PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16210565-3	2005	METHODS AND RESULTS: Through the use of 2 functional models, aortic rings and intravital video microscopy of the cremaster, we found that arterial relaxation in response to the endothelium-dependent vessel relaxant, acetylcholine or the nitric oxide synthase (NOS) activator (A23187), was significantly impaired in cystathionine beta-synthase null (CBS(-/-)) mice.	Acetylcholine	216-229	cystathionine beta-synthase	Mus musculus	315-342	
10953023-4	2000	CBS(-/+) mice demonstrated impaired acetylcholine-induced aortic relaxation and a paradoxical vasoconstriction of mesenteric microvessels in response to superfusion of methacholine and bradykinin.	Acetylcholine	36-49	cystathionine beta-synthase	Mus musculus	0-3	
10993757-8	2000	In contrast, in mice fed a low-folate diet, maximal relaxation to acetylcholine was markedly impaired in CBS +/- mice (58 +/- 9%) compared with CBS +/+ mice (84 +/- 4%) (P = 0.01).	Acetylcholine	66-79	cystathionine beta-synthase	Mus musculus	105-108	
10953023-5	2000	Cyclic GMP accumulation following acetylcholine treatment was also impaired in isolated aortic segments from CBS(-/+) mice, but aortic relaxation and mesenteric arteriolar dilation in response to sodium nitroprusside were similar to wild-type.	Acetylcholine	34-47	cystathionine beta-synthase	Mus musculus	109-112	
28847570-5	2017	Furthermore, acetylcholine-induced relaxations were attenuated by cystathionine-gamma-lyase (CSE) inhibitor d,l-propargylglycine (PAG, 10-2 M) and cystathionine-beta-synthase inhibitor (CBS) aminooxyacetic acid (AOAA, 10-3 M).	Acetylcholine	13-26	cystathionine beta-synthase	Mus musculus	147-174	
28665886-8	2017	CBS+/- mice aorta had lower response to phenylephrine and acetylcholine compared with other groups; however, CBS+/-/C3H mice response was improved.	Acetylcholine	58-71	cystathionine beta-synthase	Mus musculus	0-3