PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21258071-3 2011 Cytochrome P450 (CYP) 1A1 proteins can metabolize some dioxins and PCBs by hydroxylation, but the activities of human and rat CYP1A1 proteins are very different. Polychlorinated Biphenyls 67-71 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-25 23785672-7 2013 We observed a significant difference in serum polychlorinated biphenyl (CB-153) and the pesticide 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p"-DDE) levels between Inuit and Europeans, and for Inuit also associations between the POP levels and genotypes for CYP1A1, CYP1B1 and COMT. Polychlorinated Biphenyls 46-70 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 264-270 22521609-6 2012 Exposure to PCB 126 significantly increased cytochrome P450 1A1 (Cyp1A1) mRNA and protein expression and superoxide production, events which were significantly attenuated following pretreatment with EGCG. Polychlorinated Biphenyls 12-15 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 44-63 22521609-6 2012 Exposure to PCB 126 significantly increased cytochrome P450 1A1 (Cyp1A1) mRNA and protein expression and superoxide production, events which were significantly attenuated following pretreatment with EGCG. Polychlorinated Biphenyls 12-15 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 65-71 21540284-2 2011 Individual PCB congeners can activate the TR in vitro when the metabolic enzyme cytochrome P4501A1 (CYP1A1) is induced, suggesting that specific PCB metabolites act as TR agonists. Polychlorinated Biphenyls 11-14 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 80-98 21540284-2 2011 Individual PCB congeners can activate the TR in vitro when the metabolic enzyme cytochrome P4501A1 (CYP1A1) is induced, suggesting that specific PCB metabolites act as TR agonists. Polychlorinated Biphenyls 11-14 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 100-106 21540284-2 2011 Individual PCB congeners can activate the TR in vitro when the metabolic enzyme cytochrome P4501A1 (CYP1A1) is induced, suggesting that specific PCB metabolites act as TR agonists. Polychlorinated Biphenyls 145-148 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 80-98 21540284-2 2011 Individual PCB congeners can activate the TR in vitro when the metabolic enzyme cytochrome P4501A1 (CYP1A1) is induced, suggesting that specific PCB metabolites act as TR agonists. Polychlorinated Biphenyls 145-148 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 100-106 17912254-4 2008 These order of magnitude greater IEQs compared to the TEQs for dioxins, furans, and certain PCBs suggests that human blood contains a relatively high level of AHR agonists able to activate the CYP1A1 dioxin response element (DRE)-linked reporter gene bioassay and that this AHR activity is not accounted for by PCDDs/Fs and dioxin-like PCBs based on standard HR-GC/MS and TEF analysis. Polychlorinated Biphenyls 336-340 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 193-199 19514916-14 2009 The dramatic differences between rodents and humans in sensitivity to PCB-mediated induction of CYP1A1 suggests that even occupational exposures to PCBs have never resulted in PCB body burdens approaching the levels required to initiate the sequence of events involved in the promotion of liver tumors in rodents. Polychlorinated Biphenyls 148-152 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 96-102 18786521-0 2008 Coplanar polychlorinated biphenyl-induced CYP1A1 is regulated through caveolae signaling in vascular endothelial cells. Polychlorinated Biphenyls 9-33 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 42-48 18786521-4 2008 We focused on the role of caveolae and their major protein component, caveolin-1 (Cav-1), on aryl hydrocarbon receptor (AhR)-mediated induction of cytochrome P450 1A1 (CYP1A1) by coplanar PCBs. Polychlorinated Biphenyls 188-192 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 147-166 18786521-4 2008 We focused on the role of caveolae and their major protein component, caveolin-1 (Cav-1), on aryl hydrocarbon receptor (AhR)-mediated induction of cytochrome P450 1A1 (CYP1A1) by coplanar PCBs. Polychlorinated Biphenyls 188-192 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 168-174 17912254-4 2008 These order of magnitude greater IEQs compared to the TEQs for dioxins, furans, and certain PCBs suggests that human blood contains a relatively high level of AHR agonists able to activate the CYP1A1 dioxin response element (DRE)-linked reporter gene bioassay and that this AHR activity is not accounted for by PCDDs/Fs and dioxin-like PCBs based on standard HR-GC/MS and TEF analysis. Polychlorinated Biphenyls 92-96 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 193-199 20819910-0 2010 Analysis of the CYP1A1 mRNA dose-response in human keratinocytes indicates that relative potencies of dioxins, furans, and PCBs are species and congener