PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6841471-3 1983 This dilatatory effect of bradykinin in vitro was found only in arteries preconstricted with prostaglandin F2 alpha or 5-hydroxytryptamine. Serotonin 119-138 kininogen 1 Homo sapiens 26-36 1012987-2 1976 A treatment with bradykinin and the low dose of amphetamine reduced the noradrenaline and enhanced the serotonin level in the striatum, and lowered the dopamine content in the cortex, while a combined treatment with the high dose of amphetamine elevated the dopamine level in the striatum and hypothalamus and depressed the serotonin level in the midbrain. Serotonin 103-112 kininogen 1 Homo sapiens 17-27 887505-1 1977 The influence of bradykinin on the action of compounds affecting predominantly the dopaminergic receptor was studied in behavioral tests (Lat test and sterotypy) and biochemically (estimation of the level of biogenic amines--noradrenaline, dopamine and serotonin, and their metabolites--normetanephrine, homovanillic and 5-hydroxyindoleacetic acids in the brain tissue). Serotonin 253-262 kininogen 1 Homo sapiens 17-27 6136000-3 1983 On the cat middle cerebral artery in vitro (but not the basilar artery), under resting tension and when contracted with 5-hydroxytryptamine (5-HT) or KCl, concentration related relaxations were produced by BK, M-L-BK, and des-Arg9-BK, this being the order of relative potency of the three kinins. Serotonin 120-139 kininogen 1 Homo sapiens 206-208 6136000-3 1983 On the cat middle cerebral artery in vitro (but not the basilar artery), under resting tension and when contracted with 5-hydroxytryptamine (5-HT) or KCl, concentration related relaxations were produced by BK, M-L-BK, and des-Arg9-BK, this being the order of relative potency of the three kinins. Serotonin 120-139 kininogen 1 Homo sapiens 214-216 6136000-3 1983 On the cat middle cerebral artery in vitro (but not the basilar artery), under resting tension and when contracted with 5-hydroxytryptamine (5-HT) or KCl, concentration related relaxations were produced by BK, M-L-BK, and des-Arg9-BK, this being the order of relative potency of the three kinins. Serotonin 141-145 kininogen 1 Homo sapiens 206-208 6136000-3 1983 On the cat middle cerebral artery in vitro (but not the basilar artery), under resting tension and when contracted with 5-hydroxytryptamine (5-HT) or KCl, concentration related relaxations were produced by BK, M-L-BK, and des-Arg9-BK, this being the order of relative potency of the three kinins. Serotonin 141-145 kininogen 1 Homo sapiens 214-216 7435919-2 1980 The responses to the anaesthetic technique and drugs used demonstrated the interactions of serotonin and bradykinin. Serotonin 91-100 kininogen 1 Homo sapiens 105-115 1012987-2 1976 A treatment with bradykinin and the low dose of amphetamine reduced the noradrenaline and enhanced the serotonin level in the striatum, and lowered the dopamine content in the cortex, while a combined treatment with the high dose of amphetamine elevated the dopamine level in the striatum and hypothalamus and depressed the serotonin level in the midbrain. Serotonin 324-333 kininogen 1 Homo sapiens 17-27 11394922-9 2001 Bradykinin (10(-7)M) induced a significant PE, whereas serotonin was effective only at a concentration of 10(-3)M. While serotonin in lower concentrations induced moderate burning pain and an axon reflex flare but no PE, bradykinin provoked PE without pain or axon reflex flare at a concentration of 10(-7)M. Application of histamine similarly evoked PE at lower concentrations as compared to the induction of itch sensation and axon reflex flare. Serotonin 121-130 kininogen 1 Homo sapiens 221-231 4797302-0 1973 Histamine, norepinephrine, and bradykinin stimulation of fibroblast growth and modification of serotonin response. Serotonin 95-104 kininogen 1 Homo sapiens 31-41 5366278-8 1969 Production by the tumour of serotonin or other derivatives of tryptophan or of kallikrein, which activates bradykinin, is rare. Serotonin 28-37 kininogen 1 Homo sapiens 107-117 26634895-9 2016 Functional expression of B2R was confirmed by a transient disruptive action of BK on fictive locomotion generated by a combination of NMDA, 5-HT and dopamine. Serotonin 140-144 kininogen 1 Homo sapiens 79-81 12231370-6 2002 RESULTS: Exposure to cyclosporine and mycophenolate mofetil was associated with a dose-dependent decrease in endothelium-dependent relaxations to serotonin (an agonist that binds to 5-HT1D receptors