PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22934751-1 2012 The effective anti-migraine drugs triptans, all bind with high affinity to three serotonin (5-HT) subtypes, the 5-HT1B, 5-HT1D and 5-HT1F. Serotonin 81-90 5-hydroxytryptamine receptor 1B Homo sapiens 112-118 23335468-2 2013 The human 5-hydroxytryptamine (serotonin) receptor 1B, encoded by the HTR1B (5-HT1B) gene, is a presynaptic serotonin autoreceptor that plays an important role in regulating serotonin synthesis and release. Serotonin 31-40 5-hydroxytryptamine receptor 1B Homo sapiens 70-75 23335468-2 2013 The human 5-hydroxytryptamine (serotonin) receptor 1B, encoded by the HTR1B (5-HT1B) gene, is a presynaptic serotonin autoreceptor that plays an important role in regulating serotonin synthesis and release. Serotonin 31-40 5-hydroxytryptamine receptor 1B Homo sapiens 77-83 21620956-1 2011 Neurotransmission by serotonin (5-HT) is tightly regulated by several autoreceptors that fine-tune serotonergic neurotransmission through negative feedback inhibition at the cell bodies (predominantly 5-HT(1A)) or at the axon terminals (predominantly 5-HT(1B)); however, more subtle roles for 5-HT(1D) and 5-HT(2B) autoreceptors have also been detected. Serotonin 21-30 5-hydroxytryptamine receptor 1B Homo sapiens 251-258 22644202-3 2012 Triptans are serotonin (5-HT1B/1D) receptor agonists that are generally effective, well tolerated and safe. Serotonin 13-22 5-hydroxytryptamine receptor 1B Homo sapiens 24-30 21198573-2 2011 BACKGROUND: The 5-hydroxytryptamine(1B/d) (5-HT(1B/d) )-agonists naratriptan, eletriptan, and frovatriptan have been shown to reduce the frequency of ECH. Serotonin 16-35 5-hydroxytryptamine receptor 1B Homo sapiens 43-50 17241828-1 2007 BACKGROUND: Family-based evidence for association at serotonin system genes SLC6A4, HTR1B, HTR2A, and brain-derived neurotrophic factor (BDNF) has been previously reported in obsessive-compulsive disorder (OCD). Serotonin 53-62 5-hydroxytryptamine receptor 1B Homo sapiens 84-89 20187660-1 2010 We report the development of homology models of dopamine (D(2), D(3), and D(4)), serotonin (5-HT(1B), 5-HT(2A), 5-HT(2B), and 5-HT(2C)), histamine (H(1)), and muscarinic (M(1)) receptors, based on the high-resolution structure of the beta(2)-adrenergic receptor. Serotonin 81-90 5-hydroxytryptamine receptor 1B Homo sapiens 92-99 19623468-1 2009 Triptans, serotonin 5-HT1B/1D receptor agonists, more than revolutionizing the treatment of migraine, stimulated also ground breaking research that provided insights into the anatomy, physiology, and molecular pharmacology of migraine. Serotonin 10-19 5-hydroxytryptamine receptor 1B Homo sapiens 20-26 19325252-2 2009 The 5-HT1Dbeta receptor is a terminal autoreceptor involved in the regulation of serotonin synthesis and release. Serotonin 81-90 5-hydroxytryptamine receptor 1B Homo sapiens 4-14 17691977-1 2007 Serotonin was the first neurotransmitter believed to be involved in cephalic pain transfer forward to the cortex, but the precise mechanism was confirmed only after sumatriptan, a 5-HT(1B/1D0) high affinity agonist, was introduced in the acute treatment of migraine. Serotonin 0-9 5-hydroxytryptamine receptor 1B Homo sapiens 180-187 20144065-9 2007 In particular, recent research suggests that serotonin 5-HT(1B) antagonists alone or combined with selective serotonin re-uptake inhibitors might hold unique promise as efficacious antidepressants. Serotonin 45-54 5-hydroxytryptamine receptor 1B Homo sapiens 55-62 20837046-4 2010 Recent refined genetic studies now indicate that a primary mechanism through which serotonin influences appetite and body weight is via serotonin 2C receptor (5-HT(2C)R) and serotonin 1B receptor (5-HT(1B)R) influencing the activity of endogenous melanocortin receptor agonists and antagonists at the melanocortin 4 receptor (MC4R). Serotonin 83-92 5-hydroxytryptamine receptor 1B Homo sapiens 197-204 20687618-3 2010 Triptans are serotonin (5-HT)(1B/1D) receptor agonists that are generally effective, well tolerated and safe. Serotonin 13-22 5-hydroxytryptamine receptor 1B Homo sapiens 24-35 20152720-1 2010 The serotonin 5-HT(1B) receptors regulate the release of serotonin and are involved in various disease states, including depression and schizophrenia. Serotonin 4-13 5-hydroxytryptamine receptor 1B Homo sapiens 14-21 19809810-1 2010 PURPOSE: Serotonin receptor 1B (HTR1B) is involved in the regulation of the serotonin system, playing different roles in specific areas of the brain. Serotonin 76-85 5-hydroxytryptamine receptor 1B Homo sapiens 9-30 19809810-1 2010 PURPOSE: Serotonin receptor 1B (HTR1B) is involved in the regulation of the serotonin system, playing different roles in specific areas of the brain. Serotonin 76-85 5-hydroxytryptamine receptor 1B Homo sapiens 32-37 17948897-3 2008 Since the 5-HT1B receptor is involved in the release of serotonin at terminal endings of cortical neurons, this study addressed the question whether single nucleotide polymorphism (SNP) in the gene coding for this receptor (HTR1B) are related to LDAEP of the primary auditory cortex (tangential dipole) investigating a community-based sample of 127 healthy subjects randomly selected from the general population. Serotonin 56-65 5-hydroxytryptamine receptor 1B Homo sapiens 10-16 17948897-6 2008 Carriers of the G-alleles may be characterized by a particularly strong feedback