens 27-31 32495670-1 2020 OBJECTIVE: To investigate the relationship between 5-hydroxytryptamine transporter gene promoter region (5-HTTLPR) gene polymorphism and post-stroke depression (PSD). Serotonin 51-70 solute carrier family 6 member 4 Homo sapiens 105-113 32333296-0 2020 Reduction of the serotonin 5-HT1B and 5-HT2A receptor-mediated contraction of human pulmonary artery by the combined 5-HT1B receptor antagonist and serotonin transporter inhibitor LY393558. Serotonin 17-26 solute carrier family 6 member 4 Homo sapiens 148-169 32333296-7 2020 Administration of the SERT inhibitor citalopram (at a concentration that failed to modify the 5-HT-induced vasoconstriction) in combination with SB224289 or GR55562 was more effective in inhibiting the response to 5-HT than the 5-HT1B antagonists alone. Serotonin 214-218 solute carrier family 6 member 4 Homo sapiens 22-26 32073004-1 2020 Vilazodone is a novel antidepressant used for the treatment of major depressive disorder (MDD) with a primary action mechanism of inhibiting the human serotonin reuptake transporter (hSERT) and acting as a 5-HT1A receptor partial agonist. Serotonin 151-160 solute carrier family 6 member 4 Homo sapiens 183-188 32333296-9 2020 CONCLUSIONS: LY393558 reduces the 5-HT-induced contraction antagonizing 5-HT1B and 5-HT2A receptors probably due to synergic interaction between SERT inhibition and 5-HT1B receptor antagonism. Serotonin 34-38 solute carrier family 6 member 4 Homo sapiens 145-149 32432141-2 2020 Previous studies have found that cholecystokinin (CCK) can enhance colon movement and that serotonin transporter (SERT) is a transmembrane transport protein with high affinity for 5-hydroxytryptamine, which can rapidly reuptake 5-hydroxytryptamine and then regulate its action time and intensity. Serotonin 180-199 solute carrier family 6 member 4 Homo sapiens 91-112 32432141-2 2020 Previous studies have found that cholecystokinin (CCK) can enhance colon movement and that serotonin transporter (SERT) is a transmembrane transport protein with high affinity for 5-hydroxytryptamine, which can rapidly reuptake 5-hydroxytryptamine and then regulate its action time and intensity. Serotonin 180-199 solute carrier family 6 member 4 Homo sapiens 114-118 32432141-2 2020 Previous studies have found that cholecystokinin (CCK) can enhance colon movement and that serotonin transporter (SERT) is a transmembrane transport protein with high affinity for 5-hydroxytryptamine, which can rapidly reuptake 5-hydroxytryptamine and then regulate its action time and intensity. Serotonin 228-247 solute carrier family 6 member 4 Homo sapiens 91-112 32432141-2 2020 Previous studies have found that cholecystokinin (CCK) can enhance colon movement and that serotonin transporter (SERT) is a transmembrane transport protein with high affinity for 5-hydroxytryptamine, which can rapidly reuptake 5-hydroxytryptamine and then regulate its action time and intensity. Serotonin 228-247 solute carrier family 6 member 4 Homo sapiens 114-118 31711155-5 2020 Increasing number of pregnant women at risk of depression are being treated with selective serotonin reuptake inhibitors (SSRI) that bind to serotonin transporters (SERT), which prevents 5-HT binding and cellular internalization, allowing for accumulation of extracellular 5-HT available to bind to 5-HT(2A) receptor (R). Serotonin 91-100 solute carrier family 6 member 4 Homo sapiens 141-163 31711155-5 2020 Increasing number of pregnant women at risk of depression are being treated with selective serotonin reuptake inhibitors (SSRI) that bind to serotonin transporters (SERT), which prevents 5-HT binding and cellular internalization, allowing for accumulation of extracellular 5-HT available to bind to 5-HT(2A) receptor (R). Serotonin 91-100 solute carrier family 6 member 4 Homo sapiens 165-169 31711155-5 2020 Increasing number of pregnant women at risk of depression are being treated with selective serotonin reuptake inhibitors (SSRI) that bind to serotonin transporters (SERT), which prevents 5-HT binding and cellular internalization, allowing for accumulation of extracellular 5-HT available to bind to 5-HT(2A) receptor (R). Serotonin 187-191 solute carrier family 6 member 4 Homo sapiens 141-163 31711155-5 2020 Increasing number of pregnant women at risk of depression are being treated with selective serotonin reuptake inhibitors (SSRI) that bind to serotonin transporters (SERT), which prevents 5-HT binding and cellular internalization, allowing for accumulation of extracellular 5-HT available to bind to 5-HT(2A) receptor (R). Serotonin 187-191 solute carrier family 6 member 4 Homo sapiens 165-169 31711155-5 2020 Increasing number of pregnant women at risk of depression are being treated with selective serotonin reuptake inhibitors (SSRI) that bind to serotonin transporters (SERT), which prevents 5-HT binding and cellular internalization, allowing for accumulation of extracellular 5-HT available to bind to 5-HT(2A) receptor (R). Serotonin 273-277 solute carrier family 6 member 4 Homo sapiens 141-163 31711155-5 2020 Increasing number of pregnant women at risk of depression are being treated with selective serotonin reuptake inhibitors (SSRI) that bind to serotonin transporters (SERT), which prevents 5-HT binding and cellular internalization, allowing for accumulation of extracellular 5-HT available to bind to 5-HT(2A) receptor (R). Serotonin 273-277 solute carrier family 6 member 4 Homo sapiens 165-169 31711155-5 2020 Increasing number of pregnant women at risk of depression are being treated with selective serotonin reuptake inhibitors (SSRI) that bind to serotonin transporters (SERT), which prevents 5-HT binding and cellular internalization, allowing for accumulation of extracellular 5-HT available to bind to 5-HT(2A) receptor (R). Serotonin 273-277 solute carrier family 6 member 4 Homo sapiens 141-163 31711155-5 2020 Increasing number of pregnant women at risk of depression are being treated with selective serotonin reuptake inhibitors (SSRI) that bind to serotonin transporters (SERT), which prevents 5-HT binding and cellular internalization, allowing for accumulation of extracellular 5-HT available to bind to 5-HT(2A) receptor (R). Serotonin 273-277 solute carrier family 6 member 4 Homo sapiens 165-169 30391505-1 2019 The serotonin transporter (SERT) is one of the primary targets for medications to treat neuropsychiatric disorders and functions by exploiting pre-existing ion gradients of Na+, Cl-, and K+ to translocate serotonin from the synaptic cleft into the presynaptic neuron. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 32329748-2 2020 Drugs from this class alter the functioning of the serotonin system by the potentiation of serotonin through the negative allosteric modulation of its neuronal uptake by the human serotonin transporter. Serotonin 51-60 solute carrier family 6 member 4 Homo sapiens 180-201 32329748-2 2020 Drugs from this class alter the functioning of the serotonin system by the potentiation of serotonin through the negative allosteric modulation of its neuronal uptake by the human serotonin transporter. Serotonin 91-100 solute carrier family 6 member 4 Homo sapiens 180-201 31751182-2 2020 Serotonin is also a vasoactive signaling molecule, the effects of which are modulated by both nitric oxide (NO) and the serotonin transporter [the primary target of selective serotonin reuptake inhibitors (SSRI)]. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 120-141 31772023-1 2019 Susceptibility to stress-related psychopathology is associated with reduced expression of the serotonin transporter (5-HTT), particularly in combination with stress exposure. Serotonin 94-103 solute carrier family 6 member 4 Homo sapiens 117-122 30807752-2 2019 SERT is essential for regulating serotonergic signaling by the reuptake of serotonin from the synaptic cleft back into the presynaptic neuron. Serotonin 75-84 solute carrier family 6 member 4 Homo sapiens 0-4 30738809-5 2020 Understanding the molecular regulation of placental SERT and 5-HT receptors using selective pharmacological agonists or antagonists may identify the therapeutic potential of serotonin pathway to improve long-term health outcomes of mothers and her infants exposed to GDM and obesity. Serotonin 174-183 solute carrier family 6 member 4 Homo sapiens 52-56 31707246-4 2020 We hypothesized that, consistent with the gene X environment (GXE) framework, an interaction between serotonin receptor (5-HTTLPR) gene and drug use would influence suicidal behaviors in BD patients. Serotonin 101-110 solute carrier family 6 member 4 Homo sapiens 120-129 31533444-1 2020 Background: Selective serotonin reuptake inhibitors (SSRIs) block the serotonin transporter on neurons, but also on platelets, thus decreasing platelet serotonin concentrations in users of SSRIs. Serotonin 22-31 solute carrier family 6 member 4 Homo sapiens 70-91 31653394-4 2020 The serotonin transporter (SERT) maintains low serotonin concentrations and is important for the reuptake of the neurotransmitter into the presynaptic nerve terminals. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 31653394-5 2020 Some opioids inhibit the reuptake of serotonin by inhibiting SERT, thus increasing the plasma and synaptic cleft serotonin concentrations that activate the serotonin receptors. Serotonin 37-46 solute carrier family 6 member 4 Homo sapiens 61-65 31653394-5 2020 Some opioids inhibit the reuptake of serotonin by inhibiting SERT, thus increasing the plasma and synaptic cleft serotonin concentrations that activate the serotonin receptors. Serotonin 113-122 solute carrier family 6 member 4 Homo sapiens 61-65 31653394-5 2020 Some opioids inhibit the reuptake of serotonin by inhibiting SERT, thus increasing the plasma and synaptic cleft serotonin concentrations that activate the serotonin receptors. Serotonin 113-122 solute carrier family 6 member 4 Homo sapiens 61-65 31653394-6 2020 Opioids that are good inhibitors of SERT (tramadol, dextromethorphan, methadone, and meperidine) are most frequently associated with serotonin toxicity. Serotonin 133-142 solute carrier family 6 member 4 Homo sapiens 36-40 31856211-1 2019 Previous research has suggested that the short (S)-allele of the 5-HT transporter gene-linked polymorphic region (5-HTTLPR) may confer "differential susceptibility" to environmental impact with regard to the expression of personality traits, depressivity and impulsivity. Serotonin 65-69 solute carrier family 6 member 4 Homo sapiens 114-122 31520274-11 2019 The SERT expression in patients with CSU was higher compared with controls, which can demonstrate the role of serotonin in the pathogenesis of this disease. Serotonin 110-119 solute carrier family 6 member 4 Homo sapiens 4-8 31835640-1 2019 Vortioxetine is a novel, multimodal antidepressant with unique targets, including the inhibition of the serotonin transporter (SET), of serotonin 5-HT3 (5-HT3R), and of 5-HT7 (5-HT7R) receptors and partial agonism to serotonin 5-HT1A (5-HT1AR) receptors in humans. Serotonin 104-113 solute carrier family 6 member 4 Homo sapiens 127-130 30587400-2 2019 For example, nicotine and other constituents of tobacco smoke elevate serotonin (5-HT) levels in the brain and may thereby cause homeostatic adaptations in 5-HTT availability that moderate effects of 5-HTTLPR genotype. Serotonin 70-79 solute carrier family 6 member 4 Homo sapiens 156-161 31667540-3 2019 Several common genetic variants have been identified in the human serotonin transporter (5-HTT) gene, including a repetitive sequence located in the promoter region of the locus called the serotonin transporter-linked polymorphic region (5-HTT-LPR). Serotonin 66-75 solute carrier family 6 member 4 Homo sapiens 89-94 31570504-1 2019 Serotonin (5-hydroxytryptamine [5-HT]) is accumulated within nerve endings by the serotonin transporter (SERT), which terminates its extracellular action and provides cytoplasmic 5-HT for refilling of synaptic vesicles. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 82-103 31570504-1 2019 Serotonin (5-hydroxytryptamine [5-HT]) is accumulated within nerve endings by the serotonin transporter (SERT), which terminates its extracellular action and provides cytoplasmic 5-HT for refilling of synaptic vesicles. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 105-109 31570504-1 2019 Serotonin (5-hydroxytryptamine [5-HT]) is accumulated within nerve endings by the serotonin transporter (SERT), which terminates its extracellular action and provides cytoplasmic 5-HT for refilling of synaptic vesicles. Serotonin 11-30 solute carrier family 6 member 4 Homo sapiens 82-103 31570504-1 2019 Serotonin (5-hydroxytryptamine [5-HT]) is accumulated within nerve endings by the serotonin transporter (SERT), which terminates its extracellular action and provides cytoplasmic 5-HT for refilling of synaptic vesicles. Serotonin 11-30 solute carrier family 6 member 4 Homo sapiens 105-109 31570504-1 2019 Serotonin (5-hydroxytryptamine [5-HT]) is accumulated within nerve endings by the serotonin transporter (SERT), which terminates its extracellular action and provides cytoplasmic 5-HT for refilling of synaptic vesicles. Serotonin 32-36 solute carrier family 6 member 4 Homo sapiens 82-103 31570504-1 2019 Serotonin (5-hydroxytryptamine [5-HT]) is accumulated within nerve endings by the serotonin transporter (SERT), which terminates its extracellular action and provides cytoplasmic 5-HT for refilling of synaptic vesicles. Serotonin 32-36 solute carrier family 6 member 4 Homo sapiens 105-109 31570504-1 2019 Serotonin (5-hydroxytryptamine [5-HT]) is accumulated within nerve endings by the serotonin transporter (SERT), which terminates its extracellular action and provides cytoplasmic 5-HT for refilling of synaptic vesicles. Serotonin 179-183 solute carrier family 6 member 4 Homo sapiens 82-103 31570504-1 2019 Serotonin (5-hydroxytryptamine [5-HT]) is accumulated within nerve endings by the serotonin transporter (SERT), which terminates its extracellular action and provides cytoplasmic 5-HT for refilling of synaptic vesicles. Serotonin 179-183 solute carrier family 6 member 4 Homo sapiens 105-109 31547761-3 2019 Furthermore, an important modulator of serotonin signalling, a genetic variation in the promoter region of the serotonin transporter gene (5-HTTLPR), has not been investigated for temporal discounting so far. Serotonin 39-48 solute carrier family 6 member 4 Homo sapiens 111-132 31547761-3 2019 Furthermore, an important modulator of serotonin signalling, a genetic variation in the promoter region of the serotonin transporter gene (5-HTTLPR), has not been investigated for temporal discounting so far. Serotonin 39-48 solute carrier family 6 member 4 Homo sapiens 139-147 31480244-3 2019 Their primary mechanism of action is considered to be the increased synaptic concentration of serotonin through blockade of the serotonin transporter (SERT). Serotonin 94-103 solute carrier family 6 member 4 Homo sapiens 128-149 31424193-1 2019 The serotonin transporter (SERT) is the primary target for the selective serotonin reuptake inhibitors (SSRIs). Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 31506681-1 2019 Inspired by the roles of serotonin in an emotional aversion to harmful actions, we examined to what extent serotonin transporter gene (5-HTT) linked polymorphic region (5-HTTLPR), a proxy for measuring serotonin function, underpinned the individual differences in moral judgment through cross-sectional analysis and two-wave comparison. Serotonin 107-116 solute carrier family 6 member 4 Homo sapiens 135-140 31506681-1 2019 Inspired by the roles of serotonin in an emotional aversion to harmful actions, we examined to what extent serotonin transporter gene (5-HTT) linked polymorphic region (5-HTTLPR), a proxy for measuring serotonin function, underpinned the individual differences in moral judgment through cross-sectional analysis and two-wave comparison. Serotonin 107-116 solute carrier family 6 member 4 Homo sapiens 169-177 31506681-2 2019 The cross-sectional analysis with a larger cohort (N = 1197) showed that the SS carriers of the 5-HTTLPR polymorphism, corresponding to the low ratio of serotonin recycling from the synaptic cleft, rated impersonal harmful actions (e.g., flipping a switch to divert a train to hit one person instead of five people) as more permissible as compared with the L allele carriers. Serotonin 153-162 solute carrier family 6 member 4 Homo sapiens 96-104 31480244-3 2019 Their primary mechanism of action is considered to be the increased synaptic concentration of serotonin through blockade of the serotonin transporter (SERT). Serotonin 94-103 solute carrier family 6 member 4 Homo sapiens 151-155 31237183-1 2019 BACKGROUND: The low-expressive short (S) allele of a functional polymorphism (5-HTTLPR) within the serotonin (5-hydroxytriptamine; 5-HT) transporter gene (SLC6A4) has been associated with a reduced functioning of the brain 5-HT system relative to the long (L) allele. Serotonin 99-108 solute carrier family 6 member 4 Homo sapiens 155-161 31270129-1 2019 Transporters of the solute carrier 6 (SLC6) family translocate their cognate substrate together with Na+ and Cl- Detailed kinetic models exist for the transporters of GABA (GAT1/SLC6A1) and the monoamines dopamine (DAT/SLC6A3) and serotonin (SERT/SLC6A4). Serotonin 231-240 solute carrier family 6 member 4 Homo sapiens 242-246 31270129-1 2019 Transporters of the solute carrier 6 (SLC6) family translocate their cognate substrate together with Na+ and Cl- Detailed kinetic models exist for the transporters of GABA (GAT1/SLC6A1) and the monoamines dopamine (DAT/SLC6A3) and serotonin (SERT/SLC6A4). Serotonin 231-240 solute carrier family 6 member 4 Homo sapiens 247-253 31237183-1 2019 BACKGROUND: The low-expressive short (S) allele of a functional polymorphism (5-HTTLPR) within the serotonin (5-hydroxytriptamine; 5-HT) transporter gene (SLC6A4) has been associated with a reduced functioning of the brain 5-HT system relative to the long (L) allele. Serotonin 110-129 solute carrier family 6 member 4 Homo sapiens 155-161 31237183-1 2019 BACKGROUND: The low-expressive short (S) allele of a functional polymorphism (5-HTTLPR) within the serotonin (5-hydroxytriptamine; 5-HT) transporter gene (SLC6A4) has been associated with a reduced functioning of the brain 5-HT system relative to the long (L) allele. Serotonin 78-82 solute carrier family 6 member 4 Homo sapiens 155-161 31237183-1 2019 BACKGROUND: The low-expressive short (S) allele of a functional polymorphism (5-HTTLPR) within the serotonin (5-hydroxytriptamine; 5-HT) transporter gene (SLC6A4) has been associated with a reduced functioning of the brain 5-HT system relative to the long (L) allele. Serotonin 131-135 solute carrier family 6 member 4 Homo sapiens 155-161 31379997-3 2019 The polymorphism of the serotonin transporter gene linked promoter region (5-HTTLPR) might influence 5-HTT expression and serotonin uptake. Serotonin 24-33 solute carrier family 6 member 4 Homo sapiens 75-83 31213395-1 2019 BACKGROUND: Previous studies indicate that shift work tolerance may be associated with individual factors including genetic variability in the gene encoding the serotonin transporter 5-HTT (SLC6A4). Serotonin 161-170 solute carrier family 6 member 4 Homo sapiens 190-196 30668912-1 2019 The antidepressant-sensitive serotonin (5-HT) transporter (SERT) dictates rapid, high-affinity clearance of the neurotransmitter in both the brain and periphery. Serotonin 29-38 solute carrier family 6 member 4 Homo sapiens 40-57 30668912-1 2019 The antidepressant-sensitive serotonin (5-HT) transporter (SERT) dictates rapid, high-affinity clearance of the neurotransmitter in both the brain and periphery. Serotonin 29-38 solute carrier family 6 member 4 Homo sapiens 59-63 30668912-2 2019 In a study of families with multiple individuals diagnosed with autism spectrum disorder (ASD), we previously identified several, rare, missense coding variants that impart elevated 5-HT transport activity, relative to wild-type SERT, upon heterologous expression as well as in ASD subject lymphoblasts. Serotonin 182-186 solute carrier family 6 member 4 Homo sapiens 229-233 31266890-0 2019 Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates. Serotonin 7-16 solute carrier family 6 member 4 Homo sapiens 71-92 31201246-0 2019 Withdrawal: Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter. Serotonin 12-21 solute carrier family 6 member 4 Homo sapiens 90-111 31251747-1 2019 The human serotonin transporter hSERT facilitates the reuptake of its endogenous substrate serotonin from the synaptic cleft into presynaptic neurons after signaling. Serotonin 10-19 solute carrier family 6 member 4 Homo sapiens 32-37 31251747-6 2019 Here, we present a serotonin-bound homology model of hSERT in an outward-occluded state, a key intermediate in the physiological cycle, in which the interactions with the substrate are likely to be optimal. Serotonin 19-28 solute carrier family 6 member 4 Homo sapiens 53-58 31251747-8 2019 According to microsecond-long molecular dynamics simulations, this model exhibits interactions between the gating residues in the extracellular pathway, and these interactions differ from those in an outward-open conformation of hSERT bound to serotonin. Serotonin 244-253 solute carrier family 6 member 4 Homo sapiens 229-234 31178771-12 2019 Conclusion: Upregulated SERT leading to lower synaptic levels of serotonin is a possible mechanism of depression in HIV+ patients, and extrapolating our conclusions from SIV to HIV should be sought using translational human studies. Serotonin 65-74 solute carrier family 6 member 4 Homo sapiens 24-28 30976000-1 2019 The serotonin transporter (SERT), a member of the neurotransmitter:sodium symporter family, is responsible for termination of serotonergic signaling by re-uptake of serotonin (5-HT) into the presynaptic neuron. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 29683385-1 2019 BACKGROUND: In the general population, variation in the serotonin-transporter-linked polymorphic region ( 5-HTTLPR) has been shown to modify the association between stressful events and depression/anxiety. Serotonin 56-65 solute carrier family 6 member 4 Homo sapiens 106-114 31019304-1 2019 The serotonin transporter (SERT) regulates neurotransmitter homeostasis through the sodium- and chloride-dependent recycling of serotonin into presynaptic neurons1-3. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 30622309-2 2019 SLC6A4 is an important mediator of serotonin bioavailability, and has a key role in energy balance. Serotonin 35-44 solute carrier family 6 member 4 Homo sapiens 0-6 31024427-1 2019 Introduction: Level of serotonin is mainly regulated by the serotonin reuptake transporter encoded by SLC6A4. Serotonin 23-32 solute carrier family 6 member 4 Homo sapiens 102-108 30872996-13 2019 Taken together, fundamental differences in SERT, and putatively in other transporters capable of serotonin clearance, may provide a mechanistic basis for the relative inefficiency of SSRIs to treat pediatric depression, relative to adults. Serotonin 97-106 solute carrier family 6 member 4 Homo sapiens 43-47 30535103-0 2019 Evidence that ITGB3 promoter variants increase serotonin blood levels by regulating platelet serotonin transporter trafficking. Serotonin 47-56 solute carrier family 6 member 4 Homo sapiens 93-114 31933907-1 2019 The serotonin-transporter-linked polymorphic region (5-HTTLPR) gene has been reported to predispose individuals experiencing trauma to affective disorders such as anxiety and depression. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 53-61 30926757-0 2019 Expression of Concern: Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter. Serotonin 23-32 solute carrier family 6 member 4 Homo sapiens 101-122 30873030-1 2019 The entactogen MDMA (3,4-methylenedioxy-methamphetamine, "Ecstasy") exerts its psychotropic effects acting primarily as a substrate of the serotonin transporter (SERT) to induce a non-exocytotic release of serotonin. Serotonin 139-148 solute carrier family 6 member 4 Homo sapiens 162-166 30809118-1 2019 Serotonin transporter, SERT (SLC64A for solute carrier family 6, member A4), is a twelve transmembrane domain (TMDs) protein that assumes the uptake of serotonin (5-HT) through dissipation of the Na+ gradient established by the electrogenic pump Na/K ATPase. Serotonin 152-161 solute carrier family 6 member 4 Homo sapiens 0-21 30809118-1 2019 Serotonin transporter, SERT (SLC64A for solute carrier family 6, member A4), is a twelve transmembrane domain (TMDs) protein that assumes the uptake of serotonin (5-HT) through dissipation of the Na+ gradient established by the electrogenic pump Na/K ATPase. Serotonin 152-161 solute carrier family 6 member 4 Homo sapiens 23-27 30055194-4 2019 In contrast to NET, DAT and SERT, OCT3 has higher capacity and lower affinity for substrates, is sodium-independent, and is multi-specific, with the capacity to transport norepinephrine, dopamine, serotonin and histamine. Serotonin 197-206 solute carrier family 6 member 4 Homo sapiens 28-32 30844812-2 2019 The serotonin transporter (SERT) regulates brain serotonin levels through reuptake into neurons. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 29673739-6 2019 Polymorphisms 5-HTTLPR and STin2 of serotonin and rs2279020 and rs3219151 of the GABA pathway were analyzed and results correlated with age at first use quantity consumed, duration of use, dependence and age at onset of dependence. Serotonin 36-45 solute carrier family 6 member 4 Homo sapiens 14-22 30394319-3 2019 This review discusses the post-translational modifications and their importance on the structure, maturation, and serotonin (5-HT) uptake ability of SERT. Serotonin 114-123 solute carrier family 6 member 4 Homo sapiens 149-153 30687199-3 2018 Availability of serotonin in the synaptic cleft is regulated by the serotonin transporter (SERT), which can be imaged in the living human brain by use of positron emission tomography (PET) and the radiotracer [11C]DASB. Serotonin 16-25 solute carrier family 6 member 4 Homo sapiens 68-89 30687199-3 2018 Availability of serotonin in the synaptic cleft is regulated by the serotonin transporter (SERT), which can be imaged in the living human brain by use of positron emission tomography (PET) and the radiotracer [11C]DASB. Serotonin 16-25 solute carrier family 6 member 4 Homo sapiens 91-95 30844812-3 2019 The gene encoding this transporter, the SERT gene, has several functional polymorphisms affecting the number of transporters and thereby the serotonin levels. Serotonin 141-150 solute carrier family 6 member 4 Homo sapiens 40-44 30031795-1 2018 Previous studies suggested that serotonergic neurons and platelets share similarities in serotonin (5-HT) uptake by serotonin transporter (SERT), storage, metabolism and release mechanisms, indicating that platelets may be used as a reliable peripheral surrogate to measure central SERT activity in neuropsychiatric research. Serotonin 89-98 solute carrier family 6 member 4 Homo sapiens 116-137 30457395-6 2019 Expert opinion: Vortioxetine displays high affinity for serotonin transporter (SERT), and serotonin 5-HT3, 5HT1A, 5HT7 receptors. Serotonin 56-65 solute carrier family 6 member 4 Homo sapiens 79-83 30468670-7 2019 Several immune cells express the serotonin transporter SERT and enzymes for serotonin metabolism (monoamine oxygenase, MAO). Serotonin 33-42 solute carrier family 6 member 4 Homo sapiens 55-59 31491815-2 2019 A recent report proposed that body image distortion (BID), a core symptom of AN, may relate to abnormalities of the serotonin system, especially the serotonin transporter (5HTT). Serotonin 116-125 solute carrier family 6 member 4 Homo sapiens 149-170 30077433-1 2018 We have recently shown that the emergence and severity of seasonal affective disorder (SAD) symptoms in the winter is associated with an increase in cerebral serotonin (5-HT) transporter (SERT) binding. Serotonin 158-167 solute carrier family 6 member 4 Homo sapiens 169-186 30077433-1 2018 We have recently shown that the emergence and severity of seasonal affective disorder (SAD) symptoms in the winter is associated with an increase in cerebral serotonin (5-HT) transporter (SERT) binding. Serotonin 158-167 solute carrier family 6 member 4 Homo sapiens 188-192 31594239-1 2019 BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) target the serotonin transporter (SERT) and are commonly prescribed for depression in Huntington"s disease (HD) patients. Serotonin 22-31 solute carrier family 6 member 4 Homo sapiens 71-92 31594239-1 2019 BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) target the serotonin transporter (SERT) and are commonly prescribed for depression in Huntington"s disease (HD) patients. Serotonin 22-31 solute carrier family 6 member 4 Homo sapiens 94-98 30031795-1 2018 Previous studies suggested that serotonergic neurons and platelets share similarities in serotonin (5-HT) uptake by serotonin transporter (SERT), storage, metabolism and release mechanisms, indicating that platelets may be used as a reliable peripheral surrogate to measure central SERT activity in neuropsychiatric research. Serotonin 89-98 solute carrier family 6 member 4 Homo sapiens 139-143 30886676-8 2018 Conclusion: In addition to SERT gene polymorphisms, modulation of serotonin at the synapses may also be regulated by genetic variations in tryptophan hydroxylase type 2 and serotonin receptors. Serotonin 66-75 solute carrier family 6 member 4 Homo sapiens 27-31 30180828-1 2018 BACKGROUND: Disrupted serotonergic signaling is often a feature of depression and the role of the serotonin transporter gene (SLC6A4), responsible for serotonin re-uptake, has received much attention in this regard. Serotonin 98-107 solute carrier family 6 member 4 Homo sapiens 126-132 30147642-1 2018 The serotonin (5-hydroxytryptamine, 5-HT) transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) is thought to alter 5-HT signaling and contribute to behavioral and cognitive phenotypes in depression as well as Alzheimer disease (AD). Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 55-60 30147642-1 2018 The serotonin (5-hydroxytryptamine, 5-HT) transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) is thought to alter 5-HT signaling and contribute to behavioral and cognitive phenotypes in depression as well as Alzheimer disease (AD). Serotonin 15-34 solute carrier family 6 member 4 Homo sapiens 55-60 30123264-4 2018 All the subjects were genotyped for 5HTR1A rs6295, 5HTR1B rs13212041, and SLC6A4 5HTTLPR polymorphisms in the serotonin system. Serotonin 110-119 solute carrier family 6 member 4 Homo sapiens 74-80 30089832-9 2018 Although causality cannot be determined here, SLC6A4 promoter methylation may be one of the mechanisms underlying how environmental factors influence the serotonin system, potentially affecting emotional processing through frontal-limbic areas. Serotonin 154-163 solute carrier family 6 member 4 Homo sapiens 46-52 29916050-8 2018 Although the opioids most often associated with serotonin toxicity in humans inhibit human SERT in vitro, fentanyl and oxycodone are not inhibitory even though their clinical involvement has been reported. Serotonin 48-57 solute carrier family 6 member 4 Homo sapiens 91-95 30039833-2 2018 Since the neurotrophin Brain-Derived Neurotrophic Factor (BDNF) and the serotonin (5-HT) transporter (SERT) are known to modulate human adaptive behavior, we appraised these two proteins in mild-HD using blood platelets, with the aim at finding relationships with cognitive/psychosocial skills. Serotonin 72-81 solute carrier family 6 member 4 Homo sapiens 102-106 30039833-2 2018 Since the neurotrophin Brain-Derived Neurotrophic Factor (BDNF) and the serotonin (5-HT) transporter (SERT) are known to modulate human adaptive behavior, we appraised these two proteins in mild-HD using blood platelets, with the aim at finding relationships with cognitive/psychosocial skills. Serotonin 83-87 solute carrier family 6 member 4 Homo sapiens 102-106 29922128-4 2018 Polymorphisms in the serotonin transporter gene (SLC6A4) and the hypocretin receptor 1 gene (HCRTR1) may be risk factors for migraine development due to their ability to affect serotonin and hypocretin-1 (HCRT-1) concentrations. Serotonin 21-30 solute carrier family 6 member 4 Homo sapiens 49-55 29801770-8 2018 Activation of the 5-HT2A receptors expressed on GABAergic interneurons following SERT-inhibition induces an increase in serotonin leading to inhibitory effect on NE release. Serotonin 120-129 solute carrier family 6 member 4 Homo sapiens 81-85 29381782-12 2018 We conclude that serotonin is conveyed from the maternal blood stream through syncytiotrophoblasts, cytotrophoblasts and the villus core to the fetus through a physiological pathway that involves at least SERT, gap junctions, P-gp, OCT3, and MAOA. Serotonin 17-26 solute carrier family 6 member 4 Homo sapiens 205-209 29427067-3 2018 The present study investigates the susceptibility properties of the serotonin transporter-linked polymorphic region (5HTTLPR) in relation to depressive symptoms and delinquency in two separate adolescent community samples: n = 1457, collected in 2006; and n = 191, collected in 2001. Serotonin 68-77 solute carrier family 6 member 4 Homo sapiens 117-124 29487159-1 2018 The serotonin transporter (SERT) functions in the uptake of the neurotransmitter serotonin (5-HT) from the extracellular milieu and is the molecular target of the selective serotonin re-uptake inhibitors (SSRIs), a common group of anti-depressants. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 29487159-1 2018 The serotonin transporter (SERT) functions in the uptake of the neurotransmitter serotonin (5-HT) from the extracellular milieu and is the molecular target of the selective serotonin re-uptake inhibitors (SSRIs), a common group of anti-depressants. Serotonin 81-90 solute carrier family 6 member 4 Homo sapiens 27-31 29468941-4 2018 Pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (TPH1) is increased in patients with PAH and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (PASMCs), In humans, serotonin can enter PASMCs via the serotonin transporter (SERT) or activate the 5-HT1B receptor; 5-HT1B activation and SERT activity cooperate to induce PASMC contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. Serotonin 22-31 solute carrier family 6 member 4 Homo sapiens 265-286 29468941-4 2018 Pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (TPH1) is increased in patients with PAH and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (PASMCs), In humans, serotonin can enter PASMCs via the serotonin transporter (SERT) or activate the 5-HT1B receptor; 5-HT1B activation and SERT activity cooperate to induce PASMC contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. Serotonin 22-31 solute carrier family 6 member 4 Homo sapiens 288-292 29468941-4 2018 Pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (TPH1) is increased in patients with PAH and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (PASMCs), In humans, serotonin can enter PASMCs via the serotonin transporter (SERT) or activate the 5-HT1B receptor; 5-HT1B activation and SERT activity cooperate to induce PASMC contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. Serotonin 22-31 solute carrier family 6 member 4 Homo sapiens 349-353 29468941-4 2018 Pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (TPH1) is increased in patients with PAH and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (PASMCs), In humans, serotonin can enter PASMCs via the serotonin transporter (SERT) or activate the 5-HT1B receptor; 5-HT1B activation and SERT activity cooperate to induce PASMC contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. Serotonin 115-124 solute carrier family 6 member 4 Homo sapiens 265-286 29468941-4 2018 Pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (TPH1) is increased in patients with PAH and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (PASMCs), In humans, serotonin can enter PASMCs via the serotonin transporter (SERT) or activate the 5-HT1B receptor; 5-HT1B activation and SERT activity cooperate to induce PASMC contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. Serotonin 115-124 solute carrier family 6 member 4 Homo sapiens 288-292 29468941-4 2018 Pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (TPH1) is increased in patients with PAH and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (PASMCs), In humans, serotonin can enter PASMCs via the serotonin transporter (SERT) or activate the 5-HT1B receptor; 5-HT1B activation and SERT activity cooperate to induce PASMC contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. Serotonin 115-124 solute carrier family 6 member 4 Homo sapiens 349-353 29468941-4 2018 Pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (TPH1) is increased in patients with PAH and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (PASMCs), In humans, serotonin can enter PASMCs via the serotonin transporter (SERT) or activate the 5-HT1B receptor; 5-HT1B activation and SERT activity cooperate to induce PASMC contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. Serotonin 115-124 solute carrier family 6 member 4 Homo sapiens 265-286 29468941-4 2018 Pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (TPH1) is increased in patients with PAH and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (PASMCs), In humans, serotonin can enter PASMCs via the serotonin transporter (SERT) or activate the 5-HT1B receptor; 5-HT1B activation and SERT activity cooperate to induce PASMC contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. Serotonin 115-124 solute carrier family 6 member 4 Homo sapiens 288-292 29468941-4 2018 Pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (TPH1) is increased in patients with PAH and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (PASMCs), In humans, serotonin can enter PASMCs via the serotonin transporter (SERT) or activate the 5-HT1B receptor; 5-HT1B activation and SERT activity cooperate to induce PASMC contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. Serotonin 115-124 solute carrier family 6 member 4 Homo sapiens 349-353 28899958-4 2018 Availability of DAT and SERT may thus provide an in vivo measure for the integrity of both dopamine and serotonin neurons. Serotonin 104-113 solute carrier family 6 member 4 Homo sapiens 24-28 29352106-1 2018 The serotonin transporter (SERT) is important for reuptake of the neurotransmitter serotonin from the synaptic cleft and is also the target of most antidepressants. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 29472624-1 2018 Citalopram prevents serotonin (5-HT) uptake into platelets by blocking the serotonin reuptake transporter (SERT). Serotonin 20-29 solute carrier family 6 member 4 Homo sapiens 75-105 29472624-1 2018 Citalopram prevents serotonin (5-HT) uptake into platelets by blocking the serotonin reuptake transporter (SERT). Serotonin 20-29 solute carrier family 6 member 4 Homo sapiens 107-111 29309998-5 2018 In this paper selected compounds which inhibit serotonin reuptake by acting on the serotonin transporter (SERT) and various serotoninergic receptors are presented. Serotonin 47-56 solute carrier family 6 member 4 Homo sapiens 83-104 29309998-5 2018 In this paper selected compounds which inhibit serotonin reuptake by acting on the serotonin transporter (SERT) and various serotoninergic receptors are presented. Serotonin 47-56 solute carrier family 6 member 4 Homo sapiens 106-110 29102815-2 2018 The serotonin transporter (SLC6A4) gene has been extensively investigated in relation to OCD, since serotonin reuptake inhibitors are the pharmacological treatment of choice for the disorder. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-33 29614501-2 2018 The serotonin transporter (SERT) is responsible for the uptake of serotonin into platelets. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 29614501-3 2018 Functional polymorphisms in the SERT gene may influence platelet activity, as they result in different levels of transporters and thereby different levels of serotonin in platelets. Serotonin 158-167 solute carrier family 6 member 4 Homo sapiens 32-36 28805431-0 2017 Disentangling the effects of serotonin on risk perception: S-carriers of 5-HTTLPR are primarily concerned with the magnitude of the outcomes, not the uncertainty. Serotonin 29-38 solute carrier family 6 member 4 Homo sapiens 73-81 28797691-8 2017 This in silico part comprised molecular docking of enantiomers of venlafaxine to human transporters for serotonin (hSERT), norepinephrine (hNET) and dopamine (hDAT). Serotonin 104-113 solute carrier family 6 member 4 Homo sapiens 115-120 28711621-9 2017 Greater length of axons expressing SERT in younger subjects with MDD may result in a significant deficit in serotonin availability in OFC. Serotonin 108-117 solute carrier family 6 member 4 Homo sapiens 35-39 28969722-3 2017 A short (S) allele polymorphism in the serotonin transporter gene (5-HTTLPR) is associated with a less efficient functioning brain serotonin system and therefore higher stress vulnerability. Serotonin 39-48 solute carrier family 6 member 4 Homo sapiens 67-75 28774705-13 2017 Buccal cells may be the most sensitive cell type when studying SLC6A4 promoter methylation and its associated risk for neural vulnerability and resilience for psychopathologies in which serotonin is implicated. Serotonin 186-195 solute carrier family 6 member 4 Homo sapiens 63-69 28892067-1 2017 The serotonin transporter-linked polymorphic region (5-HTTLPR) of the serotonin transporter gene (SLC6A4) S allele is linked to pathogenesis of depression and slower response to selective serotonin reuptake inhibitors (SSRIs); depression and SSRIs are independently associated with bone loss. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 53-61 28756191-1 2017 The serotonin transporter (5-HTT) regulates serotonin homeostasis and has been used as a target for different drugs in depression treatment. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-32 28712729-3 2017 An S-allele of the 5-HTTLPR gene has been linked to decreased (brain) serotonin efficiency, leading to decreased stress resilience and increased risks for negative affect and eating related disturbances. Serotonin 70-79 solute carrier family 6 member 4 Homo sapiens 19-27 28629713-2 2017 SSRIs bind to the serotonin transporter (SERT), blocking the reabsorption of serotonin by the presynaptic neuron and increasing serotonin levels in the synaptic cleft. Serotonin 18-27 solute carrier family 6 member 4 Homo sapiens 41-45 28629713-2 2017 SSRIs bind to the serotonin transporter (SERT), blocking the reabsorption of serotonin by the presynaptic neuron and increasing serotonin levels in the synaptic cleft. Serotonin 77-86 solute carrier family 6 member 4 Homo sapiens 18-39 28629713-2 2017 SSRIs bind to the serotonin transporter (SERT), blocking the reabsorption of serotonin by the presynaptic neuron and increasing serotonin levels in the synaptic cleft. Serotonin 77-86 solute carrier family 6 member 4 Homo sapiens 41-45 28811134-2 2017 Several neurotransmitters (e.g. serotonin, norepinephrine) are low-affinity substrates for these transporters, but possess higher affinity for other transporters (e.g. the serotonin or norepinephrine transporters; SERT and NET, respectively). Serotonin 32-41 solute carrier family 6 member 4 Homo sapiens 214-218 28811134-2 2017 Several neurotransmitters (e.g. serotonin, norepinephrine) are low-affinity substrates for these transporters, but possess higher affinity for other transporters (e.g. the serotonin or norepinephrine transporters; SERT and NET, respectively). Serotonin 172-181 solute carrier family 6 member 4 Homo sapiens 214-218 28871143-3 2017 Serotonin transporter (SERT) is a transmembrane transport protein which re-uptakes excessive 5-hydroxytryptamine (5-HT) from effective location to terminate its physiological effects and involves in regulating gastrointestinal motility. Serotonin 93-112 solute carrier family 6 member 4 Homo sapiens 0-21 28871143-3 2017 Serotonin transporter (SERT) is a transmembrane transport protein which re-uptakes excessive 5-hydroxytryptamine (5-HT) from effective location to terminate its physiological effects and involves in regulating gastrointestinal motility. Serotonin 93-112 solute carrier family 6 member 4 Homo sapiens 23-27 28511918-4 2017 The serotonin transporter is a selective marker of serotonin terminals and of the integrity of serotonin projections to cortical, subcortical and limbic regions and is found in high concentrations in the serotonergic cell bodies of origin of these projections (raphe nuclei). Serotonin 51-60 solute carrier family 6 member 4 Homo sapiens 4-25 28511918-7 2017 The following hypotheses were tested: 1) the serotonin transporter would be lower in mild cognitive impairment compared to controls in cortical and limbic regions, 2) in mild cognitive impairment relative to controls, the serotonin transporter would be lower to a greater extent and observed in a more widespread pattern than lower grey matter volumes or lower regional cerebral blood flow and 3) lower cortical and limbic serotonin transporters would be correlated with greater deficits in auditory-verbal and visual-spatial memory in mild cognitive impairment, not in controls. Serotonin 45-54 solute carrier family 6 member 4 Homo sapiens 222-243 28892067-1 2017 The serotonin transporter-linked polymorphic region (5-HTTLPR) of the serotonin transporter gene (SLC6A4) S allele is linked to pathogenesis of depression and slower response to selective serotonin reuptake inhibitors (SSRIs); depression and SSRIs are independently associated with bone loss. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 70-91 28892067-1 2017 The serotonin transporter-linked polymorphic region (5-HTTLPR) of the serotonin transporter gene (SLC6A4) S allele is linked to pathogenesis of depression and slower response to selective serotonin reuptake inhibitors (SSRIs); depression and SSRIs are independently associated with bone loss. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 98-104 28892067-11 2017 The 5-HTTLPR variants may modify serotonin effects on bone with sex-specific effects. Serotonin 33-42 solute carrier family 6 member 4 Homo sapiens 4-12 28379618-4 2017 Two SERT regions of interest were selected for the analysis: the Dorsal Raphe Nuclei (DRN) and the precuneus which represent the cell bodies of origin and a cortical target of projections of the serotonin system, respectively. Serotonin 195-204 solute carrier family 6 member 4 Homo sapiens 4-8 28465138-1 2017 The neural serotonin (5-HT)/serotonin transporter (5-HTT) system is involved in the regulation of physiological processes and emotional states. Serotonin 11-20 solute carrier family 6 member 4 Homo sapiens 51-56 28343185-3 2017 Serotonin (5-hydroxytryptamine [5-HT]) has multiple pharmacological tools, well-characterized downstream signaling in mammals" species, and established 5-HT neural markers showing new insights about memory functions and dysfunctions, including receptors (5-HT1A/1B/1D, 5-HT2A/2B/2C, and 5-HT3-7), transporter (serotonin transporter [SERT]) and volume transmission present in brain areas involved in memory. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 310-331 28343185-3 2017 Serotonin (5-hydroxytryptamine [5-HT]) has multiple pharmacological tools, well-characterized downstream signaling in mammals" species, and established 5-HT neural markers showing new insights about memory functions and dysfunctions, including receptors (5-HT1A/1B/1D, 5-HT2A/2B/2C, and 5-HT3-7), transporter (serotonin transporter [SERT]) and volume transmission present in brain areas involved in memory. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 333-337 28343185-3 2017 Serotonin (5-hydroxytryptamine [5-HT]) has multiple pharmacological tools, well-characterized downstream signaling in mammals" species, and established 5-HT neural markers showing new insights about memory functions and dysfunctions, including receptors (5-HT1A/1B/1D, 5-HT2A/2B/2C, and 5-HT3-7), transporter (serotonin transporter [SERT]) and volume transmission present in brain areas involved in memory. Serotonin 11-30 solute carrier family 6 member 4 Homo sapiens 310-331 28343185-3 2017 Serotonin (5-hydroxytryptamine [5-HT]) has multiple pharmacological tools, well-characterized downstream signaling in mammals" species, and established 5-HT neural markers showing new insights about memory functions and dysfunctions, including receptors (5-HT1A/1B/1D, 5-HT2A/2B/2C, and 5-HT3-7), transporter (serotonin transporter [SERT]) and volume transmission present in brain areas involved in memory. Serotonin 11-30 solute carrier family 6 member 4 Homo sapiens 333-337 28775986-3 2017 The functions of serotonin are mediated by members of the 7 known mammalian serotonin receptor subtype classes (15 known subtypes), the serotonin transporter (SERT), and by covalent binding of serotonin to different effector proteins. Serotonin 17-26 solute carrier family 6 member 4 Homo sapiens 136-157 28775986-3 2017 The functions of serotonin are mediated by members of the 7 known mammalian serotonin receptor subtype classes (15 known subtypes), the serotonin transporter (SERT), and by covalent binding of serotonin to different effector proteins. Serotonin 17-26 solute carrier family 6 member 4 Homo sapiens 159-163 28499269-1 2017 The serotonin (5-hydroxytryptamine, 5HT) transporter (SERT) is a member of neurotransmitter sodium symporter (NSS) family, which maintains neurotransmitter by reuptaking 5HT into synapses. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 54-58 28690502-0 2017 Serotonin 5-HTTLPR Genotype Modulates Reactive Visual Scanning of Social and Non-social Affective Stimuli in Young Children. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 10-18 28690502-1 2017 Previous studies have documented the 5-HTTLPR polymorphisms as genetic variants that are involved in serotonin availability and also associated with emotion regulation and facial emotion processing. Serotonin 101-110 solute carrier family 6 member 4 Homo sapiens 37-45 28499269-1 2017 The serotonin (5-hydroxytryptamine, 5HT) transporter (SERT) is a member of neurotransmitter sodium symporter (NSS) family, which maintains neurotransmitter by reuptaking 5HT into synapses. Serotonin 36-39 solute carrier family 6 member 4 Homo sapiens 54-58 28209599-2 2017 Inhibition of serotonin transporter (SERT), which regulates extracellular availability of serotonin (5-HT), has been implicated previously in EPEC-associated diarrhea. Serotonin 14-23 solute carrier family 6 member 4 Homo sapiens 37-41 28102201-1 2017 The human serotonin transporter (hSERT) mediates uptake of serotonin from the synaptic cleft and thereby terminates serotonergic signalling. Serotonin 10-19 solute carrier family 6 member 4 Homo sapiens 33-38 26679194-5 2017 Using large community samples, Experiments 1 and 2 (screened for psychiatric diagnosis) found that 5-HTTLPR S/LG allele homozygotes, with putatively lower serotonin transport functionality, outperformed LA allele homozygotes in a reflexive-optimal learning task. Serotonin 155-164 solute carrier family 6 member 4 Homo sapiens 99-107 26679194-6 2017 Experiment 3 used a large community sample, also screened for psychiatric diagnosis, and found that 5-HTTLPR LA homozygotes, with putatively higher serotonin transport functionality, outperformed S/LG allele homozygotes in a reflective-optimal learning task. Serotonin 148-157 solute carrier family 6 member 4 Homo sapiens 100-108 27926574-4 2017 Serotonin in mammal species has multiple neural markers, including receptors (5-HT1-7), serotonin transporter, and volume transmission, which are present in brain areas involved in memory. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 88-109 28223522-2 2017 The symporters for the biogenic amines serotonin (SERT), dopamine (DAT), and norepinephrine (NET) are targets of multiple psychoactive agents, and their dysfunction has been implicated in numerous neuropsychiatric ailments. Serotonin 39-48 solute carrier family 6 member 4 Homo sapiens 50-54 26912503-2 2016 By modulating the extracellular reuptake of serotonin, the serotonin transporter (SERT) acts as a key regulator of the bioavailability of serotonin. Serotonin 44-53 solute carrier family 6 member 4 Homo sapiens 59-80 28316763-0 2017 Serotonin Transporter Gene (SLC6A4) Polymorphism and Mucosal Serotonin Levels in Southeastern Iranian Patients with Irritable Bowel Syndrome. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 28-34 27907003-1 2016 Serotonin transporter (SERT) modulates serotonergic signaling via re-uptake of serotonin in pre-synaptic cells. Serotonin 79-88 solute carrier family 6 member 4 Homo sapiens 0-21 27907003-1 2016 Serotonin transporter (SERT) modulates serotonergic signaling via re-uptake of serotonin in pre-synaptic cells. Serotonin 79-88 solute carrier family 6 member 4 Homo sapiens 23-27 27638414-4 2016 Previously, we identified functional differences between the human and Drosophila melanogaster serotonin transporters (hSERT and dSERT, respectively) revealing that MDMA is an effective substrate for hSERT but not dSERT even though serotonin is a potent substrate for both transporters. Serotonin 95-104 solute carrier family 6 member 4 Homo sapiens 119-124 27638414-4 2016 Previously, we identified functional differences between the human and Drosophila melanogaster serotonin transporters (hSERT and dSERT, respectively) revealing that MDMA is an effective substrate for hSERT but not dSERT even though serotonin is a potent substrate for both transporters. Serotonin 95-104 solute carrier family 6 member 4 Homo sapiens 200-205 27493135-3 2016 Considering recent findings that serotonin reuptake transporter (SERT) might also be involved in metformin intestinal absorption, and the role of serotonin in gastrointestinal physiology, in this study we investigated the association between a common polymorphism in the SERT gene and metformin gastrointestinal intolerance. Serotonin 33-42 solute carrier family 6 member 4 Homo sapiens 65-69 27425420-1 2016 The transporters for the neurotransmitters serotonin and dopamine (SERT and DAT, respectively) are targets for drugs used in the treatment of mental disorders and widely used drugs of abuse. Serotonin 43-52 solute carrier family 6 member 4 Homo sapiens 67-71 27425420-4 2016 An optimized bivalent ligand comprising two serotonin moieties binds SERT with 3,800-fold increased affinity compared to that of serotonin, suggesting that the human transporters have two distinct substrate binding sites. Serotonin 44-53 solute carrier family 6 member 4 Homo sapiens 69-73 27519298-2 2016 We aimed to investigate a possible association between serotonin transmission and regulative temperament in obese and non-obese individuals by using positron emission tomography (PET) imaging of serotonin transporters (SERT) and the Adult Temperament Questionnaire. Serotonin 55-64 solute carrier family 6 member 4 Homo sapiens 195-217 27519298-2 2016 We aimed to investigate a possible association between serotonin transmission and regulative temperament in obese and non-obese individuals by using positron emission tomography (PET) imaging of serotonin transporters (SERT) and the Adult Temperament Questionnaire. Serotonin 55-64 solute carrier family 6 member 4 Homo sapiens 219-223 27488594-4 2016 The serotonin transporter (SERT), located in enterocytes, controls intestinal 5-HT availability and therefore serotonin"s effects. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 27488594-8 2016 Our results demonstrate that living L. monocytogenes inhibits serotonin uptake by reducing SERT expression at the brush border membrane. Serotonin 62-71 solute carrier family 6 member 4 Homo sapiens 91-95 27488594-11 2016 Therefore, L. monocytogenes, through TLR10-mediated SERT inhibition, may induce increased intestinal serotonin availability and potentially contributing to intestinal physiological changes and the initiation of the inflammatory response. Serotonin 101-110 solute carrier family 6 member 4 Homo sapiens 52-56 26676714-1 2016 BACKGROUND AND AIM: The serotonin reuptake transporter (SERT) terminates serotonin activity by removing it from interstitial space. Serotonin 24-33 solute carrier family 6 member 4 Homo sapiens 56-60 27143784-1 2016 The activity of serotonergic systems depends on the reuptake of extracellular serotonin via its plasma membrane serotonin [5-HT (5-hydroxytryptamine)] transporter (SERT), a member of the Na(+)/Cl(-)-dependent solute carrier 6 family. Serotonin 78-87 solute carrier family 6 member 4 Homo sapiens 164-168 27143784-1 2016 The activity of serotonergic systems depends on the reuptake of extracellular serotonin via its plasma membrane serotonin [5-HT (5-hydroxytryptamine)] transporter (SERT), a member of the Na(+)/Cl(-)-dependent solute carrier 6 family. Serotonin 112-121 solute carrier family 6 member 4 Homo sapiens 164-168 28316463-12 2017 We concluded that SERT/serotonin pathway is crucial in the process of pulmonary vascular remodeling/adaptation at birth and plays a key role in the pathobiology of ACD/MPV. Serotonin 23-32 solute carrier family 6 member 4 Homo sapiens 18-22 27692695-1 2016 Serotonin transporter (SERT) inhibitors treat depression by elevating brain extracellular 5-hydroxytryptamine (5-HTExt). Serotonin 90-109 solute carrier family 6 member 4 Homo sapiens 0-21 27692695-1 2016 Serotonin transporter (SERT) inhibitors treat depression by elevating brain extracellular 5-hydroxytryptamine (5-HTExt). Serotonin 90-109 solute carrier family 6 member 4 Homo sapiens 23-27 26464328-1 2016 The serotonin (5-hydroxytriptamine (5-HT)) transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) is a variable number tandem repeats (VNTR) located in the promoter region of the human 5-HTT-encoding gene SLC6A4. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 56-61 26464328-1 2016 The serotonin (5-hydroxytriptamine (5-HT)) transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) is a variable number tandem repeats (VNTR) located in the promoter region of the human 5-HTT-encoding gene SLC6A4. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 95-103 26464328-1 2016 The serotonin (5-hydroxytriptamine (5-HT)) transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) is a variable number tandem repeats (VNTR) located in the promoter region of the human 5-HTT-encoding gene SLC6A4. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 95-100 26464328-1 2016 The serotonin (5-hydroxytriptamine (5-HT)) transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) is a variable number tandem repeats (VNTR) located in the promoter region of the human 5-HTT-encoding gene SLC6A4. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 212-218 26464328-1 2016 The serotonin (5-hydroxytriptamine (5-HT)) transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) is a variable number tandem repeats (VNTR) located in the promoter region of the human 5-HTT-encoding gene SLC6A4. Serotonin 15-34 solute carrier family 6 member 4 Homo sapiens 56-61 26464328-1 2016 The serotonin (5-hydroxytriptamine (5-HT)) transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) is a variable number tandem repeats (VNTR) located in the promoter region of the human 5-HTT-encoding gene SLC6A4. Serotonin 15-34 solute carrier family 6 member 4 Homo sapiens 95-103 26464328-1 2016 The serotonin (5-hydroxytriptamine (5-HT)) transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) is a variable number tandem repeats (VNTR) located in the promoter region of the human 5-HTT-encoding gene SLC6A4. Serotonin 15-34 solute carrier family 6 member 4 Homo sapiens 95-100 26464328-1 2016 The serotonin (5-hydroxytriptamine (5-HT)) transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) is a variable number tandem repeats (VNTR) located in the promoter region of the human 5-HTT-encoding gene SLC6A4. Serotonin 15-34 solute carrier family 6 member 4 Homo sapiens 212-218 26464328-8 2016 A deeper knowledge of the "5-HTTLPR universe" will be useful to better understand the molecular basis of serotonin homeostasis and the pathological basis underlying serotonin-related neuropsychiatric conditions and traits. Serotonin 105-114 solute carrier family 6 member 4 Homo sapiens 27-35 26464328-8 2016 A deeper knowledge of the "5-HTTLPR universe" will be useful to better understand the molecular basis of serotonin homeostasis and the pathological basis underlying serotonin-related neuropsychiatric conditions and traits. Serotonin 165-174 solute carrier family 6 member 4 Homo sapiens 27-35 27356518-1 2016 BACKGROUND: Various antidepressants occupy brain serotonin transporter (SERT), decrease platelet serotonin (5-HT) concentration, and normalize reduced plasma brain-derived neurotrophic factor (BDNF) concentrations in depressed patients. Serotonin 49-58 solute carrier family 6 member 4 Homo sapiens 72-76 26912503-2 2016 By modulating the extracellular reuptake of serotonin, the serotonin transporter (SERT) acts as a key regulator of the bioavailability of serotonin. Serotonin 44-53 solute carrier family 6 member 4 Homo sapiens 82-86 26912503-2 2016 By modulating the extracellular reuptake of serotonin, the serotonin transporter (SERT) acts as a key regulator of the bioavailability of serotonin. Serotonin 59-68 solute carrier family 6 member 4 Homo sapiens 82-86 27112704-5 2016 Serotonin"s homeostasis involves serotoninergic autoreceptor such as 5-HT1A, 5-HT1B, 5-HT1D, the enzymatic degradation of serotonin by monoamine oxidase A (MAO-A), and a transporter (serotoninergic transporter [SERT]). Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 183-209 27112704-5 2016 Serotonin"s homeostasis involves serotoninergic autoreceptor such as 5-HT1A, 5-HT1B, 5-HT1D, the enzymatic degradation of serotonin by monoamine oxidase A (MAO-A), and a transporter (serotoninergic transporter [SERT]). Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 211-215 26577932-6 2016 Genetic linkage and association studies of both whole blood serotonin levels and of ASD risk point to the chromosomal region containing the serotonin transporter (SERT) gene in males but not in females. Serotonin 60-69 solute carrier family 6 member 4 Homo sapiens 140-161 27140629-1 2016 Serotonin transporter (SERT) is responsible for reuptake and recycling of 5-hydroxytryptamine (5-HT; serotonin) after its exocytotic release during neurotransmission. Serotonin 74-93 solute carrier family 6 member 4 Homo sapiens 0-21 27140629-1 2016 Serotonin transporter (SERT) is responsible for reuptake and recycling of 5-hydroxytryptamine (5-HT; serotonin) after its exocytotic release during neurotransmission. Serotonin 74-93 solute carrier family 6 member 4 Homo sapiens 23-27 27140629-1 2016 Serotonin transporter (SERT) is responsible for reuptake and recycling of 5-hydroxytryptamine (5-HT; serotonin) after its exocytotic release during neurotransmission. Serotonin 101-110 solute carrier family 6 member 4 Homo sapiens 0-21 27140629-1 2016 Serotonin transporter (SERT) is responsible for reuptake and recycling of 5-hydroxytryptamine (5-HT; serotonin) after its exocytotic release during neurotransmission. Serotonin 101-110 solute carrier family 6 member 4 Homo sapiens 23-27 26896742-1 2016 BACKGROUND: The short ("S") allele of the serotonin transporter (5-HTT)-linked polymorphic region (5-HTTLPR) is associated with increased negative emotion processing bias, and this polymorphism moderates acute effects of selective serotonin reuptake inhibitor (SSRI) treatment. Serotonin 42-51 solute carrier family 6 member 4 Homo sapiens 99-107 26577932-6 2016 Genetic linkage and association studies of both whole blood serotonin levels and of ASD risk point to the chromosomal region containing the serotonin transporter (SERT) gene in males but not in females. Serotonin 60-69 solute carrier family 6 member 4 Homo sapiens 163-167 26577932-7 2016 In ASD families with evidence of linkage to this region, multiple rare SERT amino acid variants lead to a convergent increase in serotonin uptake in cell models. Serotonin 129-138 solute carrier family 6 member 4 Homo sapiens 71-75 26100539-8 2016 Hence, C-SERT-siRNA (i) downregulated 5-HT1A-autoreceptors and facilitated forebrain serotonin neurotransmission, (ii) accelerated the proliferation of neuronal precursors and (iii) increased hippocampal complexity and plasticity. Serotonin 85-94 solute carrier family 6 member 4 Homo sapiens 9-13 27049939-4 2016 Antidepressants lock SERT in an outward-open conformation by lodging in the central binding site, located between transmembrane helices 1, 3, 6, 8 and 10, directly blocking serotonin binding. Serotonin 173-182 solute carrier family 6 member 4 Homo sapiens 21-25 27043930-1 2016 Although serotonin is known to play an important role in pain processing, the relationship between the polymorphism in 5-HTTLPR and pain processing is not well understood. Serotonin 9-18 solute carrier family 6 member 4 Homo sapiens 119-127 26744473-13 2016 These results suggest that IFN-gamma downregulates SERT expression, hence likely playing a role in altered serotonin metabolism of patients with IBS. Serotonin 107-116 solute carrier family 6 member 4 Homo sapiens 51-55 26941862-8 2016 CONCLUSIONS: Increased SERT availability in the brainstem of adult migraineurs indicates low serotonin neurotransmission during headache-free phase. Serotonin 93-102 solute carrier family 6 member 4 Homo sapiens 23-27 26879252-2 2016 SSRIs are defined as indirect receptor agonists since the activation of postsynaptic receptors is a consequence of an increase in extracellular concentrations of serotonin (5-HT) mediated by the blockade of serotonin transporter. Serotonin 162-171 solute carrier family 6 member 4 Homo sapiens 207-228 26674707-0 2016 Polymorphism of rs3813034 in Serotonin Transporter Gene SLC6A4 Is Associated With the Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitor Response in Depressive Disorder: Sequencing Analysis of SLC6A4. Serotonin 29-38 solute carrier family 6 member 4 Homo sapiens 56-62 26674707-0 2016 Polymorphism of rs3813034 in Serotonin Transporter Gene SLC6A4 Is Associated With the Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitor Response in Depressive Disorder: Sequencing Analysis of SLC6A4. Serotonin 29-38 solute carrier family 6 member 4 Homo sapiens 210-216 26674707-0 2016 Polymorphism of rs3813034 in Serotonin Transporter Gene SLC6A4 Is Associated With the Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitor Response in Depressive Disorder: Sequencing Analysis of SLC6A4. Serotonin 96-105 solute carrier family 6 member 4 Homo sapiens 29-50 26674707-0 2016 Polymorphism of rs3813034 in Serotonin Transporter Gene SLC6A4 Is Associated With the Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitor Response in Depressive Disorder: Sequencing Analysis of SLC6A4. Serotonin 96-105 solute carrier family 6 member 4 Homo sapiens 56-62 26674707-0 2016 Polymorphism of rs3813034 in Serotonin Transporter Gene SLC6A4 Is Associated With the Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitor Response in Depressive Disorder: Sequencing Analysis of SLC6A4. Serotonin 96-105 solute carrier family 6 member 4 Homo sapiens 210-216 27069689-6 2016 Single nucleotide polymorphisms in the SLC6A4, TPH2, and GALM genes may affect the activity of serotonin and increase the risk of HAND. Serotonin 95-104 solute carrier family 6 member 4 Homo sapiens 39-45 26508020-1 2016 BACKGROUND: This is a pilot study assessing the impact of polymorphisms of serotonin transporter (5-HTT; 5-HTTLPR (S/L)) and norepinephrine transporter (NET; rs2242446 (T/C)) genes on selective serotonin reuptake inhibitors (SSRIs) and serotonin/norepinephrine reuptake inhibitors (SNRIs) response in Korean panic disorder (PD) patients. Serotonin 194-203 solute carrier family 6 member 4 Homo sapiens 75-113 26464458-2 2016 Antidepressants influencing serotonin mainly aim at raising serotonin concentrations, thereby increasing serotonergic transmission at the level of the synapse, for example by inhibiting the serotonin transporter. Serotonin 28-37 solute carrier family 6 member 4 Homo sapiens 190-211 25642596-1 2015 Coordinated serotonin (5-HT) synthesis and reuptake depends on coexpression of Tph2, Aadc (Ddc), and Sert (Slc6a4) in brain 5-HT neurons. Serotonin 12-21 solute carrier family 6 member 4 Homo sapiens 101-105 26459992-9 2015 The results indicate that the self-transcendence trait is associated with SERT availability in specific raphe subnuclei, suggesting that the serotonin system may serve as an important biological basis for human self-transcendence. Serotonin 141-150 solute carrier family 6 member 4 Homo sapiens 74-78 26335661-4 2015 Metformin inhibited histamine and serotonin uptake by OCT1, OCT3 and SERT in a dose-dependent manner, with OCT1-mediated amine uptake being most potently inhibited (IC50 = 1.5 mM). Serotonin 34-43 solute carrier family 6 member 4 Homo sapiens 69-73 26174773-1 2015 The serotonin transporter (SERT) regulates neurotransmission by the biogenic monoamine neurotransmitter serotonin (5-HT, 5-hydroxytryptamine) in the central nervous system, and drugs inhibiting SERT are widely used for the treatment of a variety of central nervous system diseases. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 26174773-1 2015 The serotonin transporter (SERT) regulates neurotransmission by the biogenic monoamine neurotransmitter serotonin (5-HT, 5-hydroxytryptamine) in the central nervous system, and drugs inhibiting SERT are widely used for the treatment of a variety of central nervous system diseases. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 194-198 26174773-1 2015 The serotonin transporter (SERT) regulates neurotransmission by the biogenic monoamine neurotransmitter serotonin (5-HT, 5-hydroxytryptamine) in the central nervous system, and drugs inhibiting SERT are widely used for the treatment of a variety of central nervous system diseases. Serotonin 115-119 solute carrier family 6 member 4 Homo sapiens 4-25 25847498-2 2015 Recent experimental evidence implicates highly anionic phosphatidylinositol 4,5-biphosphate (PIP(2)) lipids in such functions of the serotonin (SERT) and dopamine (DAT) transporters. Serotonin 133-142 solute carrier family 6 member 4 Homo sapiens 144-148 26509115-2 2015 5-HTTLPR-s modifies the serotonergic systems that support emotion and behavioral regulation by reducing gene expression, which slows the reuptake of serotonin, and is associated with distinct morphological and functional effects. Serotonin 149-158 solute carrier family 6 member 4 Homo sapiens 0-8 26021727-3 2015 Serotonin transporter (SERT) regulates serotonin level in lymphoid tissues to ensure its proper functioning in innate and adaptive responses. Serotonin 39-48 solute carrier family 6 member 4 Homo sapiens 0-21 26021727-3 2015 Serotonin transporter (SERT) regulates serotonin level in lymphoid tissues to ensure its proper functioning in innate and adaptive responses. Serotonin 39-48 solute carrier family 6 member 4 Homo sapiens 23-27 26232751-3 2015 The serotonin transporter gene, SLC6A4/5-HTT, regulates the reuptake of serotonin. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 32-38 26232751-3 2015 The serotonin transporter gene, SLC6A4/5-HTT, regulates the reuptake of serotonin. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 39-44 26473596-1 2015 Earlier studies have shown that genetic variability in the SLC6A4 gene encoding the serotonin transporter (5-HTT) may be important for the re-uptake of serotonin (5-HT) in the central nervous system. Serotonin 84-93 solute carrier family 6 member 4 Homo sapiens 59-65 26174773-1 2015 The serotonin transporter (SERT) regulates neurotransmission by the biogenic monoamine neurotransmitter serotonin (5-HT, 5-hydroxytryptamine) in the central nervous system, and drugs inhibiting SERT are widely used for the treatment of a variety of central nervous system diseases. Serotonin 115-119 solute carrier family 6 member 4 Homo sapiens 27-31 26174773-1 2015 The serotonin transporter (SERT) regulates neurotransmission by the biogenic monoamine neurotransmitter serotonin (5-HT, 5-hydroxytryptamine) in the central nervous system, and drugs inhibiting SERT are widely used for the treatment of a variety of central nervous system diseases. Serotonin 115-119 solute carrier family 6 member 4 Homo sapiens 194-198 26174773-1 2015 The serotonin transporter (SERT) regulates neurotransmission by the biogenic monoamine neurotransmitter serotonin (5-HT, 5-hydroxytryptamine) in the central nervous system, and drugs inhibiting SERT are widely used for the treatment of a variety of central nervous system diseases. Serotonin 121-140 solute carrier family 6 member 4 Homo sapiens 4-25 26174773-1 2015 The serotonin transporter (SERT) regulates neurotransmission by the biogenic monoamine neurotransmitter serotonin (5-HT, 5-hydroxytryptamine) in the central nervous system, and drugs inhibiting SERT are widely used for the treatment of a variety of central nervous system diseases. Serotonin 121-140 solute carrier family 6 member 4 Homo sapiens 27-31 26349674-2 2015 A major genetic factor determining inter-individual differences in stress reactivity is polymorphisms of the serotonin (5-hydroxytryptamine, 5HT) transporter (5HTT) gene. Serotonin 109-118 solute carrier family 6 member 4 Homo sapiens 159-163 26349674-2 2015 A major genetic factor determining inter-individual differences in stress reactivity is polymorphisms of the serotonin (5-hydroxytryptamine, 5HT) transporter (5HTT) gene. Serotonin 120-139 solute carrier family 6 member 4 Homo sapiens 159-163 25642596-1 2015 Coordinated serotonin (5-HT) synthesis and reuptake depends on coexpression of Tph2, Aadc (Ddc), and Sert (Slc6a4) in brain 5-HT neurons. Serotonin 12-21 solute carrier family 6 member 4 Homo sapiens 107-113 25903124-1 2015 The serotonin transporter (SERT) terminates serotonergic neurotransmission by performing reuptake of released serotonin, and SERT is the primary target for antidepressants. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 25903124-1 2015 The serotonin transporter (SERT) terminates serotonergic neurotransmission by performing reuptake of released serotonin, and SERT is the primary target for antidepressants. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 125-129 25903124-2 2015 SERT mediates the reuptake of serotonin through an alternating access mechanism, implying that a central substrate site is connected to both sides of the membrane by permeation pathways, of which only one is accessible at a time. Serotonin 30-39 solute carrier family 6 member 4 Homo sapiens 0-4 26132681-9 2015 CONCLUSIONS: Within our study of older adults, hSERT antidepressants were associated with an increased body weight in women, which is supported by the biological function of serotonin in weight control and the differences in serotonergic signaling between males and females. Serotonin 174-183 solute carrier family 6 member 4 Homo sapiens 47-52 25827644-1 2015 It has been suggested that the serotonin or 5-hydroxytriptamine (5-HT) transporter (5-HTT) and its gene-linked polymorphic region (5-HTTLPR) are selective serotonin reuptake inhibitor (SSRI) response modulators in late-life depression (LLD), and particularly in late-life major depressive disorder (MDD). Serotonin 31-40 solute carrier family 6 member 4 Homo sapiens 84-89 26055783-2 2015 Commonly studied candidate genes associated with depression include those that influence serotonin (SLC6A4), dopamine (COMT), or neuroplasticity (BDNF, NTRK3). Serotonin 89-98 solute carrier family 6 member 4 Homo sapiens 100-106 25903736-0 2015 Serotonin transporter gene polymorphisms: Relation with platelet serotonin level in patients with primary Sjogren"s syndrome. Serotonin 65-74 solute carrier family 6 member 4 Homo sapiens 0-21 25954931-2 2015 The influence of TGF-beta1 on serotonin transporter (SERT) activity, the critical mechanism regulating the extracellular availability of serotonin (5-HT), is not known. Serotonin 30-39 solute carrier family 6 member 4 Homo sapiens 53-57 25652393-2 2015 The serotonin transporter (SERT), which is responsible for the reuptake of serotonin from the synaptic cleft into the neuron, as well as the serotonin-1A (5-HT1A) and -1B (5-HT1B) receptors, inhibitory auto-receptors in the raphe region and projection areas, respectively, are likely to determine serotonin release. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 25652393-2 2015 The serotonin transporter (SERT), which is responsible for the reuptake of serotonin from the synaptic cleft into the neuron, as well as the serotonin-1A (5-HT1A) and -1B (5-HT1B) receptors, inhibitory auto-receptors in the raphe region and projection areas, respectively, are likely to determine serotonin release. Serotonin 75-84 solute carrier family 6 member 4 Homo sapiens 4-25 25652393-2 2015 The serotonin transporter (SERT), which is responsible for the reuptake of serotonin from the synaptic cleft into the neuron, as well as the serotonin-1A (5-HT1A) and -1B (5-HT1B) receptors, inhibitory auto-receptors in the raphe region and projection areas, respectively, are likely to determine serotonin release. Serotonin 75-84 solute carrier family 6 member 4 Homo sapiens 27-31 25652393-10 2015 This finding suggests that the interaction between two major serotonergic structures involved in serotonin release, specifically the SERT and 5-HT1B receptor, results in a modification of the inhibitory serotonergic tone mediated via 5-HT1A receptors. Serotonin 97-106 solute carrier family 6 member 4 Homo sapiens 133-157 26281230-1 2015 Effect of ovarian steroids on serotonin neurotransmission suggests that the modulating effect of polymorphisms of the serotonin transporter gene on brain activity in women may change with age related changes in hormonal status. Serotonin 30-39 solute carrier family 6 member 4 Homo sapiens 118-139 25614630-2 2015 SERT mediates the reuptake of serotonin into the presynaptic neurons. Serotonin 30-39 solute carrier family 6 member 4 Homo sapiens 0-4 25614630-8 2015 We found a novel high affinity outward-facing conformational state of the human SERT induced by serotonin. Serotonin 96-105 solute carrier family 6 member 4 Homo sapiens 80-84 25710844-1 2015 Serotonin reuptake variation is linked to a functional polymorphism in the promoter region of the SLC6A4 gene on chromosome 17. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 98-104 25614630-10 2015 Furthermore, we found that membrane cholesterol plays a role in the dualistic conformational response in SERT induced by serotonin. Serotonin 121-130 solute carrier family 6 member 4 Homo sapiens 105-109 25614630-3 2015 Conformational changes in SERT occur upon binding of ions and substrate and are crucial for translocation of serotonin across the membrane. Serotonin 109-118 solute carrier family 6 member 4 Homo sapiens 26-30 25614630-11 2015 Our results indicate the existence of a subpopulation of SERT responding differently to serotonin binding than hitherto believed and that membrane cholesterol plays a role in this subpopulation of SERT. Serotonin 88-97 solute carrier family 6 member 4 Homo sapiens 57-61 25614630-6 2015 Here we show that serotonin induces a dualistic conformational response in SERT. Serotonin 18-27 solute carrier family 6 member 4 Homo sapiens 75-79 25775400-2 2015 Polymorphisms in the gene that encodes the serotonin transporter (5-HTT), which have differential effects on the level of serotonin transmission, display alternate responses to aversive stimuli. Serotonin 43-52 solute carrier family 6 member 4 Homo sapiens 66-71 25462800-3 2015 The serotonin transporter protein (5-HTT) regulates synaptic concentrations of serotonin and is a primary target for selective serotonin reuptake inhibitors. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 35-40 25444754-2 2015 The serotonin transporter (SERT) is the primary regulator of serotonin levels in the brain and a key target for widely used antidepressant drugs, such as selective serotonin reuptake inhibitors (SSRIs). Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 25462800-7 2015 The observed decrease in 5-HTT could either be due to direct effects on serotonin transporter expression or be the result of indirect adaptation to estrogen and /or testosterone effects on synaptic serotonin levels. Serotonin 72-81 solute carrier family 6 member 4 Homo sapiens 25-30 25568284-1 2015 BACKGROUND: Many lines of evidence suggest the role of serotonin transporter (SERT)-mediated reuptake of serotonin in the pathophysiology and treatment of major depressive disorder (MDD). Serotonin 55-64 solute carrier family 6 member 4 Homo sapiens 78-82 25486590-0 2015 The polymorphisms in serotonin-related genes (5-HT2A and SERT) and the prevalence of depressive symptoms in obese patients. Serotonin 21-30 solute carrier family 6 member 4 Homo sapiens 57-61 25026114-9 2015 CONCLUSIONS: Disruption of a microRNA binding site leads to higher expression of SLC6A4, higher expression of SLC6A4 leads to depletion of serotonin in synaptic clefts, and depletion of serotonin triggers the presynaptic autoreceptor feedback mechanism to produce more serotonin, which is protective against HFs. Serotonin 139-148 solute carrier family 6 member 4 Homo sapiens 110-116 25234400-8 2015 Effects of MDMA on transporters for serotonin (SERT) and norepinephrine (NET) were investigated by coapplication of the reuptake inhibitors citalopram and desipramine, respectively. Serotonin 36-45 solute carrier family 6 member 4 Homo sapiens 47-51 25287533-10 2015 The detrimental effect of SSRIs may result from inhibition of the serotonin transporter exposing the brain to excess amounts of 5-hydroxytryptamine (5-HT) at a critical time during fetal development. Serotonin 128-147 solute carrier family 6 member 4 Homo sapiens 66-87 25220079-0 2015 BDNF Val66met and 5-HTTLPR polymorphisms predict a human in vivo marker for brain serotonin levels. Serotonin 82-91 solute carrier family 6 member 4 Homo sapiens 18-26 25220079-11 2015 These findings implicate serotonin signaling as an important molecular mediator underlying the effects of BDNF val66met and 5-HTTLPR on behavior and related risk for neuropsychiatric illness in humans. Serotonin 25-34 solute carrier family 6 member 4 Homo sapiens 124-132 25128279-0 2015 Functional genetic variation in the serotonin 5-HTTLPR modulates brain damage in frontotemporal dementia. Serotonin 36-45 solute carrier family 6 member 4 Homo sapiens 46-54 25347540-1 2014 Functional genetic polymorphisms associated with Brain-Derived Neurotrophic Factor (BDNF) and serotonin (5-HTTLPR) have demonstrated associations with depression in interaction with environmental stressors. Serotonin 94-103 solute carrier family 6 member 4 Homo sapiens 105-113 25423193-2 2015 Vulnerability for 5-HT disturbances is considered to be genetically determined, including a short (S) allele polymorphism in the serotonin transporter gene (5-HTTLPR) that is associated with lower serotonin function. Serotonin 129-138 solute carrier family 6 member 4 Homo sapiens 157-165 25219494-2 2014 A serotonin (5-hydroxytryptamine; 5-HT) transporter-linked polymorphic region (5-HTTLPR) has been shown to influence the relationship between stress and the risk of attempting suicide in the general population, but has not been investigated in BD. Serotonin 2-11 solute carrier family 6 member 4 Homo sapiens 79-87 25219494-2 2014 A serotonin (5-hydroxytryptamine; 5-HT) transporter-linked polymorphic region (5-HTTLPR) has been shown to influence the relationship between stress and the risk of attempting suicide in the general population, but has not been investigated in BD. Serotonin 13-32 solute carrier family 6 member 4 Homo sapiens 79-87 25427177-6 2014 The monoamine uptake inhibition activity in the cloned human transporters expressed in HEK-293 cells (70.4, 9.18 and 39.7 for DAT, SERT and NET, respectively) indicates a serotonin preferring triple reuptake inhibition profile for this drug. Serotonin 171-180 solute carrier family 6 member 4 Homo sapiens 131-135 25078292-1 2014 In the three years since the most recent meta-analysis of the association between the serotonin transported promoter polymorphism (5-HTTLPR), stress and the development of depression, another 27 studies have been published on this issue, which is an increase of 50% more studies than were previously reviewed. Serotonin 86-95 solute carrier family 6 member 4 Homo sapiens 131-139 24806112-13 2014 As a potential clinical application, the data could be used as a reference to estimate SERT occupancy in addition to nigrostriatal integrity when using [(123)I]FP-CIT for DAT imaging in patients treated with selective serotonin reuptake inhibitors. Serotonin 218-227 solute carrier family 6 member 4 Homo sapiens 87-91 25127373-1 2014 PURPOSE: The aim of this study was to evaluate the correlation between sleep bruxism (SB) frequency and serotonin transporter (SERT)-driven serotonin (5-HT)-uptake in platelets. Serotonin 104-113 solute carrier family 6 member 4 Homo sapiens 127-131 24973209-1 2014 The serotonin transporter (SERT) plays a critical role in regulating serotonin signaling by mediating reuptake of serotonin from the extracellular space. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 24973209-1 2014 The serotonin transporter (SERT) plays a critical role in regulating serotonin signaling by mediating reuptake of serotonin from the extracellular space. Serotonin 69-78 solute carrier family 6 member 4 Homo sapiens 4-25 24973209-1 2014 The serotonin transporter (SERT) plays a critical role in regulating serotonin signaling by mediating reuptake of serotonin from the extracellular space. Serotonin 69-78 solute carrier family 6 member 4 Homo sapiens 27-31 24976619-1 2014 UNLABELLED: Serotonin-mediated mechanisms, in particular via the serotonin transporter (SERT), are thought to have an effect on food intake and play an important role in the pathophysiology of obesity. Serotonin 12-21 solute carrier family 6 member 4 Homo sapiens 65-86 24976619-1 2014 UNLABELLED: Serotonin-mediated mechanisms, in particular via the serotonin transporter (SERT), are thought to have an effect on food intake and play an important role in the pathophysiology of obesity. Serotonin 12-21 solute carrier family 6 member 4 Homo sapiens 88-92 24679990-9 2014 This analysis suggests that DNA hypomethylation of the 5-HTT transcriptional control region - possibly via increased serotonin transporter expression and consecutively decreased serotonin availability - might impair antidepressant treatment response in Caucasian patients with MDD. Serotonin 117-126 solute carrier family 6 member 4 Homo sapiens 55-60 24486182-7 2014 The association between subjective sleep quality and positive affect the next day varied as a function of 5-HTTLPR: it was stronger in carriers of at least one copy of the S-allele compared to homozygous L-carriers, supporting a link between sleep and affect regulation, in which serotonin may play a role. Serotonin 280-289 solute carrier family 6 member 4 Homo sapiens 106-114 24673477-4 2014 METHODS: SERT inhibition was assessed with measuring of [(3) H]-serotonin uptake using HEK-293 MSR cells. Serotonin 64-73 solute carrier family 6 member 4 Homo sapiens 9-13 25043824-2 2014 Pharmacogenetic aspects of the serotonin metabolism, specifically variation in the 5-HTTLPR may be involved. Serotonin 31-40 solute carrier family 6 member 4 Homo sapiens 83-91 24854234-9 2014 When these channels are co-expressed with hSERT in HEK293T cells, only cells expressing the lower-threshold L-type CaV1.3 channel show Ca(2+) transients evoked by 5HT or S(+)MDMA. Serotonin 163-166 solute carrier family 6 member 4 Homo sapiens 42-47 24854234-10 2014 In addition, the electrical coupling between hSERT and CaV1.3 takes place at physiological 5HT concentrations. Serotonin 91-94 solute carrier family 6 member 4 Homo sapiens 45-50 24462583-0 2014 Serotonin-induced down-regulation of cell surface serotonin transporter. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 50-71 24462583-1 2014 The serotonin transporter (SERT) terminates serotonergic signaling and enables refilling of synaptic vesicles by mediating reuptake of serotonin (5-HT) released into the synaptic cleft. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 24934532-5 2014 Previously, serotonin hypothesis was linked to the anorexigens, derivatives of fenfluramine, which are serotonin transporter (SERT) substrates. Serotonin 12-21 solute carrier family 6 member 4 Homo sapiens 103-124 24934532-5 2014 Previously, serotonin hypothesis was linked to the anorexigens, derivatives of fenfluramine, which are serotonin transporter (SERT) substrates. Serotonin 12-21 solute carrier family 6 member 4 Homo sapiens 126-130 24878716-1 2014 The serotonin transporter (SERT) is a key regulator of serotonergic signalling as it mediates the re-uptake of synaptic serotonin into nerve terminals, thereby terminating or modulating its signal. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 24450286-1 2014 In the central nervous system, synaptic levels of the monoamine neurotransmitter serotonin are mainly controlled by the serotonin transporter (SERT), and drugs used in the treatment of various psychiatric diseases have SERT as primary target. Serotonin 81-90 solute carrier family 6 member 4 Homo sapiens 120-141 24860418-2 2014 Serotonin transporters (SERT) play a crucial role in serotonin signaling by regulating its availability in the synaptic cleft. Serotonin 53-62 solute carrier family 6 member 4 Homo sapiens 24-28 24450286-1 2014 In the central nervous system, synaptic levels of the monoamine neurotransmitter serotonin are mainly controlled by the serotonin transporter (SERT), and drugs used in the treatment of various psychiatric diseases have SERT as primary target. Serotonin 81-90 solute carrier family 6 member 4 Homo sapiens 143-147 24450286-1 2014 In the central nervous system, synaptic levels of the monoamine neurotransmitter serotonin are mainly controlled by the serotonin transporter (SERT), and drugs used in the treatment of various psychiatric diseases have SERT as primary target. Serotonin 81-90 solute carrier family 6 member 4 Homo sapiens 219-223 24532229-7 2014 Vulnerability to PTSD and suicidality are also linked to brain serotonin function, including polymorphisms in the serotonin transporter gene (5-HTTLPR). Serotonin 63-72 solute carrier family 6 member 4 Homo sapiens 114-135 24532229-7 2014 Vulnerability to PTSD and suicidality are also linked to brain serotonin function, including polymorphisms in the serotonin transporter gene (5-HTTLPR). Serotonin 63-72 solute carrier family 6 member 4 Homo sapiens 142-150 24667541-1 2014 BACKGROUND: The serotonin transporter (5-HTT) is abundantly expressed in humans by the serotonin transporter gene SLC6A4 and removes serotonin (5-HT) from extracellular space. Serotonin 16-25 solute carrier family 6 member 4 Homo sapiens 87-108 24667541-1 2014 BACKGROUND: The serotonin transporter (5-HTT) is abundantly expressed in humans by the serotonin transporter gene SLC6A4 and removes serotonin (5-HT) from extracellular space. Serotonin 16-25 solute carrier family 6 member 4 Homo sapiens 114-120 26626475-3 2014 The biobehavioral model proposes that a genetic predisposition, coupled with stress, enhances midbrain serotonin transporter (SERT) binding, which results in lower post-synaptic serotonin, dysregulating circadian rhythms and decreasing satiety. Serotonin 103-112 solute carrier family 6 member 4 Homo sapiens 126-130 24521202-1 2014 The serotonin (5-hydroxytryptamine, 5-HT) transporter (SERT) plays an essential role in the termination of serotonergic neurotransmission by removing 5-HT from the synaptic cleft into the presynaptic neuron. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 55-59 24521202-1 2014 The serotonin (5-hydroxytryptamine, 5-HT) transporter (SERT) plays an essential role in the termination of serotonergic neurotransmission by removing 5-HT from the synaptic cleft into the presynaptic neuron. Serotonin 15-34 solute carrier family 6 member 4 Homo sapiens 55-59 24443391-3 2014 Several genetic variations have been suggested to associate with AD and DE, particularly in genes involved in the serotonergic system such as the serotonin transporter (SERT/SLC6A4), responsible for the removal from the synaptic cleft, and the monoamine-oxidase-A (MAOA), responsible for the presynaptic degradation of serotonin. Serotonin 146-155 solute carrier family 6 member 4 Homo sapiens 169-173 24443391-3 2014 Several genetic variations have been suggested to associate with AD and DE, particularly in genes involved in the serotonergic system such as the serotonin transporter (SERT/SLC6A4), responsible for the removal from the synaptic cleft, and the monoamine-oxidase-A (MAOA), responsible for the presynaptic degradation of serotonin. Serotonin 146-155 solute carrier family 6 member 4 Homo sapiens 174-180 26626475-4 2014 Selective serotonin reuptake inhibitors should therefore decrease SERT binding, increase postsynaptic serotonin, and restore circadian function and satiety regulation. Serotonin 10-19 solute carrier family 6 member 4 Homo sapiens 66-70 24405699-1 2014 Presynaptic serotonin (5-hydroxytryptamine, 5-HT) transporters (SERT) regulate 5-HT signaling via antidepressant-sensitive clearance of released neurotransmitter. Serotonin 12-21 solute carrier family 6 member 4 Homo sapiens 64-68 24405699-1 2014 Presynaptic serotonin (5-hydroxytryptamine, 5-HT) transporters (SERT) regulate 5-HT signaling via antidepressant-sensitive clearance of released neurotransmitter. Serotonin 23-42 solute carrier family 6 member 4 Homo sapiens 64-68 24213511-11 2014 It was concluded that the increase in ileal epithelial content of SERT increases the intracellular uptake of serotonin and its degradation in the gut epithelial cells and consequently decreases the availability of serotonin within the gut mucosa. Serotonin 109-118 solute carrier family 6 member 4 Homo sapiens 66-70 24346757-1 2014 Duloxetine selectively inhibits the serotonin (5-HT) and norepinephrine (NE) transporters (5-HTT and NET, respectively), as demonstrated in vitro and in preclinical studies; however, transporter inhibition has not been fully assessed in vivo at the approved dose of 60 mg/d. Serotonin 36-45 solute carrier family 6 member 4 Homo sapiens 91-96 25345508-1 2014 Pharmacological management of Major Depressive Disorder includes the use of serotonin reuptake inhibitors which targets serotonin transporters (SERT) to increase the synaptic concentrations of serotonin. Serotonin 76-85 solute carrier family 6 member 4 Homo sapiens 120-142 25345508-1 2014 Pharmacological management of Major Depressive Disorder includes the use of serotonin reuptake inhibitors which targets serotonin transporters (SERT) to increase the synaptic concentrations of serotonin. Serotonin 76-85 solute carrier family 6 member 4 Homo sapiens 144-148 25345508-1 2014 Pharmacological management of Major Depressive Disorder includes the use of serotonin reuptake inhibitors which targets serotonin transporters (SERT) to increase the synaptic concentrations of serotonin. Serotonin 120-129 solute carrier family 6 member 4 Homo sapiens 144-148 25345508-9 2014 Levomilnacipran was found to interact with S438, known to be the most important amino acid residue of serotonin binding site of SERT during "levomilnacipran-SERT" interaction. Serotonin 102-111 solute carrier family 6 member 4 Homo sapiens 128-132 25345508-9 2014 Levomilnacipran was found to interact with S438, known to be the most important amino acid residue of serotonin binding site of SERT during "levomilnacipran-SERT" interaction. Serotonin 102-111 solute carrier family 6 member 4 Homo sapiens 157-161 24778869-2 2014 We addressed this issue by examining serotonin transporter- (SERT-) driven [(14)C]-serotonin uptake rate (SUR) and serotonin content in platelets of 65 untreated HCV patients and 65 healthy control subjects (HCS). Serotonin 37-46 solute carrier family 6 member 4 Homo sapiens 61-65 24778869-2 2014 We addressed this issue by examining serotonin transporter- (SERT-) driven [(14)C]-serotonin uptake rate (SUR) and serotonin content in platelets of 65 untreated HCV patients and 65 healthy control subjects (HCS). Serotonin 83-92 solute carrier family 6 member 4 Homo sapiens 37-58 24778869-2 2014 We addressed this issue by examining serotonin transporter- (SERT-) driven [(14)C]-serotonin uptake rate (SUR) and serotonin content in platelets of 65 untreated HCV patients and 65 healthy control subjects (HCS). Serotonin 83-92 solute carrier family 6 member 4 Homo sapiens 61-65 24213511-11 2014 It was concluded that the increase in ileal epithelial content of SERT increases the intracellular uptake of serotonin and its degradation in the gut epithelial cells and consequently decreases the availability of serotonin within the gut mucosa. Serotonin 214-223 solute carrier family 6 member 4 Homo sapiens 66-70 24105442-2 2013 Studies of monoaminergic seasonality and the influence of the serotonin-transporter-linked polymorphic region (5-HTTLPR) on serotonin seasonality have yielded conflicting results, possibly due to lack of power and absence of multi-year analyses. Serotonin 62-71 solute carrier family 6 member 4 Homo sapiens 111-119 23601559-3 2013 Serotonin (5-HT) has been shown to be involved in PH by inducing PASMC proliferation through the activation of 5-HT1B receptors (5-HT1BR) and 5-HT transporter (5-HTT). Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 142-158 24103554-4 2013 This review seeks to provide an understanding of the biochemistry and physiological actions of serotonin and its termination of action through the serotonin reuptake transporter (SERT). Serotonin 95-104 solute carrier family 6 member 4 Homo sapiens 147-177 24093801-1 2013 AIMS: Serotonin transporter (5-HTT) plays a central role in the regulation of serotonin (5-hydroxytryptamine [5-HT]) synaptic function. Serotonin 78-87 solute carrier family 6 member 4 Homo sapiens 29-34 24093801-1 2013 AIMS: Serotonin transporter (5-HTT) plays a central role in the regulation of serotonin (5-hydroxytryptamine [5-HT]) synaptic function. Serotonin 89-108 solute carrier family 6 member 4 Homo sapiens 29-34 24150247-0 2013 How the cerebral serotonin homeostasis predicts environmental changes: a model to explain seasonal changes of brain 5-HTT as intermediate phenotype of the 5-HTTLPR. Serotonin 17-26 solute carrier family 6 member 4 Homo sapiens 155-163 24130516-2 2013 We examined long-term effects of prenatal SRI exposure on EFs to determine whether effects are moderated by maternal mood and/or genetic variations in SLC6A4 (a gene that codes for the serotonin transporter [5-HTT] central to the regulation of synaptic serotonin levels and behavior). Serotonin 185-194 solute carrier family 6 member 4 Homo sapiens 151-157 24107951-1 2013 Homeostasis of serotonergic transmission critically depends on the rate of serotonin reuptake via its plasma membrane transporter (SERT). Serotonin 75-84 solute carrier family 6 member 4 Homo sapiens 131-135 24103554-4 2013 This review seeks to provide an understanding of the biochemistry and physiological actions of serotonin and its termination of action through the serotonin reuptake transporter (SERT). Serotonin 95-104 solute carrier family 6 member 4 Homo sapiens 179-183 23953133-2 2013 Altered serotonin (5-HT) signaling has been implicated in ASD, and we and others have discovered multiple, rare, ASD-associated variants in the 5-HT transporter (SERT) gene leading to elevated 5-HT re-uptake and perturbed regulation. Serotonin 8-17 solute carrier family 6 member 4 Homo sapiens 144-160 24064711-1 2013 A number of studies have suggested DNA sequence variability in the serotonin transporter gene (SLC6A4) between European-American (EA) and African-American (AA) populations, which could be clinically important, given the central role SLC6A4 has in serotonin transmission. Serotonin 67-76 solute carrier family 6 member 4 Homo sapiens 95-101 24064711-1 2013 A number of studies have suggested DNA sequence variability in the serotonin transporter gene (SLC6A4) between European-American (EA) and African-American (AA) populations, which could be clinically important, given the central role SLC6A4 has in serotonin transmission. Serotonin 67-76 solute carrier family 6 member 4 Homo sapiens 233-239 23632081-8 2013 In functional transport assays, we found that one of the identified molecules, ATM7, increased the reuptake of serotonin, possibly by facilitating the interaction of serotonin with transport-ready conformations of SERT when concentrations of serotonin were low and rate limiting. Serotonin 111-120 solute carrier family 6 member 4 Homo sapiens 214-218 23632081-8 2013 In functional transport assays, we found that one of the identified molecules, ATM7, increased the reuptake of serotonin, possibly by facilitating the interaction of serotonin with transport-ready conformations of SERT when concentrations of serotonin were low and rate limiting. Serotonin 166-175 solute carrier family 6 member 4 Homo sapiens 214-218 23632081-8 2013 In functional transport assays, we found that one of the identified molecules, ATM7, increased the reuptake of serotonin, possibly by facilitating the interaction of serotonin with transport-ready conformations of SERT when concentrations of serotonin were low and rate limiting. Serotonin 166-175 solute carrier family 6 member 4 Homo sapiens 214-218 23953133-2 2013 Altered serotonin (5-HT) signaling has been implicated in ASD, and we and others have discovered multiple, rare, ASD-associated variants in the 5-HT transporter (SERT) gene leading to elevated 5-HT re-uptake and perturbed regulation. Serotonin 8-17 solute carrier family 6 member 4 Homo sapiens 162-166 23558235-1 2013 The serotonin transporter, encoded by the SLC6A4 gene, influences the synaptic actions of serotonin and is responsive to stress hormones. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 42-48 23583454-4 2013 3,4-Methylenedioxypyrovalerone and naphyrone had high affinity for radioligand binding sites on recombinant human dopamine (hDAT), serotonin (hSERT) and norepinephrine (hNET) transporters, potently inhibited [3H]neurotransmitter uptake, and, like cocaine, did not induce transporter-mediated release. Serotonin 131-140 solute carrier family 6 member 4 Homo sapiens 142-147 23583772-2 2013 The serotonin transporter (SERT), encoded by solute carrier family 6 member 4 (SLC6A4), regulates synaptic concentrations of serotonin and thereby strongly influences perception, mood, emotion, behavior, and cognition, all of which are severely disturbed in SZ. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 23583772-2 2013 The serotonin transporter (SERT), encoded by solute carrier family 6 member 4 (SLC6A4), regulates synaptic concentrations of serotonin and thereby strongly influences perception, mood, emotion, behavior, and cognition, all of which are severely disturbed in SZ. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 45-77 23583772-2 2013 The serotonin transporter (SERT), encoded by solute carrier family 6 member 4 (SLC6A4), regulates synaptic concentrations of serotonin and thereby strongly influences perception, mood, emotion, behavior, and cognition, all of which are severely disturbed in SZ. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 79-85 24130607-1 2013 OBJECTIVE: Several studies have implicated the 5-HTTLPR polymorphism in treatment outcomes of selective serotonin re-uptake inhibitors in patients with major depression. Serotonin 104-113 solute carrier family 6 member 4 Homo sapiens 47-55 23781172-3 2013 The regulation and functioning of serotonin is influenced by genetic risk factors, such as the serotonin transporter polymorphism in humans. Serotonin 34-43 solute carrier family 6 member 4 Homo sapiens 95-116 23594334-4 2013 The candidate genes include SLC6A4, CNR1, and TNFSF15 reflecting serotonin reuptake, cannabinoid receptors, and inflammatory-barrier functions. Serotonin 65-74 solute carrier family 6 member 4 Homo sapiens 28-34 23594365-2 2013 Serotonin signaling, including reduced serotonin transporter (SERT) expression, may be disrupted in IBS patients. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 39-60 23594365-2 2013 Serotonin signaling, including reduced serotonin transporter (SERT) expression, may be disrupted in IBS patients. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 62-66 23547754-4 2013 The present review is focused on the role of genes coding for serotonin receptors in MD pathogenesis, since the serotonin transporter and enzymes involved in serotonin metabolism have been reviewed elsewhere. Serotonin 62-71 solute carrier family 6 member 4 Homo sapiens 112-133 23409709-2 2013 The serotonin (5-hydroxytryptamine; 5-HT) transporter(SERT) in the brain clears 5-HT from extracellular spaces, modulating the strength and duration of serotonergic signaling.Outside the central nervous system, it is also present in platelets, where it takes up 5-HT from plasma, keeping levels very low (i.e., ~1 nM). Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 54-58 22921522-2 2013 The concentration of serotonin (5-hydroxytryptamine, 5-HT) in the synaptic cleft is essentially regulated by the 5-HT transporter (5-HTT). Serotonin 21-30 solute carrier family 6 member 4 Homo sapiens 113-129 22921522-2 2013 The concentration of serotonin (5-hydroxytryptamine, 5-HT) in the synaptic cleft is essentially regulated by the 5-HT transporter (5-HTT). Serotonin 21-30 solute carrier family 6 member 4 Homo sapiens 131-136 22921522-2 2013 The concentration of serotonin (5-hydroxytryptamine, 5-HT) in the synaptic cleft is essentially regulated by the 5-HT transporter (5-HTT). Serotonin 32-51 solute carrier family 6 member 4 Homo sapiens 113-129 22921522-2 2013 The concentration of serotonin (5-hydroxytryptamine, 5-HT) in the synaptic cleft is essentially regulated by the 5-HT transporter (5-HTT). Serotonin 32-51 solute carrier family 6 member 4 Homo sapiens 131-136 23266326-1 2013 BACKGROUND: The short (S) allele of the serotonin transporter gene (5-HTTLPR) is associated with reduced serotonin turnover compared to the long (L) allele in Caucasians. Serotonin 40-49 solute carrier family 6 member 4 Homo sapiens 68-76 23338678-3 2013 We first established that high-affinity serotonin uptake into C6 glioma cells occurs through a SERT-dependent mechanism. Serotonin 40-49 solute carrier family 6 member 4 Homo sapiens 95-99 23421681-4 2013 The 6-position of serotonin and the para-hydroxyl groups of dopamine and norepinephrine were found to face Ala173 in hSERT, Gly153 in hDAT, and Gly149 in hNET. Serotonin 18-27 solute carrier family 6 member 4 Homo sapiens 117-122 23421681-7 2013 Uptake experiments support that the 5-hydroxyl group of serotonin and the meta-hydroxyl group norepinephrine and dopamine are placed in the hydrophilic pocket around Ala173, Ser438, and Thr439 in hSERT corresponding to Gly149, Ser419, Ser420 in hNET and Gly153 Ser422 and Ala423 in hDAT. Serotonin 56-65 solute carrier family 6 member 4 Homo sapiens 196-201 23605455-5 2013 Additional functions of serotonin have recently been reported in which internalization of serotonin, through the serotonin transporter SERT, can exert important cytoskeletal functions in lieu of simply being degraded. Serotonin 24-33 solute carrier family 6 member 4 Homo sapiens 135-139 23605455-5 2013 Additional functions of serotonin have recently been reported in which internalization of serotonin, through the serotonin transporter SERT, can exert important cytoskeletal functions in lieu of simply being degraded. Serotonin 90-99 solute carrier family 6 member 4 Homo sapiens 135-139 23410504-2 2013 The serotonin transporter (SERT) determines the final serotonin availability and has been described as altered in inflammatory bowel diseases. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 23288844-1 2013 The serotonin transporter (SERT) maintains serotonergic neurotransmission via rapid reuptake of serotonin from the synaptic cleft. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 23274704-2 2013 We examined polymorphisms of the serotonin transporter (SLC6A4) and serotonin receptor 2A (HTR2A) genes for possible association with AD, and therefore genotyped 5-HTTLPR, STin2-VNTR and HTR2A T102C polymorphisms in 252 Hungarian AD patients and 234 ethnically matched control individuals. Serotonin 33-42 solute carrier family 6 member 4 Homo sapiens 56-62 23392679-3 2013 However, a significant 5-HTTLPR effect on receptor binding at the 5-HT(1A) receptor site has been reported in humans, suggesting the 5-HTTLPR polymorphism may play a role in serotonin (5-HT) function. Serotonin 174-183 solute carrier family 6 member 4 Homo sapiens 23-31 23392679-3 2013 However, a significant 5-HTTLPR effect on receptor binding at the 5-HT(1A) receptor site has been reported in humans, suggesting the 5-HTTLPR polymorphism may play a role in serotonin (5-HT) function. Serotonin 174-183 solute carrier family 6 member 4 Homo sapiens 133-141 23336039-2 2013 The most commonly prescribed class of antidepressants, the selective serotonin reuptake inhibitors (SSRIs), are thought to act by increasing extracellular serotonin in brain by blocking its uptake via the high-affinity serotonin transporter (SERT). Serotonin 69-78 solute carrier family 6 member 4 Homo sapiens 219-240 23336039-2 2013 The most commonly prescribed class of antidepressants, the selective serotonin reuptake inhibitors (SSRIs), are thought to act by increasing extracellular serotonin in brain by blocking its uptake via the high-affinity serotonin transporter (SERT). Serotonin 69-78 solute carrier family 6 member 4 Homo sapiens 242-246 23409709-2 2013 The serotonin (5-hydroxytryptamine; 5-HT) transporter(SERT) in the brain clears 5-HT from extracellular spaces, modulating the strength and duration of serotonergic signaling.Outside the central nervous system, it is also present in platelets, where it takes up 5-HT from plasma, keeping levels very low (i.e., ~1 nM). Serotonin 15-34 solute carrier family 6 member 4 Homo sapiens 54-58 22584237-2 2012 The 5-HTTLPR is a common genetic polymorphism within the promoter region of the gene coding for the serotonin transporter such that the S allele is associated with reduced transcriptional efficacy compared to the L allele, potentially contributing to increased serotonin levels. Serotonin 100-109 solute carrier family 6 member 4 Homo sapiens 4-12 24092348-5 2013 Serotonin is a vasoconstrictor and a potent mitogen for pulmonary smooth muscle cells (PA-SMC), an effect which depends upon activity of both the 5-HT transporter (5-HTT) and the 5-HT receptors. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 146-162 24092348-5 2013 Serotonin is a vasoconstrictor and a potent mitogen for pulmonary smooth muscle cells (PA-SMC), an effect which depends upon activity of both the 5-HT transporter (5-HTT) and the 5-HT receptors. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 164-169 23086945-1 2012 The serotonin transporter (SERT) and the norepinephrine transporter (NET) are sodium-dependent neurotransmitter transporters responsible for reuptake of released serotonin and norepinephrine, respectively, into nerve terminals in the brain. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 23007398-1 2012 The serotonin transporter (SERT) controls synaptic serotonin levels and is the primary target for antidepressants, including selective serotonin reuptake inhibitors (e.g. (S)-citalopram) and tricyclic antidepressants (e.g. clomipramine). Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 22683764-3 2012 Studies also indicate that inflammatory cytokines upregulate the serotonin transporter (SERT), representing another mechanism by which inflammation could influence serotonin availability. Serotonin 65-74 solute carrier family 6 member 4 Homo sapiens 88-92 22826533-1 2012 First line treatment of major depression is based on selective serotonin re-uptake inhibitors (SSRIs) that enhance serotonergic neurotransmission by blocking the serotonin transporter. Serotonin 63-72 solute carrier family 6 member 4 Homo sapiens 162-183 22940131-5 2012 Recent studies suggest that microRNA-16 (miR-16) targets serotonin transporter (SERT) involved in the serotonin (5-HT) transmitter system. Serotonin 57-66 solute carrier family 6 member 4 Homo sapiens 80-84 23019496-1 2012 The human serotonin transporter (hSERT), the human dopamine transporter (hDAT), and the human norepinephrine transporter (hNET) facilitate the active uptake of the neurotransmitters serotonin, dopamine, and norepinephrine from the synaptic cleft. Serotonin 10-19 solute carrier family 6 member 4 Homo sapiens 33-38 22826342-1 2012 Serotonin (5-HT) 5-HT(1A) autoreceptors (5-HT(1A)autoR) and the plasmalemmal 5-HT transporter (SERT) are key elements in the regulation of central 5-HT function and its responsiveness to antidepressant drugs. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 95-99 22390669-9 2012 Findings demonstrate that stress may affect adolescents" likelihood of experiencing anxious/depressed symptoms when they have a low serotonin TE (A/G-modified 5-HTTLPR) genotype and suggest that the vulnerability may be stronger in late than early adolescence. Serotonin 132-141 solute carrier family 6 member 4 Homo sapiens 159-167 22584237-9 2012 Our findings are consistent with a model wherein the 5-HTTLPR S allele is associated with relatively increased serotonin levels. Serotonin 111-120 solute carrier family 6 member 4 Homo sapiens 53-61 22348680-5 2012 This suggests that the higher synaptic availability of serotonin, associated with the low-functioning 5-HTTLPR genotypes, may confer differential susceptibility to decision making under risk, and that almost half of this effect is explained by facilitated somatic markers during IGT. Serotonin 55-64 solute carrier family 6 member 4 Homo sapiens 102-110 22451652-3 2012 Because of the structural similarity between ibogaine and serotonin, it had been suggested that ibogaine binds to the substrate site of SERT. Serotonin 58-67 solute carrier family 6 member 4 Homo sapiens 136-140 22038691-3 2012 Correlations of variation at one polymorphism located in the promoter region (known as 5HTTLPR) and variation at SLC6A4 expression levels, serotonin turnover and behaviour has been widely studied. Serotonin 139-148 solute carrier family 6 member 4 Homo sapiens 87-94 22038691-3 2012 Correlations of variation at one polymorphism located in the promoter region (known as 5HTTLPR) and variation at SLC6A4 expression levels, serotonin turnover and behaviour has been widely studied. Serotonin 139-148 solute carrier family 6 member 4 Homo sapiens 113-119 22038691-9 2012 Taken together our results suggest that the tandem repeat in the third intron of the SLC6A4 gene of Old World monkeys could constitute a second transcriptional regulator as suggested for the 5HTTLPR and therefore contribute to diversification of serotonin-related behaviour in these primates. Serotonin 246-255 solute carrier family 6 member 4 Homo sapiens 85-91 22038691-9 2012 Taken together our results suggest that the tandem repeat in the third intron of the SLC6A4 gene of Old World monkeys could constitute a second transcriptional regulator as suggested for the 5HTTLPR and therefore contribute to diversification of serotonin-related behaviour in these primates. Serotonin 246-255 solute carrier family 6 member 4 Homo sapiens 191-198 22431634-3 2012 Here, we test whether genetic variation in serotonin signaling in the form of a common human serotonin transporter polyadenylation polymorphism (STPP/rs3813034) is associated with spontaneous fear recovery after extinction. Serotonin 43-52 solute carrier family 6 member 4 Homo sapiens 93-114 22774398-2 2012 AIM: The links between the serotonin (5-HT) system and mood prompted us to investigate the 5-HT platelet transporter (SERT), which is considered a reliable, peripheral marker of the same structure present in presynaptic neurons, in 30 healthy volunteers before (t0) and 30 minutes after (t1) thermal balneotherapy with ozonized water, as compared with a similar group who underwent a bath in non-mineral water. Serotonin 27-36 solute carrier family 6 member 4 Homo sapiens 118-122 22557982-2 2012 Research has focused primarily on the serotonin transporter (SERT) due in part to its role in regulating extracellular levels of serotonin. Serotonin 38-47 solute carrier family 6 member 4 Homo sapiens 61-65 22072712-1 2012 Serotonin (5-HT) uptake by the human serotonin transporter (hSERT) is driven by ion gradients. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 37-58 22291010-6 2012 APP(+) uptake is Na(+)- and Cl(-)-dependent, displaced by 5HT, and inhibited by fluoxetine, suggesting APP(+) specifically monitors hSERT activity. Serotonin 58-61 solute carrier family 6 member 4 Homo sapiens 132-137 21951270-2 2012 Serotonin (5-HT) is actively cleared from synaptic cleft by serotonin transporter (5-HTT). Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 60-81 21951270-2 2012 Serotonin (5-HT) is actively cleared from synaptic cleft by serotonin transporter (5-HTT). Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 83-88 22457857-2 2012 The aim of this study was to evaluate the association between SLC6A4 polymorphism of SERT-P and serotonin (5-hydroxytryptamine, 5-HT) concentration in IBS as compared with controls. Serotonin 96-105 solute carrier family 6 member 4 Homo sapiens 62-68 22457857-2 2012 The aim of this study was to evaluate the association between SLC6A4 polymorphism of SERT-P and serotonin (5-hydroxytryptamine, 5-HT) concentration in IBS as compared with controls. Serotonin 96-105 solute carrier family 6 member 4 Homo sapiens 85-89 22457857-2 2012 The aim of this study was to evaluate the association between SLC6A4 polymorphism of SERT-P and serotonin (5-hydroxytryptamine, 5-HT) concentration in IBS as compared with controls. Serotonin 107-126 solute carrier family 6 member 4 Homo sapiens 62-68 22457857-2 2012 The aim of this study was to evaluate the association between SLC6A4 polymorphism of SERT-P and serotonin (5-hydroxytryptamine, 5-HT) concentration in IBS as compared with controls. Serotonin 107-126 solute carrier family 6 member 4 Homo sapiens 85-89 22072712-1 2012 Serotonin (5-HT) uptake by the human serotonin transporter (hSERT) is driven by ion gradients. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 60-65 21658141-11 2012 CONCLUSIONS: Bupropion and nortriptyline seem to be more effective in smoking cessation among SLC6A4 high-activity variant carriers, probably by blocking the increased serotonin transporter activity, thereby increasing serotonin levels. Serotonin 168-177 solute carrier family 6 member 4 Homo sapiens 94-100 21992875-14 2012 These results provide the first evidence that SERT tyrosine phosphorylation supports transporter protein stability and 5HT transport. Serotonin 119-122 solute carrier family 6 member 4 Homo sapiens 46-50 22158014-1 2012 The therapeutic effects induced by serotonin-selective reuptake inhibitor (SSRI) antidepressants are initially triggered by blocking the serotonin transporter and rely on long-term adaptations of pre- and post-synaptic receptors. Serotonin 35-44 solute carrier family 6 member 4 Homo sapiens 137-158 23095326-1 2012 OBJECTIVE: Various studies have shown that short (s)/long (l) polymorphisms of the serotonin transporter-linked polymorphic region (5-HTTLPR) might predict treatment outcome to selective serotonin reuptake inhibitors. Serotonin 83-92 solute carrier family 6 member 4 Homo sapiens 132-140 22150667-5 2012 We highlight the therapeutic possibilities of some drugs, especially selective serotonin re-uptake inhibitors (SSRIs), which reduce the hyperactivity of the serotonin transporter in NES and significantly improve the clinical picture of this disease. Serotonin 79-88 solute carrier family 6 member 4 Homo sapiens 157-178 22013141-10 2011 We hypothesize that the deficiency of serotonin transport may be part of a complex cellular membrane trafficking dysfunction involving not only the serotonin transporter but also other transporters and ion channels. Serotonin 38-47 solute carrier family 6 member 4 Homo sapiens 148-169 21901317-5 2012 RESULTS: The primary target for escitalopram is the serotonin transporter (SERT), which is responsible for serotonin (or 5-hydroxytryptamine [5-HT]) reuptake at the terminals and cell bodies of serotonergic neurons. Serotonin 52-61 solute carrier family 6 member 4 Homo sapiens 75-79 21901317-5 2012 RESULTS: The primary target for escitalopram is the serotonin transporter (SERT), which is responsible for serotonin (or 5-hydroxytryptamine [5-HT]) reuptake at the terminals and cell bodies of serotonergic neurons. Serotonin 121-140 solute carrier family 6 member 4 Homo sapiens 52-73 21901317-5 2012 RESULTS: The primary target for escitalopram is the serotonin transporter (SERT), which is responsible for serotonin (or 5-hydroxytryptamine [5-HT]) reuptake at the terminals and cell bodies of serotonergic neurons. Serotonin 121-140 solute carrier family 6 member 4 Homo sapiens 75-79 22745770-0 2012 Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression. Serotonin 85-94 solute carrier family 6 member 4 Homo sapiens 11-17 22047697-5 2011 Fluorescent serotonin analogs can be used for direct visualization of SERT distribution and activity in live tissue. Serotonin 12-21 solute carrier family 6 member 4 Homo sapiens 70-74 21970724-1 2011 The serotonin (5-hydroxytryptamine, 5-HT) transporter (SERT) protein plays a central role in terminating 5-HT neurotransmission and is the most important therapeutic target for the treatment of major depression and anxiety disorders. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 55-59 21970724-1 2011 The serotonin (5-hydroxytryptamine, 5-HT) transporter (SERT) protein plays a central role in terminating 5-HT neurotransmission and is the most important therapeutic target for the treatment of major depression and anxiety disorders. Serotonin 15-34 solute carrier family 6 member 4 Homo sapiens 55-59 22832606-1 2011 The serotonin transporter, called SLC6A4, SERT or 5-HTT, modulates neurotransmission by removal of serotonin from the synapse of serotonergic neurons, facilitating serotonin reuptake into the presynaptic terminus. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 34-40 22833193-1 2011 The serotonin transporter (SERT) is a key molecule involved in the homeostasis of extracellular levels of serotonin and is regulated developmentally. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 22833193-2 2011 Genetic deletion of SERT in rodents increases extracellular levels of serotonin and affects cellular processes involved in neocortical circuit assembly such as barrel cortex wiring and cortical interneuron migration. Serotonin 70-79 solute carrier family 6 member 4 Homo sapiens 20-24 20818612-2 2011 Serotonin (5-HT) depletion has been obtained via targeting of genes involved in 5-HT synthesis (Tph1 and Tph2), specification and determination of the 5-HT phenotype during development (GATA3, Pet1, and Lmx1b), and 5-HT storage or clearance (Vmat2 and SERT). Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 252-256 21834587-1 2011 The serotonin transporter (SERT), a member of the neurotransmitter sodium symporter (NSS) family, is responsible for the reuptake of serotonin from the synaptic cleft to maintain neurotransmitter homeostasis. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 22832606-1 2011 The serotonin transporter, called SLC6A4, SERT or 5-HTT, modulates neurotransmission by removal of serotonin from the synapse of serotonergic neurons, facilitating serotonin reuptake into the presynaptic terminus. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 42-46 22832606-1 2011 The serotonin transporter, called SLC6A4, SERT or 5-HTT, modulates neurotransmission by removal of serotonin from the synapse of serotonergic neurons, facilitating serotonin reuptake into the presynaptic terminus. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 50-55 22832606-1 2011 The serotonin transporter, called SLC6A4, SERT or 5-HTT, modulates neurotransmission by removal of serotonin from the synapse of serotonergic neurons, facilitating serotonin reuptake into the presynaptic terminus. Serotonin 99-108 solute carrier family 6 member 4 Homo sapiens 4-25 22832606-1 2011 The serotonin transporter, called SLC6A4, SERT or 5-HTT, modulates neurotransmission by removal of serotonin from the synapse of serotonergic neurons, facilitating serotonin reuptake into the presynaptic terminus. Serotonin 99-108 solute carrier family 6 member 4 Homo sapiens 34-40 22832606-1 2011 The serotonin transporter, called SLC6A4, SERT or 5-HTT, modulates neurotransmission by removal of serotonin from the synapse of serotonergic neurons, facilitating serotonin reuptake into the presynaptic terminus. Serotonin 99-108 solute carrier family 6 member 4 Homo sapiens 42-46 22832606-1 2011 The serotonin transporter, called SLC6A4, SERT or 5-HTT, modulates neurotransmission by removal of serotonin from the synapse of serotonergic neurons, facilitating serotonin reuptake into the presynaptic terminus. Serotonin 99-108 solute carrier family 6 member 4 Homo sapiens 50-55 21789812-0 2011 Yes, there is a "happiness" gene...but it"s not that simple...The 5-HTT gene that transports serotonin in the brain can lead to feelings of satisfaction in life. Serotonin 93-102 solute carrier family 6 member 4 Homo sapiens 66-71 21718840-10 2011 Importantly, enhanced 5HTR responsiveness due to increased 5HTR2A and 2B expression results in a significantly greater response in remodeling endpoints (proliferation, collagen, and GAG production) to 5HT in the presence of 5HT transporter blockade. Serotonin 22-25 solute carrier family 6 member 4 Homo sapiens 224-239 21329710-0 2011 Increased serotonin axons (immunoreactive to 5-HT transporter) in postmortem brains from young autism donors. Serotonin 10-19 solute carrier family 6 member 4 Homo sapiens 45-61 23983930-2 2011 Its putative mechanism of antidepressant action enhances the release of serotonin across the brain"s serotonergic pathways specifically by inhibiting the serotonin transporter, similar to a selective serotonin reuptake inhibitor (SSRI), and simultaneously stimulating serotonin-1a receptors via partial agonism, similar to the anxiolytic bus-pirone. Serotonin 72-81 solute carrier family 6 member 4 Homo sapiens 154-175 21545724-9 2011 Subsequent to combat-related trauma, these SLC6A4 polymorphisms may bias serotonin signaling and the neural circuitry mediating cognitive control of emotion in patients with PTSD. Serotonin 73-82 solute carrier family 6 member 4 Homo sapiens 43-49 21473030-0 2004 2beta-Carbo[(11)C]methoxy-3beta-(3 -((Z)-2-iodoethenyl)phenyl)nortropane Serotonin (5-hydroxytryptamine (5HT)) is a neurotransmitter that is transported across the cell membrane by the serotonin transporter (SERT or 5HTT) (1) and is expressed in several tissues of the body, such as those of the brain, lungs (2-4), bone (5, 6), gastrointestinal tract (7), blood platelets (8, 9), and the cardiovascular system (10-12). Serotonin 73-82 solute carrier family 6 member 4 Homo sapiens 208-212 21364196-9 2011 CONCLUSIONS: The 5-HTTLPR moderates cardiovascular reactivity to stress in a threatening evaluative social context, which suggests that the serotonin system may be involved in the processes by which stressful, conflict-ridden social environments affect risk for cardiovascular-related health outcomes. Serotonin 140-149 solute carrier family 6 member 4 Homo sapiens 17-25 21273531-1 2011 Serotonin transporter (SERT) regulates extracellular availability of serotonin and is a potential pharmacological target for gastrointestinal disorders. Serotonin 69-78 solute carrier family 6 member 4 Homo sapiens 0-21 21273531-1 2011 Serotonin transporter (SERT) regulates extracellular availability of serotonin and is a potential pharmacological target for gastrointestinal disorders. Serotonin 69-78 solute carrier family 6 member 4 Homo sapiens 23-27 21183371-1 2011 The known Gly56Ala mutation in the serotonin transporter SERT (or 5-HTT), encoded by the SLC6A4 gene, causes increased serotonin reuptake and has been associated with autism and rigid-compulsive behavior. Serotonin 35-44 solute carrier family 6 member 4 Homo sapiens 57-61 21183371-1 2011 The known Gly56Ala mutation in the serotonin transporter SERT (or 5-HTT), encoded by the SLC6A4 gene, causes increased serotonin reuptake and has been associated with autism and rigid-compulsive behavior. Serotonin 35-44 solute carrier family 6 member 4 Homo sapiens 89-95 21225419-5 2011 RESULTS: The majority of published studies have focused on candidates that regulate the serotonin system, especially the serotonin transporter. Serotonin 88-97 solute carrier family 6 member 4 Homo sapiens 121-142 21129485-1 2011 The serotonin transporter (SERT), a member of the solute carrier 6 family, is responsible for reuptake of the monoamine neurotransmitter serotonin (5-hydroxytryptamine) from the synaptic cleft on the neural cells, and a vital target for several antidepressants. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 21129485-1 2011 The serotonin transporter (SERT), a member of the solute carrier 6 family, is responsible for reuptake of the monoamine neurotransmitter serotonin (5-hydroxytryptamine) from the synaptic cleft on the neural cells, and a vital target for several antidepressants. Serotonin 148-167 solute carrier family 6 member 4 Homo sapiens 4-25 21129485-1 2011 The serotonin transporter (SERT), a member of the solute carrier 6 family, is responsible for reuptake of the monoamine neurotransmitter serotonin (5-hydroxytryptamine) from the synaptic cleft on the neural cells, and a vital target for several antidepressants. Serotonin 148-167 solute carrier family 6 member 4 Homo sapiens 27-31 21473026-0 2004 2beta-Carbo[(11)C]methoxy-3beta-(4 -((Z)-2-iodoethenyl)phenyl)nortropane Serotonin (5-hydroxytryptamine (5HT)) is a neurotransmitter that is transported across the cell membrane by the serotonin transporter (SERT or 5HTT) (1) and is expressed in several tissues of the body, such as those of the brain, lungs (2-4), bone (5, 6), gastrointestinal tract (7), blood platelets (8, 9), and the cardiovascular system (10-12). Serotonin 73-82 solute carrier family 6 member 4 Homo sapiens 208-212 21473026-0 2004 2beta-Carbo[(11)C]methoxy-3beta-(4 -((Z)-2-iodoethenyl)phenyl)nortropane Serotonin (5-hydroxytryptamine (5HT)) is a neurotransmitter that is transported across the cell membrane by the serotonin transporter (SERT or 5HTT) (1) and is expressed in several tissues of the body, such as those of the brain, lungs (2-4), bone (5, 6), gastrointestinal tract (7), blood platelets (8, 9), and the cardiovascular system (10-12). Serotonin 84-103 solute carrier family 6 member 4 Homo sapiens 208-212 21473035-0 2004 2beta-Carbo(2-[(18)F]fluoroethoxy)-3beta-(3 -((Z)-2-iodoethenyl)phenyl)nortropane Serotonin (5-hydroxytryptamine (5HT)) is a neurotransmitter that is transported across the cell membrane by the serotonin transporter (SERT or 5HTT) (1) and is expressed in several tissues of the body, such as those of the brain, lungs (2-4), bone (5, 6), gastrointestinal tract (7), blood platelets (8, 9), and the cardiovascular system (10-12). Serotonin 82-91 solute carrier family 6 member 4 Homo sapiens 217-221 21473037-0 2004 2beta-Carbo(2-[(18)F]fluoroethoxy)-3beta-(4 -((Z)-2-iodoethenyl)phenyl)nortropane Serotonin (5-hydroxytryptamine (5HT)) is a neurotransmitter that is transported across the cell membrane by the serotonin transporter (SERT or 5HTT) (1) and is expressed in several tissues of the body, such as those of the brain, lungs (2-4), bone (5, 6), gastrointestinal tract (7), blood platelets (8, 9), and the cardiovascular system (10-12). Serotonin 82-91 solute carrier family 6 member 4 Homo sapiens 194-215 21473037-0 2004 2beta-Carbo(2-[(18)F]fluoroethoxy)-3beta-(4 -((Z)-2-iodoethenyl)phenyl)nortropane Serotonin (5-hydroxytryptamine (5HT)) is a neurotransmitter that is transported across the cell membrane by the serotonin transporter (SERT or 5HTT) (1) and is expressed in several tissues of the body, such as those of the brain, lungs (2-4), bone (5, 6), gastrointestinal tract (7), blood platelets (8, 9), and the cardiovascular system (10-12). Serotonin 82-91 solute carrier family 6 member 4 Homo sapiens 217-221 21186266-3 2011 We have previously demonstrated that SERT transactivates PDGFRbeta in serotonin-stimulated PASMC proliferation. Serotonin 70-79 solute carrier family 6 member 4 Homo sapiens 37-41 20640435-1 2011 The role of a functional polymorphism in the transcriptional control region of serotonin transporter gene (5-HTTLPR, SERTPR) has been studied intensively in major depression and in the response to selective serotonin inhibitors (SSRIs) in major depression. Serotonin 79-88 solute carrier family 6 member 4 Homo sapiens 107-115 21183371-4 2011 These changes are reported to be responsible for elevated SERT activity and expression, suggesting that these alterations were responsible in our patient for low serotonin turnover in the central nervous system (CNS). Serotonin 162-171 solute carrier family 6 member 4 Homo sapiens 58-62 21183371-6 2011 We speculate that the mutated 56Ala SERT transporter with elevated expression and basal activity for serotonin re-uptake is accompanied with serotonin accumulation within pre-synaptic axons and their vesicles in the CNS, resulting in a steady-state of lowered serotonin turnover and degradation by monoamine-oxidase (MAO) enzymes in pre-synaptic or neighboring cells. Serotonin 101-110 solute carrier family 6 member 4 Homo sapiens 36-40 21183371-6 2011 We speculate that the mutated 56Ala SERT transporter with elevated expression and basal activity for serotonin re-uptake is accompanied with serotonin accumulation within pre-synaptic axons and their vesicles in the CNS, resulting in a steady-state of lowered serotonin turnover and degradation by monoamine-oxidase (MAO) enzymes in pre-synaptic or neighboring cells. Serotonin 141-150 solute carrier family 6 member 4 Homo sapiens 36-40 21183371-6 2011 We speculate that the mutated 56Ala SERT transporter with elevated expression and basal activity for serotonin re-uptake is accompanied with serotonin accumulation within pre-synaptic axons and their vesicles in the CNS, resulting in a steady-state of lowered serotonin turnover and degradation by monoamine-oxidase (MAO) enzymes in pre-synaptic or neighboring cells. Serotonin 141-150 solute carrier family 6 member 4 Homo sapiens 36-40 21473030-0 2004 2beta-Carbo[(11)C]methoxy-3beta-(3 -((Z)-2-iodoethenyl)phenyl)nortropane Serotonin (5-hydroxytryptamine (5HT)) is a neurotransmitter that is transported across the cell membrane by the serotonin transporter (SERT or 5HTT) (1) and is expressed in several tissues of the body, such as those of the brain, lungs (2-4), bone (5, 6), gastrointestinal tract (7), blood platelets (8, 9), and the cardiovascular system (10-12). Serotonin 84-103 solute carrier family 6 member 4 Homo sapiens 208-212 22778858-1 2011 The human serotonin (5-hydroxytryptamine, 5-HT) transporter (hSERT) is responsible for the reuptake of 5-HT following synaptic release, as well as for import of the biogenic amine into several non-5-HT synthesizing cells including platelets. Serotonin 10-19 solute carrier family 6 member 4 Homo sapiens 61-66 20974189-6 2011 Strikingly, only heterozygous serotonin transporter knockout pups experiencing high maternal care showed increased hippocampal levels of serotonin and norepinephrine and decreased serotonin turnover compared to wild-type littermates. Serotonin 137-146 solute carrier family 6 member 4 Homo sapiens 30-51 21912191-1 2011 OBJECTIVE: The purpose of this study was to evaluate the influences of major serotonin-related genetic variants of the serotonin transporter-linked promoter region (5-HTTLPR), tryptophan hydroxylase 1 gene (TPH1) and monoamine oxidase A gene (MAOA-EcoRV) on trait emotional intelligence (EI). Serotonin 77-86 solute carrier family 6 member 4 Homo sapiens 119-140 21439906-1 2011 Recent major findings from studies of SLC6A4 and its corresponding protein, the serotonin (5-HT) transporter (SERT) in humans, rodents and non-human primates indicate that combinations of SLC6A4 non-coding 5", 3" UTRs and intronic regions plus coding variants acting together can change 5HT transport as much as 40-fold in vitro. Serotonin 287-290 solute carrier family 6 member 4 Homo sapiens 38-44 21439906-1 2011 Recent major findings from studies of SLC6A4 and its corresponding protein, the serotonin (5-HT) transporter (SERT) in humans, rodents and non-human primates indicate that combinations of SLC6A4 non-coding 5", 3" UTRs and intronic regions plus coding variants acting together can change 5HT transport as much as 40-fold in vitro. Serotonin 287-290 solute carrier family 6 member 4 Homo sapiens 110-114 21439906-1 2011 Recent major findings from studies of SLC6A4 and its corresponding protein, the serotonin (5-HT) transporter (SERT) in humans, rodents and non-human primates indicate that combinations of SLC6A4 non-coding 5", 3" UTRs and intronic regions plus coding variants acting together can change 5HT transport as much as 40-fold in vitro. Serotonin 287-290 solute carrier family 6 member 4 Homo sapiens 188-194 20623110-3 2011 The serotonin transporter (SERT) protein is a key regulator in the serotonin system. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 20623110-4 2011 We hypothesized that higher performance on tests sensitive to serotonin would be associated with higher SERT levels in specific fronto-striatal brain regions. Serotonin 62-71 solute carrier family 6 member 4 Homo sapiens 104-108 21097501-1 2011 By transporting serotonin (5-HT) into neurons and other cells, serotonin transporter (SERT) modulates the action of 5-HT at cell surface receptors. Serotonin 16-25 solute carrier family 6 member 4 Homo sapiens 63-84 21097501-1 2011 By transporting serotonin (5-HT) into neurons and other cells, serotonin transporter (SERT) modulates the action of 5-HT at cell surface receptors. Serotonin 16-25 solute carrier family 6 member 4 Homo sapiens 86-90 20584994-2 2011 It has been suggested that the vulnerability to CO(2) is moderated by differences in serotonin (5-HT) activity, caused by a functional polymorphism in the promoter region of the 5-HT transporter (5-HTTLPR) gene. Serotonin 85-94 solute carrier family 6 member 4 Homo sapiens 178-194 20584994-2 2011 It has been suggested that the vulnerability to CO(2) is moderated by differences in serotonin (5-HT) activity, caused by a functional polymorphism in the promoter region of the 5-HT transporter (5-HTTLPR) gene. Serotonin 85-94 solute carrier family 6 member 4 Homo sapiens 196-204 20637736-1 2010 The serotonin transporter (SERT) regulates the serotonin concentration in the synapse and is a target of several antidepressant and psychostimulant drugs. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 20948451-4 2010 Basal extracellular serotonin, which is strongly influenced by serotonin transporter (SERT), was proposed as a potential trigger for this modulation; however, the data remain inconclusive. Serotonin 20-29 solute carrier family 6 member 4 Homo sapiens 63-84 20948451-4 2010 Basal extracellular serotonin, which is strongly influenced by serotonin transporter (SERT), was proposed as a potential trigger for this modulation; however, the data remain inconclusive. Serotonin 20-29 solute carrier family 6 member 4 Homo sapiens 86-90 20452607-6 2010 The serotonin transporter (5-HTT) is responsible for pre-synaptic re-uptake of serotonin, making this transporter a logical candidate gene for prediction of clozapine response and to increase understanding about mechanisms of refractoriness. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-32 20528162-6 2011 We identified a strong expression of the serotonin transporter and confirmed the high-affinity serotonin transporter-mediated uptake of serotonin (5-HT), along with uptake via the norepinephrine transporter, and an evidence of 5-HT breakdown due to the expression of the degradative enzymes monoamine oxidase A and B. Serotonin 41-50 solute carrier family 6 member 4 Homo sapiens 95-116 20889976-2 2010 SERT plays a crucial role in synaptic neurotransmission by retrieving released serotonin. Serotonin 79-88 solute carrier family 6 member 4 Homo sapiens 0-4 20598843-2 2010 Because the serotonin transporter (5-HTT) functions to remove serotonin from the synapse, it is thought that increased reuptake (indicated by the number of high-expressing L(A) alleles present in the 5-HTT gene-linked polymorphic region [5-HTTLPR] of the SLC6A4 gene) is associated with an increase in obsessive-compulsive alcohol craving. Serotonin 12-21 solute carrier family 6 member 4 Homo sapiens 35-40 20073575-9 2010 Finally, exposure of the cells to serotonin promoted an increase in MSCs apoptosis prevented by pargyline and the SERT inhibitor imipramine. Serotonin 34-43 solute carrier family 6 member 4 Homo sapiens 114-118 20096463-13 2010 CONCLUSIONS: Our study showed that serotonin polymorphism (5-HTTLPR) is strongly associated with violent suicidal behavior in BD patients. Serotonin 35-44 solute carrier family 6 member 4 Homo sapiens 59-67 21098407-9 2010 CONCLUSION: Depressive symptoms in antidepressant-naive patients with PD correlate with relatively higher 5-HTT binding in raphe nuclei and limbic structures possibly reflecting lower extracellular serotonin levels. Serotonin 198-207 solute carrier family 6 member 4 Homo sapiens 106-111 20416884-4 2010 We hypothesized that the short allele of the 5-HTTLPR polymorphism in the serotonin transporter gene, which is associated with lower serotonin activity, would moderate the relation between depressive feelings and the increase in emotional eating, particularly in females. Serotonin 74-83 solute carrier family 6 member 4 Homo sapiens 45-53 20598843-2 2010 Because the serotonin transporter (5-HTT) functions to remove serotonin from the synapse, it is thought that increased reuptake (indicated by the number of high-expressing L(A) alleles present in the 5-HTT gene-linked polymorphic region [5-HTTLPR] of the SLC6A4 gene) is associated with an increase in obsessive-compulsive alcohol craving. Serotonin 12-21 solute carrier family 6 member 4 Homo sapiens 200-205 20598843-2 2010 Because the serotonin transporter (5-HTT) functions to remove serotonin from the synapse, it is thought that increased reuptake (indicated by the number of high-expressing L(A) alleles present in the 5-HTT gene-linked polymorphic region [5-HTTLPR] of the SLC6A4 gene) is associated with an increase in obsessive-compulsive alcohol craving. Serotonin 12-21 solute carrier family 6 member 4 Homo sapiens 238-246 20598843-2 2010 Because the serotonin transporter (5-HTT) functions to remove serotonin from the synapse, it is thought that increased reuptake (indicated by the number of high-expressing L(A) alleles present in the 5-HTT gene-linked polymorphic region [5-HTTLPR] of the SLC6A4 gene) is associated with an increase in obsessive-compulsive alcohol craving. Serotonin 12-21 solute carrier family 6 member 4 Homo sapiens 255-261 19936882-5 2010 The main target of antidepressant treatments belonging to the serotonin selective reuptake inhibitors (SSRI) type is the serotonin transporter (SERT); a well-studied polymorphic variant, in the promoter region of the gene (SERTPR), has been demonstrated to influence the availability of serotonin in the synaptic cleft. Serotonin 62-71 solute carrier family 6 member 4 Homo sapiens 121-142 20524964-1 2010 The serotonin transporter (SERT) mediates clearance of serotonin from the synapse, thereby, regulating extracellular serotonin concentrations. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 20524964-1 2010 The serotonin transporter (SERT) mediates clearance of serotonin from the synapse, thereby, regulating extracellular serotonin concentrations. Serotonin 55-64 solute carrier family 6 member 4 Homo sapiens 4-25 20524964-1 2010 The serotonin transporter (SERT) mediates clearance of serotonin from the synapse, thereby, regulating extracellular serotonin concentrations. Serotonin 55-64 solute carrier family 6 member 4 Homo sapiens 27-31 20729489-0 2010 Molecular mechanisms of SERT in platelets: regulation of plasma serotonin levels. Serotonin 64-73 solute carrier family 6 member 4 Homo sapiens 24-28 20664233-1 2010 BACKGROUND: Polymorphisms of serotonin transporter, especially serotonin transporter linked promoter region (5- HTTLPR) and serotonin transporter intron 2 variable number tandem repeat (5-HTTVNTR), have been suggested to be associated with treatment response to selective serotonin reuptake inhibitors. Serotonin 29-38 solute carrier family 6 member 4 Homo sapiens 63-84 20664233-1 2010 BACKGROUND: Polymorphisms of serotonin transporter, especially serotonin transporter linked promoter region (5- HTTLPR) and serotonin transporter intron 2 variable number tandem repeat (5-HTTVNTR), have been suggested to be associated with treatment response to selective serotonin reuptake inhibitors. Serotonin 29-38 solute carrier family 6 member 4 Homo sapiens 63-84 20110086-4 2010 Furthermore, in the putamen, an anatomic region with relatively dense serotonin innervation, we found a significant gene x daylight effect, such that there was a negative correlation between 5-HTT binding and daylight minutes in carriers of the short 5-HTTLPR allele but not in homozygote carriers of the long allele. Serotonin 70-79 solute carrier family 6 member 4 Homo sapiens 251-259 20729489-1 2010 The serotonin transporter (SERT) on platelets is a primary mechanism for serotonin (5HT) uptake from the blood plasma. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 20729489-1 2010 The serotonin transporter (SERT) on platelets is a primary mechanism for serotonin (5HT) uptake from the blood plasma. Serotonin 84-87 solute carrier family 6 member 4 Homo sapiens 4-25 20729489-1 2010 The serotonin transporter (SERT) on platelets is a primary mechanism for serotonin (5HT) uptake from the blood plasma. Serotonin 84-87 solute carrier family 6 member 4 Homo sapiens 27-31 20729489-5 2010 Specifically, in platelets, plasma membrane SERT levels and platelet 5HT uptake initially rise as plasma 5HT levels are increased but then fall below normal as the plasma 5HT level continues to rise. Serotonin 105-108 solute carrier family 6 member 4 Homo sapiens 44-48 20729489-5 2010 Specifically, in platelets, plasma membrane SERT levels and platelet 5HT uptake initially rise as plasma 5HT levels are increased but then fall below normal as the plasma 5HT level continues to rise. Serotonin 105-108 solute carrier family 6 member 4 Homo sapiens 44-48 20729489-6 2010 Therefore, we propose that elevated plasma 5HT limits its own uptake in platelets by down-regulating SERT as well as modifying the characteristics of SERT partners in the membrane trafficking pathway. Serotonin 43-46 solute carrier family 6 member 4 Homo sapiens 101-105 20729489-6 2010 Therefore, we propose that elevated plasma 5HT limits its own uptake in platelets by down-regulating SERT as well as modifying the characteristics of SERT partners in the membrane trafficking pathway. Serotonin 43-46 solute carrier family 6 member 4 Homo sapiens 150-154 20729489-7 2010 This review will summarize current findings regarding the biochemical mechanisms by which elevated 5HT downregulates the expression of SERT on the platelet membrane. Serotonin 99-102 solute carrier family 6 member 4 Homo sapiens 135-139 20394820-5 2010 Our results also suggest that serotonin levels during early development determine later sensitivity of spheroid formation to manipulations of the serotonin transporter (SERT). Serotonin 30-39 solute carrier family 6 member 4 Homo sapiens 146-167 20394820-5 2010 Our results also suggest that serotonin levels during early development determine later sensitivity of spheroid formation to manipulations of the serotonin transporter (SERT). Serotonin 30-39 solute carrier family 6 member 4 Homo sapiens 169-173 20739786-3 2010 It is also well known that dopamine and serotonin transporters (DAT and SERT) are monoamine neurotransmitter transporters, which participate in the metabolism of DA and 5-HT, respectively. Serotonin 40-49 solute carrier family 6 member 4 Homo sapiens 72-76 20739786-3 2010 It is also well known that dopamine and serotonin transporters (DAT and SERT) are monoamine neurotransmitter transporters, which participate in the metabolism of DA and 5-HT, respectively. Serotonin 169-173 solute carrier family 6 member 4 Homo sapiens 72-76 20052688-2 2010 Tryptophan hydroxylase (TPH), the rate limiting enzyme of serotonin biosynthesis and the serotonin transporter (SLC6A4), involved in the reuptake of serotonin from the synaptic gap, play major role in serotonergic signaling. Serotonin 89-98 solute carrier family 6 member 4 Homo sapiens 112-118 20518729-7 2010 These lines of evidences encourage us to design new generation 5-HT(1A) ligands such as 5-HT(1A) agonists with greater potency, higher selectivity and improved pharmacokinetic properties, and 5-HT(1A) ligands which combine multiple pharmacological actions (e.g., inhibition of serotonin transporter, dopamine D(2) receptors and other 5-HT receptor subtypes). Serotonin 63-67 solute carrier family 6 member 4 Homo sapiens 277-298 19936882-5 2010 The main target of antidepressant treatments belonging to the serotonin selective reuptake inhibitors (SSRI) type is the serotonin transporter (SERT); a well-studied polymorphic variant, in the promoter region of the gene (SERTPR), has been demonstrated to influence the availability of serotonin in the synaptic cleft. Serotonin 62-71 solute carrier family 6 member 4 Homo sapiens 144-148 19936882-5 2010 The main target of antidepressant treatments belonging to the serotonin selective reuptake inhibitors (SSRI) type is the serotonin transporter (SERT); a well-studied polymorphic variant, in the promoter region of the gene (SERTPR), has been demonstrated to influence the availability of serotonin in the synaptic cleft. Serotonin 121-130 solute carrier family 6 member 4 Homo sapiens 144-148 20592043-3 2010 Genetic association studies suggest that variation within the genes of central neurotransmitter systems, particularly the serotonin (5-HTTLPR, MAOA-uVNTR) and opioid (OPRM1 A118G), are associated with individual differences in social sensitivity, which reflects the degree of emotional responsivity to social events and experiences. Serotonin 122-131 solute carrier family 6 member 4 Homo sapiens 133-141 20332182-1 2010 Monoamine oxidase A (MAOA) and the transporters for serotonin (5-HTT) and norepinephrine (NET) may play important roles in regulating maternal monoamine neurotransmitters transferred across the placenta to the fetus. Serotonin 52-61 solute carrier family 6 member 4 Homo sapiens 63-68 20332182-7 2010 Placentas with the 5-HTTLPR short (S)-allele (S/S+S/L) had significantly lower 5-HTT mRNA levels and serotonin uptake rate than those homozygous for the long (L)-allele (L/L) (mRNA: P < 0.001; serotonin transporting activity: P < 0.001). Serotonin 101-110 solute carrier family 6 member 4 Homo sapiens 19-27 20332182-7 2010 Placentas with the 5-HTTLPR short (S)-allele (S/S+S/L) had significantly lower 5-HTT mRNA levels and serotonin uptake rate than those homozygous for the long (L)-allele (L/L) (mRNA: P < 0.001; serotonin transporting activity: P < 0.001). Serotonin 101-110 solute carrier family 6 member 4 Homo sapiens 19-24 20332182-7 2010 Placentas with the 5-HTTLPR short (S)-allele (S/S+S/L) had significantly lower 5-HTT mRNA levels and serotonin uptake rate than those homozygous for the long (L)-allele (L/L) (mRNA: P < 0.001; serotonin transporting activity: P < 0.001). Serotonin 196-205 solute carrier family 6 member 4 Homo sapiens 19-27 20332182-7 2010 Placentas with the 5-HTTLPR short (S)-allele (S/S+S/L) had significantly lower 5-HTT mRNA levels and serotonin uptake rate than those homozygous for the long (L)-allele (L/L) (mRNA: P < 0.001; serotonin transporting activity: P < 0.001). Serotonin 196-205 solute carrier family 6 member 4 Homo sapiens 19-24 20118234-1 2010 The serotonin transporter (SERT) terminates neurotransmission by removing serotonin from the synaptic cleft. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 20480448-4 2010 Three results from recent IN SILICO experiments with the dopaminergic and serotonergic synapse models are described: (1) influence of substrate inhibition on the stability of dopamine and serotonin synthesis; (2) a predicted connection between serotonin reuptake transporter (SERT) density on terminals and tonic firing rates; (3) an explanation of data from autoreceptor knock-out experiments. Serotonin 188-197 solute carrier family 6 member 4 Homo sapiens 244-274 20480448-4 2010 Three results from recent IN SILICO experiments with the dopaminergic and serotonergic synapse models are described: (1) influence of substrate inhibition on the stability of dopamine and serotonin synthesis; (2) a predicted connection between serotonin reuptake transporter (SERT) density on terminals and tonic firing rates; (3) an explanation of data from autoreceptor knock-out experiments. Serotonin 188-197 solute carrier family 6 member 4 Homo sapiens 276-280 20207008-1 2010 Dysfunctions in serotonin neurotransmission have been implicated in some psychiatric disorders, and in particular, altered serotonin transporter function has been noted in panic disorder. Serotonin 16-25 solute carrier family 6 member 4 Homo sapiens 123-144 19948720-9 2010 Consonant with the well established competitive inhibition of uptake by TCAs, the resulting binding site for TCAs in hSERT is fully overlapping with the serotonin binding site in hSERT and dissimilar to the low affinity noncompetitive TCA site reported in the leucine transporter (LeuT). Serotonin 153-162 solute carrier family 6 member 4 Homo sapiens 117-122 19997855-9 2010 The results suggest that an assessment of SERT function in platelets may help to elucidate the differences between IBS patients in response to drugs affecting the 5HT system. Serotonin 163-166 solute carrier family 6 member 4 Homo sapiens 42-46 20043001-2 2010 We tested the hypothesis that variations in serotonergic genes (TPH2, TPH1, SLC6A4, HTR1A), which influence serotonin availability, affect choice behavior in a probabilistic gambling task. Serotonin 108-117 solute carrier family 6 member 4 Homo sapiens 76-82 19948720-9 2010 Consonant with the well established competitive inhibition of uptake by TCAs, the resulting binding site for TCAs in hSERT is fully overlapping with the serotonin binding site in hSERT and dissimilar to the low affinity noncompetitive TCA site reported in the leucine transporter (LeuT). Serotonin 153-162 solute carrier family 6 member 4 Homo sapiens 179-184 20006597-1 2010 The serotonin transporter (SERT) terminates serotonergic neurotransmission by the rapid removal of serotonin (5-hydroxytryptamine, 5-HT) from the extracellular space back into serotonergic neurons. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 20006597-1 2010 The serotonin transporter (SERT) terminates serotonergic neurotransmission by the rapid removal of serotonin (5-hydroxytryptamine, 5-HT) from the extracellular space back into serotonergic neurons. Serotonin 110-129 solute carrier family 6 member 4 Homo sapiens 4-25 20006597-1 2010 The serotonin transporter (SERT) terminates serotonergic neurotransmission by the rapid removal of serotonin (5-hydroxytryptamine, 5-HT) from the extracellular space back into serotonergic neurons. Serotonin 110-129 solute carrier family 6 member 4 Homo sapiens 27-31 19853044-10 2010 Higher mean regional BP(ND) values in HIV-D compared to HIV-ND subjects could reflect increased density of 5-HTT, leading to increased clearance of serotonin from the synapse, which could account, in part, for symptoms of depression. Serotonin 148-157 solute carrier family 6 member 4 Homo sapiens 107-112 20203198-2 2010 Within the serotonin transmitter system, both the postsynaptically located serotonin 2A (5-HT(2A)) receptor and the presynaptic serotonin transporter (SERT) are sensitive to chronic changes in cerebral 5-HT levels. Serotonin 11-20 solute carrier family 6 member 4 Homo sapiens 128-149 20203198-2 2010 Within the serotonin transmitter system, both the postsynaptically located serotonin 2A (5-HT(2A)) receptor and the presynaptic serotonin transporter (SERT) are sensitive to chronic changes in cerebral 5-HT levels. Serotonin 11-20 solute carrier family 6 member 4 Homo sapiens 151-155 20586185-2 2010 Serotonin transporter regulates the levels of serotonin by the reuptake of this neurotransmitter from the synaptic cleft. Serotonin 46-55 solute carrier family 6 member 4 Homo sapiens 0-21 19885717-2 2010 An insertion/deletion (L/S) promoter polymorphism (5-HTTLPR) of the 5-HT transporter (5-HHT) gene (SLC6A4) has been shown to influence transcriptional activity. Serotonin 51-55 solute carrier family 6 member 4 Homo sapiens 99-105 20145277-3 2010 Building on recent studies of genetic variation in the serotonin system, particularly focusing on a polymorphism (5-HTTLPR) in the serotonin transporter gene, we provide evidence that activity within the serotonin system is critically involved in setting sensitivity to social experiences. Serotonin 55-64 solute carrier family 6 member 4 Homo sapiens 114-122 20145277-3 2010 Building on recent studies of genetic variation in the serotonin system, particularly focusing on a polymorphism (5-HTTLPR) in the serotonin transporter gene, we provide evidence that activity within the serotonin system is critically involved in setting sensitivity to social experiences. Serotonin 55-64 solute carrier family 6 member 4 Homo sapiens 131-152 20145277-3 2010 Building on recent studies of genetic variation in the serotonin system, particularly focusing on a polymorphism (5-HTTLPR) in the serotonin transporter gene, we provide evidence that activity within the serotonin system is critically involved in setting sensitivity to social experiences. Serotonin 131-140 solute carrier family 6 member 4 Homo sapiens 114-122 20145277-9 2010 The serotonin system, as indexed by the 5-HTTLPR, is an important link between the social environment and health. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 40-48 19963284-2 2010 These drugs target the serotonin transporter (5-HTT) and increase serotonin signalling. Serotonin 23-32 solute carrier family 6 member 4 Homo sapiens 46-51 20352073-2 2010 Here, we use chronoamperometry to investigate variations in serotonin transport in primary lymphocytes associated with the rhesus serotonin transporter gene-linked polymorphism (rh5-HTTLPR), a promoter polymorphism whose orthologs occur only in higher order primates including humans. Serotonin 60-69 solute carrier family 6 member 4 Homo sapiens 130-151 20204739-5 2010 Serotonin then acts at the 5-HT(1B) receptor and the SERT to mediate constriction and proliferation of pulmonary artery smooth muscle cells. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 53-57 19549114-1 2010 OBJECTIVE: To test the hypothesis that polymorphism within the gene-linked polymorphic region (5-HTTLPR) and second intron of SLC6A4 gene (STin2) is associated with selective serotonin-reuptake inhibitors (SSRIs) response in subjects with premature ejaculation (PE). Serotonin 175-184 solute carrier family 6 member 4 Homo sapiens 95-103 19549114-1 2010 OBJECTIVE: To test the hypothesis that polymorphism within the gene-linked polymorphic region (5-HTTLPR) and second intron of SLC6A4 gene (STin2) is associated with selective serotonin-reuptake inhibitors (SSRIs) response in subjects with premature ejaculation (PE). Serotonin 175-184 solute carrier family 6 member 4 Homo sapiens 126-132 20373668-5 2010 Among the earliest "target genes" was the serotonin transporter gene (SLC6A4) which has variants that have been shown to influence the clinical response of patients of European ancestry when they are treated with selective serotonin reuptake inhibitors. Serotonin 42-51 solute carrier family 6 member 4 Homo sapiens 70-76 19699062-6 2010 This indicates that the 5-HTTLPR ss homozygous genotype might influence serotonin function affecting susceptibility to both borderline-specific, depressive, anxious and obsessive-compulsive symptoms in BPD, and leading to a more severe symptomatology related to these clinical features. Serotonin 72-81 solute carrier family 6 member 4 Homo sapiens 24-32 19837674-1 2009 Serotonin transporter (SERT) is responsible for the re-uptake of 5-hydroxytryptamine (5-HT) from the synaptic cleft after release from serotonergic neurons. Serotonin 65-84 solute carrier family 6 member 4 Homo sapiens 0-21 19897250-2 2009 Six polymorphisms in four genes related to the serotonin system, including the HTTLPR and HTTVNTR in the SLC6A4 gene, rs6295 in the HTR1A gene, rs11568817 and rs130058 in the HTR1B gene, and rs6313 in the HTR2A gene, were studied in 420 patients with MD to investigate the relationship between these genes and suicidal ideation in MD. Serotonin 47-56 solute carrier family 6 member 4 Homo sapiens 105-111 19837674-1 2009 Serotonin transporter (SERT) is responsible for the re-uptake of 5-hydroxytryptamine (5-HT) from the synaptic cleft after release from serotonergic neurons. Serotonin 65-84 solute carrier family 6 member 4 Homo sapiens 23-27 19747920-1 2009 BACKGROUND & AIMS: Serotonin transporter (SERT) plays a critical role in regulating serotonin (5-hydroxytryptamine [5-HT]) availability in the gut. Serotonin 88-97 solute carrier family 6 member 4 Homo sapiens 23-44 19912224-1 2009 BACKGROUND AND PURPOSE: Although the amino acid sequences of rat and human 5-hydroxytryptamine (5-HT) and noradrenaline (NA) transporters (i.e. SERT and NET) are highly homologous, species differences exist in the inhibitory effects of drugs acting at these transporters. Serotonin 75-94 solute carrier family 6 member 4 Homo sapiens 144-148 19747920-1 2009 BACKGROUND & AIMS: Serotonin transporter (SERT) plays a critical role in regulating serotonin (5-hydroxytryptamine [5-HT]) availability in the gut. Serotonin 88-97 solute carrier family 6 member 4 Homo sapiens 46-50 19747920-1 2009 BACKGROUND & AIMS: Serotonin transporter (SERT) plays a critical role in regulating serotonin (5-hydroxytryptamine [5-HT]) availability in the gut. Serotonin 99-118 solute carrier family 6 member 4 Homo sapiens 23-44 19747920-1 2009 BACKGROUND & AIMS: Serotonin transporter (SERT) plays a critical role in regulating serotonin (5-hydroxytryptamine [5-HT]) availability in the gut. Serotonin 99-118 solute carrier family 6 member 4 Homo sapiens 46-50 19570226-3 2009 The serotonin transporter (5-HTT) is a key regulator of serotonin metabolism and availability and its gene harbors several known polymorphisms that are known to affect 5-HTT expression (e.g. 5-HTTLPR, rs25531). Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 191-199 19722525-2 2009 In general, this series of compounds potently blocked the human norepinephrine transporter (hNET) while exhibiting selectivity at hNET against both the human serotonin (hSERT) and dopamine transporters (hDAT). Serotonin 158-167 solute carrier family 6 member 4 Homo sapiens 169-174 19549517-7 2009 Heterologous expression of the two cDNAs in mammalian cells resulted in saturable, sodium-dependent serotonin transport activity with an apparent affinity for serotonin comparable to that of the human serotonin transporter. Serotonin 100-109 solute carrier family 6 member 4 Homo sapiens 201-222 19387615-2 2009 This prefrontal-limbic interaction has been shown to be modulated by serotonin (5-HTT) genotype, indicating a higher risk for major depressive disorder (MDD) with increasing number of 5-HTT low-expression alleles. Serotonin 69-78 solute carrier family 6 member 4 Homo sapiens 80-85 19387615-2 2009 This prefrontal-limbic interaction has been shown to be modulated by serotonin (5-HTT) genotype, indicating a higher risk for major depressive disorder (MDD) with increasing number of 5-HTT low-expression alleles. Serotonin 69-78 solute carrier family 6 member 4 Homo sapiens 184-189 19849804-6 2009 This hypothesis implies that reduction of SERT activity should increase postsynaptic serotonin transmission and relieve NES. Serotonin 85-94 solute carrier family 6 member 4 Homo sapiens 42-46 19638296-7 2009 As the 5-HTTLPR polymorphism is associated with genetically defined alteration in the brain serotonergic neurotransmission our result provides an evidence of the involvement of the central serotonin system in creativity regulation. Serotonin 189-198 solute carrier family 6 member 4 Homo sapiens 7-15 19910872-1 2009 OBJECTIVE: The authors attempted to understand the role of two serotonin system genes, HTR2A and SLC6A4, on psychosis associated with Alzheimer dementia (AD). Serotonin 63-72 solute carrier family 6 member 4 Homo sapiens 97-103 19238308-2 2009 We show that both selective serotonin re-uptake inhibitors (SSRIs) and tricyclic anti-depressants (TCAs) increase the risk of hip/femur fracture and that this risk is time related and depends on the degree of serotonin transporter inhibition. Serotonin 28-37 solute carrier family 6 member 4 Homo sapiens 209-230 19560507-1 2009 BACKGROUND: Four serotonin-related genes including guanine nucleotide binding protein beta polypeptide 3 (GNB3), 5-hydroxytryptamine receptor 1A (HTR1A; serotonin receptor 1A), 5-hydroxytryptamine receptor 2A (HTR2A; serotonin receptor 2A), and solute carrier family 6 member 4 (SLC6A4; serotonin neurotransmitter transporter) have been suggested to be candidate genes for influencing antidepressant treatment outcome. Serotonin 17-26 solute carrier family 6 member 4 Homo sapiens 245-277 19560507-1 2009 BACKGROUND: Four serotonin-related genes including guanine nucleotide binding protein beta polypeptide 3 (GNB3), 5-hydroxytryptamine receptor 1A (HTR1A; serotonin receptor 1A), 5-hydroxytryptamine receptor 2A (HTR2A; serotonin receptor 2A), and solute carrier family 6 member 4 (SLC6A4; serotonin neurotransmitter transporter) have been suggested to be candidate genes for influencing antidepressant treatment outcome. Serotonin 17-26 solute carrier family 6 member 4 Homo sapiens 279-285 19713975-1 2009 Serotonin (5-hydroxytryptamine (5-HT)) transporter (SLC6A4) is known to influence mood, emotion, cognition and efficacy of antidepressants, particularly that of selective serotonin reuptake inhibitors. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 52-58 19713975-1 2009 Serotonin (5-hydroxytryptamine (5-HT)) transporter (SLC6A4) is known to influence mood, emotion, cognition and efficacy of antidepressants, particularly that of selective serotonin reuptake inhibitors. Serotonin 171-180 solute carrier family 6 member 4 Homo sapiens 52-58 19500602-1 2009 The human serotonin transporter (hSERT) is responsible for reuptake of serotonin (5-HT) from the synaptic cleft and is target for antidepressant medicine. Serotonin 10-19 solute carrier family 6 member 4 Homo sapiens 33-38 19286424-3 2009 The rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (SERT) and serotonin can induce pulmonary vasoconstriction via the 5-HT1B receptor in man. Serotonin 56-65 solute carrier family 6 member 4 Homo sapiens 184-205 18792946-1 2009 Through active reuptake of serotonin into presynaptic neurons, the serotonin transporter (5-HTT) plays an important role in regulating serotonin concentrations in the brain, and it is the site of binding for tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs). Serotonin 27-36 solute carrier family 6 member 4 Homo sapiens 67-88 18792946-1 2009 Through active reuptake of serotonin into presynaptic neurons, the serotonin transporter (5-HTT) plays an important role in regulating serotonin concentrations in the brain, and it is the site of binding for tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs). Serotonin 27-36 solute carrier family 6 member 4 Homo sapiens 90-95 18792946-1 2009 Through active reuptake of serotonin into presynaptic neurons, the serotonin transporter (5-HTT) plays an important role in regulating serotonin concentrations in the brain, and it is the site of binding for tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs). Serotonin 67-76 solute carrier family 6 member 4 Homo sapiens 90-95 19286424-3 2009 The rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (SERT) and serotonin can induce pulmonary vasoconstriction via the 5-HT1B receptor in man. Serotonin 56-65 solute carrier family 6 member 4 Homo sapiens 207-211 19286424-3 2009 The rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (SERT) and serotonin can induce pulmonary vasoconstriction via the 5-HT1B receptor in man. Serotonin 102-111 solute carrier family 6 member 4 Homo sapiens 184-205 19286424-3 2009 The rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (SERT) and serotonin can induce pulmonary vasoconstriction via the 5-HT1B receptor in man. Serotonin 102-111 solute carrier family 6 member 4 Homo sapiens 207-211 19286424-3 2009 The rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (SERT) and serotonin can induce pulmonary vasoconstriction via the 5-HT1B receptor in man. Serotonin 102-111 solute carrier family 6 member 4 Homo sapiens 184-205 19286424-3 2009 The rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (SERT) and serotonin can induce pulmonary vasoconstriction via the 5-HT1B receptor in man. Serotonin 102-111 solute carrier family 6 member 4 Homo sapiens 207-211 19272758-1 2009 Several studies and meta-analyses have implicated a polymorphism in the promoter region of the serotonin transporter (5-HTT) gene, 5-HTTLPR in treatment outcomes of selective serotonin re-uptake inhibitors in patients with major depression. Serotonin 95-104 solute carrier family 6 member 4 Homo sapiens 131-139 19429111-5 2009 The present study is to investigate the association between the polymorphisms in the promoter of the 5-HTT gene (including 5-HTTLPR and rs25531), which determine either a higher or lower 5-HT uptake, and risk for depression of PD. Serotonin 101-105 solute carrier family 6 member 4 Homo sapiens 123-131 18792946-1 2009 Through active reuptake of serotonin into presynaptic neurons, the serotonin transporter (5-HTT) plays an important role in regulating serotonin concentrations in the brain, and it is the site of binding for tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs). Serotonin 67-76 solute carrier family 6 member 4 Homo sapiens 90-95 18581270-1 2009 The serotonin transporter (SERT) belongs to a family of sodium- and chloride-dependent neurotransmitter transporters that are responsible for the active re-uptake of the neurotransmitter serotonin from the synapse. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 19213730-1 2009 The serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 19213730-1 2009 The serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. Serotonin 78-97 solute carrier family 6 member 4 Homo sapiens 4-25 19213730-1 2009 The serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. Serotonin 78-97 solute carrier family 6 member 4 Homo sapiens 27-31 19213730-1 2009 The serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. Serotonin 99-102 solute carrier family 6 member 4 Homo sapiens 4-25 19213730-1 2009 The serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. Serotonin 99-102 solute carrier family 6 member 4 Homo sapiens 27-31 19213730-1 2009 The serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. Serotonin 133-136 solute carrier family 6 member 4 Homo sapiens 4-25 19213730-1 2009 The serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. Serotonin 133-136 solute carrier family 6 member 4 Homo sapiens 27-31 19213730-6 2009 We have identified a residue (Ser-438) located within the 5HT-binding pocket in hSERT to be a critical determinant for the potency of several antidepressants, including the selective serotonin reuptake inhibitor citalopram and the tricyclic antidepressants imipramine, clomipramine, and amitriptyline. Serotonin 58-61 solute carrier family 6 member 4 Homo sapiens 80-85 19213730-9 2009 This suggests that these antidepressants interact directly with Ser-438 during binding to hSERT, implying an overlapping localization of substrate- and inhibitor-binding sites in hSERT suggesting that antidepressants function by a mechanism that involves direct occlusion of the 5HT-binding site. Serotonin 279-282 solute carrier family 6 member 4 Homo sapiens 90-95 19704949-3 2009 Thus, we confirmed that the degree of central fatigue depends on the function of the serotonin system and revealed gender differences in adaptive capacities of carriers of different variants of serotonin transporter. Serotonin 85-94 solute carrier family 6 member 4 Homo sapiens 194-215 19568851-6 2009 The 5-hydroxytryptamine (serotonin) transporter (5-HTT) has received particular attention because it is involved in the reuptake of serotonin at brain synapses. Serotonin 25-34 solute carrier family 6 member 4 Homo sapiens 49-54 19568851-7 2009 One common polymorphic variant of the 5-HTT-linked polymorphic region (5-HTTLPR), which affects the promoter of the 5-HTT gene, causes reduced uptake of the neurotransmitter serotonin into the presynaptic cells in the brain. Serotonin 174-183 solute carrier family 6 member 4 Homo sapiens 38-69 19568851-7 2009 One common polymorphic variant of the 5-HTT-linked polymorphic region (5-HTTLPR), which affects the promoter of the 5-HTT gene, causes reduced uptake of the neurotransmitter serotonin into the presynaptic cells in the brain. Serotonin 174-183 solute carrier family 6 member 4 Homo sapiens 71-79 19568851-7 2009 One common polymorphic variant of the 5-HTT-linked polymorphic region (5-HTTLPR), which affects the promoter of the 5-HTT gene, causes reduced uptake of the neurotransmitter serotonin into the presynaptic cells in the brain. Serotonin 174-183 solute carrier family 6 member 4 Homo sapiens 38-43 19361459-4 2009 Serotonin is inactivated by the serotonin reuptake transporter (SERT) in the enterocytes or neurons. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 32-62 19361459-4 2009 Serotonin is inactivated by the serotonin reuptake transporter (SERT) in the enterocytes or neurons. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 64-68 18581270-6 2009 The co-expression of SERT with M6B results in a significant decrease in SERT-mediated serotonin uptake caused by a down-regulation of SERT surface expression. Serotonin 86-95 solute carrier family 6 member 4 Homo sapiens 21-25 18581270-6 2009 The co-expression of SERT with M6B results in a significant decrease in SERT-mediated serotonin uptake caused by a down-regulation of SERT surface expression. Serotonin 86-95 solute carrier family 6 member 4 Homo sapiens 72-76 18581270-6 2009 The co-expression of SERT with M6B results in a significant decrease in SERT-mediated serotonin uptake caused by a down-regulation of SERT surface expression. Serotonin 86-95 solute carrier family 6 member 4 Homo sapiens 72-76 18581270-8 2009 Taken together, our data suggest that M6B regulates the serotonin uptake by affecting cellular trafficking of the serotonin transporter. Serotonin 56-65 solute carrier family 6 member 4 Homo sapiens 114-135 18663366-1 2009 The discovery that a common polymorphism (5-HTTLPR, short variant) in the human serotonin transporter gene (SLC6A4) can influence personality traits and increase the risk for depression in adulthood has led to the hypothesis that a relative increase in the extracellular levels of serotonin (5-HT) during development could be critical for the establishment of brain circuits. Serotonin 80-89 solute carrier family 6 member 4 Homo sapiens 108-114 18841348-9 2009 Decreased brain SERT could also be related to the clinical finding that treatment with a selective serotonin re-uptake inhibitor might increase relapse to MA. Serotonin 99-108 solute carrier family 6 member 4 Homo sapiens 16-20 19323988-4 2009 However, the entire serotonergic system is mainly regulated by the serotonin transporter SERT which modulates serotonin concentration in extracellular fluid. Serotonin 67-76 solute carrier family 6 member 4 Homo sapiens 89-93 19625753-3 2009 This functional polymorphism modulates SLC6A4 transcription rate, with the S-allele having a 2-fold reduced efficiency, leading to a diminished availability of 5-HT that might in turn trigger behavioral and cognitive alterations. Serotonin 160-164 solute carrier family 6 member 4 Homo sapiens 39-45 19032576-2 2009 One hypothesis suggests that differential response may be due to a functional polymorphism of the 5-HTTLPR promoter region of the serotonin re-uptake transporter (5-HTT). Serotonin 130-139 solute carrier family 6 member 4 Homo sapiens 98-106 19209991-8 2009 The authors hypothesize that the increased susceptibility to unresolved attachment among carriers of the short allele of 5-HTTLPR is consistent with the role of serotonin in modulation of frontal-amygdala circuitry. Serotonin 161-170 solute carrier family 6 member 4 Homo sapiens 121-129 19179283-1 2009 The human serotonin (5-hydroxytryptamine, 5-HT) transporter (hSERT, SLC6A4) figures prominently in the etiology and treatment of many prevalent neurobehavioral disorders including anxiety, alcoholism, depression, autism, and obsessive-compulsive disorder (OCD). Serotonin 10-19 solute carrier family 6 member 4 Homo sapiens 61-66 19179283-1 2009 The human serotonin (5-hydroxytryptamine, 5-HT) transporter (hSERT, SLC6A4) figures prominently in the etiology and treatment of many prevalent neurobehavioral disorders including anxiety, alcoholism, depression, autism, and obsessive-compulsive disorder (OCD). Serotonin 10-19 solute carrier family 6 member 4 Homo sapiens 68-74 19179283-1 2009 The human serotonin (5-hydroxytryptamine, 5-HT) transporter (hSERT, SLC6A4) figures prominently in the etiology and treatment of many prevalent neurobehavioral disorders including anxiety, alcoholism, depression, autism, and obsessive-compulsive disorder (OCD). Serotonin 21-40 solute carrier family 6 member 4 Homo sapiens 61-66 19179283-1 2009 The human serotonin (5-hydroxytryptamine, 5-HT) transporter (hSERT, SLC6A4) figures prominently in the etiology and treatment of many prevalent neurobehavioral disorders including anxiety, alcoholism, depression, autism, and obsessive-compulsive disorder (OCD). Serotonin 21-40 solute carrier family 6 member 4 Homo sapiens 68-74 18957375-1 2009 Rare, functional, non-synonymous variants in the human serotonin (5-hydroxytryptamine, 5-HT) transporter (hSERT) gene (SLC6A4) have been identified in both autism and obsessive-compulsive disorder (OCD). Serotonin 55-64 solute carrier family 6 member 4 Homo sapiens 106-111 18957375-1 2009 Rare, functional, non-synonymous variants in the human serotonin (5-hydroxytryptamine, 5-HT) transporter (hSERT) gene (SLC6A4) have been identified in both autism and obsessive-compulsive disorder (OCD). Serotonin 55-64 solute carrier family 6 member 4 Homo sapiens 119-125 18957375-1 2009 Rare, functional, non-synonymous variants in the human serotonin (5-hydroxytryptamine, 5-HT) transporter (hSERT) gene (SLC6A4) have been identified in both autism and obsessive-compulsive disorder (OCD). Serotonin 66-85 solute carrier family 6 member 4 Homo sapiens 106-111 18957375-1 2009 Rare, functional, non-synonymous variants in the human serotonin (5-hydroxytryptamine, 5-HT) transporter (hSERT) gene (SLC6A4) have been identified in both autism and obsessive-compulsive disorder (OCD). Serotonin 66-85 solute carrier family 6 member 4 Homo sapiens 119-125 18957375-1 2009 Rare, functional, non-synonymous variants in the human serotonin (5-hydroxytryptamine, 5-HT) transporter (hSERT) gene (SLC6A4) have been identified in both autism and obsessive-compulsive disorder (OCD). Serotonin 87-91 solute carrier family 6 member 4 Homo sapiens 106-111 18957375-1 2009 Rare, functional, non-synonymous variants in the human serotonin (5-hydroxytryptamine, 5-HT) transporter (hSERT) gene (SLC6A4) have been identified in both autism and obsessive-compulsive disorder (OCD). Serotonin 87-91 solute carrier family 6 member 4 Homo sapiens 119-125 18957375-2 2009 Within autism, rare hSERT coding variants associate with rigid-compulsive traits, suggesting both phenotypic overlap with OCD and a shared relationship with disrupted 5-HT signalling. Serotonin 167-171 solute carrier family 6 member 4 Homo sapiens 20-25 18973248-2 2009 Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD. Serotonin 81-90 solute carrier family 6 member 4 Homo sapiens 73-79 19351213-1 2009 BACKGROUND AND AIM: The human serotonin (5-hydroxytryptamine) transporter, encoded by the SLC6A4 gene on chromosome 17q11.1-q12, is the cellular reuptake site for serotonin and a site of action for several drugs with central nervous system effects, including both therapeutic agents (e.g. antidepressants) and drugs of abuse (e.g. cocaine). Serotonin 30-39 solute carrier family 6 member 4 Homo sapiens 90-96 19209222-2 2009 Here we show that variants of two genes that regulate dopamine and serotonin neurotransmission and have been previously linked to emotional behavior, anxiety and addiction (5-HTTLPR and DRD4) are significant determinants of risk taking in investment decisions. Serotonin 67-76 solute carrier family 6 member 4 Homo sapiens 173-181 19022290-1 2009 Biogenic amine transporters for serotonin, norepinephrine and dopamine (SERT, NET and DAT respectively), are the key players terminating transmission of these amines in the central nervous system by their high-affinity uptake. Serotonin 32-41 solute carrier family 6 member 4 Homo sapiens 72-76 18672092-4 2008 Several studies have described an excess of 5HT in IBS-D and abnormally low 5HT availability in IBS-C. Serotonin transporter (SERT) is only weakly expressed in the colon and whether this is further reduced in IBS is unclear with conflicting reports. Serotonin 44-47 solute carrier family 6 member 4 Homo sapiens 126-130 18672092-4 2008 Several studies have described an excess of 5HT in IBS-D and abnormally low 5HT availability in IBS-C. Serotonin transporter (SERT) is only weakly expressed in the colon and whether this is further reduced in IBS is unclear with conflicting reports. Serotonin 76-79 solute carrier family 6 member 4 Homo sapiens 126-130 18672092-5 2008 SERT promoter polymorphisms are inconsistently related to IBS subtypes but appear to partly predict response to both 5HT(3) antagonists and 5HT(4) agonists. Serotonin 117-120 solute carrier family 6 member 4 Homo sapiens 0-4 18672092-5 2008 SERT promoter polymorphisms are inconsistently related to IBS subtypes but appear to partly predict response to both 5HT(3) antagonists and 5HT(4) agonists. Serotonin 140-143 solute carrier family 6 member 4 Homo sapiens 0-4 19040324-3 2008 The serotonin transporter (5-HTT) is the principal site of initial action for several antidepressants, including serotonin re-uptake inhibitors (SSRIs). Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-32 18036835-3 2008 Of the biomarkers in the serotonin system, serotonin(1A) (5-HT(1A)) receptor is implicated in depression, and anxiety and serotonin transporter (5-HTT) is a target for selective serotonin reuptake inhibitors, psychotropic drugs used in the treatment of these disorders. Serotonin 25-34 solute carrier family 6 member 4 Homo sapiens 122-143 19270731-4 2009 METHODOLOGY/PRINCIPAL FINDINGS: We tested the impact of 5HT-stimulation on vimentin-SERT association and found that 5HT-stimulation accelerates the translocation of SERT from the plasma membrane via enhancing the level of association between phosphovimentin and SERT. Serotonin 56-59 solute carrier family 6 member 4 Homo sapiens 84-88 19270731-4 2009 METHODOLOGY/PRINCIPAL FINDINGS: We tested the impact of 5HT-stimulation on vimentin-SERT association and found that 5HT-stimulation accelerates the translocation of SERT from the plasma membrane via enhancing the level of association between phosphovimentin and SERT. Serotonin 56-59 solute carrier family 6 member 4 Homo sapiens 165-169 19270731-4 2009 METHODOLOGY/PRINCIPAL FINDINGS: We tested the impact of 5HT-stimulation on vimentin-SERT association and found that 5HT-stimulation accelerates the translocation of SERT from the plasma membrane via enhancing the level of association between phosphovimentin and SERT. Serotonin 56-59 solute carrier family 6 member 4 Homo sapiens 165-169 19270731-4 2009 METHODOLOGY/PRINCIPAL FINDINGS: We tested the impact of 5HT-stimulation on vimentin-SERT association and found that 5HT-stimulation accelerates the translocation of SERT from the plasma membrane via enhancing the level of association between phosphovimentin and SERT. Serotonin 116-119 solute carrier family 6 member 4 Homo sapiens 84-88 19270731-4 2009 METHODOLOGY/PRINCIPAL FINDINGS: We tested the impact of 5HT-stimulation on vimentin-SERT association and found that 5HT-stimulation accelerates the translocation of SERT from the plasma membrane via enhancing the level of association between phosphovimentin and SERT. Serotonin 116-119 solute carrier family 6 member 4 Homo sapiens 165-169 19270731-4 2009 METHODOLOGY/PRINCIPAL FINDINGS: We tested the impact of 5HT-stimulation on vimentin-SERT association and found that 5HT-stimulation accelerates the translocation of SERT from the plasma membrane via enhancing the level of association between phosphovimentin and SERT. Serotonin 116-119 solute carrier family 6 member 4 Homo sapiens 165-169 19270731-12 2009 Conversely, following 5HT stimulation, the association between vimentin-SERT is enhanced which changes the cellular distribution of SERT on an altered vimentin network. Serotonin 22-25 solute carrier family 6 member 4 Homo sapiens 72-76 19270731-12 2009 Conversely, following 5HT stimulation, the association between vimentin-SERT is enhanced which changes the cellular distribution of SERT on an altered vimentin network. Serotonin 22-25 solute carrier family 6 member 4 Homo sapiens 132-136 18801947-1 2008 Although several antidepressants (including fluoxetine, imipramine, citalopram, venlafaxine, and duloxetine) are known to inhibit the serotonin transporter (SERT), whether or not these molecules compete with 5-hydroxytryptamine (serotonin) (5-HT) for binding to SERT has remained controversial. Serotonin 208-227 solute carrier family 6 member 4 Homo sapiens 157-161 18801947-1 2008 Although several antidepressants (including fluoxetine, imipramine, citalopram, venlafaxine, and duloxetine) are known to inhibit the serotonin transporter (SERT), whether or not these molecules compete with 5-hydroxytryptamine (serotonin) (5-HT) for binding to SERT has remained controversial. Serotonin 134-143 solute carrier family 6 member 4 Homo sapiens 157-161 18801947-1 2008 Although several antidepressants (including fluoxetine, imipramine, citalopram, venlafaxine, and duloxetine) are known to inhibit the serotonin transporter (SERT), whether or not these molecules compete with 5-hydroxytryptamine (serotonin) (5-HT) for binding to SERT has remained controversial. Serotonin 134-143 solute carrier family 6 member 4 Homo sapiens 262-266 19000377-1 2008 The aim of this work was to investigate the effect of short- and long-term high-glucose exposure on the plasmalemmal serotonin transporter (SERT)-mediated uptake of [(3)H]-serotonin (5-HT) by Caco-2 cells. Serotonin 117-126 solute carrier family 6 member 4 Homo sapiens 140-144 18804097-2 2008 Serotonin transporter gene (SLC6A4) that regulates synaptic serotonin level has been investigated as a candidate gene for autism, but consensus opinion on possible association is still lacking. Serotonin 60-69 solute carrier family 6 member 4 Homo sapiens 0-21 18804097-2 2008 Serotonin transporter gene (SLC6A4) that regulates synaptic serotonin level has been investigated as a candidate gene for autism, but consensus opinion on possible association is still lacking. Serotonin 60-69 solute carrier family 6 member 4 Homo sapiens 28-34 18815045-1 2008 Norepinephrine transporter (NET) and serotonin transporter (SERT) proteins regulate norepinephrine (NE) and serotonin via their reuptake function and are targets of antidepressants action. Serotonin 37-46 solute carrier family 6 member 4 Homo sapiens 60-64 18824000-0 2008 How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems. Serotonin 8-17 solute carrier family 6 member 4 Homo sapiens 96-102 18824000-0 2008 How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems. Serotonin 8-17 solute carrier family 6 member 4 Homo sapiens 108-129 18824000-0 2008 How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems. Serotonin 108-117 solute carrier family 6 member 4 Homo sapiens 96-102 18824000-4 2008 The serotonin transporter (SERT) has been the most comprehensively studied of the serotonin system molecular components, and will be the primary focus of this review. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 18824000-5 2008 We provide in-depth examples of gene-based discoveries primarily related to SLC6A4 that have clarified serotonin"s many important homeostatic functions in humans, non-human primates, mice and other species. Serotonin 103-112 solute carrier family 6 member 4 Homo sapiens 76-82 19014073-1 2008 BACKGROUND: Since the serotonin (5-HT) is associated with circadian rhythm and breathing regulation, the serotonin transporter (5-HTT), which plays an important role in serotoninergic transmission, might be a strong candidate gene in the pathogenesis of obstructive sleep apnea syndrome (OSAS). Serotonin 22-31 solute carrier family 6 member 4 Homo sapiens 128-133 18270976-3 2008 Serotonin transporter (SERT) modulates serotonin levels, and is a major therapeutic target in autism. Serotonin 39-48 solute carrier family 6 member 4 Homo sapiens 0-21 18270976-3 2008 Serotonin transporter (SERT) modulates serotonin levels, and is a major therapeutic target in autism. Serotonin 39-48 solute carrier family 6 member 4 Homo sapiens 23-27 18216289-3 2008 We have analyzed cellular serotonin transporter (SERT) expression on exposure to the selective serotonin reuptake inhibitor citalopram in serotonergic neurons expressing the native SERT allele in its natural surroundings. Serotonin 26-35 solute carrier family 6 member 4 Homo sapiens 49-53 18354055-1 2008 The human serotonin transporter (hSERT) regulates the spatial and temporal actions of serotonin (5-HT) neurotransmission by removing 5-HT from the synapse. Serotonin 10-19 solute carrier family 6 member 4 Homo sapiens 33-38 17882235-2 2008 The serotonin transporter (5-HTT, SERT) is a key molecule for the control of synaptic serotonin levels. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-32 17882235-2 2008 The serotonin transporter (5-HTT, SERT) is a key molecule for the control of synaptic serotonin levels. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 34-38 18081886-1 2008 AIM: The aim of this study was to determine the effect of long-term serotonin (5-hydroxytryptamine, 5-HT) treatment on the human serotonin transporter (hSERT) function and its expression. Serotonin 68-77 solute carrier family 6 member 4 Homo sapiens 129-150 18081886-1 2008 AIM: The aim of this study was to determine the effect of long-term serotonin (5-hydroxytryptamine, 5-HT) treatment on the human serotonin transporter (hSERT) function and its expression. Serotonin 68-77 solute carrier family 6 member 4 Homo sapiens 152-157 18081886-1 2008 AIM: The aim of this study was to determine the effect of long-term serotonin (5-hydroxytryptamine, 5-HT) treatment on the human serotonin transporter (hSERT) function and its expression. Serotonin 79-98 solute carrier family 6 member 4 Homo sapiens 129-150 18081886-1 2008 AIM: The aim of this study was to determine the effect of long-term serotonin (5-hydroxytryptamine, 5-HT) treatment on the human serotonin transporter (hSERT) function and its expression. Serotonin 79-98 solute carrier family 6 member 4 Homo sapiens 152-157 18081886-4 2008 We measured serotonin transport, levels of mRNA expression and of the SERT protein after treating the cells with serotonin. Serotonin 113-122 solute carrier family 6 member 4 Homo sapiens 70-74 18081886-5 2008 RESULTS: Serotonin treatment diminished hSERT activity in a concentration and period-dependent way by increasing the K(t) value and reducing V(max). Serotonin 9-18 solute carrier family 6 member 4 Homo sapiens 40-45 18081886-10 2008 CONCLUSION: The chronic increase in serotonin in the extracellular medium diminishes the function of the SERT. Serotonin 36-45 solute carrier family 6 member 4 Homo sapiens 105-109 18227069-0 2008 Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 78-99 18227069-1 2008 The serotonin transporter (SERT) on the plasma membrane is the major mechanism for the clearance of plasma serotonin (5-hydroxytryptamine (5HT)). Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 18227069-1 2008 The serotonin transporter (SERT) on the plasma membrane is the major mechanism for the clearance of plasma serotonin (5-hydroxytryptamine (5HT)). Serotonin 118-137 solute carrier family 6 member 4 Homo sapiens 4-25 18227069-1 2008 The serotonin transporter (SERT) on the plasma membrane is the major mechanism for the clearance of plasma serotonin (5-hydroxytryptamine (5HT)). Serotonin 118-137 solute carrier family 6 member 4 Homo sapiens 27-31 18227069-1 2008 The serotonin transporter (SERT) on the plasma membrane is the major mechanism for the clearance of plasma serotonin (5-hydroxytryptamine (5HT)). Serotonin 139-142 solute carrier family 6 member 4 Homo sapiens 4-25 18227069-1 2008 The serotonin transporter (SERT) on the plasma membrane is the major mechanism for the clearance of plasma serotonin (5-hydroxytryptamine (5HT)). Serotonin 139-142 solute carrier family 6 member 4 Homo sapiens 27-31 18227069-3 2008 Interestingly, the number of SERT molecules on the platelet surface is down-regulated when plasma 5HT ([5HT](ex)) is elevated. Serotonin 98-101 solute carrier family 6 member 4 Homo sapiens 29-33 18227069-6 2008 Although investigating the mechanism by which elevated plasma 5HT level down-regulates the density of SERT molecules on the plasma membrane, we studied Rab4 and SERT in heterologous and platelet expression systems. Serotonin 62-65 solute carrier family 6 member 4 Homo sapiens 102-106 18227069-11 2008 This finding provides an explanation for the role of the C terminus in the localization and trafficking of SERT via Rab4 in a plasma 5HT-dependent manner. Serotonin 133-136 solute carrier family 6 member 4 Homo sapiens 107-111 18227069-12 2008 Therefore, we propose that elevated [5HT](ex)"paralyzes" the translocation of SERT from intracellular locations to the plasma membrane by controlling transamidation and Rab4-GTP formation. Serotonin 37-40 solute carrier family 6 member 4 Homo sapiens 78-82 18055562-9 2008 Our results contribute to a better understanding of SLC6A4 expression genetics and provide a functional haplotype framework for future serotonin-related studies. Serotonin 135-144 solute carrier family 6 member 4 Homo sapiens 52-58 18602929-4 2008 When not bound to syntaxin 1A, SERT shows both substrate-independent Na(+) fluxes and substrate-dependent Na(+) fluxes of variable stoichiometry; these fluxes are eliminated in the presence of syntaxin 1A as Na(+) flux becomes strictly coupled to 5HT uptake. Serotonin 247-250 solute carrier family 6 member 4 Homo sapiens 31-35 18762593-15 2008 Since higher serotonin transporter density is associated with lower synaptic serotonin levels, regulation of serotonin transporter density by season is a previously undescribed physiologic mechanism that has the potential to explain seasonal changes in normal and pathologic behaviors. Serotonin 13-22 solute carrier family 6 member 4 Homo sapiens 109-130 18308792-0 2008 Interferon-alpha-induced serotonin uptake in Jurkat T cells via mitogen-activated protein kinase and transcriptional regulation of the serotonin transporter. Serotonin 25-34 solute carrier family 6 member 4 Homo sapiens 135-156 18657242-2 2008 Several family and population-based studies have reported associations between the BDNF gene and serotonin-related genes, specifically the serotonin transporter (5HTT) gene, with bipolar disorder (BD) and SB. Serotonin 97-106 solute carrier family 6 member 4 Homo sapiens 139-160 18550438-1 2008 Serotonin transporter (SERT) mediates the intracellular reuptake of released serotonin, thus regulating its biological functions. Serotonin 77-86 solute carrier family 6 member 4 Homo sapiens 0-21 18550438-1 2008 Serotonin transporter (SERT) mediates the intracellular reuptake of released serotonin, thus regulating its biological functions. Serotonin 77-86 solute carrier family 6 member 4 Homo sapiens 23-27 18193379-2 2008 Having a high affinity for the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT), serotonin transporter controls the duration, availability and signaling capacity of 5-HT in the synapse. Serotonin 48-57 solute carrier family 6 member 4 Homo sapiens 87-108 18193379-2 2008 Having a high affinity for the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT), serotonin transporter controls the duration, availability and signaling capacity of 5-HT in the synapse. Serotonin 59-78 solute carrier family 6 member 4 Homo sapiens 87-108 18622082-1 2008 The discovery of a functional serotonin (5-hydroxytryptamine; 5-HT) transporter (5-HTT) in bone has given rise to questions about the physiologic role of 5-HT in bone, and the possible clinical implications for humans. Serotonin 30-39 solute carrier family 6 member 4 Homo sapiens 62-79 18622082-1 2008 The discovery of a functional serotonin (5-hydroxytryptamine; 5-HT) transporter (5-HTT) in bone has given rise to questions about the physiologic role of 5-HT in bone, and the possible clinical implications for humans. Serotonin 30-39 solute carrier family 6 member 4 Homo sapiens 81-86 18622082-1 2008 The discovery of a functional serotonin (5-hydroxytryptamine; 5-HT) transporter (5-HTT) in bone has given rise to questions about the physiologic role of 5-HT in bone, and the possible clinical implications for humans. Serotonin 41-60 solute carrier family 6 member 4 Homo sapiens 62-79 18622082-1 2008 The discovery of a functional serotonin (5-hydroxytryptamine; 5-HT) transporter (5-HTT) in bone has given rise to questions about the physiologic role of 5-HT in bone, and the possible clinical implications for humans. Serotonin 41-60 solute carrier family 6 member 4 Homo sapiens 81-86 18314975-0 2008 Binding of serotonin to the human serotonin transporter. Serotonin 11-20 solute carrier family 6 member 4 Homo sapiens 34-55 18314975-2 2008 Molecular modeling and structure-activity relationship studies were performed to propose a model for binding of the neurotransmitter serotonin (5-HT) to the human serotonin transporter (hSERT). Serotonin 133-142 solute carrier family 6 member 4 Homo sapiens 163-184 18314975-2 2008 Molecular modeling and structure-activity relationship studies were performed to propose a model for binding of the neurotransmitter serotonin (5-HT) to the human serotonin transporter (hSERT). Serotonin 133-142 solute carrier family 6 member 4 Homo sapiens 186-191 17991706-1 2008 The enteric serotonin transporter (SERT) plays a critical role in modulating serotonin availability and thus has been implicated in the pathogenesis of various intestinal disorders. Serotonin 12-21 solute carrier family 6 member 4 Homo sapiens 35-39 17957753-3 2007 The serotonin transporter (SERT) regulates the entire serotonergic system, including serotonin receptors by means of modulation of serotonin concentration in the extracellular fluid. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 17957753-10 2007 We suggest that SERT might have an important role in mammalian CPs, possibly regulating the serotonin flow between brain and rest of the body. Serotonin 92-101 solute carrier family 6 member 4 Homo sapiens 16-20 18209475-0 2008 Serotonin (5-HT) transport in human platelets is modulated by Src-catalysed Tyr-phosphorylation of the plasma membrane transporter SERT. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 131-135 19075665-0 2008 Computational approaches for the study of serotonin and its membrane transporter SERT: implications for drug design in neurological sciences. Serotonin 42-51 solute carrier family 6 member 4 Homo sapiens 81-85 17991706-9 2008 Functional studies showed that uptake of [(3)H]serotonin (150 nM) in human ileal AMVs was 1) significantly increased in the presence of both Na(+) and Cl(-); 2) inhibited ( approximately 50%) by the neuronal SERT inhibitor, fluoxetine (10 microM) and by unlabeled 5-HT; and 3) exhibited saturation kinetics indicating the presence of a carrier-mediated process. Serotonin 47-56 solute carrier family 6 member 4 Homo sapiens 208-212 17991706-10 2008 Our studies demonstrated differential expression of SERT across various regions of the human intestine and provide evidence for the existence of a functional SERT capable of removing intraluminal serotonin in human ileal epithelial cells. Serotonin 196-205 solute carrier family 6 member 4 Homo sapiens 52-56 17991706-10 2008 Our studies demonstrated differential expression of SERT across various regions of the human intestine and provide evidence for the existence of a functional SERT capable of removing intraluminal serotonin in human ileal epithelial cells. Serotonin 196-205 solute carrier family 6 member 4 Homo sapiens 158-162 17715266-1 2007 Serotonin [5-hydroxytryptamine (5HT)] acts through multiple G protein-coupled 5-HT receptors, and its activity is also regulated by the 5-HT transporter. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 136-152 17874074-9 2007 A suggested clinical implication is that the inter-individual variability in 5-HT1A-receptor and 5-HTT densities, as well as the ratio of these, is of particular interest in relation to individual responses to selective serotonin reuptake inhibitor treatment. Serotonin 220-229 solute carrier family 6 member 4 Homo sapiens 97-102 17715266-1 2007 Serotonin [5-hydroxytryptamine (5HT)] acts through multiple G protein-coupled 5-HT receptors, and its activity is also regulated by the 5-HT transporter. Serotonin 11-30 solute carrier family 6 member 4 Homo sapiens 136-152 17715266-1 2007 Serotonin [5-hydroxytryptamine (5HT)] acts through multiple G protein-coupled 5-HT receptors, and its activity is also regulated by the 5-HT transporter. Serotonin 32-35 solute carrier family 6 member 4 Homo sapiens 136-152 17974934-2 2007 The authors tested the hypothesis that a polymorphism in the serotonin transporter gene (locus, SLC6A4; variant, serotonin 5-HTTLPR) moderates risk of posthurricane PTSD and major depression given high hurricane exposure and low social support. Serotonin 61-70 solute carrier family 6 member 4 Homo sapiens 96-102 17877505-1 2007 BACKGROUND: Serotonin is associated with symptoms of the irritable bowel syndrome, its action is terminated by the serotonin transporter protein. Serotonin 12-21 solute carrier family 6 member 4 Homo sapiens 115-136 17709099-5 2007 The structure-activity relationship readily distinguished the pro-apoptotic and growth inhibitory effect of SSRIs from their eponymous action (blockage of the serotonin transporter): acetylation of the SSRIs fluvoxamine and paroxetine abrogated the ability of these compounds to inhibit 5HT-uptake, but did not impair their cytotoxic action. Serotonin 287-290 solute carrier family 6 member 4 Homo sapiens 159-180 17698848-1 2007 Ibogaine, a hallucinogenic alkaloid with purported anti-addiction properties, inhibited serotonin transporter (SERT) noncompetitively by decreasing V(max) with little change in the K(m) for serotonin (5-HT). Serotonin 88-97 solute carrier family 6 member 4 Homo sapiens 111-115 17606812-1 2007 CONTEXT: The HTTLPR, a functional polymorphism of the serotonin transporter gene solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4), promoter, affects transcription and may be involved in antidepressant drug treatment outcome, although response rates with antidepressants can be lower in patients who experience adverse effects. Serotonin 54-63 solute carrier family 6 member 4 Homo sapiens 158-164 17575980-4 2007 Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin (5-HT), magnesium, vitamin C and zinc, respectively. Serotonin 128-137 solute carrier family 6 member 4 Homo sapiens 58-64 17690258-1 2007 Tricyclic antidepressants exert their pharmacological effect-inhibiting the reuptake of serotonin, norepinephrine, and dopamine-by directly blocking neurotransmitter transporters (SERT, NET, and DAT, respectively) in the presynaptic membrane. Serotonin 88-97 solute carrier family 6 member 4 Homo sapiens 180-184 17663674-3 2007 The serotonin is released and can then: (i) pass into the underlying pulmonary smooth muscle cells through the serotonin transporter (SERT) to initiate proliferation and/or (ii) activate serotonin receptors on pulmonary smooth muscle cells to evoke proliferation and/or contraction. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 111-132 17663674-3 2007 The serotonin is released and can then: (i) pass into the underlying pulmonary smooth muscle cells through the serotonin transporter (SERT) to initiate proliferation and/or (ii) activate serotonin receptors on pulmonary smooth muscle cells to evoke proliferation and/or contraction. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 134-138 17663674-4 2007 Serotonin may also mediate pulmonary fibroblast proliferation via the SERT and/or serotonin receptors. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 70-74 17766685-2 2007 Serotonin (5HT) is involved in sleep regulation and the 5HT transporter (5HTT) regulates 5HT function. Serotonin 56-59 solute carrier family 6 member 4 Homo sapiens 73-77 17766685-3 2007 A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro. Serotonin 98-101 solute carrier family 6 member 4 Homo sapiens 62-70 17715358-2 2007 A postulated key component of the neurochemical regulation of amygdala function is the neurotransmitter 5-hydroxytryptamine (5-HT), and synaptic levels of 5-HT in the amygdala and elsewhere are critically regulated by the 5-HT transporter (5-HTT). Serotonin 104-123 solute carrier family 6 member 4 Homo sapiens 222-238 17715358-2 2007 A postulated key component of the neurochemical regulation of amygdala function is the neurotransmitter 5-hydroxytryptamine (5-HT), and synaptic levels of 5-HT in the amygdala and elsewhere are critically regulated by the 5-HT transporter (5-HTT). Serotonin 104-123 solute carrier family 6 member 4 Homo sapiens 240-245 17582522-8 2007 The heterologously expressed protein was inhibited by classic SERT blockers (clomipramine, fluoxetine, citalopram) and the same drugs also inhibited [(3)H]-5HT uptake by intact schistosomula in culture, suggesting that SmSERT may be responsible for this transport. Serotonin 156-159 solute carrier family 6 member 4 Homo sapiens 62-66 17506858-4 2007 Therefore, SERT is a major mechanism that regulates plasma 5HT levels to prevent vasoconstriction and thereby secure a stable blood flow. Serotonin 59-62 solute carrier family 6 member 4 Homo sapiens 11-15 17506858-5 2007 In this study, the response of platelet SERT to the plasma 5HT levels was examined within two models: (i) in subjects with chronic hypertension or normotension; (ii) on platelets isolated from normotensive subjects and pretreated with 5HT at various concentrations. Serotonin 59-62 solute carrier family 6 member 4 Homo sapiens 40-44 17506858-6 2007 The platelet 5HT uptake rates were lower during hypertension due to a decrease in Vmax with a similar Km; also, the decrease in Vmax was primarily due to a decrease in the density of SERT on the platelet membrane, with no change in whole cell expression. Serotonin 13-16 solute carrier family 6 member 4 Homo sapiens 183-187 17506858-8 2007 Furthermore, exogenous 5HT altered the 5HT uptake rates by changing the density of SERT molecules on the plasma membrane in a biphasic manner. Serotonin 23-26 solute carrier family 6 member 4 Homo sapiens 83-87 17506858-8 2007 Furthermore, exogenous 5HT altered the 5HT uptake rates by changing the density of SERT molecules on the plasma membrane in a biphasic manner. Serotonin 39-42 solute carrier family 6 member 4 Homo sapiens 83-87 17506858-9 2007 Therefore, we hypothesize that in a hypertensive state, the elevated plasma 5HT levels induces a loss in 5HT uptake function in platelets via a decrease in the density of SERT molecules on the plasma membrane. Serotonin 76-79 solute carrier family 6 member 4 Homo sapiens 171-175 17506858-10 2007 Through the feedback effect of this proposed mechanism, plasma 5HT controls its own concentration levels by modulating the uptake properties of platelet SERT. Serotonin 63-66 solute carrier family 6 member 4 Homo sapiens 153-157 17436258-1 2007 We have performed molecular dynamics simulations of a homology model of the human serotonin transporter (hSERT) in a membrane environment and in complex with either the natural substrate 5-HT or the selective serotonin reuptake inhibitor escitalopram. Serotonin 82-91 solute carrier family 6 member 4 Homo sapiens 105-110 17944104-4 2007 5-HTT and COMT genes, regulating activity of serotonin and dopamine respectively, are related with accuracy of orientation in time. Serotonin 45-54 solute carrier family 6 member 4 Homo sapiens 0-5 17437611-3 2007 To address this question we measured, by positron emission tomography imaging, levels of the brain serotonin transporter (SERT), a marker for serotonin neurones, as inferred from binding of [11C]-3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile (DASB), a second generation SERT radioligand, in subcortical and cerebral cortical brain areas of clinically advanced non-depressed (confirmed by structured psychiatric interview) patients with PD. Serotonin 99-108 solute carrier family 6 member 4 Homo sapiens 122-126 17561689-3 2007 Attenuation of serotonin neurotransmission can be caused by increased expression of serotonin transporter, which results either from viral infection and subsequent production of interferon--alpha or from abnormal promoter for serotonin transporter gene. Serotonin 15-24 solute carrier family 6 member 4 Homo sapiens 84-105 17561689-3 2007 Attenuation of serotonin neurotransmission can be caused by increased expression of serotonin transporter, which results either from viral infection and subsequent production of interferon--alpha or from abnormal promoter for serotonin transporter gene. Serotonin 15-24 solute carrier family 6 member 4 Homo sapiens 226-247 17452640-4 2007 Coexpression of nNOS with SERT in HEK293 cells decreased SERT cell surface localization and 5-hydroxytryptamine (5-HT) uptake. Serotonin 92-111 solute carrier family 6 member 4 Homo sapiens 26-30 17437611-3 2007 To address this question we measured, by positron emission tomography imaging, levels of the brain serotonin transporter (SERT), a marker for serotonin neurones, as inferred from binding of [11C]-3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile (DASB), a second generation SERT radioligand, in subcortical and cerebral cortical brain areas of clinically advanced non-depressed (confirmed by structured psychiatric interview) patients with PD. Serotonin 99-108 solute carrier family 6 member 4 Homo sapiens 286-290 17241828-1 2007 BACKGROUND: Family-based evidence for association at serotonin system genes SLC6A4, HTR1B, HTR2A, and brain-derived neurotrophic factor (BDNF) has been previously reported in obsessive-compulsive disorder (OCD). Serotonin 53-62 solute carrier family 6 member 4 Homo sapiens 76-82 17414739-3 2007 This study evaluates the association between adverse events during selective serotonin reuptake inhibitor treatment and two polymorphisms in the serotonin transporter (5-HTTLPR and STin2) gene. Serotonin 77-86 solute carrier family 6 member 4 Homo sapiens 145-166 17414739-3 2007 This study evaluates the association between adverse events during selective serotonin reuptake inhibitor treatment and two polymorphisms in the serotonin transporter (5-HTTLPR and STin2) gene. Serotonin 77-86 solute carrier family 6 member 4 Homo sapiens 168-176 17355243-2 2007 The 5HT transporter (SERT) on the membranes of the placental trophoblast cells controls 5HT levels in the maternal bloodstream to maintain stable transplacental blood flow and simultaneously provide 5HT to the embryo. Serotonin 4-7 solute carrier family 6 member 4 Homo sapiens 21-25 17355243-2 2007 The 5HT transporter (SERT) on the membranes of the placental trophoblast cells controls 5HT levels in the maternal bloodstream to maintain stable transplacental blood flow and simultaneously provide 5HT to the embryo. Serotonin 88-91 solute carrier family 6 member 4 Homo sapiens 21-25 17355243-3 2007 The 5HT uptake rate of placental SERT is important for both the mother and the developing embryo. Serotonin 4-7 solute carrier family 6 member 4 Homo sapiens 33-37 17355243-11 2007 Therefore, we propose that under uncontrolled diabetic conditions, glucose down-regulates 5HT uptake rates of placental SERT by interfering with its functional expression in a cell-cycle-dependent manner. Serotonin 90-93 solute carrier family 6 member 4 Homo sapiens 120-124 17123473-1 2007 BACKGROUND: SLC6A4 encodes the serotonin transporter, the protein primarily responsible for the termination of serotonin neurotransmission. Serotonin 31-40 solute carrier family 6 member 4 Homo sapiens 12-18 17295220-4 2007 Common alleles of some serotonin pathway genes, including those involved in its degradation (monoamine oxidase A, MAOA), or its re-uptake into pre-synaptic neurones (serotonin transporter, SERT) have been shown to confer functional variation. Serotonin 23-32 solute carrier family 6 member 4 Homo sapiens 166-187 17295220-4 2007 Common alleles of some serotonin pathway genes, including those involved in its degradation (monoamine oxidase A, MAOA), or its re-uptake into pre-synaptic neurones (serotonin transporter, SERT) have been shown to confer functional variation. Serotonin 23-32 solute carrier family 6 member 4 Homo sapiens 189-193 17613943-12 2007 Serotonin transporter genotyping suggested that increased whole brain serotonin turnover most likely derived not from impaired serotonin reuptake, but from increased firing in serotonergic midbrain raphe neurons projecting to both subcortical brain regions and the cerebral cortex. Serotonin 70-79 solute carrier family 6 member 4 Homo sapiens 0-21 17203304-0 2007 Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels. Serotonin 104-113 solute carrier family 6 member 4 Homo sapiens 31-37 17203304-8 2007 The most significant models contributing to serotonin distribution were found for interactions between TPH1 rs4537731 and SLC6A4 haplotypes (P = 0.002) and between HTR1D rs6300 and SLC6A4 haplotypes (P = 0.013). Serotonin 44-53 solute carrier family 6 member 4 Homo sapiens 122-128 17203304-8 2007 The most significant models contributing to serotonin distribution were found for interactions between TPH1 rs4537731 and SLC6A4 haplotypes (P = 0.002) and between HTR1D rs6300 and SLC6A4 haplotypes (P = 0.013). Serotonin 44-53 solute carrier family 6 member 4 Homo sapiens 181-187 17203304-10 2007 The overall results implicate SLC6A4 and ITGB3 gene interactions in autism etiology and in serotonin level determination, providing evidence for a common underlying genetic mechanism and a molecular explanation for the association of platelet hyperserotonemia with autism. Serotonin 91-100 solute carrier family 6 member 4 Homo sapiens 30-36 17224717-3 2007 The current study measured SERT occupancy and modulation of DAT by the serotonin/norepinephrine reuptake inhibitor (SNRI) venlafaxine using [123I]2beta-carbomethoxy-3beta-(4-iodophenyl)-tropane SPECT. Serotonin 71-80 solute carrier family 6 member 4 Homo sapiens 27-31 17046718-1 2007 The high affinity serotonin transporter (SERT) constitutes the principal pathway for removal of serotonin (5-HT) from extracellular fluid of brain, but evidence indicates that other transporters may also be involved in this process. Serotonin 18-27 solute carrier family 6 member 4 Homo sapiens 41-45 17009264-2 2006 Two serotonin-related gene polymorphisms, the serotonin receptor 1A (5-HT1A) polymorphism at -1019C>G and the serotonin transporter LS polymorphism, have been reported to affect stress-related behaviors. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 113-134 17241888-6 2007 Serotonin is inactivated by the serotonin reuptake transporter (SERT)-mediated uptake into enterocytes or neurons. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 32-62 17241888-6 2007 Serotonin is inactivated by the serotonin reuptake transporter (SERT)-mediated uptake into enterocytes or neurons. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 64-68 16220332-3 2007 OBJECTIVES: To clarify whether SERT-selective effects of MDMA at human monoamine transporters can account for the reported MDMA-induced selective toxicity of serotonin neurons in primate brain. Serotonin 158-167 solute carrier family 6 member 4 Homo sapiens 31-35 17094925-2 2006 Since the development of the selective serotonin (5-HT) reuptake inhibitors, a putative role for the 5-HT transporter (SERT) in the etiology of depression has been explored. Serotonin 39-48 solute carrier family 6 member 4 Homo sapiens 119-123 17099247-1 2006 Both the tricyclic and specific serotonin reuptake inhibitor classes of antidepressants act primarily by inhibiting the reuptake of released serotonin by the human serotonin reuptake transporter (hSERT). Serotonin 32-41 solute carrier family 6 member 4 Homo sapiens 196-201 16452989-1 2006 We studied in vivo expression of the serotonin transporter (SERT) protein after 3,4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine (PCA), or fenfluramine (FEN) treatments, and compared the effects of substituted amphetamines to those of 5,7-dihydroxytryptamine (5,7-DHT), an established serotonin (5-HT) neurotoxin. Serotonin 37-46 solute carrier family 6 member 4 Homo sapiens 60-64 17008313-1 2006 Serotonin transporter (SERT) catalyzes reuptake of the neurotransmitter serotonin (5-HT) and is a target for antidepressant drugs and psychostimulants. Serotonin 72-81 solute carrier family 6 member 4 Homo sapiens 0-21 17008313-1 2006 Serotonin transporter (SERT) catalyzes reuptake of the neurotransmitter serotonin (5-HT) and is a target for antidepressant drugs and psychostimulants. Serotonin 72-81 solute carrier family 6 member 4 Homo sapiens 23-27 17042919-3 2006 The serotonin (5-hydroxtryptamine; 5-HT) transporter (SERT), which controls the synaptic 5-HT concentration through re-uptake of this neurotransmitter into presynaptic terminals, has been a primary therapeutic target for various psychiatric and peripheral disorders. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 35-52 17079812-1 2006 UNLABELLED: PET studies of the serotonin (5-hydroxytryptamine, or 5-HT) transporter are increasingly using (11)C-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile (DASB). Serotonin 31-40 solute carrier family 6 member 4 Homo sapiens 66-83 17008722-1 2006 The human serotonin transporter (hSERT) regulates neurotransmission by removing released serotonin (5-HT) from the synapse. Serotonin 10-19 solute carrier family 6 member 4 Homo sapiens 33-38 16878724-3 2006 This abnormal response is due to overexpression of the serotonin transporter (5-HTT) which mediates the mitogenic action of serotonin. Serotonin 55-64 solute carrier family 6 member 4 Homo sapiens 78-83 16497275-1 2006 BACKGROUND: A low level of response to alcohol has been associated with both the genetic constitution of the regulatory region (SLC6A4) of the human serotonin (5-hydroxytryptamine, 5-HT) transporter (5-HTT) and with future alcohol intake and an increased risk for alcoholism. Serotonin 149-158 solute carrier family 6 member 4 Homo sapiens 128-134 16497275-1 2006 BACKGROUND: A low level of response to alcohol has been associated with both the genetic constitution of the regulatory region (SLC6A4) of the human serotonin (5-hydroxytryptamine, 5-HT) transporter (5-HTT) and with future alcohol intake and an increased risk for alcoholism. Serotonin 160-179 solute carrier family 6 member 4 Homo sapiens 128-134 16721604-2 2006 The integrin beta3 (ITGB3) and serotonin transporter (SLC6A4) genes were both recently identified as male quantitative trait loci (QTLs) for serotonin levels and alleles of each have been associated with autism. Serotonin 31-40 solute carrier family 6 member 4 Homo sapiens 54-60 16918708-5 2006 This serotonin dual action in binding to two sites on the serotonin transporter (both the primary site and the allosteric site) is hypothesised to be responsible for a longer binding to, and therefore greater inhibition of the serotonin transporter by escitalopram. Serotonin 5-14 solute carrier family 6 member 4 Homo sapiens 58-79 16918708-5 2006 This serotonin dual action in binding to two sites on the serotonin transporter (both the primary site and the allosteric site) is hypothesised to be responsible for a longer binding to, and therefore greater inhibition of the serotonin transporter by escitalopram. Serotonin 5-14 solute carrier family 6 member 4 Homo sapiens 227-248 16614302-1 2006 One intrinsic abnormality of pulmonary artery smooth muscle cells (PA-SMCs) in human idiopathic pulmonary hypertension (iPH) is an exaggerated proliferative response to internalized serotonin (5-HT) caused by increased expression of the 5-HT transporter (5-HTT). Serotonin 182-191 solute carrier family 6 member 4 Homo sapiens 237-253 16614302-1 2006 One intrinsic abnormality of pulmonary artery smooth muscle cells (PA-SMCs) in human idiopathic pulmonary hypertension (iPH) is an exaggerated proliferative response to internalized serotonin (5-HT) caused by increased expression of the 5-HT transporter (5-HTT). Serotonin 182-191 solute carrier family 6 member 4 Homo sapiens 255-260 16412987-1 2006 BACKGROUND: A promoter polymorphism in the serotonin transporter (5HTTLPR) has functional effects on an important physiologic process involved in serotonin (5HT) signaling. Serotonin 43-52 solute carrier family 6 member 4 Homo sapiens 66-73 20641424-3 2004 SERT, located on the cell bodies and terminals of 5-HT neurons, is a specific marker for the number and integrity of presynaptic terminals of serotonin-producing neurons. Serotonin 142-151 solute carrier family 6 member 4 Homo sapiens 0-4 16606791-4 2006 Fluoxetine, which inhibits serotonin-induced mitogenesis by blocking the serotonin transporter, and p-chlorophenylalanine, which inhibits serotonin synthesis by blocking tryptophan hydroxylase (TPH), caused a similar 60% reduction in the growth-promoting effect of P-EC media, whereas endothelin receptor blockers had no effect. Serotonin 27-36 solute carrier family 6 member 4 Homo sapiens 73-94 20641500-2 2004 The serotonergic neurons - present in wide areas of the brain, including the raphe nuclei, hypothalamus, thalamus, and cerebral cortex - bear a protein called "serotonin transporter" (SERT) (4).The SERT, located on the cell bodies and terminals of 5-HT neurons, is a specific marker for the number and integrity of presynaptic terminals of serotonin-producing neurons. Serotonin 160-169 solute carrier family 6 member 4 Homo sapiens 184-188 20641500-2 2004 The serotonergic neurons - present in wide areas of the brain, including the raphe nuclei, hypothalamus, thalamus, and cerebral cortex - bear a protein called "serotonin transporter" (SERT) (4).The SERT, located on the cell bodies and terminals of 5-HT neurons, is a specific marker for the number and integrity of presynaptic terminals of serotonin-producing neurons. Serotonin 160-169 solute carrier family 6 member 4 Homo sapiens 198-202 16631080-1 2006 INTRODUCTION: Imaging of the serotonergic innervation of the brain using positron emission tomography (PET) with the serotonin transporter (SERT) ligand [11C] (+)McN5652 might be affected by serotonin in the synaptic cleft if there is relevant interaction between [11C] (+)McN5652 and serotonin at the SERT. Serotonin 117-126 solute carrier family 6 member 4 Homo sapiens 140-144 16631080-1 2006 INTRODUCTION: Imaging of the serotonergic innervation of the brain using positron emission tomography (PET) with the serotonin transporter (SERT) ligand [11C] (+)McN5652 might be affected by serotonin in the synaptic cleft if there is relevant interaction between [11C] (+)McN5652 and serotonin at the SERT. Serotonin 191-200 solute carrier family 6 member 4 Homo sapiens 117-138 16631080-1 2006 INTRODUCTION: Imaging of the serotonergic innervation of the brain using positron emission tomography (PET) with the serotonin transporter (SERT) ligand [11C] (+)McN5652 might be affected by serotonin in the synaptic cleft if there is relevant interaction between [11C] (+)McN5652 and serotonin at the SERT. Serotonin 191-200 solute carrier family 6 member 4 Homo sapiens 140-144 16631080-2 2006 The aim of the present study therefore was to pharmacologically characterize the interaction of [11C] (+)McN5652 and serotonin at the SERT. Serotonin 117-126 solute carrier family 6 member 4 Homo sapiens 134-138 16631080-5 2006 RESULTS: Unlabelled (+)McN5652 significantly reduced the maximal rate of serotonin transport V(max) of SERT without affecting the Michaelis-Menten constant K(M). Serotonin 73-82 solute carrier family 6 member 4 Homo sapiens 103-107 16631080-6 2006 CONCLUSIONS: This finding indicates that (+)McN5652 inhibits serotonin transport through the SERT in a noncompetitive manner. Serotonin 61-70 solute carrier family 6 member 4 Homo sapiens 93-97 16434615-3 2006 Serotonin (5-hydroxytryptamine) and certain SERT inhibitors possess affinity for both sites. Serotonin 11-30 solute carrier family 6 member 4 Homo sapiens 44-48 16434615-11 2006 The finding of an allosteric mechanism at SERT is likely to be of physiological importance, in that serotonin was also found to act as an allosteric effector at duloxetine, RTI-55 and (S)-citalopram. Serotonin 100-109 solute carrier family 6 member 4 Homo sapiens 42-46 16733400-4 2006 Serotonin transporter (5-HTT), the mediator of the mitogenic activity of serotonin, and the expression of which is increased in the course of idiopathic or secondary PAH, is the basis of these effects. Serotonin 73-82 solute carrier family 6 member 4 Homo sapiens 23-28 20641685-3 2004 The SERT, located on the cell bodies and terminals of 5-hydroxytryptamine (5-HT) neurons, is a specific marker for the number and integrity of presynaptic terminals of serotonin-producing neurons. Serotonin 54-73 solute carrier family 6 member 4 Homo sapiens 4-8 20641685-3 2004 The SERT, located on the cell bodies and terminals of 5-hydroxytryptamine (5-HT) neurons, is a specific marker for the number and integrity of presynaptic terminals of serotonin-producing neurons. Serotonin 168-177 solute carrier family 6 member 4 Homo sapiens 4-8 20641685-4 2004 The SERT regulates neurotransmission by removing released serotonin from the extracellular space back into the presynaptic neuron. Serotonin 58-67 solute carrier family 6 member 4 Homo sapiens 4-8 16515684-2 2006 The transporters for the monoamines dopamine, norepinephrine, and serotonin (DAT, NET, and SERT) are targets for several popular psychostimulant drugs of abuse. Serotonin 66-75 solute carrier family 6 member 4 Homo sapiens 91-95 16490163-4 2006 RESULTS: hSERT-expressing oocytes were perfused with 10 micromol/L serotonin (5-HT) to induce hSERT-current. Serotonin 67-76 solute carrier family 6 member 4 Homo sapiens 9-14 16490163-4 2006 RESULTS: hSERT-expressing oocytes were perfused with 10 micromol/L serotonin (5-HT) to induce hSERT-current. Serotonin 67-76 solute carrier family 6 member 4 Homo sapiens 94-99 20641336-3 2004 The SERT, located on the cell bodies and terminals of 5-HT neurons, is a specific marker for the number and integrity of presynaptic terminals of serotonin-producing neurons. Serotonin 146-155 solute carrier family 6 member 4 Homo sapiens 4-8 20641346-2 2004 The SERT is a specific marker for the number and integrity of presynaptic terminals of serotonin-producing neurons. Serotonin 87-96 solute carrier family 6 member 4 Homo sapiens 4-8 16476009-3 2006 Serotonin transporter (5-HTT), via uptake of serotonin (5-HT) into presynaptic serotoninergic neurons, is an initial action site for antidepressants. Serotonin 45-54 solute carrier family 6 member 4 Homo sapiens 0-21 16476009-3 2006 Serotonin transporter (5-HTT), via uptake of serotonin (5-HT) into presynaptic serotoninergic neurons, is an initial action site for antidepressants. Serotonin 45-54 solute carrier family 6 member 4 Homo sapiens 23-28 16272152-3 2006 The hSERT I172M mutant displays a marked loss of inhibitor potency for multiple inhibitors such as (RS)-CIT, clomipramine, RTI-55, fluoxetine, cocaine, nisoxetine, mazindol, and nomifensine, whereas recognition of substrates, including serotonin and 3,4-methylenedioxymethamphetamine, is unaffected. Serotonin 236-245 solute carrier family 6 member 4 Homo sapiens 4-9 16272152-9 2006 A double mutant hSERT Y95F/I172M had a synergistic impact on (RS)-CIT recognition ( approximately 10,000-fold decrease in (RS)-CIT potency) in the context of normal serotonin recognition. Serotonin 165-174 solute carrier family 6 member 4 Homo sapiens 16-21 16393306-12 2006 These data suggest that both release and elimination of 5-hydroxytryptamine by serotonin transporter are involved in the control of colonic motility in man. Serotonin 56-75 solute carrier family 6 member 4 Homo sapiens 79-100 16249995-2 2006 There is evidence that abnormalities in brain serotonin (5HT) play an important role in binge eating behavior, therefore genes involved in 5HT transmission, such as the 5HT transporter (5HTT) gene, may contribute to the biological vulnerability to BED. Serotonin 46-55 solute carrier family 6 member 4 Homo sapiens 169-184 16249995-2 2006 There is evidence that abnormalities in brain serotonin (5HT) play an important role in binge eating behavior, therefore genes involved in 5HT transmission, such as the 5HT transporter (5HTT) gene, may contribute to the biological vulnerability to BED. Serotonin 46-55 solute carrier family 6 member 4 Homo sapiens 186-190 16790074-1 2006 The aim of the study was to evaluate the kinetic parameters of a specific serotonin transporter (SERT) and serotonin uptake in a mentally healthy subset of patients with fibromyalgia. Serotonin 74-83 solute carrier family 6 member 4 Homo sapiens 97-101 16790074-3 2006 SERT expression and functionality were evaluated through the measurement of [3H]paroxetine binding and the [3H]serotonin uptake itself. Serotonin 111-120 solute carrier family 6 member 4 Homo sapiens 0-4 16209960-2 2005 Recently, the S allele of the serotonin transporter (5-HTT) gene-linked polymorphic region was shown to reduce transcription of this gene and thus reduce serotonin reuptake, and this allele is linked with depressive symptoms as well as other psychiatric diseases. Serotonin 30-39 solute carrier family 6 member 4 Homo sapiens 53-58 16722230-1 2006 Serotonin transporter (SERT) serves the important function of taking up serotonin (5-HT) released during serotonergic neurotransmission. Serotonin 72-81 solute carrier family 6 member 4 Homo sapiens 0-21 16722230-1 2006 Serotonin transporter (SERT) serves the important function of taking up serotonin (5-HT) released during serotonergic neurotransmission. Serotonin 72-81 solute carrier family 6 member 4 Homo sapiens 23-27 16185723-2 2005 SERT can operate in reverse direction and be induced by SERT substrates including 5-HT, tyramine and the positively charged methyl-phenylpyridinium (MPP(+)), as well as the amphetamine derivatives para-chloroamphetamine (pCA) and methylene-dioxy-methamphetamine (MDMA). Serotonin 82-86 solute carrier family 6 member 4 Homo sapiens 0-4 16185723-2 2005 SERT can operate in reverse direction and be induced by SERT substrates including 5-HT, tyramine and the positively charged methyl-phenylpyridinium (MPP(+)), as well as the amphetamine derivatives para-chloroamphetamine (pCA) and methylene-dioxy-methamphetamine (MDMA). Serotonin 82-86 solute carrier family 6 member 4 Homo sapiens 56-60 16163530-2 2005 OBJECTIVES: To investigate the effects of an acute manipulation of serotonin and genotype at a functional polymorphism in a gene coding for the serotonin transporter (5-HTT) on an established measure of response inhibition. Serotonin 67-76 solute carrier family 6 member 4 Homo sapiens 144-165 16989291-3 2006 For the majority of antidepressants, these changes are the result of their ability to block serotonin and/or norepinephrine activity at their "presynaptic uptake sites" (i.e., at the serotonin transporter [SERT] or the norepinephrine transporter [NET]). Serotonin 92-101 solute carrier family 6 member 4 Homo sapiens 183-204 16989291-3 2006 For the majority of antidepressants, these changes are the result of their ability to block serotonin and/or norepinephrine activity at their "presynaptic uptake sites" (i.e., at the serotonin transporter [SERT] or the norepinephrine transporter [NET]). Serotonin 92-101 solute carrier family 6 member 4 Homo sapiens 206-210 16300628-3 2006 We found that the serotonin modulators fluoxetine and tianeptine, but not desipramine, increase the density of 5-HT and serotonin transporter (SERT)-immunoreactive axons in the neocortical layer IV and certain forebrain limbic areas, such as piriform cortex and the shell region of nucleus accumbens. Serotonin 18-27 solute carrier family 6 member 4 Homo sapiens 120-141 16300628-3 2006 We found that the serotonin modulators fluoxetine and tianeptine, but not desipramine, increase the density of 5-HT and serotonin transporter (SERT)-immunoreactive axons in the neocortical layer IV and certain forebrain limbic areas, such as piriform cortex and the shell region of nucleus accumbens. Serotonin 18-27 solute carrier family 6 member 4 Homo sapiens 143-147 16082698-2 2005 Because of an interaction between the serotonin (5-HT) and DA systems, the serotonin transporter gene (SLC6A4) has been considered as a candidate ADHD susceptibility gene. Serotonin 38-47 solute carrier family 6 member 4 Homo sapiens 75-96 16082698-2 2005 Because of an interaction between the serotonin (5-HT) and DA systems, the serotonin transporter gene (SLC6A4) has been considered as a candidate ADHD susceptibility gene. Serotonin 38-47 solute carrier family 6 member 4 Homo sapiens 103-109 16245546-7 2005 Osteoblasts and osteoclasts have receptors for serotonin and both cells express the membrane protein that is responsible for serotonin reuptake (5-HTT). Serotonin 125-134 solute carrier family 6 member 4 Homo sapiens 145-150 16109120-2 2005 BACKGROUND: The 5-HT metabolism is believed to play an important part in the pathophysiology of migraines, and a polymorphism of the serotonin transporter (5-HTT) promoter region might influence 5-HTT expression and serotonin uptake. Serotonin 133-142 solute carrier family 6 member 4 Homo sapiens 156-161 16109120-2 2005 BACKGROUND: The 5-HT metabolism is believed to play an important part in the pathophysiology of migraines, and a polymorphism of the serotonin transporter (5-HTT) promoter region might influence 5-HTT expression and serotonin uptake. Serotonin 133-142 solute carrier family 6 member 4 Homo sapiens 195-200 15852063-2 2005 The short allele of a 44 bp insertion/deletion polymorphism (S-allele) within the promoter region of the 5-HTT gene (5-HTTLPR) confers lower transcriptional activity relative to the long allele (L-allele) and may act to modify the risk of serotonin-mediated outcomes such as anxiety and substance use behaviours. Serotonin 239-248 solute carrier family 6 member 4 Homo sapiens 105-110 15852063-2 2005 The short allele of a 44 bp insertion/deletion polymorphism (S-allele) within the promoter region of the 5-HTT gene (5-HTTLPR) confers lower transcriptional activity relative to the long allele (L-allele) and may act to modify the risk of serotonin-mediated outcomes such as anxiety and substance use behaviours. Serotonin 239-248 solute carrier family 6 member 4 Homo sapiens 117-125 16142050-33 2005 Finally, serotonin-mediated vulnerability to the psychobehavioural effects of IFNalpha could be underlain by a polymorphism of serotonin transporter gene. Serotonin 9-18 solute carrier family 6 member 4 Homo sapiens 127-148 15955412-1 2005 The serotonin transporter (SERT) is responsible for terminating or modulating the action of serotonin released from the presynaptic neuron and is the major target for most antidepressants including the tricyclic antidepressants and the selective serotonin uptake inhibitors. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 15955412-1 2005 The serotonin transporter (SERT) is responsible for terminating or modulating the action of serotonin released from the presynaptic neuron and is the major target for most antidepressants including the tricyclic antidepressants and the selective serotonin uptake inhibitors. Serotonin 92-101 solute carrier family 6 member 4 Homo sapiens 4-25 15955412-1 2005 The serotonin transporter (SERT) is responsible for terminating or modulating the action of serotonin released from the presynaptic neuron and is the major target for most antidepressants including the tricyclic antidepressants and the selective serotonin uptake inhibitors. Serotonin 92-101 solute carrier family 6 member 4 Homo sapiens 27-31 15955412-2 2005 Two binding sites for uptake inhibitors and serotonin (5-HT) have been found on SERT. Serotonin 44-53 solute carrier family 6 member 4 Homo sapiens 80-84 15870169-1 2005 Following our previous description of the serotonin transporter (SERT) acting as a conduit to 5-hydroxytryptamine (5-HT)-mediated apoptosis, specifically in Burkitt"s lymphoma, we now detail its expression among a broad spectrum of B cell malignancy, while exploring additional SERT substrates for potential therapeutic activity. Serotonin 94-113 solute carrier family 6 member 4 Homo sapiens 42-63 15870169-1 2005 Following our previous description of the serotonin transporter (SERT) acting as a conduit to 5-hydroxytryptamine (5-HT)-mediated apoptosis, specifically in Burkitt"s lymphoma, we now detail its expression among a broad spectrum of B cell malignancy, while exploring additional SERT substrates for potential therapeutic activity. Serotonin 94-113 solute carrier family 6 member 4 Homo sapiens 65-69 15882779-3 2005 The serotonin transporter gene (SLC6A4) is of special interest given the nature of the biological findings and the reported effects of selective serotonin reuptake inhibitors of autistic symptoms. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 32-38 15642926-1 2005 An association study was performed in 197 migraineurs with regard to a functional serotonin (5-HT) transporter (5-HTT) gene promoter polymorphism that leads to low or high 5-HT uptake activity. Serotonin 82-91 solute carrier family 6 member 4 Homo sapiens 93-110 15867649-4 2005 The synaptic 5-hydroxytryptamine (HT) is inactivated by presynaptic reuptake, which is mediated by the serotonin transporter. Serotonin 13-32 solute carrier family 6 member 4 Homo sapiens 103-124 15867649-4 2005 The synaptic 5-hydroxytryptamine (HT) is inactivated by presynaptic reuptake, which is mediated by the serotonin transporter. Serotonin 34-36 solute carrier family 6 member 4 Homo sapiens 103-124 15804496-1 2005 Deficient serotonin neurotransmission in suicide is indicated by reduced brainstem serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA), fewer 5-HT(1A) autoreceptors and reduced cortical serotonin transporter binding in suicide victims. Serotonin 10-19 solute carrier family 6 member 4 Homo sapiens 191-212 15719397-9 2005 Thus, we show here that SLC6A4, which has a major influence on brain serotonin availability, may be a QTL for ADHD. Serotonin 69-78 solute carrier family 6 member 4 Homo sapiens 24-30 15786496-7 2005 Other candidate genes should be examined with respect to FASD risk, including those for the enzymes of serotonin metabolism, in particular the serotonin transporter. Serotonin 103-112 solute carrier family 6 member 4 Homo sapiens 143-164 15638952-1 2005 The gene coding for the 5-HT transporter (5-HTT) is considered as a candidate gene for schizophrenia, because this transporter plays a key role in serotonin neurotransmission. Serotonin 147-156 solute carrier family 6 member 4 Homo sapiens 24-40 15638952-1 2005 The gene coding for the 5-HT transporter (5-HTT) is considered as a candidate gene for schizophrenia, because this transporter plays a key role in serotonin neurotransmission. Serotonin 147-156 solute carrier family 6 member 4 Homo sapiens 42-47 15322730-2 2005 Serotonin reuptake is controlled by the serotonin transporter (5-HTT) and by a common functional insertion/deletion polymorphism in the corresponding gene"s promoter region (5-HTTLPR). Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 174-182 20641463-2 2004 SERT is a specific marker for the number and integrity of presynaptic terminals of serotonin-producing neurons. Serotonin 83-92 solute carrier family 6 member 4 Homo sapiens 0-4 15642926-1 2005 An association study was performed in 197 migraineurs with regard to a functional serotonin (5-HT) transporter (5-HTT) gene promoter polymorphism that leads to low or high 5-HT uptake activity. Serotonin 82-91 solute carrier family 6 member 4 Homo sapiens 112-117 15642926-1 2005 An association study was performed in 197 migraineurs with regard to a functional serotonin (5-HT) transporter (5-HTT) gene promoter polymorphism that leads to low or high 5-HT uptake activity. Serotonin 93-97 solute carrier family 6 member 4 Homo sapiens 112-117 15581469-5 2004 The genetic analyses of serotonin in alcohol-dependence are mainly focused on the serotonin transporter gene (5-HTT), as one polymorphism within the promoter has a functional impact. Serotonin 24-33 solute carrier family 6 member 4 Homo sapiens 110-115 15634764-1 2005 The serotonin transporter (SERT) is regulated by various signaling mechanisms that may operate to maintain appropriate levels of synaptic serotonin (5-HT). Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 15606893-2 2005 In the present study we show that the dissociation rate, of [3H]S-citalopram from human SERT, is retarded by the presence of serotonin, as well as by several antidepressants, when present in the dissociation buffer. Serotonin 125-134 solute carrier family 6 member 4 Homo sapiens 88-92 15606893-3 2005 Dissociation of [3H]S-citalopram from SERT is most potently inhibited by S-citalopram followed by R-citalopram, sertraline, serotonin and paroxetine. Serotonin 124-133 solute carrier family 6 member 4 Homo sapiens 38-42 15610939-0 2005 Platelet serotonin uptake and paroxetine binding among allelic genotypes of the serotonin transporter in alcoholics. Serotonin 9-18 solute carrier family 6 member 4 Homo sapiens 80-101 15308297-2 2004 Several studies have suggested that dopamine (DA) uptake into serotonin (5-HT) terminals by the 5-HT reuptake transporter (SERT) and subsequent deamination by monoamine oxidase-B (MAO-B) leads to the formation of hydrogen peroxide and may be major contributors to this serotonergic toxicity. Serotonin 62-71 solute carrier family 6 member 4 Homo sapiens 123-127 15337646-2 2004 The purpose of the present study was to determine whether norepinephrine transporter gene (NET) and serotonin transporter gene (5-HTT) polymorphisms are associated with the antidepressant response to milnacipran, a dual serotonin/norepinephrine reuptake inhibitor. Serotonin 100-109 solute carrier family 6 member 4 Homo sapiens 128-133 15302679-0 2004 Nitric oxide donors inhibit 5-hydroxytryptamine (5-HT) uptake by the human 5-HT transporter (SERT). Serotonin 28-47 solute carrier family 6 member 4 Homo sapiens 75-91 15302679-0 2004 Nitric oxide donors inhibit 5-hydroxytryptamine (5-HT) uptake by the human 5-HT transporter (SERT). Serotonin 28-47 solute carrier family 6 member 4 Homo sapiens 93-97 15354180-2 2004 The goal of the present study was to evaluate the association between the 5-HTTLPR and the functional response of the serotonin system as measured by the neuroendocrine and cerebral metabolic response to intravenous administration of the selective serotonin reuptake inhibitor citalopram in normal control subjects. Serotonin 118-127 solute carrier family 6 member 4 Homo sapiens 74-82 15354180-2 2004 The goal of the present study was to evaluate the association between the 5-HTTLPR and the functional response of the serotonin system as measured by the neuroendocrine and cerebral metabolic response to intravenous administration of the selective serotonin reuptake inhibitor citalopram in normal control subjects. Serotonin 248-257 solute carrier family 6 member 4 Homo sapiens 74-82 15354180-9 2004 These findings suggest that 5-HTTLPR is associated with an altered functional response of the serotonin system, which may represent a neurobiologic substrate for the differential response to antidepressant treatment in late life and the emergence of neuropsychiatric symptoms in neurodegenerative disorders. Serotonin 94-103 solute carrier family 6 member 4 Homo sapiens 28-36 15455161-7 2004 Screening of the libraries towards binding and inhibition of uptake of the human dopamine (hDAT), serotonin (hSERT) and norepinephrine transporters (hNET) was carried out. Serotonin 98-107 solute carrier family 6 member 4 Homo sapiens 109-114 15167705-1 2004 OBJECTIVES: Serotonin transporter (SLC6A4) is responsible for serotonin re-uptake into presynaptic terminals, thus fine-tuning brain serotonergic neurotransmission. Serotonin 62-71 solute carrier family 6 member 4 Homo sapiens 12-33 15291238-1 2004 The serotonin transporter (SET) is a member of the Na+/Cl(-)-dependent neurotransmitter transporter family and functions as a membrane protein which terminates the serotonergic neuronal transmission by re-uptaking serotonin into the pre-synaptic terminal. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-30 15056483-1 2004 The serotonin transporter (5-HTT) plays a critical role in the termination of serotonin neurotransmission and represents the prime target for selective serotonin reuptake inhibitors (SSRIs). Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-32 15073266-15 2004 This property will be especially important for the measurement of SERT in regions with moderate density, such as the limbic regions, where alterations of serotonin transmission might be associated with anxiety and depression. Serotonin 154-163 solute carrier family 6 member 4 Homo sapiens 66-70 15087484-1 2004 The highly evolutionarily conserved serotonin transporter (SERT) regulates the entire serotoninergic system and its receptors via modulation of extracellular fluid serotonin concentrations. Serotonin 36-45 solute carrier family 6 member 4 Homo sapiens 59-63 14993096-2 2004 Binding of the novel radioligand (3)H-2-(2-dimethylaminomethyl-phenylsulphanyl)-5-methyl-phenylamine ((3)H-MADAM) to the serotonin transporter (SERT) was used to characterise a range of selective serotonin re-uptake inhibitors (SSRIs) in vitro and in vivo. Serotonin 121-130 solute carrier family 6 member 4 Homo sapiens 144-148 15094787-2 2004 High levels of platelet serotonin (5-HT) have been consistently found in a proportion of patients, and it is known that specific 5-HT transporter gene (SLC6A4) variants modulate transporter reuptake function, therefore possibly influencing the occurrence of hyperserotonemia in a subset of autistic patients. Serotonin 24-33 solute carrier family 6 member 4 Homo sapiens 152-158 15094787-3 2004 We have examined the association of platelet serotonin levels with two SLC6A4 polymorphisms, 5-HTT gene-linked polymorphic region (HTTLPR) in the promoter and intron 2 variable number of tandem repeats (VNTR), in a sample of 105 ASD patients, their parents, and 52 control children. Serotonin 45-54 solute carrier family 6 member 4 Homo sapiens 93-98 15534946-4 2004 There is compelling evidence from research in biological psychiatry that abnormalities in the functioning of the central serotonergic system are involved in the pathogenesis of suicidal behavior, and the results of association studies suggest that the gene coding for tryptophan hydroxylase, which is the serotonin synthesis enzyme, and the serotonin transporter gene are involved in susceptibility to suicidal behavior. Serotonin 305-314 solute carrier family 6 member 4 Homo sapiens 341-362 15236602-10 2004 It is possible that one of the cleaved SERT species is required for serotonin transport activity. Serotonin 68-77 solute carrier family 6 member 4 Homo sapiens 39-43 15168220-2 2004 Tryptophan hydroxylase (TPH) and 5-hydroxytryptamine transporter (5HTt) are the main regulators of 5HT signaling. Serotonin 66-69 solute carrier family 6 member 4 Homo sapiens 33-64 14735161-2 2004 5-HTT is the major site of serotonin reuptake into the presynaptic neuron, and it has been shown that the polymorphic repeat polymorphism in the 5-HTT promotor region (5-HTTLPR) may affect gene-transcription activity. Serotonin 27-36 solute carrier family 6 member 4 Homo sapiens 0-5 14735161-2 2004 5-HTT is the major site of serotonin reuptake into the presynaptic neuron, and it has been shown that the polymorphic repeat polymorphism in the 5-HTT promotor region (5-HTTLPR) may affect gene-transcription activity. Serotonin 27-36 solute carrier family 6 member 4 Homo sapiens 145-150 15285608-1 2004 The interindividual variation of temperament features (such as anxiety, neuroticism, harm avoidance) is determined, in particular, by allele polymorphism of genes involved in serotonin metabolism and has earlier been associated with the insertion/deletion polymorphism of the serotonin transporter gene. Serotonin 175-184 solute carrier family 6 member 4 Homo sapiens 276-297 15034919-9 2004 The present findings thus demonstrate that ADAM is a specific SERT radioligand which can be used for in vivo study of central serotonin systems, and supports its use as a tracer for SPECT studies in human disorders involving dysfunction of serotonergic neurotransmission. Serotonin 126-135 solute carrier family 6 member 4 Homo sapiens 62-66 15167705-1 2004 OBJECTIVES: Serotonin transporter (SLC6A4) is responsible for serotonin re-uptake into presynaptic terminals, thus fine-tuning brain serotonergic neurotransmission. Serotonin 62-71 solute carrier family 6 member 4 Homo sapiens 35-41 14593087-1 2004 In this study, human embryonic kidney (HEK)-293 cells stably expressing human, Drosophila, or a chimeric serotonin (5-hydroxytryptamine, 5-HT) transporter (hSERT, dSERT, and H(1-281)D(282-476)H(477-638), respectively) were used to explore the ability of two libraries of structurally distinct psychostimulants to inhibit 5-HT uptake. Serotonin 105-114 solute carrier family 6 member 4 Homo sapiens 156-161 14700733-2 2004 Dopamine and serotonin uptake by human SERT expressed in HEK-293 cells was compared at 37 and 40 degrees C. Elevated temperature was found to alter serotonin transport, but had no significant effect on dopamine transport. Serotonin 13-22 solute carrier family 6 member 4 Homo sapiens 39-43 14700733-2 2004 Dopamine and serotonin uptake by human SERT expressed in HEK-293 cells was compared at 37 and 40 degrees C. Elevated temperature was found to alter serotonin transport, but had no significant effect on dopamine transport. Serotonin 148-157 solute carrier family 6 member 4 Homo sapiens 39-43 14706424-2 2004 We aim to determine the predictive value of two serotonin-related genes, the tryptophan hydroxylase (TPH) and serotonin transporter (5-HTTLPR) genes that have been involved in the susceptibility to suicidal behavior. Serotonin 48-57 solute carrier family 6 member 4 Homo sapiens 110-131 15539857-2 2004 The serotonin transporter (5-HTT), which reuptakes serotonin into the nerve terminal, plays a critical role in the regulation of serotonergic function. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-32 14687821-1 2003 OBJECTIVES: Serotonin reuptake is mediated by a transporter protein (SERT), and its dysfunctions can alter serotonergic transmission. Serotonin 12-21 solute carrier family 6 member 4 Homo sapiens 69-73 14687821-10 2003 CONCLUSIONS: The present results indicate that SERT expressed on platelet membranes of D-IBS patients is characterized by low density and binding affinity and suggest a possible correlation between the reduced capacity of serotonin reuptake and the severity of D-IBS symptoms. Serotonin 222-231 solute carrier family 6 member 4 Homo sapiens 47-51 14729130-6 2003 The specific transporter for serotonin, serotonin transporter (SERT) has been detected in fibers of the internal capsule (IC) during the restricted time period of 12-14 gestational weeks in humans. Serotonin 29-38 solute carrier family 6 member 4 Homo sapiens 40-61 14729130-6 2003 The specific transporter for serotonin, serotonin transporter (SERT) has been detected in fibers of the internal capsule (IC) during the restricted time period of 12-14 gestational weeks in humans. Serotonin 29-38 solute carrier family 6 member 4 Homo sapiens 63-67 14987118-13 2004 SLC6A4 genotyping would allow physicians to individualize selective serotonin reuptake therapy for their patients. Serotonin 68-77 solute carrier family 6 member 4 Homo sapiens 0-6 15510373-9 2004 CONCLUSION: Increases in [Ca2+]c and [Na+]c independently induce serotonin efflux through the outward directed plasma membrane serotonin transporter SERT. Serotonin 65-74 solute carrier family 6 member 4 Homo sapiens 149-153 14609729-6 2003 15 (2001) 6348), we assume that the low apparent Vmax of platelet-5HT uptake reflects the low expression of 5HT transporter not only in platelets, but also in the gut mucosa and enteric serotonergic neurons, which probably increases the risk of typical gastrointestinal symptoms such as appetite loss and nausea occurring in some depressed patients. Serotonin 66-69 solute carrier family 6 member 4 Homo sapiens 108-123 12944413-8 2003 A physical interaction between myosin and SERT was apparent; however, defects in sialylated N-glycans impaired association of SERT with myosin as well as the stimulation of the serotonin uptake function in the cGMP-dependent pathway. Serotonin 177-186 solute carrier family 6 member 4 Homo sapiens 42-46 14593431-2 2003 We now report an uncommon coding region SERT mutation, Ile425Val, in two unrelated families with OCD and other serotonin-related disorders. Serotonin 111-120 solute carrier family 6 member 4 Homo sapiens 40-44 12962916-0 2003 Despite the general correlation of the serotonin transporter gene regulatory region polymorphism (5-HTTLPR) and platelet serotonin concentration, lower platelet serotonin concentration in migraine patients is independent of the 5-HTTLPR variants. Serotonin 39-48 solute carrier family 6 member 4 Homo sapiens 98-106 12759157-2 2003 The serotonin transporter (5-HTT) gene is one of the important genes involved in the regulation of serotonin transmission. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-32 12911615-1 2003 Mood, emotion and cognition are modulated by serotonergic neurotransmission, while the physiological function of serotonergic synapses depends on serotonin reuptake, which is mediated by the serotonin transporter (5-HTT). Serotonin 146-155 solute carrier family 6 member 4 Homo sapiens 214-219 12849929-0 2003 Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter. Serotonin 15-24 solute carrier family 6 member 4 Homo sapiens 116-137 12887693-1 2003 Re-uptake of the neurotransmitters serotonin and noradrenaline out of the synaptic cleft is mediated by selective transporter proteins, the serotonin transporter and the noradrenaline transporter respectively. Serotonin 35-44 solute carrier family 6 member 4 Homo sapiens 140-161 12876460-4 2003 Since serotonin-synthesizing neurons are known to be lost in the AD cortex, this study suggests that the preservation of 5-HTT may exacerbate serotonergic deficits and underlie anxiety symptoms in AD. Serotonin 6-15 solute carrier family 6 member 4 Homo sapiens 121-126 12773327-3 2003 The mitogenic effect of serotonin on pulmonary vascular smooth muscle cells is mediated by the serotonin transporter (5-hydroxytryptamine transporter [5-HTT]), whereas its constricting effect is mediated by 5-HT1B/1D and 5-HT2A receptors. Serotonin 24-33 solute carrier family 6 member 4 Homo sapiens 95-116 12815744-1 2003 The aim of this study was to investigate any possible association between depressed mood in the elderly and two candidate SNPs in the serotonin system: one in the 5-HTR2A gene promotor (-1438 G/A) and one in the 5-HT transporter gene (-925 C/A). Serotonin 134-143 solute carrier family 6 member 4 Homo sapiens 212-228 12682215-2 2003 hSERT and dSERT showed similar Km values for 5-hydroxytryptamine (5-HT; serotonin) transport (1.2 and 0.9 micro M, respectively), suggesting similar recognition of 5-HT by the two species variants. Serotonin 45-64 solute carrier family 6 member 4 Homo sapiens 0-5 12682215-2 2003 hSERT and dSERT showed similar Km values for 5-hydroxytryptamine (5-HT; serotonin) transport (1.2 and 0.9 micro M, respectively), suggesting similar recognition of 5-HT by the two species variants. Serotonin 72-81 solute carrier family 6 member 4 Homo sapiens 0-5 12682218-0 2003 Uptake of serotonin at the apical and basolateral membranes of human intestinal epithelial (Caco-2) cells occurs through the neuronal serotonin transporter (SERT). Serotonin 10-19 solute carrier family 6 member 4 Homo sapiens 134-155 12682218-0 2003 Uptake of serotonin at the apical and basolateral membranes of human intestinal epithelial (Caco-2) cells occurs through the neuronal serotonin transporter (SERT). Serotonin 10-19 solute carrier family 6 member 4 Homo sapiens 157-161 12759553-1 2003 BACKGROUND: Depression has been associated with a decrease in intracellular serotonin (5-HT) reuptake through its transporter, SERT. Serotonin 76-85 solute carrier family 6 member 4 Homo sapiens 127-131 12605580-1 2003 This study was designed to analyse possible associations between DNA polymorphisms in the 5-hydroxytryptamine (5-HT; serotonin) 5-HT(2A) receptor and the 5-HT transporter (5-HTT) genes, and myocardial infarction (MI). Serotonin 90-109 solute carrier family 6 member 4 Homo sapiens 154-170 12605580-1 2003 This study was designed to analyse possible associations between DNA polymorphisms in the 5-hydroxytryptamine (5-HT; serotonin) 5-HT(2A) receptor and the 5-HT transporter (5-HTT) genes, and myocardial infarction (MI). Serotonin 90-109 solute carrier family 6 member 4 Homo sapiens 172-177 12658617-2 2003 Other studies have implicated the neurotransmitter serotonin or polymorphisms in the serotonin transporter gene (5HTT) as an important source of variability in "externalizing" behaviors such as aggressivity, conduct disorder, and attention deficit-hyperactivity disorders (ADHD). Serotonin 51-60 solute carrier family 6 member 4 Homo sapiens 85-106 12658617-2 2003 Other studies have implicated the neurotransmitter serotonin or polymorphisms in the serotonin transporter gene (5HTT) as an important source of variability in "externalizing" behaviors such as aggressivity, conduct disorder, and attention deficit-hyperactivity disorders (ADHD). Serotonin 51-60 solute carrier family 6 member 4 Homo sapiens 113-117 12660809-1 2003 The serotonin reuptake transporter (SERT) plays an important role in serotonin neurotransmission and in several psychopathological disorders such as depression and anxiety disorders. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 36-40 12660809-9 2003 These findings suggest that ovarian hormones regulate SERT protein expression and distribution, perhaps via extracellular serotonin or mRNA stability, but not solely at the level of gene transcription. Serotonin 122-131 solute carrier family 6 member 4 Homo sapiens 54-58 12586388-5 2003 All the mammalian cell lines expressed functional SERT, but SERT expressed in E. coli or P. pastoris was nonfunctional as assessed by 5-hydroxytryptamine uptake and inhibitor binding assays. Serotonin 134-153 solute carrier family 6 member 4 Homo sapiens 60-64 12586388-8 2003 All the mammalian stable cell lines expressed SERT at the plasma membrane as assessed by [3H]-5-hydroxytryptamine uptake into whole cells, but the V(max) for the T-Rex-SERT cell line was 10-fold higher than any of the other cell lines. Serotonin 94-113 solute carrier family 6 member 4 Homo sapiens 46-50 12784104-9 2003 Although 5-HTTLPR modulates serotonin reuptake by the serotonin transporter, our analyses provide no evidence that susceptibility to AN is modified by 5-HTTLPR alone, nor in concert with as yet undetermined functional effects of the NETpPR polymorphism. Serotonin 28-37 solute carrier family 6 member 4 Homo sapiens 54-75 12794307-1 2003 Ovarian steroid hormones, estrogen and progestin, affect the function of the serotonin neural system by inhibiting serotonin re-uptake through allosteric interaction with the serotonin transporter (SERT) in a nongenomic mechanism. Serotonin 77-86 solute carrier family 6 member 4 Homo sapiens 175-196 12794307-1 2003 Ovarian steroid hormones, estrogen and progestin, affect the function of the serotonin neural system by inhibiting serotonin re-uptake through allosteric interaction with the serotonin transporter (SERT) in a nongenomic mechanism. Serotonin 77-86 solute carrier family 6 member 4 Homo sapiens 198-202 12794307-1 2003 Ovarian steroid hormones, estrogen and progestin, affect the function of the serotonin neural system by inhibiting serotonin re-uptake through allosteric interaction with the serotonin transporter (SERT) in a nongenomic mechanism. Serotonin 115-124 solute carrier family 6 member 4 Homo sapiens 175-196 12794307-1 2003 Ovarian steroid hormones, estrogen and progestin, affect the function of the serotonin neural system by inhibiting serotonin re-uptake through allosteric interaction with the serotonin transporter (SERT) in a nongenomic mechanism. Serotonin 115-124 solute carrier family 6 member 4 Homo sapiens 198-202 12794307-4 2003 The effect of these compounds on the re-uptake of radioactive serotonin was assayed in HEK-293 cells stably expressed the recombinant human serotonin transporter (hSERT). Serotonin 62-71 solute carrier family 6 member 4 Homo sapiens 140-161 12794307-4 2003 The effect of these compounds on the re-uptake of radioactive serotonin was assayed in HEK-293 cells stably expressed the recombinant human serotonin transporter (hSERT). Serotonin 62-71 solute carrier family 6 member 4 Homo sapiens 163-168 12657510-2 2003 As JAR cells, as well as the placenta, express the neuronal serotonin transporter (SERT), a comparison between the uptake of (3)H-MPP(+) and (3)H-serotonin ((3)H-5HT) was made. Serotonin 60-69 solute carrier family 6 member 4 Homo sapiens 83-87 12573307-5 2003 The results support the assumption that serotonin-related psychiatric disorders-such as premenstrual dysphoria-may be associated with a reduction in platelet [(3)H]paroxetine binding, but argue against the notion that this reduction is due to certain variants of the serotonin transporter gene being more common in patients than in controls. Serotonin 40-49 solute carrier family 6 member 4 Homo sapiens 267-288 12824740-1 2003 This study was aimed to test the association between schizophrenia and a functional serotonin polymorphism (5-HTTLPR) in the upstream regulatory region. Serotonin 84-93 solute carrier family 6 member 4 Homo sapiens 108-116 12135035-1 2002 OBJECTIVES: Serotonin is a key mediator of intestinal peristalsis, and after it is secreted, it is effectively cleansed from the neuronal gap by means of a high affinity substance called serotonin transporter (SERT), which depends on the Na+ and Cl- ions localized in the presynaptic neuronal membranes. Serotonin 12-21 solute carrier family 6 member 4 Homo sapiens 187-208 12496095-1 2002 The serotonin (5-hydroxytryptamine; 5HT) transporter (SERT) catalyzes the movement of 5HT across cellular membranes. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 54-58 12496095-1 2002 The serotonin (5-hydroxytryptamine; 5HT) transporter (SERT) catalyzes the movement of 5HT across cellular membranes. Serotonin 15-34 solute carrier family 6 member 4 Homo sapiens 54-58 12496095-1 2002 The serotonin (5-hydroxytryptamine; 5HT) transporter (SERT) catalyzes the movement of 5HT across cellular membranes. Serotonin 36-39 solute carrier family 6 member 4 Homo sapiens 54-58 12496095-5 2002 Analysis of the time course of net transport, the equilibrium 5HT gradient sustained, and the ratio of the unidirectional influx to efflux of 5HT indicate that mechanistically, human SERT functions as a 5HT channel rather than a classical carrier. Serotonin 62-65 solute carrier family 6 member 4 Homo sapiens 183-187 12496095-5 2002 Analysis of the time course of net transport, the equilibrium 5HT gradient sustained, and the ratio of the unidirectional influx to efflux of 5HT indicate that mechanistically, human SERT functions as a 5HT channel rather than a classical carrier. Serotonin 142-145 solute carrier family 6 member 4 Homo sapiens 183-187 12585696-9 2002 To assess the serotonin function in major depression, we investigated serotonin transporter density in blood lymphocytes from patients with this disorder and selected according to the interview of the American Psychiatric Association. Serotonin 14-23 solute carrier family 6 member 4 Homo sapiens 70-91 12163129-1 2002 A variety of drugs release serotonin (5-HT, 5-hydroxytryptamine) from neurons by acting as substrates for 5-HT transporter (SERT) proteins. Serotonin 27-36 solute carrier family 6 member 4 Homo sapiens 124-128 12163129-1 2002 A variety of drugs release serotonin (5-HT, 5-hydroxytryptamine) from neurons by acting as substrates for 5-HT transporter (SERT) proteins. Serotonin 38-42 solute carrier family 6 member 4 Homo sapiens 124-128 12163129-1 2002 A variety of drugs release serotonin (5-HT, 5-hydroxytryptamine) from neurons by acting as substrates for 5-HT transporter (SERT) proteins. Serotonin 44-63 solute carrier family 6 member 4 Homo sapiens 124-128 11997877-5 2002 SERT is a marker of the serotoninergic axons and allows visualization of the serotonin afferents of the raphe in the human telencephalon. Serotonin 24-33 solute carrier family 6 member 4 Homo sapiens 0-4 12175857-6 2002 The 5HT uptake data were consistent with biotinylation experiments showing a decrease in the surface expression of SERT following toxin treatment. Serotonin 4-7 solute carrier family 6 member 4 Homo sapiens 115-119 12491807-1 2002 Following exocytotic release, the biogenic amine neurotransmitters, norepinephrine, dopamine, and serotonin are removed from the synaptic cleft by the respective transporter, NET, DAT, and SERT, located on the plasma membrane and then re-stored into synaptic vesicles by vesicular monoamine transporter, VMAT. Serotonin 98-107 solute carrier family 6 member 4 Homo sapiens 189-193 12135035-1 2002 OBJECTIVES: Serotonin is a key mediator of intestinal peristalsis, and after it is secreted, it is effectively cleansed from the neuronal gap by means of a high affinity substance called serotonin transporter (SERT), which depends on the Na+ and Cl- ions localized in the presynaptic neuronal membranes. Serotonin 12-21 solute carrier family 6 member 4 Homo sapiens 210-214 11971705-2 2002 Unlike unconjugated nanocrystals, SNACs were found to dose-dependently inhibit transport of radiolabeled serotonin by hSERT and dSERT, with an estimated half-maximal activity (EC(50)) of 33 (dSERT) and 99 microM (hSERT). Serotonin 105-114 solute carrier family 6 member 4 Homo sapiens 118-123 11971705-3 2002 When serotonin was conjugated to the nanocrystal through a linker arm (LSNACs), the EC(50) for hSERT was determined to be 115 microM. Serotonin 5-14 solute carrier family 6 member 4 Homo sapiens 95-100 11994534-1 2002 UNLABELLED: There has been considerable interest in the development of a PET radioligand selective for the serotonin (5-hydroxytryptamine [5-HT]) transporter (SERT) that can be used to image 5-HT neurons in the living human brain. Serotonin 107-116 solute carrier family 6 member 4 Homo sapiens 159-163 11920857-0 2002 Correlation between serotonin uptake in human blood platelets with the 44-bp polymorphism and the 17-bp variable number of tandem repeat of the serotonin transporter. Serotonin 20-29 solute carrier family 6 member 4 Homo sapiens 144-165 11919520-1 2002 SUMMARY: [11C](+)McN5652 is a selective serotonin reuptake inhibitor with subnanomolar potency for the serotonin transporter, and is currently being used for positron emission tomography studies. Serotonin 40-49 solute carrier family 6 member 4 Homo sapiens 103-124 11817517-1 2002 The presence of the long (l) variant of the serotonin (5-hydroxytryptamine: 5-HT) transporter gene-linked polymorphic region (5-HTTLPR) is reported to be associated with a more favorable and faster antidepressant effect of selective serotonin reuptake inhibitors in Caucasians. Serotonin 44-53 solute carrier family 6 member 4 Homo sapiens 76-93 11888575-4 2002 To date, neuroimaging studies designed to establish whether levels of brain serotonin neurons are lower than normal in ecstasy users have employed radioligands that bind to one component of the serotonin neuron, the serotonin transporter (SERT). Serotonin 76-85 solute carrier family 6 member 4 Homo sapiens 216-237 11888575-4 2002 To date, neuroimaging studies designed to establish whether levels of brain serotonin neurons are lower than normal in ecstasy users have employed radioligands that bind to one component of the serotonin neuron, the serotonin transporter (SERT). Serotonin 194-203 solute carrier family 6 member 4 Homo sapiens 216-237 11888575-4 2002 To date, neuroimaging studies designed to establish whether levels of brain serotonin neurons are lower than normal in ecstasy users have employed radioligands that bind to one component of the serotonin neuron, the serotonin transporter (SERT). Serotonin 194-203 solute carrier family 6 member 4 Homo sapiens 239-243 11817517-1 2002 The presence of the long (l) variant of the serotonin (5-hydroxytryptamine: 5-HT) transporter gene-linked polymorphic region (5-HTTLPR) is reported to be associated with a more favorable and faster antidepressant effect of selective serotonin reuptake inhibitors in Caucasians. Serotonin 55-74 solute carrier family 6 member 4 Homo sapiens 76-93 11817517-1 2002 The presence of the long (l) variant of the serotonin (5-hydroxytryptamine: 5-HT) transporter gene-linked polymorphic region (5-HTTLPR) is reported to be associated with a more favorable and faster antidepressant effect of selective serotonin reuptake inhibitors in Caucasians. Serotonin 233-242 solute carrier family 6 member 4 Homo sapiens 76-93 12378120-3 2002 The serotonin transporter is the major site of serotonin reuptake into the presynaptic neuron, and it has been determined that variants in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) may affect gene transcription activity. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 143-164 12143401-7 2002 The localized reduction in SERT binding in ventral PFC found in suicide victims may reflect reduced serotonin input to that brain region, underlying the predisposition to act on suicidal thoughts. Serotonin 100-109 solute carrier family 6 member 4 Homo sapiens 27-31 11746710-12 2001 The similar affinities of non-amines and conventional antidepressant drugs for the SERT support the view that an amine nitrogen is not essential for drugs to block serotonin transport with high affinity. Serotonin 164-173 solute carrier family 6 member 4 Homo sapiens 83-87 11739616-1 2001 The dopamine (DAT) and serotonin (SERT) transporter genes both contain variable number of tandem repeats (VNTR) in non-coding gene regions which have been correlated with a predisposition to a variety of CNS disorders. Serotonin 23-32 solute carrier family 6 member 4 Homo sapiens 34-38 11179447-1 2001 The serotonin (5-hydroxytryptamine, 5-HT) transporter (SERT) is responsible for the inactivation of synaptic 5-HT and is also a target for multiple psychostimulants. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 55-59 11408487-5 2001 The addition of either cocaine or serotonin (5-HT) protected SERT against MTSET inactivation. Serotonin 34-43 solute carrier family 6 member 4 Homo sapiens 61-65 11443529-1 2001 The promoter polymorphism of the serotonin transporter gene (HTT, locus SLC6A4) is of special interest in autism given the well-replicated platelet hyperserotonemia of autism, treatment effects of serotonin reuptake inhibitors, and the role of serotonin in limbic functioning and neurodevelopment. Serotonin 33-42 solute carrier family 6 member 4 Homo sapiens 72-78 11443529-1 2001 The promoter polymorphism of the serotonin transporter gene (HTT, locus SLC6A4) is of special interest in autism given the well-replicated platelet hyperserotonemia of autism, treatment effects of serotonin reuptake inhibitors, and the role of serotonin in limbic functioning and neurodevelopment. Serotonin 197-206 solute carrier family 6 member 4 Homo sapiens 33-54 11443529-1 2001 The promoter polymorphism of the serotonin transporter gene (HTT, locus SLC6A4) is of special interest in autism given the well-replicated platelet hyperserotonemia of autism, treatment effects of serotonin reuptake inhibitors, and the role of serotonin in limbic functioning and neurodevelopment. Serotonin 197-206 solute carrier family 6 member 4 Homo sapiens 72-78 11326308-3 2001 Since there is extensive evidence of degeneration of serotonin (5HT) neurons and loss of the 5HT transporter (5HTT) in PD, we assessed whether a functional polymorphism in the promoter of the 5HTT gene (5HTT gene-linked polymorphic region, 5HTTLPR), which determines high or low 5HT uptake, is associated with depressive symptomatology in PD patients. Serotonin 53-62 solute carrier family 6 member 4 Homo sapiens 192-196 11326308-3 2001 Since there is extensive evidence of degeneration of serotonin (5HT) neurons and loss of the 5HT transporter (5HTT) in PD, we assessed whether a functional polymorphism in the promoter of the 5HTT gene (5HTT gene-linked polymorphic region, 5HTTLPR), which determines high or low 5HT uptake, is associated with depressive symptomatology in PD patients. Serotonin 53-62 solute carrier family 6 member 4 Homo sapiens 192-196 11326308-3 2001 Since there is extensive evidence of degeneration of serotonin (5HT) neurons and loss of the 5HT transporter (5HTT) in PD, we assessed whether a functional polymorphism in the promoter of the 5HTT gene (5HTT gene-linked polymorphic region, 5HTTLPR), which determines high or low 5HT uptake, is associated with depressive symptomatology in PD patients. Serotonin 64-67 solute carrier family 6 member 4 Homo sapiens 192-196 11326308-3 2001 Since there is extensive evidence of degeneration of serotonin (5HT) neurons and loss of the 5HT transporter (5HTT) in PD, we assessed whether a functional polymorphism in the promoter of the 5HTT gene (5HTT gene-linked polymorphic region, 5HTTLPR), which determines high or low 5HT uptake, is associated with depressive symptomatology in PD patients. Serotonin 64-67 solute carrier family 6 member 4 Homo sapiens 192-196 11326308-3 2001 Since there is extensive evidence of degeneration of serotonin (5HT) neurons and loss of the 5HT transporter (5HTT) in PD, we assessed whether a functional polymorphism in the promoter of the 5HTT gene (5HTT gene-linked polymorphic region, 5HTTLPR), which determines high or low 5HT uptake, is associated with depressive symptomatology in PD patients. Serotonin 93-96 solute carrier family 6 member 4 Homo sapiens 110-114 11326308-3 2001 Since there is extensive evidence of degeneration of serotonin (5HT) neurons and loss of the 5HT transporter (5HTT) in PD, we assessed whether a functional polymorphism in the promoter of the 5HTT gene (5HTT gene-linked polymorphic region, 5HTTLPR), which determines high or low 5HT uptake, is associated with depressive symptomatology in PD patients. Serotonin 93-96 solute carrier family 6 member 4 Homo sapiens 192-196 11326308-3 2001 Since there is extensive evidence of degeneration of serotonin (5HT) neurons and loss of the 5HT transporter (5HTT) in PD, we assessed whether a functional polymorphism in the promoter of the 5HTT gene (5HTT gene-linked polymorphic region, 5HTTLPR), which determines high or low 5HT uptake, is associated with depressive symptomatology in PD patients. Serotonin 93-96 solute carrier family 6 member 4 Homo sapiens 192-196 11602621-2 2001 Here we found that PA-SMCs from patients with PPH grow faster than PA-SMCs from controls when stimulated by serotonin or serum and that these effects are due to increased expression of the serotonin transporter (5-HTT), which mediates internalization of indoleamine. Serotonin 108-117 solute carrier family 6 member 4 Homo sapiens 189-210 11677251-1 2001 The serotonin transporter (SERT) is a high-affinity sodium/chloride-dependent neurotransmitter transporter responsible for reuptake of serotonin from the extracellular space. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 11523992-1 2001 The synaptic actions of the neurotransmitter serotonin are terminated by a selective high-affinity reuptake mediated by the serotonin transporter (SERT). Serotonin 45-54 solute carrier family 6 member 4 Homo sapiens 124-145 11523992-1 2001 The synaptic actions of the neurotransmitter serotonin are terminated by a selective high-affinity reuptake mediated by the serotonin transporter (SERT). Serotonin 45-54 solute carrier family 6 member 4 Homo sapiens 147-151 11900612-1 2001 Studies indicate that the serotonin system, particularly the serotonin transporter (5-HTT), may modulate the central effects of cocaine. Serotonin 26-35 solute carrier family 6 member 4 Homo sapiens 84-89 11306696-2 2001 Uptake and superfusion experiments were performed on human embryonic kidney 293 cells permanently expressing the hSERT using [(3)H]serotonin (5-HT) and [(3)H]1-methyl-4-phenylpyridinium (MPP(+)) as substrates. Serotonin 142-146 solute carrier family 6 member 4 Homo sapiens 113-118 11179447-1 2001 The serotonin (5-hydroxytryptamine, 5-HT) transporter (SERT) is responsible for the inactivation of synaptic 5-HT and is also a target for multiple psychostimulants. Serotonin 15-34 solute carrier family 6 member 4 Homo sapiens 55-59 10962219-2 2000 Following serotonin release, the serotonin transporter (5-HTT) is the major determinant of serotonin inactivation. Serotonin 10-19 solute carrier family 6 member 4 Homo sapiens 33-54 11166082-2 2000 The serotonin transporter gene (5-HTT) is one of the important genes involved in the regulation of serotonin neurotransmission. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 32-37 10962219-2 2000 Following serotonin release, the serotonin transporter (5-HTT) is the major determinant of serotonin inactivation. Serotonin 10-19 solute carrier family 6 member 4 Homo sapiens 56-61 10962219-2 2000 Following serotonin release, the serotonin transporter (5-HTT) is the major determinant of serotonin inactivation. Serotonin 33-42 solute carrier family 6 member 4 Homo sapiens 56-61 10960164-2 2000 In this case-control study we investigated whether the serotonin transporter (5-HTT) gene encoding the protein responsible for the reuptake of serotonin from the synapse after its release from serotonergic neurons is a susceptibility factor for suicidal behavior. Serotonin 55-64 solute carrier family 6 member 4 Homo sapiens 78-83 10920459-10 2000 The localized reduction in 5-HTT binding in the ventral PFC of suicides may reflect reduced serotonin input to that brain region, underlying the predisposition to act on suicidal thoughts. Serotonin 92-101 solute carrier family 6 member 4 Homo sapiens 27-32 11256582-2 2000 These agents bind to the serotonin transporter (5-HTT) and inhibit its capacity to transport serotonin (5-hydroxytryptamine; 5-HT). Serotonin 25-34 solute carrier family 6 member 4 Homo sapiens 48-53 11256582-2 2000 These agents bind to the serotonin transporter (5-HTT) and inhibit its capacity to transport serotonin (5-hydroxytryptamine; 5-HT). Serotonin 104-123 solute carrier family 6 member 4 Homo sapiens 25-46 11256582-2 2000 These agents bind to the serotonin transporter (5-HTT) and inhibit its capacity to transport serotonin (5-hydroxytryptamine; 5-HT). Serotonin 104-123 solute carrier family 6 member 4 Homo sapiens 48-53 10862800-1 2000 BACKGROUND: The involvement of serotonin in depression and suicide has been proposed, because major depression is successfully treated by medications that specifically block the serotonin transporter, and there is evidence for a decrease in serotonin transporters in major depression and suicide. Serotonin 31-40 solute carrier family 6 member 4 Homo sapiens 178-199 10965163-2 2000 Serotonin concentrations in neural tissue are controlled by a presynaptic serotonin transporter protein that is encoded by a single gene. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 74-95 10655481-1 2000 The third transmembrane domain (TM3) of serotonin transporter (SERT) contains two isoleucine residues previously proposed to be involved in binding and transport of serotonin. Serotonin 40-49 solute carrier family 6 member 4 Homo sapiens 63-67 11205152-2 2000 In both disorders there is an extensive degeneration of serotonergic neurons, with corresponding losses of the serotonin (5HT) transporter (5HTT), which is responsible for the reuptake of 5HT from the synaptic cleft. Serotonin 111-120 solute carrier family 6 member 4 Homo sapiens 140-144 11205152-2 2000 In both disorders there is an extensive degeneration of serotonergic neurons, with corresponding losses of the serotonin (5HT) transporter (5HTT), which is responsible for the reuptake of 5HT from the synaptic cleft. Serotonin 122-125 solute carrier family 6 member 4 Homo sapiens 140-144 11205152-3 2000 An increasing body of evidence indicates that allelic variation of the 5HTT gene promoter (5HTT gene-linked polymorphic region, 5HTTLPR) determines high or low 5HT uptake in normal human brain. Serotonin 71-74 solute carrier family 6 member 4 Homo sapiens 91-95 11205152-3 2000 An increasing body of evidence indicates that allelic variation of the 5HTT gene promoter (5HTT gene-linked polymorphic region, 5HTTLPR) determines high or low 5HT uptake in normal human brain. Serotonin 71-74 solute carrier family 6 member 4 Homo sapiens 128-135 10454705-11 1999 Human placenta is therefore a direct target for cannabinoids, and marijuana use during pregnancy is likely to affect the placental clearance of serotonin through the serotonin transporter. Serotonin 144-153 solute carrier family 6 member 4 Homo sapiens 166-187 10436197-1 1999 Development of selective serotonin transporter (SERT) tracers for single-photon emission tomography (SPET) is important for studying the underlying pharmacology and interaction of specific serotonin reuptake site inhibitors, commonly used antidepressants, at the SERT sites in the human brain. Serotonin 25-34 solute carrier family 6 member 4 Homo sapiens 48-52 10436197-1 1999 Development of selective serotonin transporter (SERT) tracers for single-photon emission tomography (SPET) is important for studying the underlying pharmacology and interaction of specific serotonin reuptake site inhibitors, commonly used antidepressants, at the SERT sites in the human brain. Serotonin 25-34 solute carrier family 6 member 4 Homo sapiens 263-267 10780268-1 1999 The serotonin transporter gene (SERT) plays an important role in the serotonin uptake into neurons. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 32-36 10427004-4 1999 Ligands that can permeate the transporter, such as serotonin or the amphetamines, prevented PKC-dependent SERT phosphorylation. Serotonin 51-60 solute carrier family 6 member 4 Homo sapiens 106-110 10427004-5 1999 Nontransported SERT antagonists such as cocaine and antidepressants were permissive for SERT phosphorylation but blocked serotonin effects. Serotonin 121-130 solute carrier family 6 member 4 Homo sapiens 15-19 10427004-6 1999 PKC-dependent SERT sequestration was also blocked by serotonin. Serotonin 53-62 solute carrier family 6 member 4 Homo sapiens 14-18 26468552-0 1999 Serotonin transporter genotype and seasonal variation in serotonin function. Serotonin 57-66 solute carrier family 6 member 4 Homo sapiens 0-21 10192830-0 1999 Serotonin transporter genotype and seasonal variation in serotonin function. Serotonin 57-66 solute carrier family 6 member 4 Homo sapiens 0-21 10404755-2 1999 Platelets acquire serotonin from the extracellular space by serotonin transporter and release it following aggregation. Serotonin 18-27 solute carrier family 6 member 4 Homo sapiens 60-81 10206229-1 1999 We examined a panel of 21 patients diagnosed with compulsive buying for two DNA sequence polymorphisms found in the gene that encodes the serotonin transport (5-HTT). Serotonin 138-147 solute carrier family 6 member 4 Homo sapiens 159-164 10347811-5 1999 It has been demonstrated that the short variant(s) of this 5-HTT gene-linked polymorphic region (5-HTTLPR) is associated with a different transcriptional efficiency of the 5-HTT gene promoter resulting in decreased 5-HTT expression and 5-HT uptake in lymphocytes. Serotonin 59-63 solute carrier family 6 member 4 Homo sapiens 97-102 10347811-5 1999 It has been demonstrated that the short variant(s) of this 5-HTT gene-linked polymorphic region (5-HTTLPR) is associated with a different transcriptional efficiency of the 5-HTT gene promoter resulting in decreased 5-HTT expression and 5-HT uptake in lymphocytes. Serotonin 59-63 solute carrier family 6 member 4 Homo sapiens 97-102 9472845-1 1998 This study aims to determine whether the newly introduced serotonin type 2 (5-HT2) antagonist nefazodone has serotonin (5-HT) transporter-blocking properties at clinical doses in depressed patients. Serotonin 58-67 solute carrier family 6 member 4 Homo sapiens 120-137 9845763-1 1998 OBJECTIVE: The serotonin transporter gene (SERT) plays an important role in the serotonin uptake into neurons. Serotonin 15-24 solute carrier family 6 member 4 Homo sapiens 43-47 9766763-1 1998 OBJECTIVE: The SLC6A4 locus encodes the serotonin transporter, which in turn mediates the synaptic inactivation of the neurotransmitter serotonin. Serotonin 40-49 solute carrier family 6 member 4 Homo sapiens 15-21 9627746-1 1998 BACKGROUND: We tested the hypothesis that a functional biallelic repetitive element in the 5" regulatory region of the human serotonin transporter gene (SLC6A4) confers susceptibility to serotonin-related personality traits underlying alcohol dependence with dissocial behavior. Serotonin 125-134 solute carrier family 6 member 4 Homo sapiens 153-159 9578395-4 1998 Serotonin transporter, a plasma membrane protein located on serotonin neurons, regulates the amount of serotonin available for neurotransmission by re-accumulating released serotonin into presynaptic neurons; expression of Fos in the suprachiasmatic nucleus identifies light-activated cells involved in photic resetting of circadian clock phase. Serotonin 103-112 solute carrier family 6 member 4 Homo sapiens 0-21 9578395-7 1998 Serotonin transporter immunostaining was abolished by pretreatment with the serotonin neurotoxin, 5,7-dihydroxytryptamine. Serotonin 76-85 solute carrier family 6 member 4 Homo sapiens 0-21 9718590-1 1998 3, 4-methylenedioxymethamphetamine (MDMA or Ecstasy) is a substituted amphetamine whose acute and long-term effects on the serotonin system are dependent on an interaction with the 5-HT uptake transporter (SERT). Serotonin 123-132 solute carrier family 6 member 4 Homo sapiens 206-210 9733975-2 1998 The major role of the 5-HTT has long been considered to be to inactivate serotonin transmission through the elimination of serotonin at release sites. Serotonin 73-82 solute carrier family 6 member 4 Homo sapiens 22-27 9733975-2 1998 The major role of the 5-HTT has long been considered to be to inactivate serotonin transmission through the elimination of serotonin at release sites. Serotonin 123-132 solute carrier family 6 member 4 Homo sapiens 22-27 9578395-0 1998 A role for serotonin in the circadian system revealed by the distribution of serotonin transporter and light-induced Fos immunoreactivity in the suprachiasmatic nucleus and intergeniculate leaflet. Serotonin 11-20 solute carrier family 6 member 4 Homo sapiens 77-98 9578395-4 1998 Serotonin transporter, a plasma membrane protein located on serotonin neurons, regulates the amount of serotonin available for neurotransmission by re-accumulating released serotonin into presynaptic neurons; expression of Fos in the suprachiasmatic nucleus identifies light-activated cells involved in photic resetting of circadian clock phase. Serotonin 60-69 solute carrier family 6 member 4 Homo sapiens 0-21 9578395-4 1998 Serotonin transporter, a plasma membrane protein located on serotonin neurons, regulates the amount of serotonin available for neurotransmission by re-accumulating released serotonin into presynaptic neurons; expression of Fos in the suprachiasmatic nucleus identifies light-activated cells involved in photic resetting of circadian clock phase. Serotonin 103-112 solute carrier family 6 member 4 Homo sapiens 0-21 9543202-1 1998 BACKGROUND: The serotonin transporter protein (SERT) reuptakes serotonin from synapses and has been implied as the site of therapeutic action of many antidepressant drugs. Serotonin 16-25 solute carrier family 6 member 4 Homo sapiens 47-51 8950411-2 1996 The reuptake of serotonin (5-HT) from synaptic terminals is mediated by a specific transporter (5-HTT). Serotonin 16-25 solute carrier family 6 member 4 Homo sapiens 96-101 9322235-3 1997 SRIs block the reuptake of serotonin (5-HT) into the presynaptic neuron, a process mediated by the serotonin transporter (5-HTT). Serotonin 27-36 solute carrier family 6 member 4 Homo sapiens 99-120 8929413-3 1996 The short variant of the polymorphism reduces the transcriptional efficiency of the 5-HTT gene promoter, resulting in decreased 5-HTT expression and 5-HT uptake in lymphoblasts. Serotonin 84-88 solute carrier family 6 member 4 Homo sapiens 128-133 9402979-1 1997 The SLC6A4 locus encodes the serotonin transporter, which in turn mediates the synaptic inactivation of the neurotransmitter serotonin. Serotonin 29-38 solute carrier family 6 member 4 Homo sapiens 4-10 9063880-4 1997 This chimera transports serotonin very slowly compared to wild type SERT. Serotonin 24-33 solute carrier family 6 member 4 Homo sapiens 68-72 8764569-1 1996 After a single intraperitoneal injection of the irreversible tryptophan hydroxylase inhibitor p-chlorophenylalanine (PCPA; 300 mg/kg), there was a rapid down-regulation of serotonin (5-HT) transporter mRNA levels in cell bodies. Serotonin 172-181 solute carrier family 6 member 4 Homo sapiens 183-200 8863842-6 1996 Interactions with other SERT antagonists, including paroxetine and cocaine, as well as the SERT substrates 5-hydroxytryptamine and d-amphetamine were unaffected by interconversion of this residue. Serotonin 107-126 solute carrier family 6 member 4 Homo sapiens 91-95 8837711-2 1996 The selective response of obsessive-compulsive disorder to treatment with agents which block serotonin reuptake suggests the gene coding for the serotonin transporter as a candidate gene. Serotonin 93-102 solute carrier family 6 member 4 Homo sapiens 145-166 8542310-0 1995 Acute depletion of serotonin down-regulates serotonin transporter mRNA in raphe neurons. Serotonin 19-28 solute carrier family 6 member 4 Homo sapiens 44-65 8595191-0 1995 The serotonin agonist m-chlorophenylpiperazine (mCPP) binds to serotonin transporter sites in human brain. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 63-84 7615516-10 1995 It is concluded that staurosporine up-regulates the serotonin transport activity in JAR cells by increasing the steady state levels of the serotonin transporter mRNA and by the consequent increase in the transporter density in the plasma membrane and that the process involves a cAMP-independent signaling pathway. Serotonin 52-61 solute carrier family 6 member 4 Homo sapiens 139-160 7869097-6 1995 SERT-immunoreactive proteins are also detectable in platelet and pulmonary membranes, sites of peripheral 5HT uptake, but not in liver. Serotonin 106-109 solute carrier family 6 member 4 Homo sapiens 0-4 7711157-2 1995 Decreased platelet serotonin (5-HT) transport and reduced binding of imipramine or paroxetine to brain and platelet 5-HT uptake sites/transporters in patients with depression and suicide victims define the 5-HT transporter (5-HTT) as a candidate gene. Serotonin 19-28 solute carrier family 6 member 4 Homo sapiens 206-222 7789954-2 1995 Serotonin transporter protein (SERT) allows neurons to retrieve serotonin that has been released into a synapse. Serotonin 64-73 solute carrier family 6 member 4 Homo sapiens 0-29 7789954-2 1995 Serotonin transporter protein (SERT) allows neurons to retrieve serotonin that has been released into a synapse. Serotonin 64-73 solute carrier family 6 member 4 Homo sapiens 31-35 7508830-0 1994 Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Serotonin 8-17 solute carrier family 6 member 4 Homo sapiens 69-90 7969065-5 1994 Serotonin uptake and radioligand binding assays revealed that rat and human SERTs show different sensitivities to some but not all transporter ligands; most tricyclic antidepressants were significantly more potent at the human SERT, relative to rat SERT, whereas d-amphetamine was a more potent inhibitor of rat SERT. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 76-80 8066050-2 1994 The function of the placental serotonin transporter was assayed using three different approaches: serotonin uptake in purified human placental brush border membrane vesicles, paroxetine binding in placental brush border membrane vesicles, and serotonin uptake in cultured human placental choriocarcinoma cells. Serotonin 98-107 solute carrier family 6 member 4 Homo sapiens 30-51 33764333-1 2021 The serotonin transporter 5-HTT is encoded by a single gene SLC6A4. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 60-66 1534559-1 1992 A 68-kDa glycoprotein bearing the biological activity of the plasma membrane serotonin (5-hydroxytryptamine, 5-HT) transporter has been purified from human blood platelets, a classical cell model for the study of 5-HT uptake. Serotonin 77-86 solute carrier family 6 member 4 Homo sapiens 109-126 1824783-1 1991 Citalopram, a selective serotonin (5-HT) uptake inhibitor with antidepressant properties, was found to bind with high affinity to the 5-HT transporter from human neuronal and platelet membranes. Serotonin 24-33 solute carrier family 6 member 4 Homo sapiens 134-150 8408014-1 1993 Cholera toxin-induced stimulation of serotonin uptake in human placental choriocarcinoma cells is accompanied by increased serotonin transporter mRNA levels and serotonin transporter-specific ligand binding. Serotonin 37-46 solute carrier family 6 member 4 Homo sapiens 123-144 8408014-1 1993 Cholera toxin-induced stimulation of serotonin uptake in human placental choriocarcinoma cells is accompanied by increased serotonin transporter mRNA levels and serotonin transporter-specific ligand binding. Serotonin 37-46 solute carrier family 6 member 4 Homo sapiens 161-182 7684072-0 1993 Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter. Serotonin 40-49 solute carrier family 6 member 4 Homo sapiens 87-108 1994152-2 1991 The conformation of fluoxetine, which resembles that of sertraline and other serotonin uptake inhibitors, appears to be a key feature that enables its high affinity and selective interaction with the serotonin transporter. Serotonin 77-86 solute carrier family 6 member 4 Homo sapiens 200-221 33807811-3 2021 The present study investigated the association of nine polymorphisms in the four 5-hydroxytryptamine receptor (HTR) genes HTR1A, HTR2A, HTR3A, and HTR2C and the gene encoding for the serotonin transporter SLC6A4 with MetS in patients with schizophrenia. Serotonin 81-100 solute carrier family 6 member 4 Homo sapiens 205-211 33807811-3 2021 The present study investigated the association of nine polymorphisms in the four 5-hydroxytryptamine receptor (HTR) genes HTR1A, HTR2A, HTR3A, and HTR2C and the gene encoding for the serotonin transporter SLC6A4 with MetS in patients with schizophrenia. Serotonin 183-192 solute carrier family 6 member 4 Homo sapiens 205-211 32797733-1 2021 Serotonin (5-HT) transporter (SERT) plays a crucial role in serotonergic transmission in the central nervous system, and any aberration causes serious mental illnesses. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 11-28 32797733-1 2021 Serotonin (5-HT) transporter (SERT) plays a crucial role in serotonergic transmission in the central nervous system, and any aberration causes serious mental illnesses. Serotonin 0-9 solute carrier family 6 member 4 Homo sapiens 30-34 34798166-2 2022 Methylation of the SLC6A4 gene is associated with decreased transcription of the serotonin transporter, leading to increased serotonin in the synapse. Serotonin 125-134 solute carrier family 6 member 4 Homo sapiens 19-25 19892699-1 2010 The serotonin transporter (SERT) regulates extracellular levels of the neurotransmitter serotonin (5-hydroxytryptamine) in the brain by facilitating uptake of released 5-hydroxytryptamine into neuronal cells. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 19892699-1 2010 The serotonin transporter (SERT) regulates extracellular levels of the neurotransmitter serotonin (5-hydroxytryptamine) in the brain by facilitating uptake of released 5-hydroxytryptamine into neuronal cells. Serotonin 99-118 solute carrier family 6 member 4 Homo sapiens 4-25 19892699-1 2010 The serotonin transporter (SERT) regulates extracellular levels of the neurotransmitter serotonin (5-hydroxytryptamine) in the brain by facilitating uptake of released 5-hydroxytryptamine into neuronal cells. Serotonin 99-118 solute carrier family 6 member 4 Homo sapiens 27-31 19892699-1 2010 The serotonin transporter (SERT) regulates extracellular levels of the neurotransmitter serotonin (5-hydroxytryptamine) in the brain by facilitating uptake of released 5-hydroxytryptamine into neuronal cells. Serotonin 168-187 solute carrier family 6 member 4 Homo sapiens 4-25 19892699-1 2010 The serotonin transporter (SERT) regulates extracellular levels of the neurotransmitter serotonin (5-hydroxytryptamine) in the brain by facilitating uptake of released 5-hydroxytryptamine into neuronal cells. Serotonin 168-187 solute carrier family 6 member 4 Homo sapiens 27-31 23811734-4 2013 Although the 5-HT system uses one transporter (SERT) and 14 receptor sub-types, most of the studies in PD have focussed on SERT and serotonergic type 1A and 2A receptors (5-HT1A and 5-HT2A). Serotonin 13-17 solute carrier family 6 member 4 Homo sapiens 47-51 34798166-2 2022 Methylation of the SLC6A4 gene is associated with decreased transcription of the serotonin transporter, leading to increased serotonin in the synapse. Serotonin 125-134 solute carrier family 6 member 4 Homo sapiens 81-102 34624331-3 2022 MDMA produces its acute subjective effects primarily by stimulating the release of serotonin via action at the serotonin transporter (SERT). Serotonin 83-92 solute carrier family 6 member 4 Homo sapiens 111-132 34910986-2 2022 One important hypothesis of SCZ pathology is serotonin (5-HT) impairment, and the 5-HT transporter, encoded by the SLC6A4 gene, plays a key role in regulating 5-HT levels. Serotonin 159-163 solute carrier family 6 member 4 Homo sapiens 82-98 34910986-2 2022 One important hypothesis of SCZ pathology is serotonin (5-HT) impairment, and the 5-HT transporter, encoded by the SLC6A4 gene, plays a key role in regulating 5-HT levels. Serotonin 159-163 solute carrier family 6 member 4 Homo sapiens 115-121 34624331-3 2022 MDMA produces its acute subjective effects primarily by stimulating the release of serotonin via action at the serotonin transporter (SERT). Serotonin 83-92 solute carrier family 6 member 4 Homo sapiens 134-138 34919986-6 2022 Additionally, selective serotonin reuptake inhibitors with a high affinity for the serotonin transporter, resulted in poor treatment outcomes for those with history of ACEs. Serotonin 24-33 solute carrier family 6 member 4 Homo sapiens 83-104 34958348-6 2022 Inhibition of SERT was estimated using the depletion of whole blood 5-HT. Serotonin 68-72 solute carrier family 6 member 4 Homo sapiens 14-18 34799637-9 2021 TLR-2 activation by enteropathogenic bacteria inhibited SERT activity in the presence of exogenous 5-HT by up to 50%. Serotonin 99-103 solute carrier family 6 member 4 Homo sapiens 56-60 34799637-10 2021 These effects were increasing gradually over 72 h, and MAP infection had the greatest effect on SERT inhibition when cells were exposed to 5-HT in a concentration dependent manner. Serotonin 139-143 solute carrier family 6 member 4 Homo sapiens 96-100 34799637-2 2021 Availability of the intestinal 5-HT is dependent on serotonin transporter (SERT), which uptakes 5-HT and facilitates its degradation. Serotonin 31-35 solute carrier family 6 member 4 Homo sapiens 52-73 34799637-2 2021 Availability of the intestinal 5-HT is dependent on serotonin transporter (SERT), which uptakes 5-HT and facilitates its degradation. Serotonin 31-35 solute carrier family 6 member 4 Homo sapiens 75-79 34799637-2 2021 Availability of the intestinal 5-HT is dependent on serotonin transporter (SERT), which uptakes 5-HT and facilitates its degradation. Serotonin 96-100 solute carrier family 6 member 4 Homo sapiens 52-73 34799637-2 2021 Availability of the intestinal 5-HT is dependent on serotonin transporter (SERT), which uptakes 5-HT and facilitates its degradation. Serotonin 96-100 solute carrier family 6 member 4 Homo sapiens 75-79 34550056-1 2021 The serotonin transporter (SERT) readily takes up serotonin (5-HT), thereby regulating the availability of 5-HT within the intestine. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 34867196-1 2021 The serotonin transporter (SERT) is the primary target for selective serotonin reuptake inhibitor (SSRI) antidepressants that are thought to exert their therapeutic effects by increasing the synaptic concentration of serotonin. Serotonin 69-78 solute carrier family 6 member 4 Homo sapiens 4-25 34867196-1 2021 The serotonin transporter (SERT) is the primary target for selective serotonin reuptake inhibitor (SSRI) antidepressants that are thought to exert their therapeutic effects by increasing the synaptic concentration of serotonin. Serotonin 69-78 solute carrier family 6 member 4 Homo sapiens 27-31 34867196-1 2021 The serotonin transporter (SERT) is the primary target for selective serotonin reuptake inhibitor (SSRI) antidepressants that are thought to exert their therapeutic effects by increasing the synaptic concentration of serotonin. Serotonin 217-226 solute carrier family 6 member 4 Homo sapiens 4-25 34867196-1 2021 The serotonin transporter (SERT) is the primary target for selective serotonin reuptake inhibitor (SSRI) antidepressants that are thought to exert their therapeutic effects by increasing the synaptic concentration of serotonin. Serotonin 217-226 solute carrier family 6 member 4 Homo sapiens 27-31 34867196-5 2021 We demonstrated that IDT785 enabled quantum dot (QD) labeling of membrane SERT in transfected HEK-293 cultures that could be blocked using the high affinity serotonin reuptake inhibitor paroxetine. Serotonin 157-166 solute carrier family 6 member 4 Homo sapiens 74-78 34550056-1 2021 The serotonin transporter (SERT) readily takes up serotonin (5-HT), thereby regulating the availability of 5-HT within the intestine. Serotonin 50-59 solute carrier family 6 member 4 Homo sapiens 27-31 34550056-1 2021 The serotonin transporter (SERT) readily takes up serotonin (5-HT), thereby regulating the availability of 5-HT within the intestine. Serotonin 61-65 solute carrier family 6 member 4 Homo sapiens 27-31 34550056-1 2021 The serotonin transporter (SERT) readily takes up serotonin (5-HT), thereby regulating the availability of 5-HT within the intestine. Serotonin 107-111 solute carrier family 6 member 4 Homo sapiens 27-31 34181363-2 2021 There is some evidence that a substance"s degree of serotonin reuptake inhibition in terms of its binding affinity to the serotonin transporter (SERT) affects the magnitude of bleeding risk increase. Serotonin 52-61 solute carrier family 6 member 4 Homo sapiens 122-143 34493397-1 2021 INTRODUCTION: Serotonin is highly implicated in the regulation of emotional state and the execution of cognitive tasks, so much so that the serotonin transporter genes (5-HTT, SLC6A4) and the serotonin receptor genes (HTR1A, HTR1B, HTR2A) have become the perfect candidates when studying the effects that these genes and their polymorphic variations have on depression characteristics. Serotonin 14-23 solute carrier family 6 member 4 Homo sapiens 140-161 34493397-1 2021 INTRODUCTION: Serotonin is highly implicated in the regulation of emotional state and the execution of cognitive tasks, so much so that the serotonin transporter genes (5-HTT, SLC6A4) and the serotonin receptor genes (HTR1A, HTR1B, HTR2A) have become the perfect candidates when studying the effects that these genes and their polymorphic variations have on depression characteristics. Serotonin 14-23 solute carrier family 6 member 4 Homo sapiens 169-174 34493397-1 2021 INTRODUCTION: Serotonin is highly implicated in the regulation of emotional state and the execution of cognitive tasks, so much so that the serotonin transporter genes (5-HTT, SLC6A4) and the serotonin receptor genes (HTR1A, HTR1B, HTR2A) have become the perfect candidates when studying the effects that these genes and their polymorphic variations have on depression characteristics. Serotonin 14-23 solute carrier family 6 member 4 Homo sapiens 176-182 34564289-2 2021 The preferential targeting of serotonin receptor (SERT) by selective serotonin reuptake inhibitors (SSRIs) has offered an opportunity to reduce the range of these side effects and improve patient adherence to pharmacotherapy. Serotonin 69-78 solute carrier family 6 member 4 Homo sapiens 30-48 34564289-2 2021 The preferential targeting of serotonin receptor (SERT) by selective serotonin reuptake inhibitors (SSRIs) has offered an opportunity to reduce the range of these side effects and improve patient adherence to pharmacotherapy. Serotonin 69-78 solute carrier family 6 member 4 Homo sapiens 50-54 34452265-3 2021 We hypothesize that antidepressants disturb serotonin homeostasis in the fetoplacental unit by inhibiting serotonin transporter (SERT) and organic cation transporter 3 (OCT3) in the maternal- and fetal-facing placental membranes, respectively. Serotonin 44-53 solute carrier family 6 member 4 Homo sapiens 106-127 34452265-3 2021 We hypothesize that antidepressants disturb serotonin homeostasis in the fetoplacental unit by inhibiting serotonin transporter (SERT) and organic cation transporter 3 (OCT3) in the maternal- and fetal-facing placental membranes, respectively. Serotonin 44-53 solute carrier family 6 member 4 Homo sapiens 129-133 34452265-5 2021 All tested antidepressants significantly inhibited SERT- and OCT3-mediated serotonin uptake in a dose-dependent manner. Serotonin 75-84 solute carrier family 6 member 4 Homo sapiens 51-55 34452265-10 2021 As accurate fetal programming requires optimal serotonin levels in the fetoplacental unit throughout gestation, inhibition of SERT-/OCT3-mediated serotonin uptake may help explain the poor outcomes of antidepressant use in pregnancy. Serotonin 146-155 solute carrier family 6 member 4 Homo sapiens 126-130 34458620-8 2021 Finally, we designed a pharmacophore that may be used to recognise hSERT-mediated serotonin releasers and uptake inhibitors of diverse chemical structure, identifying their active conformations and interacting residues. Serotonin 82-91 solute carrier family 6 member 4 Homo sapiens 67-72 34449705-4 2021 The primary mechanism of action of SSRIs is to inhibit presynaptic reuptake of serotonin at the serotonin transporter, subsequently increasing serotonin at the postsynaptic membrane in the serotonergic synapse. Serotonin 79-88 solute carrier family 6 member 4 Homo sapiens 96-117 34360573-4 2021 Trophoblasts and cord blood platelets showed 5-HT uptake with similar Michaelis constant (Km) values (~0.6 muM), typical of the high-affinity serotonin transporter (SERT). Serotonin 45-49 solute carrier family 6 member 4 Homo sapiens 142-163 34360573-4 2021 Trophoblasts and cord blood platelets showed 5-HT uptake with similar Michaelis constant (Km) values (~0.6 muM), typical of the high-affinity serotonin transporter (SERT). Serotonin 45-49 solute carrier family 6 member 4 Homo sapiens 165-169 34360573-5 2021 The uptake of 5-HT into trophoblasts was efficiently inhibited by various SERT-targeting drugs. Serotonin 14-18 solute carrier family 6 member 4 Homo sapiens 74-78 34181363-2 2021 There is some evidence that a substance"s degree of serotonin reuptake inhibition in terms of its binding affinity to the serotonin transporter (SERT) affects the magnitude of bleeding risk increase. Serotonin 52-61 solute carrier family 6 member 4 Homo sapiens 145-149 34181363-6 2021 IMPLICATIONS/CONCLUSIONS: Our findings strengthen the hypothesis that inhibition of serotonin uptake contributes to the antidepressant-related bleeding risk and suggest an association between the degree of the SERT binding affinity and the bleeding risk. Serotonin 84-93 solute carrier family 6 member 4 Homo sapiens 210-214 34149362-4 2021 Results support a tonic elevation of 5-HT transport activity in transfected cells and human lymphoblasts by the variant in vitro that leads to an increased 5-HT clearance rate in vivo when studied in the SERT Ala56 mouse model, along with altered sensitivity to SERT regulatory signaling pathways. Serotonin 37-41 solute carrier family 6 member 4 Homo sapiens 204-208 34149362-4 2021 Results support a tonic elevation of 5-HT transport activity in transfected cells and human lymphoblasts by the variant in vitro that leads to an increased 5-HT clearance rate in vivo when studied in the SERT Ala56 mouse model, along with altered sensitivity to SERT regulatory signaling pathways. Serotonin 156-160 solute carrier family 6 member 4 Homo sapiens 204-208 34061030-1 2021 The concentrative power of the transporters for dopamine (DAT), norepinephrine (NET) and serotonin (SERT) is thought to be fueled by the transmembrane Na+ gradient, but it is conceivable that they can also tap other energy sources, e.g. membrane voltage and/or the transmembrane K+ gradient. Serotonin 89-98 solute carrier family 6 member 4 Homo sapiens 100-104 34079356-3 2021 The S allele of 5-HTTLPR induces low 5-HT tone, and it may influence the modulation of chronic pain. Serotonin 37-41 solute carrier family 6 member 4 Homo sapiens 16-24 34282486-3 2021 SSRIs act by blocking the serotonin transporter (SERT), the high-affinity, low-capacity, uptake-1 transporter for serotonin. Serotonin 114-123 solute carrier family 6 member 4 Homo sapiens 26-47 34196807-3 2021 Uptake 1 describes uptake of the monoamine via its designated transporter (SERT for serotonin, NET for norepinephrine, and DAT for dopamine), whereas Uptake 2 details multiple transporter types on neurons and glia taking up different types of modulators, not necessarily specific to the monoamine. Serotonin 84-93 solute carrier family 6 member 4 Homo sapiens 75-79 34282486-3 2021 SSRIs act by blocking the serotonin transporter (SERT), the high-affinity, low-capacity, uptake-1 transporter for serotonin. Serotonin 114-123 solute carrier family 6 member 4 Homo sapiens 49-53 35607850-9 2022 High 5-HTT supposedly leads to high clearance of 5-HT, and thus, a negative bias could result from low extracellular 5-HT. Serotonin 49-53 solute carrier family 6 member 4 Homo sapiens 5-10 34981428-1 2022 Serotonin transporter (SERT) is a presynaptically localized membrane protein that regulates the serotonin transmission via its reuptake of released serotonin. Serotonin 96-105 solute carrier family 6 member 4 Homo sapiens 0-21 34981428-1 2022 Serotonin transporter (SERT) is a presynaptically localized membrane protein that regulates the serotonin transmission via its reuptake of released serotonin. Serotonin 96-105 solute carrier family 6 member 4 Homo sapiens 23-27 34981428-1 2022 Serotonin transporter (SERT) is a presynaptically localized membrane protein that regulates the serotonin transmission via its reuptake of released serotonin. Serotonin 148-157 solute carrier family 6 member 4 Homo sapiens 0-21 34981428-1 2022 Serotonin transporter (SERT) is a presynaptically localized membrane protein that regulates the serotonin transmission via its reuptake of released serotonin. Serotonin 148-157 solute carrier family 6 member 4 Homo sapiens 23-27 35167867-16 2022 CONCLUSIONS: Fecal LPS acting in concert with trypsin in IBS-D patients, stimulates mucosal mast cells to release PGE2, which downregulates mucosal SERT, resulting in increased mucosal 5-HT. Serotonin 185-189 solute carrier family 6 member 4 Homo sapiens 148-152 35341788-0 2022 Disruption of the Mucosal Serotonin Reuptake Transporter (SERT) through Gut Dysbiosis. Serotonin 26-35 solute carrier family 6 member 4 Homo sapiens 58-62 35491679-4 2022 METHODS: We used REACT to estimate the dominant fMRI signal related to the serotonin (5-HT) transporter (SERT) distribution during processing of aversive facial emotion in adults with and without ASD. Serotonin 75-84 solute carrier family 6 member 4 Homo sapiens 86-103 35491679-4 2022 METHODS: We used REACT to estimate the dominant fMRI signal related to the serotonin (5-HT) transporter (SERT) distribution during processing of aversive facial emotion in adults with and without ASD. Serotonin 75-84 solute carrier family 6 member 4 Homo sapiens 105-109 35566327-3 2022 This drug inhibits the reuptake of 5-HT (serotonin) and reverses its flow, acting as a substrate for the SERT, which possesses a central binding site (S1) for antidepressants as well as an allosteric (S2) one. Serotonin 35-39 solute carrier family 6 member 4 Homo sapiens 105-109 35623482-1 2022 BACKGROUND: While the serotonin transporter (SLC6A4) gene, 5-HTTLPR, interacts with the social environment to influence both emotional self-regulation and smoking behavior, less is known about interactions between emotional self-regulation and 5-HTTLPR or their joint influence on tobacco use. Serotonin 22-31 solute carrier family 6 member 4 Homo sapiens 59-67 35623482-1 2022 BACKGROUND: While the serotonin transporter (SLC6A4) gene, 5-HTTLPR, interacts with the social environment to influence both emotional self-regulation and smoking behavior, less is known about interactions between emotional self-regulation and 5-HTTLPR or their joint influence on tobacco use. Serotonin 22-31 solute carrier family 6 member 4 Homo sapiens 244-252 35566327-3 2022 This drug inhibits the reuptake of 5-HT (serotonin) and reverses its flow, acting as a substrate for the SERT, which possesses a central binding site (S1) for antidepressants as well as an allosteric (S2) one. Serotonin 41-50 solute carrier family 6 member 4 Homo sapiens 105-109 35566327-7 2022 Simulations on all hSERT available structures with Gibbs free energy estimations (DeltaG) revealed a favourable and pervasive dual binding mode for MDMA at S2, i.e., adopting either a 5-HT or an escitalopram-like orientation. Serotonin 184-188 solute carrier family 6 member 4 Homo sapiens 19-24 35065961-0 2022 Occlusion of the human serotonin transporter is mediated by serotonin-induced conformational changes in the bundle domain. Serotonin 60-69 solute carrier family 6 member 4 Homo sapiens 23-44 35329857-3 2022 This sham-controlled study aimed to evaluate the effects of accelerated high frequency rTMS (aHF-rTMS) over the left frontal cortex on the serotonin transporter (SERT) in healthy beagle dogs. Serotonin 139-148 solute carrier family 6 member 4 Homo sapiens 162-166 35114149-1 2022 The serotonin transporter, SERT, initiates the reuptake of extracellular serotonin in the synapse to terminate neurotransmission. Serotonin 73-82 solute carrier family 6 member 4 Homo sapiens 4-25 35114149-1 2022 The serotonin transporter, SERT, initiates the reuptake of extracellular serotonin in the synapse to terminate neurotransmission. Serotonin 73-82 solute carrier family 6 member 4 Homo sapiens 27-31 35114149-2 2022 The cryo-EM structures of SERT bound to ibogaine and the physiological substrate serotonin resolved in different states provided a glimpse of functional conformations at atomistic resolution. Serotonin 81-90 solute carrier family 6 member 4 Homo sapiens 26-30 35419600-2 2022 SLC6A4 (serotonin transporter) is a master regulator of 5-HT signaling and involved in the regulation of aggressive behavior in humans and rodents. Serotonin 56-60 solute carrier family 6 member 4 Homo sapiens 0-6 35419600-2 2022 SLC6A4 (serotonin transporter) is a master regulator of 5-HT signaling and involved in the regulation of aggressive behavior in humans and rodents. Serotonin 56-60 solute carrier family 6 member 4 Homo sapiens 8-29 35462922-14 2022 The observed patterns of SERT, NET P-gp, BCRP and MRP3 expression and activity may be associated with transporter activity or decreased placental permeability in the 1st trimester to transporter specific substrates including commonly used psychoactive medications such as anti-depressants, anti-psychotics, and amphetamines, while transport of nutrients and serotonin is important in the 1st trimester. Serotonin 358-367 solute carrier family 6 member 4 Homo sapiens 25-29 35065961-1 2022 The human serotonin transporter (hSERT) terminates neurotransmission by removing serotonin (5HT) from the synaptic cleft, an essential process for proper functioning of serotonergic neurons. Serotonin 81-90 solute carrier family 6 member 4 Homo sapiens 10-31 35065961-1 2022 The human serotonin transporter (hSERT) terminates neurotransmission by removing serotonin (5HT) from the synaptic cleft, an essential process for proper functioning of serotonergic neurons. Serotonin 81-90 solute carrier family 6 member 4 Homo sapiens 33-38 35177208-1 2022 Serotonin transporter (SERT) is a membrane transporter which terminates neurotransmission of serotonin through its reuptake. Serotonin 93-102 solute carrier family 6 member 4 Homo sapiens 0-21 35043462-3 2022 The serotonin transporter (SERT) is important in these disorders as it regulates synaptic serotonin and therapeutically is the target of selective serotonin reuptake inhibitors which are a major class of anti-depressant drug. Serotonin 90-99 solute carrier family 6 member 4 Homo sapiens 4-25 35043462-3 2022 The serotonin transporter (SERT) is important in these disorders as it regulates synaptic serotonin and therapeutically is the target of selective serotonin reuptake inhibitors which are a major class of anti-depressant drug. Serotonin 90-99 solute carrier family 6 member 4 Homo sapiens 27-31 35043462-3 2022 The serotonin transporter (SERT) is important in these disorders as it regulates synaptic serotonin and therapeutically is the target of selective serotonin reuptake inhibitors which are a major class of anti-depressant drug. Serotonin 147-156 solute carrier family 6 member 4 Homo sapiens 4-25 35177208-1 2022 Serotonin transporter (SERT) is a membrane transporter which terminates neurotransmission of serotonin through its reuptake. Serotonin 93-102 solute carrier family 6 member 4 Homo sapiens 23-27 35043462-3 2022 The serotonin transporter (SERT) is important in these disorders as it regulates synaptic serotonin and therapeutically is the target of selective serotonin reuptake inhibitors which are a major class of anti-depressant drug. Serotonin 147-156 solute carrier family 6 member 4 Homo sapiens 27-31 35020138-2 2022 The presynaptic serotonin transporter (SERT) is a marker of 5-HT innervation. Serotonin 60-64 solute carrier family 6 member 4 Homo sapiens 16-37 35066017-2 2022 The serotonin reuptake transporter (SERT) is an important regulator of synaptic serotonin, being an important pharmacological target with genetic variants implicated with risk of developing NSD. Serotonin 80-89 solute carrier family 6 member 4 Homo sapiens 4-34 35066017-2 2022 The serotonin reuptake transporter (SERT) is an important regulator of synaptic serotonin, being an important pharmacological target with genetic variants implicated with risk of developing NSD. Serotonin 80-89 solute carrier family 6 member 4 Homo sapiens 36-40 35316963-2 2022 Whether the supernatants of these three probiotics can improve gastrointestinal sensation and movement by regulating the serotonin transporter (SERT) expression needs to be clarified. Serotonin 121-130 solute carrier family 6 member 4 Homo sapiens 144-148 35053371-1 2022 The human serotonin transporter (hSERT) removes the neurotransmitter serotonin from the synaptic cleft by reuptake into the presynaptic nerve terminal. Serotonin 69-78 solute carrier family 6 member 4 Homo sapiens 10-31 35053371-1 2022 The human serotonin transporter (hSERT) removes the neurotransmitter serotonin from the synaptic cleft by reuptake into the presynaptic nerve terminal. Serotonin 69-78 solute carrier family 6 member 4 Homo sapiens 33-38 35020138-2 2022 The presynaptic serotonin transporter (SERT) is a marker of 5-HT innervation. Serotonin 60-64 solute carrier family 6 member 4 Homo sapiens 39-43 34136961-5 2022 Also, we discuss the recent findings on KOR-mediated differential regulation of serotonin and dopamine transporters (SERT and DAT). Serotonin 80-89 solute carrier family 6 member 4 Homo sapiens 117-121 35071391-2 2021 The serotonin transporter (SERT), responsible for serotonin reuptake and signaling termination, plays a prominent role in gastrointestinal physiology, representing a promising therapeutic target in digestive disorders. Serotonin 4-13 solute carrier family 6 member 4 Homo sapiens 27-31 35071391-2 2021 The serotonin transporter (SERT), responsible for serotonin reuptake and signaling termination, plays a prominent role in gastrointestinal physiology, representing a promising therapeutic target in digestive disorders. Serotonin 50-59 solute carrier family 6 member 4 Homo sapiens 27-31 35071391-7 2021 Since the majority of the serotonin produced by the body is synthesized in the gastrointestinal tract, SERT-expressing cells may exert a role in the mechanism of serotonin reuptake. Serotonin 26-35 solute carrier family 6 member 4 Homo sapiens 103-107 35071391-7 2021 Since the majority of the serotonin produced by the body is synthesized in the gastrointestinal tract, SERT-expressing cells may exert a role in the mechanism of serotonin reuptake. Serotonin 162-171 solute carrier family 6 member 4 Homo sapiens 103-107 2898799-5 1988 Although the exact relationship between the [3H]imipramine recognition site and the serotonin transporter remains to be elucidated, it appears that the [3H]imipramine labelled component of the serotonin transporter represents a novel receptor that functions to modulate serotonin uptake. Serotonin 84-93 solute carrier family 6 member 4 Homo sapiens 193-214 2528702-3 1989 Previously reported data show a temperature dependence for tricyclic but not for nontricyclic inhibitors of the uptake of serotonin in their interaction with radioligand binding to the serotonin transporter. Serotonin 122-131 solute carrier family 6 member 4 Homo sapiens 185-206 3380080-11 1988 The results suggest that these antidepressant drugs and serotonin all bind to the same site, or to overlapping sites on the serotonin transporter, or to sites on the transporter whose occupation is mutually exclusive with substrate site occupation. Serotonin 56-65 solute carrier family 6 member 4 Homo sapiens 124-145