specific. Polychlorinated Biphenyls 123-127 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 16-22 18583386-3 2008 Dioxin-like PCBs have been shown to tightly bind the active site of cytochrome P450 (CYP) 1A isoforms, primarily CYP1A1, resulting in inhibition of CYP activity and the generation of reactive oxygen species (ROS) as a result of uncoupling of the catalytic cycle. Polychlorinated Biphenyls 12-16 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 113-119 21783860-0 2008 CYP1A1 and MT1K are congener specific biomarker genes for liver diseases induced by PCBs. Polychlorinated Biphenyls 84-88 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 18025053-3 2007 The mRNA levels of eNOS, aryl hydrocarbon receptor (AhR) and cytochrome P450 (CYP) 1A1 in cells treated with 5 microM PCBs for 24 hours were analysed by real-time RT-PCR. Polychlorinated Biphenyls 118-122 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 61-86 18222549-10 2008 In all dolphins, CYP1A1 expression in the deep blubber layer was positively related to concentrations of hydroxylated PCBs (OH-PCBs) in plasma. Polychlorinated Biphenyls 118-122 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 17-23 15642161-6 2005 Statistically significant multiplicative interactions were observed between CYP1A1 M2-containing genotypes and elevated plasma total PCBs among white women (P value for likelihood ratio test = 0.02). Polychlorinated Biphenyls 133-137 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 76-82 17051818-3 2006 This study examined the capacity of CYP1 enzyme induction to be a biomarker of exposure to a mixture of PCBs and PCDFs and of adverse human health effects. Polychlorinated Biphenyls 104-108 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-40 16580705-0 2006 Genetic polymorphisms in CYP1A1 and GSTM1 predispose humans to PCBs/PCDFs-induced skin lesions. Polychlorinated Biphenyls 63-67 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 25-31 16580705-14 2006 CONCLUSION: CYP1A1 and GSTM1 genotypic polymorphisms might be related to the susceptibility to PCB/PCDF-induced skin manifestations. Polychlorinated Biphenyls 95-98 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 12-18 15915151-2 2005 The CYP1 family is of particular interest in environmental toxicology because its members are dominant in the metabolism of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and aryl amines. Polychlorinated Biphenyls 165-190 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-8 15915151-2 2005 The CYP1 family is of particular interest in environmental toxicology because its members are dominant in the metabolism of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and aryl amines. Polychlorinated Biphenyls 192-196 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-8 17512696-8 2007 Exposure of H295R to PCBs with different AhR activation abilities also varied CYP19 and CYP1A1 expression in dissimilar patterns, although the CYP19 mRNA levels were in line with the AhR activation abilities of the congeners. Polychlorinated Biphenyls 21-25 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 88-94 16291828-6 2006 However, treatment with TCDD and PCB 126 induced an AhR signaling response, as indicated by the expression of the AhR-target gene cytochrome P-450 1A1 (CYP1A1). Polychlorinated Biphenyls 33-36 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 130-150 16291828-6 2006 However, treatment with TCDD and PCB 126 induced an AhR signaling response, as indicated by the expression of the AhR-target gene cytochrome P-450 1A1 (CYP1A1). Polychlorinated Biphenyls 33-36 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 152-158 15583370-1 2004 Recent epidemiologic studies have suggested that genetic polymorphisms in the cytochrome P-450 1A1 gene (CYP1A1) may affect the relation between environmental exposure to polychlorinated biphenyls (PCBs) and breast cancer risk. Polychlorinated Biphenyls 171-196 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 78-98 15583370-1 2004 Recent epidemiologic studies have suggested that genetic polymorphisms in the cytochrome P-450 1A1 gene (CYP1A1) may affect the relation between environmental exposure to polychlorinated biphenyls (PCBs) and breast cancer risk. Polychlorinated Biphenyls 171-196 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 105-111 15583370-1 2004 Recent epidemiologic studies have suggested that genetic polymorphisms in the cytochrome P-450 1A1 gene (CYP1A1) may affect the relation between environmental exposure to polychlorinated biphenyls (PCBs) and breast cancer risk. Polychlorinated Biphenyls 198-202 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 78-98 15583370-1 2004 Recent epidemiologic studies have suggested that genetic polymorphisms in the cytochrome P-450 1A1 gene (CYP1A1) may affect the relation between environmental exposure to polychlorinated biphenyls (PCBs) and breast