PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25964092-8	2015	Furthermore, ACh stimulation increased the production of IL-8 and time-dependently induced the activation of EGFR, PI3K, and AKT through M3R.	Acetylcholine	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	57-61	
25964092-11	2015	ACh-induced activation of EGFR/PI3K/AKT pathway and subsequent IL-8 upregulation may be one of the important mechanisms of M3R function.	Acetylcholine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	63-67	
25683465-12	2015	Furthermore, in epithelial cells from resection material of patients with Crohn"s disease and ulcerative colitis, high expression of CXCL-8 was associated with a reduced choline acetyl transferase expression, suggesting an aberrant epithelial production of ACh in inflammatory context.	Acetylcholine	257-260	C-X-C motif chemokine ligand 8	Homo sapiens	133-139	
23142559-7	2013	Taken as a whole, these results suggest that ACh release by A549 cells enhances TNF-alpha-induced CXCL8 secretion through activation of the M3R.	Acetylcholine	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	98-103	
23142559-10	2013	Our results suggest that the TNF-alpha-induced secretion of CXCL8 in A549 cells is regulated by the release of ACh, the latter"s binding to the M3R and the downstream activation of NF-kappaB and the ERK1/2 and p38 MAPK signaling pathways.	Acetylcholine	111-114	C-X-C motif chemokine ligand 8	Homo sapiens	60-65	
18975306-10	2008	ACh significantly reduced the production of IL-6, CXCL8, CCL2, CCL3, CCL5, and granulocyte colony-stimulating factor by IL-1-stimulated FLS.	Acetylcholine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	50-55	
18242599-0	2008	Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism.	Acetylcholine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	38-42	
18242599-4	2008	Additionally, we tested the IL-8-mediated neutrophil chemotactic activity of 16HBE supernatants stimulated with acetylcholine in the presence or absence of tiotropium.	Acetylcholine	112-125	C-X-C motif chemokine ligand 8	Homo sapiens	28-32	
18242599-6	2008	Acetylcholine (10 microM) significantly stimulated ERK1/2 and NFkB activation as well as IL-8 release in 16HBE cells when compared to basal values.	Acetylcholine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	89-93	
18242599-8	2008	Additionally, acetylcholine-mediated IL-8 release from 16HBE cells significantly increased chemotaxis toward neutrophils and this effect was blocked by tiotropium.	Acetylcholine	14-27	C-X-C motif chemokine ligand 8	Homo sapiens	37-41	
18242599-9	2008	In conclusion, acetylcholine activates the release of IL-8 from 16HBE involving PKC, ERK1/2 and NFkB pathways via muscarinic receptors, suggesting that it is likely to contribute to IL-8 related neutrophilic inflammatory disorders in the airway.	Acetylcholine	15-28	C-X-C motif chemokine ligand 8	Homo sapiens	54-58	
18242599-9	2008	In conclusion, acetylcholine activates the release of IL-8 from 16HBE involving PKC, ERK1/2 and NFkB pathways via muscarinic receptors, suggesting that it is likely to contribute to IL-8 related neutrophilic inflammatory disorders in the airway.	Acetylcholine	15-28	C-X-C motif chemokine ligand 8	Homo sapiens	182-186	
7609578-8	1995	NaF (10 mM), which stimulates ACh release, produced parallel increases in EPPs and perineural Ca2+ currents.	Acetylcholine	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	0-3