inhibition of serotonin release at cortical terminals in the primary auditory cortex, possibly mediated by higher sensitivity of 5-HT1B receptors associated with low serotonergic activity. Serotonin 95-104 5-hydroxytryptamine receptor 1B Homo sapiens 210-216 18710081-1 2008 Introducing serotonin 5-HT1B/1D agonists in the migraine treatment in the early 1990s had for the first time set guidelines for targeting a hypothetic physiologic source of the sequence of events in migraine, and results thus achieved were considerably better than those accomplished with earlier nonselective pharmacological approach. Serotonin 12-21 5-hydroxytryptamine receptor 1B Homo sapiens 22-28 16942467-10 2006 Serotonin was also present in neurons containing 5HT-1B. Serotonin 0-9 5-hydroxytryptamine receptor 1B Homo sapiens 49-55 17209663-3 2007 Numerous serotonin receptor subtypes have been identified; of these, serotonin 5-HT1B and 5-HT2C receptors have been specifically recognised as mediators of serotonin-induced satiety.A number of serotonergic drugs, including selective serotonin reuptake inhibitors (SSRIs), dexfenfluramine and 5-HT2C receptor agonists, have been shown to significantly attenuate rodent bodyweight gain. Serotonin 9-18 5-hydroxytryptamine receptor 1B Homo sapiens 79-85 17169440-2 2007 5-Hydroxytryptamine (5-HT or serotonin) is involved in ejaculatory control, with its ejaculation-retarding effects likely to be attributable to activation of 5-HT1B and 5-HT2C receptors, both spinally and supraspinally. Serotonin 0-19 5-hydroxytryptamine receptor 1B Homo sapiens 158-164 17169440-2 2007 5-Hydroxytryptamine (5-HT or serotonin) is involved in ejaculatory control, with its ejaculation-retarding effects likely to be attributable to activation of 5-HT1B and 5-HT2C receptors, both spinally and supraspinally. Serotonin 21-25 5-hydroxytryptamine receptor 1B Homo sapiens 158-164 17169440-2 2007 5-Hydroxytryptamine (5-HT or serotonin) is involved in ejaculatory control, with its ejaculation-retarding effects likely to be attributable to activation of 5-HT1B and 5-HT2C receptors, both spinally and supraspinally. Serotonin 29-38 5-hydroxytryptamine receptor 1B Homo sapiens 158-164 16942467-13 2006 Colocalization of serotonin with 5HT-1B suggests that this receptor functions as an autoreceptor to regulate serotonin release. Serotonin 18-27 5-hydroxytryptamine receptor 1B Homo sapiens 33-39 16942467-13 2006 Colocalization of serotonin with 5HT-1B suggests that this receptor functions as an autoreceptor to regulate serotonin release. Serotonin 109-118 5-hydroxytryptamine receptor 1B Homo sapiens 33-39 16571351-2 2006 It has been proven that selective serotonin re-uptake inhibitors are effective antidepressants but the delay to therapeutic onset of these agents is thought to be due to the time required for 5-HT1A, and possibly 5-HT1B, autoreceptor desensitisation. Serotonin 34-43 5-hydroxytryptamine receptor 1B Homo sapiens 213-219 16847428-0 2006 5-Hydroxytryptamine-induced contraction of human temporal arteries coexpressing 5-HT2A receptors and wild-type or variant (Phe124Cys) 5-HT1B receptors: increased contribution of 5-HT1B receptors to the total contractile amplitude in arteries from Phe124Cys heterozygous individuals. Serotonin 0-19 5-hydroxytryptamine receptor 1B Homo sapiens 134-140 16847428-0 2006 5-Hydroxytryptamine-induced contraction of human temporal arteries coexpressing 5-HT2A receptors and wild-type or variant (Phe124Cys) 5-HT1B receptors: increased contribution of 5-HT1B receptors to the total contractile amplitude in arteries from Phe124Cys heterozygous individuals. Serotonin 0-19 5-hydroxytryptamine receptor 1B Homo sapiens 178-184 16847428-1 2006 OBJECTIVES: Expression studies of the rare Phe124Cys sequence variant of the human 5-HT1B receptor in HEK293 cells demonstrated that 5-hydroxytryptamine (5-HT) and sumatriptan had both three times higher binding affinity and agonist potency at the variant receptor than wild-type receptor. Serotonin 133-152 5-hydroxytryptamine receptor 1B Homo sapiens 83-89 16861147-10 2006 Additionally, because 5-HT, acting through presynaptic 5-HT1B receptors, inhibits glutamatergic synaptic transmission, lowered 5-HT activity would lead to increased synaptic glutamate release. Serotonin 22-26 5-hydroxytryptamine receptor 1B Homo sapiens 55-61 16039851-2 2005 The template was N-substituted to give a series of compounds showing binding to human cloned 5-HT1A, 5-HT1B and 5-HT1D receptors with pKi"s greater than 9 and selectivities up to 1000-fold against other serotonin, dopamine and adrenergic receptors. Serotonin 203-212 5-hydroxytryptamine receptor 1B Homo sapiens 101-107 15670643-0 2005 Selective 5-HT1B receptor agonist reduces serotonin synthesis following acute, and not chronic, drug administration: results of an autoradiographic study. Serotonin 42-51 5-hydroxytryptamine receptor 1B Homo sapiens 10-16 15836007-3 2005 Research has shown that serotonin (5HT(1B/D)) receptor agonists reduce healthcare costs, improve health-related QOL (HR-QOL), decrease migraine disability and keep patients effective in the workplace. Serotonin 24-33 5-hydroxytryptamine receptor 1B Homo sapiens 35-41 12716341-3 2003 In contrast to the well-established role of serotonin (5-hydroxytryptamine; 5-HT) 5-HT1B receptors in the common carotid vascular bed, the role of alpha-adrenoceptors and their subtypes has