cancer risk. Polychlorinated Biphenyls 198-202 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 105-111 15642161-7 2005 Multiplicative interactions were also observed between CYP1A1 M3-containing genotypes and elevated total PCBs among African American women (P value for likelihood ratio test = 0.10). Polychlorinated Biphenyls 105-109 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 55-61 15750580-2 2004 The CYP1 family is of particular interest in environmental toxicology because its members are dominant in the metabolism of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and aryl amines. Polychlorinated Biphenyls 165-190 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-8 15750580-2 2004 The CYP1 family is of particular interest in environmental toxicology because its members are dominant in the metabolism of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and aryl amines. Polychlorinated Biphenyls 192-196 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-8 7992230-4 1994 Exposure to contaminated rice oil containing large doses of polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs) also resulted in massive elevation of CYP 1A1 in human placenta but formation of DNA adducts directly from this exposure has not previously been reported. Polychlorinated Biphenyls 60-85 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 173-180 11054538-1 2000 Tetrapod cytochrome P4501 family (CYP1A1, CYP1A2 and CYP1B1) enzymes are most active in hydroxylating a variety of environmental contaminants including polyaromatic hydrocarbons (PAH), planar polychlorinated biphenyls and arylamines and thus play a pivotal role in the toxicology of these compounds. Polychlorinated Biphenyls 192-217 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 34-40 10403516-0 1999 Inductive and inhibitory effects of non-ortho-substituted polychlorinated biphenyls on estrogen metabolism and human cytochromes P450 1A1 and 1B1. Polychlorinated Biphenyls 58-83 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 117-145 10403516-1 1999 The effects of a series of non-ortho-substituted polychlorinated biphenyls (PCBs) on human cytochrome P450 1A1 (CYP1A1), a 17beta-estradiol (E2) 2-hydroxylase, and P450 1B1 (CYP1B1), an E2 4-hydroxylase, were investigated in HepG2 and MCF-7 cells. Polychlorinated Biphenyls 49-74 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 91-110 10403516-2 1999 Elevated rates of 2- and 4-methoxyestradiol (2- and 4-MeOE2) formation in PCB-treated cultures were measured as activities of CYP1A1 and CYP1B1, respectively. Polychlorinated Biphenyls 74-77 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 126-132 10403516-4 1999 Northern blot analyses confirmed that exposure of MCF-7 cells to PCBs 81, 126, and 39 caused highly elevated levels of the CYP1A1 and CYP1B1 mRNAs. Polychlorinated Biphenyls 65-69 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 123-129 10403516-5 1999 Exposure of MCF-7 cells to 3,3",4,4",5,5"-hexachlorobiphenyl (PCB 169) resulted in elevated levels of the CYP1A1 and CYP1B1 mRNAs, but did not cause elevated rates of E2 metabolism; rather, 4-MeOE2 production was depressed to below control levels in PCB 169-treated cultures. Polychlorinated Biphenyls 62-65 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 106-112 10403516-8 1999 These studies with one subgroup of PCBs, the non-ortho-substituted congeners, underscore the complexity and diversity of effects of PCBs, as individual congeners were found both to induce expression and to inhibit activity of human CYP1B1 and CYP1A1. Polychlorinated Biphenyls 132-136 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 243-249 9950238-1 1999 In experimental systems, polychlorinated biphenyls (PCBs) induce cytochrome P4501A1 (CYP1A1), which is involved in metabolism of steroid hormones and polycyclic aromatic hydrocarbons in humans. Polychlorinated Biphenyls 25-50 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 65-83 9950238-1 1999 In experimental systems, polychlorinated biphenyls (PCBs) induce cytochrome P4501A1 (CYP1A1), which is involved in metabolism of steroid hormones and polycyclic aromatic hydrocarbons in humans. Polychlorinated Biphenyls 25-50 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 85-91 9950238-1 1999 In experimental systems, polychlorinated biphenyls (PCBs) induce cytochrome P4501A1 (CYP1A1), which is involved in metabolism of steroid hormones and polycyclic aromatic hydrocarbons in humans. Polychlorinated Biphenyls 52-56 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 65-83 9950238-1 1999 In experimental systems, polychlorinated biphenyls (PCBs) induce cytochrome P4501A1 (CYP1A1), which is involved in metabolism of steroid hormones and polycyclic aromatic hydrocarbons in humans. Polychlorinated Biphenyls 52-56 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 85-91 12496044-2 2002 An individual"s susceptibility to the effects