PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12423652-0 2002 Induction of cytochrome P450 1B1 in MDA-MB-231 human breast cancer cells by non-ortho-substituted polychlorinated biphenyls. Polychlorinated Biphenyls 98-123 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 13-32 18583386-0 2008 Reactive oxygen species from the uncoupling of human cytochrome P450 1B1 may contribute to the carcinogenicity of dioxin-like polychlorinated biphenyls. Polychlorinated Biphenyls 126-151 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 53-72 18583386-7 2008 In the current study, the ability of three dioxin-like PCBs 3,3",4,4"-tetrachlorobiphenyl, 3,3",4,4",5-pentachlorobiphenyl and 3,3",4,4",5,5"-hexachlorobiphenyl (PCB169) to inhibit hCYP1B1 and stimulate the formation of ROS in V79MZ cells (which lack endogenous CYPs) expressing hCYP1B1 was demonstrated. Polychlorinated Biphenyls 55-59 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 181-188 18583386-7 2008 In the current study, the ability of three dioxin-like PCBs 3,3",4,4"-tetrachlorobiphenyl, 3,3",4,4",5-pentachlorobiphenyl and 3,3",4,4",5,5"-hexachlorobiphenyl (PCB169) to inhibit hCYP1B1 and stimulate the formation of ROS in V79MZ cells (which lack endogenous CYPs) expressing hCYP1B1 was demonstrated. Polychlorinated Biphenyls 55-59 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 279-286 12423652-1 2002 The effects of 12 non-ortho-substituted polychlorinated biphenyl (PCB) congeners on the induction of human cytochrome P450 1B1 (CYP1B1), an estradiol 4-hydroxylase, were investigated in MDA-MB-231 breast cancer cells. Polychlorinated Biphenyls 40-64 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 107-126 12423652-1 2002 The effects of 12 non-ortho-substituted polychlorinated biphenyl (PCB) congeners on the induction of human cytochrome P450 1B1 (CYP1B1), an estradiol 4-hydroxylase, were investigated in MDA-MB-231 breast cancer cells. Polychlorinated Biphenyls 40-64 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 128-134 12423652-1 2002 The effects of 12 non-ortho-substituted polychlorinated biphenyl (PCB) congeners on the induction of human cytochrome P450 1B1 (CYP1B1), an estradiol 4-hydroxylase, were investigated in MDA-MB-231 breast cancer cells. Polychlorinated Biphenyls 66-69 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 107-126 12423652-1 2002 The effects of 12 non-ortho-substituted polychlorinated biphenyl (PCB) congeners on the induction of human cytochrome P450 1B1 (CYP1B1), an estradiol 4-hydroxylase, were investigated in MDA-MB-231 breast cancer cells. Polychlorinated Biphenyls 66-69 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 128-134 12423652-4 2002 Exposure to 3,3",4,4",5,5"-hexachlorobiphenyl (PCB 169) resulted in elevated CYP1B1 mRNA and increased CYP1B1-promoter driven luciferase activity, but caused depressed rather than elevated rates of E(2) metabolism due to inhibition of CYP1B1. Polychlorinated Biphenyls 47-50 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 77-83 12423652-4 2002 Exposure to 3,3",4,4",5,5"-hexachlorobiphenyl (PCB 169) resulted in elevated CYP1B1 mRNA and increased CYP1B1-promoter driven luciferase activity, but caused depressed rather than elevated rates of E(2) metabolism due to inhibition of CYP1B1. Polychlorinated Biphenyls 47-50 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 103-109 12423652-4 2002 Exposure to 3,3",4,4",5,5"-hexachlorobiphenyl (PCB 169) resulted in elevated CYP1B1 mRNA and increased CYP1B1-promoter driven luciferase activity, but caused depressed rather than elevated rates of E(2) metabolism due to inhibition of CYP1B1. Polychlorinated Biphenyls 47-50 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 103-109 12423652-5 2002 The relative magnitudes of CYP1B1 induction by the PCB congeners, as determined by the three assays, were in close agreement, with the exception noted for PCB 169. Polychlorinated Biphenyls 51-54 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 27-33 12423652-6 2002 These results indicate that PCB structure-activity relationships for the induction of human CYP1B1 are similar to those observed for human CYP1A1, but differ somewhat from what has been reported for induction of rat CYP1A1. Polychlorinated Biphenyls 28-31 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 92-98 10403516-2 1999 Elevated rates of 2- and 4-methoxyestradiol (2- and 4-MeOE2) formation in PCB-treated cultures were measured as activities of CYP1A1 and CYP1B1, respectively. Polychlorinated Biphenyls 74-77 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 137-143 11054538-1 2000 Tetrapod cytochrome P4501 family (CYP1A1, CYP1A2 and CYP1B1) enzymes are most active in hydroxylating a variety of environmental contaminants including polyaromatic hydrocarbons (PAH), planar polychlorinated biphenyls and arylamines and thus play a pivotal role in the toxicology of these compounds. Polychlorinated Biphenyls 192-217 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 53-59 