been examined only relatively recently. Serotonin 55-74 5-hydroxytryptamine receptor 1B Homo sapiens 82-88 15365222-1 2004 Serotonin 1B receptors (5-HT1B) are autoreceptors involved in the local inhibitory control of serotonin release, and have been suggested to play a role in the pathogenesis of major depressive disorder (MDD) and the antidepressant effects of the selective serotonin reuptake inhibitors in patients. Serotonin 94-103 5-hydroxytryptamine receptor 1B Homo sapiens 24-30 15365222-1 2004 Serotonin 1B receptors (5-HT1B) are autoreceptors involved in the local inhibitory control of serotonin release, and have been suggested to play a role in the pathogenesis of major depressive disorder (MDD) and the antidepressant effects of the selective serotonin reuptake inhibitors in patients. Serotonin 255-264 5-hydroxytryptamine receptor 1B Homo sapiens 24-30 15064139-1 2004 5-HT(1B) autoreceptors regulate serotonin release from terminals of dorsal raphe nucleus (DRN) projections. Serotonin 32-41 5-hydroxytryptamine receptor 1B Homo sapiens 0-7 14731309-1 2004 Pharmacological studies have shown that sumatriptan, a selective ligand of the serotonin 5-HT-1Dbeta autoreceptor, modifies obsessive-compulsive disorder (OCD) symptoms. Serotonin 79-88 5-hydroxytryptamine receptor 1B Homo sapiens 89-100 14971822-1 2004 In the past decade, several studies have reported a significant delay of gastric emptying induced by the anti-migraine agent sumatriptan (a 5-hydroxytryptamine (5-HT)1B/D receptor agonist) in healthy human beings. Serotonin 140-159 5-hydroxytryptamine receptor 1B Homo sapiens 161-168 12383060-1 2002 The triptans, selective serotonin 5-HT1B/1D agonists, are very effective acute migraine drugs. Serotonin 24-33 5-hydroxytryptamine receptor 1B Homo sapiens 34-40 12556913-2 2003 Serotonin regulates dopaminergic neurotransmission in some areas of the brain via several 5-HT receptors including 5-HT1B. Serotonin 0-9 5-hydroxytryptamine receptor 1B Homo sapiens 115-121 12486179-2 2002 For example, serotonin actions at 5-HT1B receptors in the ventral tegmental area (VTA) modulate cocaine-induced dopamine release in the nucleus accumbens (NAcc) and alter the rewarding and stimulant properties of cocaine. Serotonin 13-22 5-hydroxytryptamine receptor 1B Homo sapiens 34-40 12421573-0 2002 The negative immunoregulatory effects of serotonin (5-HT) moduline, an endogenous 5-HT1B receptor antagonist with anti-anxiety properties. Serotonin 41-50 5-hydroxytryptamine receptor 1B Homo sapiens 82-88 12582449-5 2002 It has been shown in pharmacological tests to act selectively as a potent agonist of serotonin 5-HT1B/1D receptors. Serotonin 85-94 5-hydroxytryptamine receptor 1B Homo sapiens 95-101 11386084-3 2001 The herein presented results show that serotonin alone stimulated the proliferation of CCRF-CEM cells and that this effect could be mimicked by two 5-HT1B/1D receptor agonists (L-694,247 and GR 46611). Serotonin 39-48 5-hydroxytryptamine receptor 1B Homo sapiens 148-154 12022963-2 2002 The human serotonin receptor 1B, encoded by the HTR1B gene, is a presynaptic serotonin autoreceptor that plays a role in regulating serotonin synthesis and release. Serotonin 10-19 5-hydroxytryptamine receptor 1B Homo sapiens 48-53 12022963-2 2002 The human serotonin receptor 1B, encoded by the HTR1B gene, is a presynaptic serotonin autoreceptor that plays a role in regulating serotonin synthesis and release. Serotonin 77-86 5-hydroxytryptamine receptor 1B Homo sapiens 10-31 12022963-2 2002 The human serotonin receptor 1B, encoded by the HTR1B gene, is a presynaptic serotonin autoreceptor that plays a role in regulating serotonin synthesis and release. Serotonin 77-86 5-hydroxytryptamine receptor 1B Homo sapiens 48-53 11956970-2 2002 This investigation of central serotonin neurotransmission, specifically the serotonin 1B (5HT1B) receptor gene and its role in both regulating alcohol consumption and developing alcohol dependence revealed overrepresentation of the C allele of the 861G > C polymorphism of 5HT1B in alcoholics with inactive ALDH2, compared with its frequency in nonalcoholic controls. Serotonin 30-39 5-hydroxytryptamine receptor 1B Homo sapiens 90-95 11956970-2 2002 This investigation of central serotonin neurotransmission, specifically the serotonin 1B (5HT1B) receptor gene and its role in both regulating alcohol consumption and developing alcohol dependence revealed overrepresentation of the C allele of the 861G > C polymorphism of 5HT1B in alcoholics with inactive ALDH2, compared with its frequency in nonalcoholic controls. Serotonin 30-39 5-hydroxytryptamine receptor 1B Homo sapiens 276-281 12397864-3 2001 5-HT1B receptors inhibit the release of a range of neurotransmitters, including serotonin, GABA, acetylcholine, and glutamate. Serotonin 80-89 5-hydroxytryptamine receptor 1B Homo sapiens 0-6 11478927-1 2001 5-Hydroxytryptamine (5-HT) is implicated in migraine and agonist directed against 5-HT(1B) and 5-HT(1D) receptors are commonly used as effective therapies. Serotonin 1-19 5-hydroxytryptamine receptor 1B Homo sapiens 82-89 11386084-4 2001 Serotonin- or L-694,247-induced increase in cell proliferation was inhibited by a selective 5-HT1B receptor antagonist, SB-224289. Serotonin 0-9 5-hydroxytryptamine receptor 1B Homo sapiens 92-98 10883409-2 2000 The action of 5-hydroxytryptamine (5-HT1B/1D) agonists--so-called triptans--on