of PCBs may be partially determined by polymorphisms in the gene encoding the biotransformation enzyme cytochrome P450 1A1 (CYP1A1). Polychlorinated Biphenyls 49-53 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 149-168 12496044-2 2002 An individual"s susceptibility to the effects of PCBs may be partially determined by polymorphisms in the gene encoding the biotransformation enzyme cytochrome P450 1A1 (CYP1A1). Polychlorinated Biphenyls 49-53 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 170-176 12496044-4 2002 A previous case-control study provided evidence of an interaction between high exposures to PCBs and the CYP1A1-exon 7 polymorphism (the A to G transition at nucleotide 4889), leading to a significant increase in postmenopausal breast cancer risk. Polychlorinated Biphenyls 92-96 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 105-111 12496044-5 2002 We examined the interaction of PCBs with the CYP1A1-MspI (the T to C transition at nucleotide 6235) and exon 7 polymorphisms among 367 breast cancer case-control pairs (293 postmenopausal pairs) in the Nurses" Health Study. Polychlorinated Biphenyls 31-35 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 45-51 12423652-6 2002 These results indicate that PCB structure-activity relationships for the induction of human CYP1B1 are similar to those observed for human CYP1A1, but differ somewhat from what has been reported for induction of rat CYP1A1. Polychlorinated Biphenyls 28-31 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 139-145 12055053-1 2002 Some polychlorinated biphenyl (PCB) congeners are CYP1A1 inducers, and induction of this enzyme in the placenta has been linked to adverse effects on fetal development. Polychlorinated Biphenyls 5-29 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 50-56 12055053-1 2002 Some polychlorinated biphenyl (PCB) congeners are CYP1A1 inducers, and induction of this enzyme in the placenta has been linked to adverse effects on fetal development. Polychlorinated Biphenyls 31-34 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 50-56 12055053-2 2002 The objective of this study was to determine if the body burden of PCBs is related to placental CYP1A1 activity in Inuit women from Nunavik (northern Quebec), a population highly exposed to organochlorines. Polychlorinated Biphenyls 67-71 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 96-102 7992230-4 1994 Exposure to contaminated rice oil containing large doses of polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs) also resulted in massive elevation of CYP 1A1 in human placenta but formation of DNA adducts directly from this exposure has not previously been reported. Polychlorinated Biphenyls 87-91 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 173-180 25299844-2 2014 Several chemicals including polychlorinated biphenyls are metabolized by the dioxin-inducible enzyme CYP1A1; some of their metabolites can interact with the TH receptor. Polychlorinated Biphenyls 28-53 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 101-107 24926919-1 2014 Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor. Polychlorinated Biphenyls 15-40 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 113-119 24926919-1 2014 Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor. Polychlorinated Biphenyls 42-46 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 113-119 24926919-1 2014 Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor. Polychlorinated Biphenyls 70-74 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 113-119 24926919-5 2014 Of the investigated relationships between SNPs in the CYP1A1, CYP1A2 and CYP1B1 and six PCBs (congeners 118, 126, 156, 169, 170 and 206) that captures >80% of the variation of all PCBs measured, only the relationship between CYP1A1 rs2470893 was significantly related to PCB118 levels following strict adjustment for multiple testing (p=0.00011). Polychlorinated Biphenyls 88-92 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 54-60 24926919-5 2014 Of the investigated relationships between SNPs in the CYP1A1, CYP1A2 and CYP1B1 and six PCBs (congeners 118, 126, 156, 169, 170 and 206) that captures >80% of the variation of all PCBs measured, only the relationship between CYP1A1 rs2470893 was significantly related to PCB118 levels following strict adjustment for multiple testing (p=0.00011). Polychlorinated Biphenyls 88-92 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 228-234 24926919-5 2014 Of the investigated relationships between SNPs in the CYP1A1, CYP1A2 and CYP1B1 and six PCBs (congeners 118, 126, 156, 169, 170 and 206) that captures >80% of the variation of all PCBs measured, only the relationship between CYP1A1 rs2470893 was significantly related to PCB118 levels following strict adjustment for multiple testing (p=0.00011). Polychlorinated Biphenyls 183-187 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 54-60