PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2379773-3 1990 The aborally decreasing gradient in response to motilin, known to exist in adult rabbits, was already present at day 8 (maximum contractile responses expressed as a percent of the maximal response to acetylcholine were 77% +/- 9%, 34% +/- 10%, and 25% +/- 8% for duodenal, jejunal, and ileal strips, respectively). Acetylcholine 200-213 promotilin Oryctolagus cuniculus 48-55 2725711-7 1989 The response to motilin (10(-6) M) was not only smaller than that to acetylcholine (10(-5) M), it also faded more rapidly with time. Acetylcholine 69-82 promotilin Oryctolagus cuniculus 16-23 1069362-1 1976 The interaction of 13-nle-motilin-a synthetic analogue of the natural polypeptide-with acetylcholine was studied on rabbit isolated pyloric sphincter in vitro. Acetylcholine 87-100 promotilin Oryctolagus cuniculus 26-33 1069362-2 1976 Adding subthreshold doses of 13-nle-motilin reduced the calculated acetylcholine dose for half maximal contraction from 3.68 to 1.33 X 10(-6) g/ml and increased the calculated maximal response by 15.3%. Acetylcholine 67-80 promotilin Oryctolagus cuniculus 36-43 1069362-3 1976 Thus 13-nle-motilin caused potentiation of the acetylcholine response. Acetylcholine 47-60 promotilin Oryctolagus cuniculus 12-19 1069362-4 1976 Since 13-nle-motilin induced increase of endogenous acetylcholine levels could be excluded, a direct action of motilin on or in the smooth muscle cell is suggested. Acetylcholine 52-65 promotilin Oryctolagus cuniculus 13-20 7202949-8 1981 Thus, it may be concluded that motilin produces intestinal contractions by acting directly on smooth muscles, but not by acting on pharmacologically known drug receptors nor by releasing neurotransmitters such as endogenous acetylcholine. Acetylcholine 224-237 promotilin Oryctolagus cuniculus 31-38