receptors located in meningeal arteries (5-HT1B) and trigeminovascular fiber endings (5-HT1D) has an inhibitory effect on this neurogenic inflammation. Serotonin 14-33 5-hydroxytryptamine receptor 1B Homo sapiens 35-41 11264685-1 2001 OBJECTIVE: To examine, for a set of published clinical trials of serotonin (5-HT(1B/1D)) agonists as acute treatments for migraine, whether transformation of efficacy data into therapeutic gain (TG) or number needed to treat (NNT) is useful. Serotonin 65-74 5-hydroxytryptamine receptor 1B Homo sapiens 76-83 11284452-2 2001 Pharmacological evidence obtained in rodents suggests that terminal and somatodendritic autoreceptors controlling serotonin (5-hydroxytryptamine, 5-HT) release belong to the 5-HT1B/D subtype of receptors, whereas somatodendritic autoreceptors controlling neuronal cell firing are predominantly of the 5-HT1A subtype. Serotonin 114-123 5-hydroxytryptamine receptor 1B Homo sapiens 174-180 11284452-2 2001 Pharmacological evidence obtained in rodents suggests that terminal and somatodendritic autoreceptors controlling serotonin (5-hydroxytryptamine, 5-HT) release belong to the 5-HT1B/D subtype of receptors, whereas somatodendritic autoreceptors controlling neuronal cell firing are predominantly of the 5-HT1A subtype. Serotonin 125-144 5-hydroxytryptamine receptor 1B Homo sapiens 174-180 10883409-2 2000 The action of 5-hydroxytryptamine (5-HT1B/1D) agonists--so-called triptans--on receptors located in meningeal arteries (5-HT1B) and trigeminovascular fiber endings (5-HT1D) has an inhibitory effect on this neurogenic inflammation. Serotonin 14-33 5-hydroxytryptamine receptor 1B Homo sapiens 120-126 10997600-2 2000 Both serotonin, acting through 5HT1B/2C receptors, and norepinephrine acting through beta2 and/or beta3 receptors reduce food intake and augment sympathetic activity. Serotonin 5-14 5-hydroxytryptamine receptor 1B Homo sapiens 31-36 10821329-2 2000 Serotonin (5-hydroxytryptamine, 5-HT) has been implicated in the processes of within-meal satiation and postmeal satiety (5-HT1B and 5-HT2C postsynaptic receptors) which are concerned with the signals arising form the pattern of food intake. Serotonin 0-9 5-hydroxytryptamine receptor 1B Homo sapiens 122-128 20575831-0 2000 Evaluation of an allelic association of the serotonin 5-HT1B G681C polymorphism with antisocial alcoholism in the German population. Serotonin 44-53 5-hydroxytryptamine receptor 1B Homo sapiens 54-60 10821329-2 2000 Serotonin (5-hydroxytryptamine, 5-HT) has been implicated in the processes of within-meal satiation and postmeal satiety (5-HT1B and 5-HT2C postsynaptic receptors) which are concerned with the signals arising form the pattern of food intake. Serotonin 11-30 5-hydroxytryptamine receptor 1B Homo sapiens 122-128 10708696-1 2000 Serotonin (5-HT) modulates the phase adjusting effects of light on the mammalian circadian clock through the activation of presynaptic 5-HT(1B) receptors located on retinal terminals in the suprachiasmatic nucleus (SCN). Serotonin 0-9 5-hydroxytryptamine receptor 1B Homo sapiens 135-142 11089513-0 2000 Mechanisms of action of serotonin 5-HT1B/D agonists: insights into migraine pathophysiology using rizatriptan. Serotonin 24-33 5-hydroxytryptamine receptor 1B Homo sapiens 34-40 11089513-2 2000 The serotonin 5-HT1B/1D agonists, known as the triptans, represent a major advance in the treatment of acute migraine. Serotonin 4-13 5-hydroxytryptamine receptor 1B Homo sapiens 14-20 10463349-4 1999 Sumatriptan, a specific serotonin (5-HT)1B/D agonist is used when attacks do not respond to ergotamine, or when intolerable side effects occur. Serotonin 24-33 5-hydroxytryptamine receptor 1B Homo sapiens 35-42 10677628-9 2000 Alternatively, increased serotonin reuptake, which would reduce serotonin levels in the synaptic cleft, may cause or contribute to the increase in 5-HT(1B) receptor binding in the SCN in middle aged animals. Serotonin 25-34 5-hydroxytryptamine receptor 1B Homo sapiens 147-154 9884126-2 1998 Pharmacological studies have shown that serotonin, via its action at 5HT1A and/or 5HT1B receptor sites, modulates the display of intermale aggressive behavior and that its effects serve to decrease behavioral expression. Serotonin 40-49 5-hydroxytryptamine receptor 1B Homo sapiens 82-87 9723944-2 1998 In the human temporal artery both 5-HT1-like and 5-HT2A receptors mediate the contractile effects of 5-hydroxytryptamine (5-HT) and we have suggested that the 5-HT1-like receptors resemble more closely recombinant 5-HT1B than 5-HT1D receptors. Serotonin 101-120 5-hydroxytryptamine receptor 1B Homo sapiens 214-220 9555084-0 1998 Post-lesion up-regulation of 5-HT1B binding sites in the suprachiasmatic nucleus may be reversed after spontaneous or graft-induced serotonin reinnervation. Serotonin 132-141 5-hydroxytryptamine receptor 1B Homo sapiens 29-35 9629840-0 1998 Serotonin inhibits trigeminal nucleus activity evoked by craniovascular stimulation through a 5HT1B/1D receptor: a central action in migraine? Serotonin 0-9 5-hydroxytryptamine receptor 1B Homo sapiens 94-99 9629840-1 1998 The development of serotonin (5HT1B/1D) agonists as treatments for the acute attack of migraine has resulted in considerable interest in their mechanism of action and, to some extent, renewed interest in the role of serotonin (5-hydroxytryptamine; 5HT) in the disorder. Serotonin 19-28 5-hydroxytryptamine