PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17051818-0 2006 Induced CYP1A2 activity as a phenotypic biomarker in humans highly exposed to certain PCBs/PCDFs. Polychlorinated Biphenyls 86-90 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 8-14 21797774-1 2011 Smoking appears to enhance the body"s clearance of dioxins and dioxin-like polychlorinated biphenyls (PCB) by inducing CYP1A2 activity based on studies with a limited number of participants. Polychlorinated Biphenyls 75-100 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 119-125 21797774-1 2011 Smoking appears to enhance the body"s clearance of dioxins and dioxin-like polychlorinated biphenyls (PCB) by inducing CYP1A2 activity based on studies with a limited number of participants. Polychlorinated Biphenyls 102-105 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 119-125 20961953-0 2011 In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes. Polychlorinated Biphenyls 58-83 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 119-125 17089110-0 2006 Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls. Polychlorinated Biphenyls 81-106 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 27-33 17089110-1 2006 OBJECTIVE: To investigate the CYP1A2 phenotype distribution in a population with an increased exposure to polychlorinated biphenyls (PCBs) that would likely induce an increased activity of this enzyme. Polychlorinated Biphenyls 106-131 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 30-36 17089110-1 2006 OBJECTIVE: To investigate the CYP1A2 phenotype distribution in a population with an increased exposure to polychlorinated biphenyls (PCBs) that would likely induce an increased activity of this enzyme. Polychlorinated Biphenyls 133-137 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 30-36 15659567-6 2005 Rat and human CYP1A2 enzymatic activity is inhibited by TCDD, PCDD, TCDF, 4-PeCDF, and PCBs 126, 169, 105, 118, and 156 in a concentration-dependent manner. Polychlorinated Biphenyls 87-91 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 14-20 30576102-4 2019 In silico predictions with ADMET Predictor and MetaDrug software suggested a role of CYP1A2, CYP2A6, CYP2B6, CYP2E1, and CYP3A4 in the metabolism of chiral PCBs. Polychlorinated Biphenyls 156-160 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 85-91 15743714-3 2005 To address this issue, a study was conducted of CYP1A2 activity among Native Americans exposed to polychlorinated biphenyls (PCBs) from the consumption of fish from the St. Lawrence River. Polychlorinated Biphenyls 98-123 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 48-54 15743714-3 2005 To address this issue, a study was conducted of CYP1A2 activity among Native Americans exposed to polychlorinated biphenyls (PCBs) from the consumption of fish from the St. Lawrence River. Polychlorinated Biphenyls 125-129 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 48-54 15743714-8 2005 The results support the notion that CYP1A2 activity may be a marker of an early biological effect of exposure to PCBs in humans and that the CBT may be a useful tool to monitor such effects. Polychlorinated Biphenyls 113-117 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 36-42 31159144-0 2019 Non-coplanar and coplanar polychlorinated biphenyls potentiate genotoxicity of aflatoxin B1 in a human hepatocyte line by enhancing CYP1A2 and CYP3A4 expression. Polychlorinated Biphenyls 26-51 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 132-138 11054538-1 2000 Tetrapod cytochrome P4501 family (CYP1A1, CYP1A2 and CYP1B1) enzymes are most active in hydroxylating a variety of environmental contaminants including polyaromatic hydrocarbons (PAH), planar polychlorinated biphenyls and arylamines and thus play a pivotal role in the toxicology of these compounds. Polychlorinated Biphenyls 192-217 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 42-48 33299007-7 2020 Following in vitro analysis using a liver-like CYP-cocktail, containing human orthologues of dCYP1A2, we confirm human CYP1A2 as a PCB 28 metabolizing enzyme. Polychlorinated Biphenyls 131-134 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 94-100 23168330-2 2013 In a previous study of the Yucheng cohort of humans who were exposed to high toxic levels of dioxin-like chemicals (PCDFs and PCBs), we reported marked induction of cytochrome P450 1A2 (CYP1A2) activity and this induction was an excellent biomarker of the exposure and adverse human health effects seen in the Yucheng cohort. Polychlorinated Biphenyls 126-130 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 165-184 23168330-2 2013 In a previous study of the Yucheng cohort of humans who were exposed to high toxic levels of dioxin-like chemicals (PCDFs and PCBs), we reported marked induction of cytochrome P450 1A2 (CYP1A2) activity and this induction was an excellent biomarker of the exposure and adverse human health effects seen in the Yucheng cohort. Polychlorinated Biphenyls 126-130 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 186-192 24926919-1 2014 Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor. Polychlorinated Biphenyls 15-40 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 121-127 24926919-1 2014 Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor. Polychlorinated Biphenyls 42-46 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 121-127 24926919-1 2014 Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor. Polychlorinated Biphenyls 70-74 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 121-127 24926919-5 2014 Of the investigated relationships between SNPs in the CYP1A1, CYP1A2 and CYP1B1 and six PCBs (congeners 118, 126, 156, 169, 170 and 206) that captures >80% of the variation of all PCBs measured, only the relationship between CYP1A1 rs2470893 was significantly related to PCB118 levels following strict adjustment for multiple testing (p=0.00011). Polychlorinated Biphenyls 88-92 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 62-68 24926919-5 2014 Of the investigated relationships between SNPs in the CYP1A1, CYP1A2 and CYP1B1 and six PCBs (congeners 118, 126, 156, 169, 170 and 206) that captures >80% of the variation of all PCBs measured, only the relationship between CYP1A1 rs2470893 was significantly related to PCB118 levels following strict adjustment for multiple testing (p=0.00011). Polychlorinated Biphenyls 183-187 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 62-68 24926919-10 2014 Genetic variation in CYP1A2 and CYP1B1 might also be associated with other PCBs. Polychlorinated Biphenyls 75-79 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 21-27