coupled to Gi-protein) but no impairment of relaxations to bradykinin (an agonist that binds to B2 receptors coupled to Gq-proteins). Serotonin 146-155 kininogen 1 Homo sapiens 258-268 5527210-0 1970 Bradykinin induced release of serotonin in man. Serotonin 30-39 kininogen 1 Homo sapiens 0-10 5375730-0 1969 Release of serotonin during bradykinin infusion. Serotonin 11-20 kininogen 1 Homo sapiens 28-38 10422653-11 1999 However, the combination of 5-HT and BKN (10 nmol) produced: (1) significantly higher VAS scores (P < 0.05) compared with all other combinations; (2) significantly longer pain offset (P < 0.05) compared with the combinations of isotonic saline and BKN; (3) significantly lower PPTs at 5, 20, and 40 min post-infusion (P < 0.05) compared with baseline PPT and PPTs after all other combinations. Serotonin 28-32 kininogen 1 Homo sapiens 254-257 10604529-1 1999 Bradykinin (BK) increased carotid blood flow (CBF) and jugular nitric oxide (NO) levels when administered into the common carotid artery of rabbits, and potentiated selectively, when infused together with histamine (HIST) or serotonin (5-HT), their effects on both CBF and jugular NO levels (but not vice versa). Serotonin 225-234 kininogen 1 Homo sapiens 0-10 10640624-15 2000 Serotonin may enhance the effect of bradykinin in producing experimental muscle pain and muscle hyperalgesia to mechanical stimuli. Serotonin 0-9 kininogen 1 Homo sapiens 36-46 10422653-14 1999 Pre-treatment with serotonin may enhance the effect of bradykinin in the generation of muscle pain and muscular hyperalgesia in humans. Serotonin 19-28 kininogen 1 Homo sapiens 55-65 10202208-3 1999 After local tissue injury, the release of chemical mediators such as potassium ions, ATP, bradykinin and prostaglandin E2 directly activate nerve endings and indirectly trigger the release of algesic mediators such as histamine, 5-hydroxytryptamine and nerve growth factor from other cells, which, in turn, stimulate proximal afferent nerve endings and silent nociceptors. Serotonin 229-248 kininogen 1 Homo sapiens 90-100 8185716-1 1994 By the mediation of receptors in the endothelium, bradykinin, histamine, and thrombin--besides platelet-derived substances such as adenosine diphosphate and triphosphate (ADP, ATP) and serotonin--play an essential physiological role in the activation of the protective metabolic process in the endothelium, which is so important to vessel dilatation. Serotonin 185-194 kininogen 1 Homo sapiens 50-60 9767830-4 1998 NO SYNTHESIS: Nitric oxide is synthesized from L-arginine by NO-synthetase whose activity is regulated by intracellular calcium concentration and modulated by pharmacological compounds such as acetylcholine, 5-hydroxytryptamine, bradykinin and ADP as well as the sheer forces produced by blood flow. Serotonin 208-227 kininogen 1 Homo sapiens 229-239 9083783-4 1997 The maximal response to des-Arg9-bradykinin, expressed as percentage of the maximum elicited by serotonin, was: 10 +/- 2 at 15 min, 55 +/- 5 at 120 min and 80 +/- 3 at 300 min. Serotonin 96-105 kininogen 1 Homo sapiens 33-43 8499491-4 1993 Treatment of the cells with 10(-6) M bradykinin exhausts calcium release such that the successive treatment of the cells with norepinephrine, carbachol, or serotonin results in no secondary response. Serotonin 156-165 kininogen 1 Homo sapiens 37-47 8499491-5 1993 In contrast, bradykinin treatment of the cells following exposure to norepinephrine, carbachol, or serotonin caused a secondary increase in calcium release. Serotonin 99-108 kininogen 1 Homo sapiens 13-23 2032802-4 1991 In arteries contracted with serotonin, bradykinin evoked potent endothelium-dependent relaxations; L-NMMA markedly reduced the sensitivity but not the maximal response. Serotonin 28-37 kininogen 1 Homo sapiens 39-49 7694438-8 1993 Extracranial pain and tenderness may, however, be induced experimentally by intramuscular injections of hypertonic saline and potassium chloride as well as of endogenous substances like bradykinin with 5-hydroxytryptamine and bradykinin with substance P. Serotonin 202-221 kininogen 1 Homo sapiens 186-196 1371395-3 1992 The flare evoked by bradykinin was abolished by pretreatment with lignocaine (local anesthetic), compound 48/80 (mast-cell histamine liberator), mepyramine (H1-receptor antagonist) and indomethacin (cyclo-oxygenase inhibitor) but was unaffected by atropine and ketanserin (serotonin antagonist). Serotonin 273-282 kininogen 1 Homo sapiens 20-30