receptor 1B Homo sapiens 30-35 9629840-14 1998 These data indicate that 5HT inhibits evoked trigeminal nucleus firing via the 5HT1B/1D receptor at which GR127935 is an antagonist. Serotonin 25-28 5-hydroxytryptamine receptor 1B Homo sapiens 79-84 9593971-1 1998 Using [3H]sumatriptan as a radioligand, 5-hydroxytryptamine (5-HT)1B receptors were examined in posterior striatum and midbrain post-mortem tissue sections of 12 patients who had died from representative degenerative movement disorders as compared to nine controls. Serotonin 40-59 5-hydroxytryptamine receptor 1B Homo sapiens 61-68 8865198-3 1996 Serotonin and serotonin agonists with relative selectivity for the receptor subtypes 5-HT1A, 5-HT1B, 5-HT2A/2C and 5-HT3 all significantly (P < 0.01) inhibited glutamate-evoked firing of cells in the nucleus accumbens compared to the effects of an acidic saline control solution (30-60 nA, 60 s ejection currents for all). Serotonin 0-9 5-hydroxytryptamine receptor 1B Homo sapiens 93-99 8960551-2 1996 Binding experiments at cloned human 5-HT(1B), 5-HT(1D), and 5-HT(1A) receptors show that all of these dimers are very potent ligands at 5-HT(1B/1D) receptors with increased binding selectivity vs the 5-HT(1A) receptor when compared to serotonin. Serotonin 235-244 5-hydroxytryptamine receptor 1B Homo sapiens 36-43 8960551-2 1996 Binding experiments at cloned human 5-HT(1B), 5-HT(1D), and 5-HT(1A) receptors show that all of these dimers are very potent ligands at 5-HT(1B/1D) receptors with increased binding selectivity vs the 5-HT(1A) receptor when compared to serotonin. Serotonin 235-244 5-hydroxytryptamine receptor 1B Homo sapiens 136-143 8960551-5 1996 Results analysis supports the hypothesis that the important increase in potency of the serotonin dimers can be attributed to the presence of two serotonin pharmacophores in the same molecule, while the enhanced selectivity for 5-HT(1B/1D) receptor subtypes may be due to the position of the spacer attachment to serotonin. Serotonin 87-96 5-hydroxytryptamine receptor 1B Homo sapiens 227-234 9453273-8 1997 This effect is probably the consequence of its superior lipophilicity compared to sumatriptan and of activation of prejunctional 5HT1B/D autoreceptors, which lowers central serotonin release and thus the preactivation level of sensory cortices. Serotonin 173-182 5-hydroxytryptamine receptor 1B Homo sapiens 129-134 8960551-0 1996 Serotonin dimers: application of the bivalent ligand approach to the design of new potent and selective 5-HT(1B/1D) agonists. Serotonin 0-9 5-hydroxytryptamine receptor 1B Homo sapiens 104-111 8960551-1 1996 A series of serotonin dimers of formula 4 in which two serotonin moeities are linked together through their 5-hydroxyl residue has been prepared and evaluated as 5-HT(1B/1D) receptor agonists. Serotonin 12-21 5-hydroxytryptamine receptor 1B Homo sapiens 162-169 8865198-3 1996 Serotonin and serotonin agonists with relative selectivity for the receptor subtypes 5-HT1A, 5-HT1B, 5-HT2A/2C and 5-HT3 all significantly (P < 0.01) inhibited glutamate-evoked firing of cells in the nucleus accumbens compared to the effects of an acidic saline control solution (30-60 nA, 60 s ejection currents for all). Serotonin 14-23 5-hydroxytryptamine receptor 1B Homo sapiens 93-99 8568822-0 1996 Binding of O-alkyl derivatives of serotonin at human 5-HT1D beta receptors. Serotonin 34-43 5-hydroxytryptamine receptor 1B Homo sapiens 53-64 7485252-3 1995 5-HT1D beta is a terminal serotonin autoreceptor which may play a role in regulating serotonin synthesis and release. Serotonin 26-35 5-hydroxytryptamine receptor 1B Homo sapiens 0-11 7485252-4 1995 Using an SSCP technique we screened for 5-HT1D beta coding sequence variants in psychiatrically interviewed populations, which included controls, alcoholics, and alcoholic arsonists and alcoholic violent offenders with low CSF concentrations of the main serotonin metabolite 5-HIAA. Serotonin 254-263 5-hydroxytryptamine receptor 1B Homo sapiens 40-51 7972340-1 1994 In spite of a lack of compounds acting selectively at the 5-hydroxytryptamine (5-HT)1B and 5-HT1D receptor subtypes, by cross-relating the available data, this review attempts to tentatively assign behavioural and other in vivo correlates of these receptor subtypes. Serotonin 58-77 5-hydroxytryptamine receptor 1B Homo sapiens 79-86 7984276-0 1994 A single point mutation increases the affinity of serotonin 5-HT1D alpha, 5-HT1D beta, 5-HT1E and 5-HT1F receptors for beta-adrenergic antagonists. Serotonin 50-59 5-hydroxytryptamine receptor 1B Homo sapiens 74-85 8232238-1 1993 Recent mutations of the 5-hydroxytryptamine (5-HT)1B and 5-HT1D receptor subtypes suggest that a threonine in the seventh transmembrane helix may be responsible for the selectivity of these receptors. Serotonin 24-43 5-hydroxytryptamine receptor 1B Homo sapiens 45-52 34616037-6 2021 The activity of dCA2-projecting MS cells is enhanced by the neuromodulator 5-HT acting on 5-HT1B receptors. Serotonin 75-79 5-hydroxytryptamine receptor 1B Homo sapiens 90-96 8394988-1 1993 Serotonin [5-hydroxytryptamine (5-HT)] has been implicated in the pathophysiology of migraine, and the clinical efficacy of the 5-HT1B/5-HT1D receptor agonist sumatriptan points to neural and/or vascular 5-HT1D receptors as relevant targets in migraine therapy. Serotonin 0-9 5-hydroxytryptamine receptor 1B Homo sapiens 128-134 