10403516-4 1999 Northern blot analyses confirmed that exposure of MCF-7 cells to PCBs 81, 126, and 39 caused highly elevated levels of the CYP1A1 and CYP1B1 mRNAs. Polychlorinated Biphenyls 65-69 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 134-140 10403516-5 1999 Exposure of MCF-7 cells to 3,3",4,4",5,5"-hexachlorobiphenyl (PCB 169) resulted in elevated levels of the CYP1A1 and CYP1B1 mRNAs, but did not cause elevated rates of E2 metabolism; rather, 4-MeOE2 production was depressed to below control levels in PCB 169-treated cultures. Polychlorinated Biphenyls 62-65 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 117-123 10403516-7 1999 In microsomal assays, inhibition of cDNA-expressed human CYP1B1 by PCBs 169 and 126 was demonstrated. Polychlorinated Biphenyls 67-71 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 57-63 10403516-8 1999 These studies with one subgroup of PCBs, the non-ortho-substituted congeners, underscore the complexity and diversity of effects of PCBs, as individual congeners were found both to induce expression and to inhibit activity of human CYP1B1 and CYP1A1. Polychlorinated Biphenyls 35-39 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 232-238 10403516-8 1999 These studies with one subgroup of PCBs, the non-ortho-substituted congeners, underscore the complexity and diversity of effects of PCBs, as individual congeners were found both to induce expression and to inhibit activity of human CYP1B1 and CYP1A1. Polychlorinated Biphenyls 132-136 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 232-238 405059-0 1977 Induction of hepatic aryl hydrocarbon hydroxylase in salmon exposed to petroleum dissolved in seawater and to petroleum and polychlorinated biphenyls, separate and together, in food. Polychlorinated Biphenyls 124-149 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-49 6775632-0 1980 Reconstituted human breast milk PCBs as potent inducers of aryl hydrocarbon hydroxylase. Polychlorinated Biphenyls 32-36 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 59-87 31733235-0 2020 Human CYP1B1-dependent genotoxicity of dioxin-like polychlorinated biphenyls in mammalian cells. Polychlorinated Biphenyls 51-76 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 6-12 31733235-10 2020 This study demonstrates that some DL-PCBs are clastogenic in mammalian cells following metabolic activation by human CYP1B1. Polychlorinated Biphenyls 37-41 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 117-123 24926919-1 2014 Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor. Polychlorinated Biphenyls 15-40 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 132-138 24926919-1 2014 Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor. Polychlorinated Biphenyls 42-46 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 132-138 24926919-1 2014 Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor. Polychlorinated Biphenyls 70-74 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 132-138 24926919-5 2014 Of the investigated relationships between SNPs in the CYP1A1, CYP1A2 and CYP1B1 and six PCBs (congeners 118, 126, 156, 169, 170 and 206) that captures >80% of the variation of all PCBs measured, only the relationship between CYP1A1 rs2470893 was significantly related to PCB118 levels following strict adjustment for multiple testing (p=0.00011). Polychlorinated Biphenyls 88-92 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 73-79 24926919-5 2014 Of the investigated relationships between SNPs in the CYP1A1, CYP1A2 and CYP1B1 and six PCBs (congeners 118, 126, 156, 169, 170 and 206) that captures >80% of the variation of all PCBs measured, only the relationship between CYP1A1 rs2470893 was significantly related to PCB118 levels following strict adjustment for multiple testing (p=0.00011). Polychlorinated Biphenyls 183-187 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 73-79 24926919-10 2014 Genetic variation in CYP1A2 and CYP1B1 might also be associated with other PCBs. Polychlorinated Biphenyls 75-79 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 32-38 23869875-4 2014 Our objective was to assess whether CYP1B1 and COMT gene polymorphisms modulate the effect of PCBs in breast cancer risk, among postmenopausal Danish women. Polychlorinated Biphenyls 94-98 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 36-42 27588699-9 2016 While the CYP 1A1 seems more suitable for toxicity evaluation of PCDD/Fs, the CYP 1B1 is more apt for PCDFs and PCBs and reflects different pathways. Polychlorinated Biphenyls 112-116 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 78-85 23785672-7 2013 We observed a significant difference in serum polychlorinated biphenyl (CB-153) and the pesticide 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p"-DDE) levels between Inuit and Europeans, and for Inuit also associations between the POP levels and genotypes for CYP1A1, CYP1B1 and COMT. Polychlorinated Biphenyls 46-70 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 272-278