PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27281544-2	2016	CYP2B6, a member of CYP450, is well known for being a highly inducible and polymorphic enzyme and for its important role in the oxidative metabolism of environmental pollutants, such as the Polybrominated Diphenyl Ethers (PBDEs) and Polychlorinated Biphenyls (PCBs).	Polychlorinated Biphenyls	233-258	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-6	
27281544-4	2016	In this work, a computational approach was carried out to study the interactions of 41 POPs (17 PBDEs, 17 PCBs, and 7 Dioxins) with four CYP2B6 protein structures downloaded from PDB data base (PDB: 3UA5, 3QOA, 3QU8 and 4I91) using molecular docking protocols with AutoDock Vina.	Polychlorinated Biphenyls	106-110	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	137-143	
27281544-2	2016	CYP2B6, a member of CYP450, is well known for being a highly inducible and polymorphic enzyme and for its important role in the oxidative metabolism of environmental pollutants, such as the Polybrominated Diphenyl Ethers (PBDEs) and Polychlorinated Biphenyls (PCBs).	Polychlorinated Biphenyls	260-264	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-6	
27281544-3	2016	However the mechanisms of interaction of PBDEs and PCBs with CYP2B6 is not entirely known.	Polychlorinated Biphenyls	51-55	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	61-67	
25839716-0	2015	Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample.	Polychlorinated Biphenyls	50-75	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	109-115	
25651810-6	2016	In vitro studies demonstrate that C-PCBs with a 2,3,6-trichlorosubstitution pattern in one phenyl ring are readily oxidized to hydroxylated PCB metabolites (HO-PCBs) by P450 enzymes, such as rat CYP2B1, human CYP2B6, and dog CYP2B11.	Polychlorinated Biphenyls	36-39	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	209-215	
25839716-11	2015	CONCLUSIONS: In our study, we found plasma levels of four lower-chlorinated PCBs to be significantly associated with the genetic region mapping to the CYP2B6 locus.	Polychlorinated Biphenyls	76-80	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	151-157	
25839716-12	2015	These findings show that CYP2B6 is of importance for the metabolism of PCBs in humans, and may help to identify individuals who may be susceptible to PCB toxicity.	Polychlorinated Biphenyls	71-75	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	25-31	
19209593-4	2009	Enantioselectivity was also observed for PCBs 45 (EF = 0.437) and 132 (EF = 0.537) incubated at that concentration with human CYP 2B6.	Polychlorinated Biphenyls	41-45	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	126-133	
15294351-1	2004	The effects of polychlorinated biphenyls (PCBs) on human cytochrome P450 aromatase activity in vitro were investigated using a commercially available microsomal fraction obtained from baculovirus infected insects that had been transfected with the human CYP19 gene and cytochrome P450 reductase.	Polychlorinated Biphenyls	42-46	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	68-72	
8552139-0	1995	DNA adducts and P450 induction in human, rat and avian liver cells after exposure to polychlorobiphenyls.	Polychlorinated Biphenyls	85-104	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	16-20	
30576102-0	2019	Human CYP2A6, CYP2B6, AND CYP2E1 Atropselectively Metabolize Polychlorinated Biphenyls to Hydroxylated Metabolites.	Polychlorinated Biphenyls	61-86	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	14-20	
30576102-4	2019	In silico predictions with ADMET Predictor and MetaDrug software suggested a role of CYP1A2, CYP2A6, CYP2B6, CYP2E1, and CYP3A4 in the metabolism of chiral PCBs.	Polychlorinated Biphenyls	156-160	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	101-107	
30576102-10	2019	These findings suggest that CYP2A6 and CYP2B6 play an important role in the oxidation of neurotoxic PCBs to chiral OH-PCBs in humans.	Polychlorinated Biphenyls	100-104	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	39-45