2567038-5 1989 The 5-HT1B or the 5-HT1D receptors play a role in the "defensive burying" anxiety model and probably mediate antidepressant and antianxiety effects of serotonin-uptake inhibitors. Serotonin 151-160 5-hydroxytryptamine receptor 1B Homo sapiens 4-10 34493397-1 2021 INTRODUCTION: Serotonin is highly implicated in the regulation of emotional state and the execution of cognitive tasks, so much so that the serotonin transporter genes (5-HTT, SLC6A4) and the serotonin receptor genes (HTR1A, HTR1B, HTR2A) have become the perfect candidates when studying the effects that these genes and their polymorphic variations have on depression characteristics. Serotonin 14-23 5-hydroxytryptamine receptor 1B Homo sapiens 225-230 2901381-5 1988 Development of 5HT agonists and antagonists selective for different 5HT receptor sub-types (5HT1A, 5HT1B, 5HT2, 5HT3) has opened a new avenue for investigation of the potential role of 5HT in anxiety. Serotonin 15-18 5-hydroxytryptamine receptor 1B Homo sapiens 99-104 2966310-1 1988 In human caudate and cortex membranes, [3H]serotonin ([3H]5-HT) labels 5-HT1A and 5-HT1C recognition sites which show nanomolar affinity for 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)-tetralin) and mesulergine respectively, whereas no 5-HT1B binding could be identified. Serotonin 43-52 5-hydroxytryptamine receptor 1B Homo sapiens 234-240 33785138-5 2021 The effect of 5-HT on STN neuronal activity involves several 5-HT receptor subtypes, including 5-HT1A, 5-HT1B, 5-HT2C and 5-HT4 receptors, which have garnered the highest attention on this topic. Serotonin 14-18 5-hydroxytryptamine receptor 1B Homo sapiens 103-109 3815073-1 1987 High-affinity [3H]serotonin (5-hydroxytryptamine, 5-HT) binding sites from human frontal cortex can be divided into at least 3 pharmacological subtypes (5-HT1A, 5-HT1B and 5-HT3) based on affinity for [3H]serotonin and spiperone. Serotonin 18-27 5-hydroxytryptamine receptor 1B Homo sapiens 161-167 3815073-1 1987 High-affinity [3H]serotonin (5-hydroxytryptamine, 5-HT) binding sites from human frontal cortex can be divided into at least 3 pharmacological subtypes (5-HT1A, 5-HT1B and 5-HT3) based on affinity for [3H]serotonin and spiperone. Serotonin 29-48 5-hydroxytryptamine receptor 1B Homo sapiens 161-167 33785138-5 2021 The effect of 5-HT on STN neuronal activity involves several 5-HT receptor subtypes, including 5-HT1A, 5-HT1B, 5-HT2C and 5-HT4 receptors, which have garnered the highest attention on this topic. Serotonin 61-65 5-hydroxytryptamine receptor 1B Homo sapiens 103-109 33036580-1 2020 BACKGROUND: The 5-hydroxytryptamine 1B receptor (5-HT1B) plays an essential role in the serotonin (5-HT) system and is widely involved in a variety of brain activities. Serotonin 88-97 5-hydroxytryptamine receptor 1B Homo sapiens 16-47 33036580-1 2020 BACKGROUND: The 5-hydroxytryptamine 1B receptor (5-HT1B) plays an essential role in the serotonin (5-HT) system and is widely involved in a variety of brain activities. Serotonin 88-97 5-hydroxytryptamine receptor 1B Homo sapiens 49-55 33036580-1 2020 BACKGROUND: The 5-hydroxytryptamine 1B receptor (5-HT1B) plays an essential role in the serotonin (5-HT) system and is widely involved in a variety of brain activities. Serotonin 49-53 5-hydroxytryptamine receptor 1B Homo sapiens 16-47 32689951-1 2020 BACKGROUND: The HTR1B gene encodes the 5-hydroxytryptamine (5-HT1B) receptor, which is involved in a variety of brain activities and mental disorders. Serotonin 39-58 5-hydroxytryptamine receptor 1B Homo sapiens 16-21 32088264-0 2020 Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Serotonin 49-58 5-hydroxytryptamine receptor 1B Homo sapiens 42-48 32088264-1 2020 The 5-HT1A and 5-HT1B serotonin receptors are abundantly expressed in the CNS and constitute validated as well as putative drug targets in a variety of psychiatric and cognitive disorders, alcoholism/addiction, pain and migraine. Serotonin 22-31 5-hydroxytryptamine receptor 1B Homo sapiens 15-21 32088264-3 2020 Serotonin and other agonists induced robust decreases in fluorescence levels in the 5-HT1A/GIRK2- and 5-HT1B/GIRK2-HEK293 cells in a concentration-dependent manner in the assay, and these responses could be inhibited by selective 5-HT1A/5-HT1B antagonists and by the Galphai/o-protein inhibitor pertussis toxin (PTX). Serotonin 0-9 5-hydroxytryptamine receptor 1B Homo sapiens 102-108 32088264-3 2020 Serotonin and other agonists induced robust decreases in fluorescence levels in the 5-HT1A/GIRK2- and 5-HT1B/GIRK2-HEK293 cells in a concentration-dependent manner in the assay, and these responses could be inhibited by selective 5-HT1A/5-HT1B antagonists and by the Galphai/o-protein inhibitor pertussis toxin (PTX). Serotonin 0-9 5-hydroxytryptamine receptor 1B Homo sapiens 237-243 29759300-4 2018 In vitro contractile response to serotonin was assessed by videomicroscopy in the presence or absence of serotonin alone (10-9-10-5M) or combined with the selective serotonin 1B receptor (5-HT1B) antagonist, SB224289 (10-6M). Serotonin 33-42 5-hydroxytryptamine receptor 1B Homo sapiens 188-194 32333296-1 2020 BACKGROUND: LY393558 is a combined antagonist of serotonin (5-HT) 5-HT1B receptors and inhibitor of serotonin transporter (SERT). Serotonin 49-58 5-hydroxytryptamine receptor 1B Homo sapiens 66-72 32333296-1 2020 BACKGROUND: LY393558 is a combined antagonist of serotonin (5-HT) 5-HT1B receptors and inhibitor of serotonin transporter (SERT). Serotonin 60-64 5-hydroxytryptamine receptor 1B Homo sapiens 66-72 32333296-6 2020 The 5-HT1B antagonists SB224289 and GR55562 reduced responses induced by 5-HT and 5-CT and the 5-HT2A antagonist ketanserin inhibited the effects of 5-HT and alpha-methyl-5-HT. Serotonin 73-77 5-hydroxytryptamine receptor 1B Homo sapiens 4-10 32333296-9 2020 CONCLUSIONS: LY393558 reduces the 5-HT-induced contraction antagonizing 5-HT1B and 5-HT2A receptors probably due to synergic interaction between SERT inhibition and 5-HT1B receptor antagonism. Serotonin 34-38 5-hydroxytryptamine receptor 1B Homo sapiens 72-78 30362504-7 2019 Prominent among these are the shared roles of skin, neural and spinal mu opiate receptors, kappa opiate receptor, nitric oxide, serotonin via 5HT1B/D receptors, cytokines, especially interleukins, and tumor necrosis factor. Serotonin 128-137 5-hydroxytryptamine receptor 1B Homo sapiens 142-147 32333296-9 2020 CONCLUSIONS: LY393558 reduces the 5-HT-induced contraction antagonizing 5-HT1B and 5-HT2A receptors probably due to synergic interaction between SERT inhibition and 5-HT1B receptor antagonism. Serotonin 34-38 5-hydroxytryptamine receptor 1B Homo sapiens 165-171 31291016-4 2019 Studies of serotonin pharmacology led to the development of triptans, 5-HT1B/1D receptor agonists, some of which have actions at the 5-HT1F receptor. Serotonin 11-20 5-hydroxytryptamine receptor 1B Homo sapiens 70-76 31135819-18 2019 Conclusions and Relevance: Treatment with sumatriptan during migraine attacks appeared to be associated with a decrease in 5-HT1B receptor binding, a finding that is most likely associated with the binding of sumatriptan to central 5-HT1B receptors, but the contribution of ongoing cerebral serotonin release to the lower binding cannot be excluded; the migraine attack-associated decrease in binding could indicate that migraine attacks are associated with increases in endogenous serotonin. Serotonin 291-300 5-hydroxytryptamine receptor 1B Homo sapiens 123-129 31135819-18 2019 Conclusions and Relevance: Treatment with sumatriptan during migraine attacks appeared to be associated with a decrease in 5-HT1B receptor binding, a finding that is most likely associated with the binding of sumatriptan to central 5-HT1B receptors, but the contribution of ongoing cerebral serotonin release to the lower binding cannot be excluded; the migraine attack-associated decrease in binding could indicate that migraine attacks are associated with increases in endogenous serotonin. Serotonin 482-491 5-hydroxytryptamine receptor 1B Homo sapiens 123-129 29759300-9 2018 The contractile response to serotonin was significantly inhibited by the 5-HT1B antagonist in both diabetic and non-diabetic vessels (P < .05 versus serotonin alone). Serotonin 28-37 5-hydroxytryptamine receptor 1B Homo sapiens 73-79 29759300-9 2018 The contractile response to serotonin was significantly inhibited by the 5-HT1B antagonist in both diabetic and non-diabetic vessels (P < .05 versus serotonin alone). Serotonin 152-161 5-hydroxytryptamine receptor 1B Homo sapiens 73-79 29759300-12 2018 Serotonin-induced contractile response of the peripheral arterioles was via 5-HT1B in both diabetic and non-diabetic patients. Serotonin 0-9 5-hydroxytryptamine receptor 1B Homo sapiens 76-82 30013068-0 2018 Serotonin concentration enhancers at clinically relevant doses reduce [11C]AZ10419369 binding to the 5-HT1B receptors in the nonhuman primate brain. Serotonin 0-9 5-hydroxytryptamine receptor 1B Homo sapiens 101-107 28730894-11 2018 We also provide indirect support for the dorsal raphe 5-HT1B receptors being temporarily downregulated during the migraine attack, presumably in response to higher cerebral serotonin levels in the ictal phase. Serotonin 173-182 5-hydroxytryptamine receptor 1B Homo sapiens 54-60 29468941-4 2018 Pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (TPH1) is increased in patients with PAH and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (PASMCs), In humans, serotonin can enter PASMCs via the serotonin transporter (SERT) or activate the 5-HT1B receptor; 5-HT1B activation and SERT activity cooperate to induce PASMC contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. Serotonin 22-31 5-hydroxytryptamine receptor 1B Homo sapiens 310-316 29468941-4 2018 Pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (TPH1) is increased in patients with PAH and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (PASMCs), In humans, serotonin can enter PASMCs via the serotonin transporter (SERT) or activate the 5-HT1B receptor; 5-HT1B activation and SERT activity cooperate to induce PASMC contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. Serotonin 22-31 5-hydroxytryptamine receptor 1B Homo sapiens 327-333 29468941-4 2018 Pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (TPH1) is increased in patients with PAH and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (PASMCs), In humans, serotonin can enter PASMCs via the serotonin transporter (SERT) or activate the 5-HT1B receptor; 5-HT1B activation and SERT activity cooperate to induce PASMC contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. Serotonin 115-124 5-hydroxytryptamine receptor 1B Homo sapiens 310-316 29468941-4 2018 Pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (TPH1) is increased in patients with PAH and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (PASMCs), In humans, serotonin can enter PASMCs via the serotonin transporter (SERT) or activate the 5-HT1B receptor; 5-HT1B activation and SERT activity cooperate to induce PASMC contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. Serotonin 115-124 5-hydroxytryptamine receptor 1B Homo sapiens 327-333 29468941-4 2018 Pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (TPH1) is increased in patients with PAH and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (PASMCs), In humans, serotonin can enter PASMCs via the serotonin transporter (SERT) or activate the 5-HT1B receptor; 5-HT1B activation and SERT activity cooperate to induce PASMC contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. Serotonin 115-124 5-hydroxytryptamine receptor 1B Homo sapiens 327-333 23601559-0 2013 Serotonin inhibits apoptosis of pulmonary artery smooth muscle cell by pERK1/2 and PDK through 5-HT1B receptors and 5-HT transporters. Serotonin 0-9 5-hydroxytryptamine receptor 1B Homo sapiens 95-101 29057276-4 2017 RESULTS: Dopamine (DRD2) Serotonin (5-HT1B), their Transporter (VMAT1) and Oxytocin (OXTR) were positively associated with a high level of importance of spirituality or religion (S/R) in the group at low familial risk for depression. Serotonin 25-34 5-hydroxytryptamine receptor 1B Homo sapiens 36-42 25652393-2 2015 The serotonin transporter (SERT), which is responsible for the reuptake of serotonin from the synaptic cleft into the neuron, as well as the serotonin-1A (5-HT1A) and -1B (5-HT1B) receptors, inhibitory auto-receptors in the raphe region and projection areas, respectively, are likely to determine serotonin release. Serotonin 4-13 5-hydroxytryptamine receptor 1B Homo sapiens 172-178 25652393-2 2015 The serotonin transporter (SERT), which is responsible for the reuptake of serotonin from the synaptic cleft into the neuron, as well as the serotonin-1A (5-HT1A) and -1B (5-HT1B) receptors, inhibitory auto-receptors in the raphe region and projection areas, respectively, are likely to determine serotonin release. Serotonin 75-84 5-hydroxytryptamine receptor 1B Homo sapiens 172-178 25488888-1 2014 BACKGROUND: Triptans, serotonin 5-HT1B/1D receptor agonists, exert their action by targeting serotonin 5-HT1B/1D receptors, are used for treatment of migraine attack. Serotonin 22-31 5-hydroxytryptamine receptor 1B Homo sapiens 32-38 25488888-1 2014 BACKGROUND: Triptans, serotonin 5-HT1B/1D receptor agonists, exert their action by targeting serotonin 5-HT1B/1D receptors, are used for treatment of migraine attack. Serotonin 22-31 5-hydroxytryptamine receptor 1B Homo sapiens 103-109 29468941-4 2018 Pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (TPH1) is increased in patients with PAH and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (PASMCs), In humans, serotonin can enter PASMCs via the serotonin transporter (SERT) or activate the 5-HT1B receptor; 5-HT1B activation and SERT activity cooperate to induce PASMC contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. Serotonin 115-124 5-hydroxytryptamine receptor 1B Homo sapiens 310-316 27112704-5 2016 Serotonin"s homeostasis involves serotoninergic autoreceptor such as 5-HT1A, 5-HT1B, 5-HT1D, the enzymatic degradation of serotonin by monoamine oxidase A (MAO-A), and a transporter (serotoninergic transporter [SERT]). Serotonin 0-9 5-hydroxytryptamine receptor 1B Homo sapiens 77-83 25841787-3 2015 Serotonin 1B receptors (5-HT1B), along with serotonin transporter (SERT) are among the regulators of extracellular 5-HT levels. Serotonin 0-9 5-hydroxytryptamine receptor 1B Homo sapiens 24-30 25787955-2 2015 Its axon terminals in the substantia nigra pars reticulata (SNr) express a high level of serotonin (5-HT) type 1B receptors (5-HT(1B)Rs), whereas the SNr also receives an intense 5-HT innervation that expresses 5-HT transporters, providing an anatomic substrate for 5-HT and selective 5-HT reuptake inhibitor (SSRI)-based antidepressant treatment to regulate the striatonigral output. Serotonin 89-98 5-hydroxytryptamine receptor 1B Homo sapiens 125-132 24108308-3 2014 Triptans, serotonin 5-HT1B/1D receptor agonists, effectively relieve the pain, disability, and associated symptoms of migraine while improving health-related quality of life. Serotonin 10-19 5-hydroxytryptamine receptor 1B Homo sapiens 20-26 24126162-7 2014 The demonstrated age effect on 5-HT(1B) receptors suggest a physiologic and PD-related decline of serotonin function, indicating the importance of controlling for age in clinical studies. Serotonin 98-107 5-hydroxytryptamine receptor 1B Homo sapiens 31-38 23601559-3 2013 Serotonin (5-HT) has been shown to be involved in PH by inducing PASMC proliferation through the activation of 5-HT1B receptors (5-HT1BR) and 5-HT transporter (5-HTT). Serotonin 0-9 5-hydroxytryptamine receptor 1B Homo sapiens 111-117 23954709-2 2013 Serotonin receptors are thought to contribute to LID but serotonin 1B (5-HT1B) receptors have never been investigated in any primate models of PD and LID. Serotonin 57-66 5-hydroxytryptamine receptor 1B Homo sapiens 71-77 23815106-1 2013 INTRODUCTION: The introduction of the triptans (5-hydroxytryptamine (5-HT)1B/1D receptor agonists) was a great improvement in the acute treatment of migraine. Serotonin 48-67 5-hydroxytryptamine receptor 1B Homo sapiens 69-76